Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants

Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prema...
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Autor*in:	Caserta, Mary T. [verfasserIn] Yang, Hongmei [verfasserIn] Bandyopadhyay, Sanjukta [verfasserIn] Qiu, Xing [verfasserIn] Gill, Steven R. [verfasserIn] Java, James [verfasserIn] McDavid, Andrew [verfasserIn] Falsey, Ann R. [verfasserIn] Topham, David J. [verfasserIn] Holden-Wiltse, Jeanne [verfasserIn] Scheible, Kristin [verfasserIn] Pryhuber, Gloria [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	Enthalten in: The journal of pediatrics - St. Louis, Mo. : Mosby, 1932, 214, Seite 12-19.e3
Übergeordnetes Werk:	volume:214 ; pages:12-19.e3

DOI / URN:	10.1016/j.jpeds.2019.06.061

Katalog-ID:	ELV003036987

Internformat


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100	1		\|a Caserta, Mary T. \|e verfasserin \|4 aut
245	1	0	\|a Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
264		1	\|c 2019
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score.
700	1		\|a Yang, Hongmei \|e verfasserin \|4 aut
700	1		\|a Bandyopadhyay, Sanjukta \|e verfasserin \|4 aut
700	1		\|a Qiu, Xing \|e verfasserin \|4 aut
700	1		\|a Gill, Steven R. \|e verfasserin \|4 aut
700	1		\|a Java, James \|e verfasserin \|4 aut
700	1		\|a McDavid, Andrew \|e verfasserin \|4 aut
700	1		\|a Falsey, Ann R. \|e verfasserin \|4 aut
700	1		\|a Topham, David J. \|e verfasserin \|4 aut
700	1		\|a Holden-Wiltse, Jeanne \|e verfasserin \|4 aut
700	1		\|a Scheible, Kristin \|e verfasserin \|4 aut
700	1		\|a Pryhuber, Gloria \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t The journal of pediatrics \|d St. Louis, Mo. : Mosby, 1932 \|g 214, Seite 12-19.e3 \|h Online-Ressource \|w (DE-627)315966548 \|w (DE-600)2005245-5 \|w (DE-576)090887085 \|x 1097-6833 \|7 nnns
773	1	8	\|g volume:214 \|g pages:12-19.e3
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912			\|a GBV_ILN_70
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912			\|a GBV_ILN_74
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
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912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.67 \|j Kinderheilkunde
951			\|a AR
952			\|d 214 \|h 12-19.e3

Indexfelder

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publishDate	2019
allfields	10.1016/j.jpeds.2019.06.061 doi (DE-627)ELV003036987 (ELSEVIER)S0022-3476(19)30825-X DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Caserta, Mary T. verfasserin aut Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score. Yang, Hongmei verfasserin aut Bandyopadhyay, Sanjukta verfasserin aut Qiu, Xing verfasserin aut Gill, Steven R. verfasserin aut Java, James verfasserin aut McDavid, Andrew verfasserin aut Falsey, Ann R. verfasserin aut Topham, David J. verfasserin aut Holden-Wiltse, Jeanne verfasserin aut Scheible, Kristin verfasserin aut Pryhuber, Gloria verfasserin aut Enthalten in The journal of pediatrics St. Louis, Mo. : Mosby, 1932 214, Seite 12-19.e3 Online-Ressource (DE-627)315966548 (DE-600)2005245-5 (DE-576)090887085 1097-6833 nnns volume:214 pages:12-19.e3 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 214 12-19.e3
spelling	10.1016/j.jpeds.2019.06.061 doi (DE-627)ELV003036987 (ELSEVIER)S0022-3476(19)30825-X DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Caserta, Mary T. verfasserin aut Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score. Yang, Hongmei verfasserin aut Bandyopadhyay, Sanjukta verfasserin aut Qiu, Xing verfasserin aut Gill, Steven R. verfasserin aut Java, James verfasserin aut McDavid, Andrew verfasserin aut Falsey, Ann R. verfasserin aut Topham, David J. verfasserin aut Holden-Wiltse, Jeanne verfasserin aut Scheible, Kristin verfasserin aut Pryhuber, Gloria verfasserin aut Enthalten in The journal of pediatrics St. Louis, Mo. : Mosby, 1932 214, Seite 12-19.e3 Online-Ressource (DE-627)315966548 (DE-600)2005245-5 (DE-576)090887085 1097-6833 nnns volume:214 pages:12-19.e3 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 214 12-19.e3
allfields_unstemmed	10.1016/j.jpeds.2019.06.061 doi (DE-627)ELV003036987 (ELSEVIER)S0022-3476(19)30825-X DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Caserta, Mary T. verfasserin aut Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score. Yang, Hongmei verfasserin aut Bandyopadhyay, Sanjukta verfasserin aut Qiu, Xing verfasserin aut Gill, Steven R. verfasserin aut Java, James verfasserin aut McDavid, Andrew verfasserin aut Falsey, Ann R. verfasserin aut Topham, David J. verfasserin aut Holden-Wiltse, Jeanne verfasserin aut Scheible, Kristin verfasserin aut Pryhuber, Gloria verfasserin aut Enthalten in The journal of pediatrics St. Louis, Mo. : Mosby, 1932 214, Seite 12-19.e3 Online-Ressource (DE-627)315966548 (DE-600)2005245-5 (DE-576)090887085 1097-6833 nnns volume:214 pages:12-19.e3 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 214 12-19.e3
allfieldsGer	10.1016/j.jpeds.2019.06.061 doi (DE-627)ELV003036987 (ELSEVIER)S0022-3476(19)30825-X DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Caserta, Mary T. verfasserin aut Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score. Yang, Hongmei verfasserin aut Bandyopadhyay, Sanjukta verfasserin aut Qiu, Xing verfasserin aut Gill, Steven R. verfasserin aut Java, James verfasserin aut McDavid, Andrew verfasserin aut Falsey, Ann R. verfasserin aut Topham, David J. verfasserin aut Holden-Wiltse, Jeanne verfasserin aut Scheible, Kristin verfasserin aut Pryhuber, Gloria verfasserin aut Enthalten in The journal of pediatrics St. Louis, Mo. : Mosby, 1932 214, Seite 12-19.e3 Online-Ressource (DE-627)315966548 (DE-600)2005245-5 (DE-576)090887085 1097-6833 nnns volume:214 pages:12-19.e3 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 214 12-19.e3
allfieldsSound	10.1016/j.jpeds.2019.06.061 doi (DE-627)ELV003036987 (ELSEVIER)S0022-3476(19)30825-X DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Caserta, Mary T. verfasserin aut Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score. Yang, Hongmei verfasserin aut Bandyopadhyay, Sanjukta verfasserin aut Qiu, Xing verfasserin aut Gill, Steven R. verfasserin aut Java, James verfasserin aut McDavid, Andrew verfasserin aut Falsey, Ann R. verfasserin aut Topham, David J. verfasserin aut Holden-Wiltse, Jeanne verfasserin aut Scheible, Kristin verfasserin aut Pryhuber, Gloria verfasserin aut Enthalten in The journal of pediatrics St. Louis, Mo. : Mosby, 1932 214, Seite 12-19.e3 Online-Ressource (DE-627)315966548 (DE-600)2005245-5 (DE-576)090887085 1097-6833 nnns volume:214 pages:12-19.e3 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 214 12-19.e3
language	English
source	Enthalten in The journal of pediatrics 214, Seite 12-19.e3 volume:214 pages:12-19.e3
sourceStr	Enthalten in The journal of pediatrics 214, Seite 12-19.e3 volume:214 pages:12-19.e3
format_phy_str_mv	Article
bklname	Kinderheilkunde
institution	findex.gbv.de
dewey-raw	610
isfreeaccess_bool	false
container_title	The journal of pediatrics
authorswithroles_txt_mv	Caserta, Mary T. @@aut@@ Yang, Hongmei @@aut@@ Bandyopadhyay, Sanjukta @@aut@@ Qiu, Xing @@aut@@ Gill, Steven R. @@aut@@ Java, James @@aut@@ McDavid, Andrew @@aut@@ Falsey, Ann R. @@aut@@ Topham, David J. @@aut@@ Holden-Wiltse, Jeanne @@aut@@ Scheible, Kristin @@aut@@ Pryhuber, Gloria @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	315966548
dewey-sort	3610
id	ELV003036987
language_de	englisch
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author	Caserta, Mary T.
spellingShingle	Caserta, Mary T. ddc 610 bkl 44.67 Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
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topic_title	610 DE-600 44.67 bkl Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
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title	Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
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title_full	Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
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author_browse	Caserta, Mary T. Yang, Hongmei Bandyopadhyay, Sanjukta Qiu, Xing Gill, Steven R. Java, James McDavid, Andrew Falsey, Ann R. Topham, David J. Holden-Wiltse, Jeanne Scheible, Kristin Pryhuber, Gloria
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author-letter	Caserta, Mary T.
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title_sort	measuring the severity of respiratory illness in the first 2 years of life in preterm and term infants
title_auth	Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
abstract	Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score.
abstractGer	Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score.
abstract_unstemmed	Objective: To develop a valid research tool to measure infant respiratory illness severity using parent-reported symptoms.Study design: Nose and throat swabs were collected monthly for 1 year and during respiratory illnesses for 2 years in a prospective study of term and preterm infants in the Prematurity, Respiratory Outcomes, Immune System and Microbiome study. Viral pathogens were detected using Taqman Array Cards. Parents recorded symptoms during respiratory illnesses using a Childhood Origins of Asthma (COAST) scorecard. The COAST score was validated using linear mixed effects regression modeling to evaluate associations with hospitalization and specific infections. A data-driven method was also used to compute symptom weights and derive a new score, the Infant Research Respiratory Infection Severity Score (IRRISS). Linear mixed effects regression modeling was repeated with the IRRISS illness data.Results: From April 2013 to April 2017, 50 term, 40 late preterm, and 28 extremely low gestational age (<29 weeks of gestation) infants had 303 respiratory illness visits with viral testing and parent-reported symptoms. A range of illness severity was described with 39% of illness scores suggestive of severe disease. Both the COAST score and IRRISS were associated with respiratory syncytial virus infection and hospitalization. Gestational age and human rhinovirus infection were inversely associated with both scoring systems. The IRRISS and COAST scores were highly correlated (r = 0.93; P < .0001).Conclusions: Using parent-reported symptoms, we validated the COAST score as a measure of respiratory illness severity in infants. The new IRRISS score performed as well as the COAST score.
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title_short	Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants
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author2	Yang, Hongmei Bandyopadhyay, Sanjukta Qiu, Xing Gill, Steven R. Java, James McDavid, Andrew Falsey, Ann R. Topham, David J. Holden-Wiltse, Jeanne Scheible, Kristin Pryhuber, Gloria
author2Str	Yang, Hongmei Bandyopadhyay, Sanjukta Qiu, Xing Gill, Steven R. Java, James McDavid, Andrew Falsey, Ann R. Topham, David J. Holden-Wiltse, Jeanne Scheible, Kristin Pryhuber, Gloria
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doi_str	10.1016/j.jpeds.2019.06.061
up_date	2024-07-06T18:16:58.775Z
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Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants

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