A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Suurs, Frans V. [verfasserIn] Lub-de Hooge, Marjolijn N. [verfasserIn] de Vries, Elisabeth G.E. [verfasserIn] de Groot, Derk Jan A. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials

Übergeordnetes Werk:	Enthalten in: Pharmacology & therapeutics - Amsterdam [u.a.] : Elsevier Science, 1979, 201, Seite 103-119
Übergeordnetes Werk:	volume:201 ; pages:103-119

DOI / URN:	10.1016/j.pharmthera.2019.04.006

Katalog-ID:	ELV002750252

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520			\|a Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges.
650		4	\|a Bispecific antibody (bsAb)
650		4	\|a Antibody constructs
650		4	\|a Oncology
650		4	\|a Cancer immunotherapy
650		4	\|a Clinical trials
700	1		\|a Lub-de Hooge, Marjolijn N. \|e verfasserin \|4 aut
700	1		\|a de Vries, Elisabeth G.E. \|e verfasserin \|4 aut
700	1		\|a de Groot, Derk Jan A. \|e verfasserin \|4 aut
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912			\|a GBV_ILN_2507
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912			\|a GBV_ILN_4326
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936	b	k	\|a 44.38 \|j Pharmakologie
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allfields	10.1016/j.pharmthera.2019.04.006 doi (DE-627)ELV002750252 (ELSEVIER)S0163-7258(19)30069-5 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Suurs, Frans V. verfasserin aut A review of bispecific antibodies and antibody constructs in oncology and clinical challenges 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges. Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials Lub-de Hooge, Marjolijn N. verfasserin aut de Vries, Elisabeth G.E. verfasserin aut de Groot, Derk Jan A. verfasserin aut Enthalten in Pharmacology & therapeutics Amsterdam [u.a.] : Elsevier Science, 1979 201, Seite 103-119 Online-Ressource (DE-627)306661330 (DE-600)1500663-3 (DE-576)081986904 1879-016X nnns volume:201 pages:103-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 201 103-119
spelling	10.1016/j.pharmthera.2019.04.006 doi (DE-627)ELV002750252 (ELSEVIER)S0163-7258(19)30069-5 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Suurs, Frans V. verfasserin aut A review of bispecific antibodies and antibody constructs in oncology and clinical challenges 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges. Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials Lub-de Hooge, Marjolijn N. verfasserin aut de Vries, Elisabeth G.E. verfasserin aut de Groot, Derk Jan A. verfasserin aut Enthalten in Pharmacology & therapeutics Amsterdam [u.a.] : Elsevier Science, 1979 201, Seite 103-119 Online-Ressource (DE-627)306661330 (DE-600)1500663-3 (DE-576)081986904 1879-016X nnns volume:201 pages:103-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 201 103-119
allfields_unstemmed	10.1016/j.pharmthera.2019.04.006 doi (DE-627)ELV002750252 (ELSEVIER)S0163-7258(19)30069-5 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Suurs, Frans V. verfasserin aut A review of bispecific antibodies and antibody constructs in oncology and clinical challenges 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges. Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials Lub-de Hooge, Marjolijn N. verfasserin aut de Vries, Elisabeth G.E. verfasserin aut de Groot, Derk Jan A. verfasserin aut Enthalten in Pharmacology & therapeutics Amsterdam [u.a.] : Elsevier Science, 1979 201, Seite 103-119 Online-Ressource (DE-627)306661330 (DE-600)1500663-3 (DE-576)081986904 1879-016X nnns volume:201 pages:103-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 201 103-119
allfieldsGer	10.1016/j.pharmthera.2019.04.006 doi (DE-627)ELV002750252 (ELSEVIER)S0163-7258(19)30069-5 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Suurs, Frans V. verfasserin aut A review of bispecific antibodies and antibody constructs in oncology and clinical challenges 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges. Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials Lub-de Hooge, Marjolijn N. verfasserin aut de Vries, Elisabeth G.E. verfasserin aut de Groot, Derk Jan A. verfasserin aut Enthalten in Pharmacology & therapeutics Amsterdam [u.a.] : Elsevier Science, 1979 201, Seite 103-119 Online-Ressource (DE-627)306661330 (DE-600)1500663-3 (DE-576)081986904 1879-016X nnns volume:201 pages:103-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 201 103-119
allfieldsSound	10.1016/j.pharmthera.2019.04.006 doi (DE-627)ELV002750252 (ELSEVIER)S0163-7258(19)30069-5 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Suurs, Frans V. verfasserin aut A review of bispecific antibodies and antibody constructs in oncology and clinical challenges 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges. Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials Lub-de Hooge, Marjolijn N. verfasserin aut de Vries, Elisabeth G.E. verfasserin aut de Groot, Derk Jan A. verfasserin aut Enthalten in Pharmacology & therapeutics Amsterdam [u.a.] : Elsevier Science, 1979 201, Seite 103-119 Online-Ressource (DE-627)306661330 (DE-600)1500663-3 (DE-576)081986904 1879-016X nnns volume:201 pages:103-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 201 103-119
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source	Enthalten in Pharmacology & therapeutics 201, Seite 103-119 volume:201 pages:103-119
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topic_facet	Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials
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authorswithroles_txt_mv	Suurs, Frans V. @@aut@@ Lub-de Hooge, Marjolijn N. @@aut@@ de Vries, Elisabeth G.E. @@aut@@ de Groot, Derk Jan A. @@aut@@
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author	Suurs, Frans V.
spellingShingle	Suurs, Frans V. ddc 610 fid PHARM bkl 44.38 misc Bispecific antibody (bsAb) misc Antibody constructs misc Oncology misc Cancer immunotherapy misc Clinical trials A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
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topic_title	610 DE-600 PHARM DE-84 fid 44.38 bkl A review of bispecific antibodies and antibody constructs in oncology and clinical challenges Bispecific antibody (bsAb) Antibody constructs Oncology Cancer immunotherapy Clinical trials
topic	ddc 610 fid PHARM bkl 44.38 misc Bispecific antibody (bsAb) misc Antibody constructs misc Oncology misc Cancer immunotherapy misc Clinical trials
topic_unstemmed	ddc 610 fid PHARM bkl 44.38 misc Bispecific antibody (bsAb) misc Antibody constructs misc Oncology misc Cancer immunotherapy misc Clinical trials
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title	A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
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title_full	A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
author_sort	Suurs, Frans V.
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author_browse	Suurs, Frans V. Lub-de Hooge, Marjolijn N. de Vries, Elisabeth G.E. de Groot, Derk Jan A.
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title_sort	a review of bispecific antibodies and antibody constructs in oncology and clinical challenges
title_auth	A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
abstract	Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges.
abstractGer	Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges.
abstract_unstemmed	Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions. The majority of bsAbs engage immune cells to destroy tumor cells. However, some bsAbs are also used to deliver payloads to tumors or to block tumor signaling pathways. This review provides insight into the choice of construct for bsAbs, summarizes the clinical development of bsAbs in oncology and identifies subsequent challenges.
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title_short	A review of bispecific antibodies and antibody constructs in oncology and clinical challenges
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author2	Lub-de Hooge, Marjolijn N. de Vries, Elisabeth G.E. de Groot, Derk Jan A.
author2Str	Lub-de Hooge, Marjolijn N. de Vries, Elisabeth G.E. de Groot, Derk Jan A.
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doi_str	10.1016/j.pharmthera.2019.04.006
up_date	2024-07-06T17:19:32.217Z
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A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

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