N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity
Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Landucci, Elisa [verfasserIn] Gencarelli, Manuela [verfasserIn] Mazzantini, Costanza [verfasserIn] Laurino, Annunziatina [verfasserIn] Pellegrini-Giampietro, Domenico Edoardo [verfasserIn] Raimondi, Laura [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Neurochemistry international - Amsterdam [u.a.] : Elsevier Science, 1980, 129 |
|---|---|
| Übergeordnetes Werk: |
volume:129 |
| DOI / URN: |
10.1016/j.neuint.2019.05.004 |
|---|
| Katalog-ID: |
ELV002719746 |
|---|
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| 245 | 1 | 0 | |a N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity |
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| 520 | |a Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. | ||
| 650 | 4 | |a 3-iodothyroanmine | |
| 650 | 4 | |a T1AM | |
| 650 | 4 | |a 3-iodothyroacetic acid | |
| 650 | 4 | |a TA1 | |
| 650 | 4 | |a Trace amine associated receptor isoform 1 | |
| 650 | 4 | |a TAAR1 | |
| 650 | 4 | |a Protein kinase B | |
| 650 | 4 | |a AKT | |
| 650 | 4 | |a Protein kinase A | |
| 650 | 4 | |a PKA | |
| 650 | 4 | |a Organotypic hippocampal slices | |
| 700 | 1 | |a Gencarelli, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzantini, Costanza |e verfasserin |4 aut | |
| 700 | 1 | |a Laurino, Annunziatina |e verfasserin |4 aut | |
| 700 | 1 | |a Pellegrini-Giampietro, Domenico Edoardo |e verfasserin |4 aut | |
| 700 | 1 | |a Raimondi, Laura |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurochemistry international |d Amsterdam [u.a.] : Elsevier Science, 1980 |g 129 |h Online-Ressource |w (DE-627)306661241 |w (DE-600)1500654-2 |w (DE-576)081986823 |x 1872-9754 |7 nnns |
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10.1016/j.neuint.2019.05.004 doi (DE-627)ELV002719746 (ELSEVIER)S0197-0186(19)30147-0 DE-627 ger DE-627 rda eng 610 540 DE-600 44.90 bkl Landucci, Elisa verfasserin aut N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. 3-iodothyroanmine T1AM 3-iodothyroacetic acid TA1 Trace amine associated receptor isoform 1 TAAR1 Protein kinase B AKT Protein kinase A PKA Organotypic hippocampal slices Gencarelli, Manuela verfasserin aut Mazzantini, Costanza verfasserin aut Laurino, Annunziatina verfasserin aut Pellegrini-Giampietro, Domenico Edoardo verfasserin aut Raimondi, Laura verfasserin aut Enthalten in Neurochemistry international Amsterdam [u.a.] : Elsevier Science, 1980 129 Online-Ressource (DE-627)306661241 (DE-600)1500654-2 (DE-576)081986823 1872-9754 nnns volume:129 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 129 |
| spelling |
10.1016/j.neuint.2019.05.004 doi (DE-627)ELV002719746 (ELSEVIER)S0197-0186(19)30147-0 DE-627 ger DE-627 rda eng 610 540 DE-600 44.90 bkl Landucci, Elisa verfasserin aut N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. 3-iodothyroanmine T1AM 3-iodothyroacetic acid TA1 Trace amine associated receptor isoform 1 TAAR1 Protein kinase B AKT Protein kinase A PKA Organotypic hippocampal slices Gencarelli, Manuela verfasserin aut Mazzantini, Costanza verfasserin aut Laurino, Annunziatina verfasserin aut Pellegrini-Giampietro, Domenico Edoardo verfasserin aut Raimondi, Laura verfasserin aut Enthalten in Neurochemistry international Amsterdam [u.a.] : Elsevier Science, 1980 129 Online-Ressource (DE-627)306661241 (DE-600)1500654-2 (DE-576)081986823 1872-9754 nnns volume:129 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 129 |
| allfields_unstemmed |
10.1016/j.neuint.2019.05.004 doi (DE-627)ELV002719746 (ELSEVIER)S0197-0186(19)30147-0 DE-627 ger DE-627 rda eng 610 540 DE-600 44.90 bkl Landucci, Elisa verfasserin aut N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. 3-iodothyroanmine T1AM 3-iodothyroacetic acid TA1 Trace amine associated receptor isoform 1 TAAR1 Protein kinase B AKT Protein kinase A PKA Organotypic hippocampal slices Gencarelli, Manuela verfasserin aut Mazzantini, Costanza verfasserin aut Laurino, Annunziatina verfasserin aut Pellegrini-Giampietro, Domenico Edoardo verfasserin aut Raimondi, Laura verfasserin aut Enthalten in Neurochemistry international Amsterdam [u.a.] : Elsevier Science, 1980 129 Online-Ressource (DE-627)306661241 (DE-600)1500654-2 (DE-576)081986823 1872-9754 nnns volume:129 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 129 |
| allfieldsGer |
10.1016/j.neuint.2019.05.004 doi (DE-627)ELV002719746 (ELSEVIER)S0197-0186(19)30147-0 DE-627 ger DE-627 rda eng 610 540 DE-600 44.90 bkl Landucci, Elisa verfasserin aut N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. 3-iodothyroanmine T1AM 3-iodothyroacetic acid TA1 Trace amine associated receptor isoform 1 TAAR1 Protein kinase B AKT Protein kinase A PKA Organotypic hippocampal slices Gencarelli, Manuela verfasserin aut Mazzantini, Costanza verfasserin aut Laurino, Annunziatina verfasserin aut Pellegrini-Giampietro, Domenico Edoardo verfasserin aut Raimondi, Laura verfasserin aut Enthalten in Neurochemistry international Amsterdam [u.a.] : Elsevier Science, 1980 129 Online-Ressource (DE-627)306661241 (DE-600)1500654-2 (DE-576)081986823 1872-9754 nnns volume:129 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 129 |
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610 540 DE-600 44.90 bkl N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity 3-iodothyroanmine T1AM 3-iodothyroacetic acid TA1 Trace amine associated receptor isoform 1 TAAR1 Protein kinase B AKT Protein kinase A PKA Organotypic hippocampal slices |
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ddc 610 bkl 44.90 misc 3-iodothyroanmine misc T1AM misc 3-iodothyroacetic acid misc TA1 misc Trace amine associated receptor isoform 1 misc TAAR1 misc Protein kinase B misc AKT misc Protein kinase A misc PKA misc Organotypic hippocampal slices |
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N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity |
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N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity |
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Landucci, Elisa Gencarelli, Manuela Mazzantini, Costanza Laurino, Annunziatina Pellegrini-Giampietro, Domenico Edoardo Raimondi, Laura |
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n-(3-ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (epptb) prevents 3-iodothyronamine (t1am)-induced neuroprotection against kainic acid toxicity |
| title_auth |
N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity |
| abstract |
Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. |
| abstractGer |
Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. |
| abstract_unstemmed |
Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (KA)-induced excitotoxicity included the activation of the trace amine associated receptor isoform 1 (TAAR1), one of T1AM targets. |
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| title_short |
N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity |
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