Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis

Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unkn...
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Autor*in:	Li, Zhuang [verfasserIn] Chen, Xiaoqing [verfasserIn] Chen, Yuxi [verfasserIn] Li, He [verfasserIn] Yu, Jianfeng [verfasserIn] Li, Yingqi [verfasserIn] Zhu, Wenjie [verfasserIn] Xie, Yanyan [verfasserIn] Tian, Yunzhe [verfasserIn] Su, Wenru [verfasserIn] Liang, Dan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation

Übergeordnetes Werk:	Enthalten in: Biochemical pharmacology - Amsterdam [u.a.] : Elsevier Science, 1958, 170
Übergeordnetes Werk:	volume:170

DOI / URN:	10.1016/j.bcp.2019.113645

Katalog-ID:	ELV003110133

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520			\|a Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time.
650		4	\|a Autoimmune uveitis
650		4	\|a Teriflunomide
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650		4	\|a CD4+ T cells
650		4	\|a Dendritic cells maturation
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700	1		\|a Tian, Yunzhe \|e verfasserin \|4 aut
700	1		\|a Su, Wenru \|e verfasserin \|0 (orcid)0000-0002-0506-6362 \|4 aut
700	1		\|a Liang, Dan \|e verfasserin \|4 aut
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936	b	k	\|a 44.38 \|j Pharmakologie
951			\|a AR
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allfields	10.1016/j.bcp.2019.113645 doi (DE-627)ELV003110133 (ELSEVIER)S0006-2952(19)30344-2 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Li, Zhuang verfasserin aut Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time. Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation Chen, Xiaoqing verfasserin aut Chen, Yuxi verfasserin aut Li, He verfasserin aut Yu, Jianfeng verfasserin aut Li, Yingqi verfasserin aut Zhu, Wenjie verfasserin aut Xie, Yanyan verfasserin aut Tian, Yunzhe verfasserin aut Su, Wenru verfasserin (orcid)0000-0002-0506-6362 aut Liang, Dan verfasserin aut Enthalten in Biochemical pharmacology Amsterdam [u.a.] : Elsevier Science, 1958 170 Online-Ressource (DE-627)30631777X (DE-600)1496199-4 (DE-576)081952929 1873-2968 nnns volume:170 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 170
spelling	10.1016/j.bcp.2019.113645 doi (DE-627)ELV003110133 (ELSEVIER)S0006-2952(19)30344-2 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Li, Zhuang verfasserin aut Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time. Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation Chen, Xiaoqing verfasserin aut Chen, Yuxi verfasserin aut Li, He verfasserin aut Yu, Jianfeng verfasserin aut Li, Yingqi verfasserin aut Zhu, Wenjie verfasserin aut Xie, Yanyan verfasserin aut Tian, Yunzhe verfasserin aut Su, Wenru verfasserin (orcid)0000-0002-0506-6362 aut Liang, Dan verfasserin aut Enthalten in Biochemical pharmacology Amsterdam [u.a.] : Elsevier Science, 1958 170 Online-Ressource (DE-627)30631777X (DE-600)1496199-4 (DE-576)081952929 1873-2968 nnns volume:170 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 170
allfields_unstemmed	10.1016/j.bcp.2019.113645 doi (DE-627)ELV003110133 (ELSEVIER)S0006-2952(19)30344-2 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Li, Zhuang verfasserin aut Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time. Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation Chen, Xiaoqing verfasserin aut Chen, Yuxi verfasserin aut Li, He verfasserin aut Yu, Jianfeng verfasserin aut Li, Yingqi verfasserin aut Zhu, Wenjie verfasserin aut Xie, Yanyan verfasserin aut Tian, Yunzhe verfasserin aut Su, Wenru verfasserin (orcid)0000-0002-0506-6362 aut Liang, Dan verfasserin aut Enthalten in Biochemical pharmacology Amsterdam [u.a.] : Elsevier Science, 1958 170 Online-Ressource (DE-627)30631777X (DE-600)1496199-4 (DE-576)081952929 1873-2968 nnns volume:170 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 170
allfieldsGer	10.1016/j.bcp.2019.113645 doi (DE-627)ELV003110133 (ELSEVIER)S0006-2952(19)30344-2 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Li, Zhuang verfasserin aut Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time. Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation Chen, Xiaoqing verfasserin aut Chen, Yuxi verfasserin aut Li, He verfasserin aut Yu, Jianfeng verfasserin aut Li, Yingqi verfasserin aut Zhu, Wenjie verfasserin aut Xie, Yanyan verfasserin aut Tian, Yunzhe verfasserin aut Su, Wenru verfasserin (orcid)0000-0002-0506-6362 aut Liang, Dan verfasserin aut Enthalten in Biochemical pharmacology Amsterdam [u.a.] : Elsevier Science, 1958 170 Online-Ressource (DE-627)30631777X (DE-600)1496199-4 (DE-576)081952929 1873-2968 nnns volume:170 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 170
allfieldsSound	10.1016/j.bcp.2019.113645 doi (DE-627)ELV003110133 (ELSEVIER)S0006-2952(19)30344-2 DE-627 ger DE-627 rda eng 610 DE-600 PHARM DE-84 fid 44.38 bkl Li, Zhuang verfasserin aut Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time. Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation Chen, Xiaoqing verfasserin aut Chen, Yuxi verfasserin aut Li, He verfasserin aut Yu, Jianfeng verfasserin aut Li, Yingqi verfasserin aut Zhu, Wenjie verfasserin aut Xie, Yanyan verfasserin aut Tian, Yunzhe verfasserin aut Su, Wenru verfasserin (orcid)0000-0002-0506-6362 aut Liang, Dan verfasserin aut Enthalten in Biochemical pharmacology Amsterdam [u.a.] : Elsevier Science, 1958 170 Online-Ressource (DE-627)30631777X (DE-600)1496199-4 (DE-576)081952929 1873-2968 nnns volume:170 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie AR 170
language	English
source	Enthalten in Biochemical pharmacology 170 volume:170
sourceStr	Enthalten in Biochemical pharmacology 170 volume:170
format_phy_str_mv	Article
bklname	Pharmakologie
institution	findex.gbv.de
topic_facet	Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation
dewey-raw	610
isfreeaccess_bool	false
container_title	Biochemical pharmacology
authorswithroles_txt_mv	Li, Zhuang @@aut@@ Chen, Xiaoqing @@aut@@ Chen, Yuxi @@aut@@ Li, He @@aut@@ Yu, Jianfeng @@aut@@ Li, Yingqi @@aut@@ Zhu, Wenjie @@aut@@ Xie, Yanyan @@aut@@ Tian, Yunzhe @@aut@@ Su, Wenru @@aut@@ Liang, Dan @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	30631777X
dewey-sort	3610
id	ELV003110133
language_de	englisch
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author	Li, Zhuang
spellingShingle	Li, Zhuang ddc 610 fid PHARM bkl 44.38 misc Autoimmune uveitis misc Teriflunomide misc Experimental autoimmune uveitis misc CD4+ T cells misc Dendritic cells maturation Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis
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topic_title	610 DE-600 PHARM DE-84 fid 44.38 bkl Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis Autoimmune uveitis Teriflunomide Experimental autoimmune uveitis CD4+ T cells Dendritic cells maturation
topic	ddc 610 fid PHARM bkl 44.38 misc Autoimmune uveitis misc Teriflunomide misc Experimental autoimmune uveitis misc CD4+ T cells misc Dendritic cells maturation
topic_unstemmed	ddc 610 fid PHARM bkl 44.38 misc Autoimmune uveitis misc Teriflunomide misc Experimental autoimmune uveitis misc CD4+ T cells misc Dendritic cells maturation
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title	Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis
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title_full	Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis
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author_browse	Li, Zhuang Chen, Xiaoqing Chen, Yuxi Li, He Yu, Jianfeng Li, Yingqi Zhu, Wenjie Xie, Yanyan Tian, Yunzhe Su, Wenru Liang, Dan
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title_sort	teriflunomide suppresses t helper cells and dendritic cells to alleviate experimental autoimmune uveitis
title_auth	Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis
abstract	Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time.
abstractGer	Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time.
abstract_unstemmed	Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of teriflunomide in uveitis are still unknown. In this investigation, we used a murine model of non-infectious uveitis, experimental autoimmune uveitis (EAU), to explore the anti-inflammatory features of teriflunomide. Treatment with teriflunomide resulted in reduced clinical and pathological scores of retinal inflammations, accompanied by decreased intraocular infiltration of Th17 and Th1 cells in EAU mice. Meanwhile, teriflunomide treatment inhibited the proliferation and polarization of CD4+ T cells to Th17 and Th1 cells. Moreover, adoptive transfer of teriflunomide primed IRBP1-20-T cells failed to induce EAU. Interestingly, we found that teriflunomide suppressed the maturation and function of dendritic cells (DCs) both in vivo and in vitro. In conclusion, our findings suggest that teriflunomide alleviates inflammation in EAU mice by down-regulating Th17 and Th1 cells and suppresses the maturation and function of DCs for the first time.
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title_short	Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis
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author2	Chen, Xiaoqing Chen, Yuxi Li, He Yu, Jianfeng Li, Yingqi Zhu, Wenjie Xie, Yanyan Tian, Yunzhe Su, Wenru Liang, Dan
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up_date	2024-07-06T18:31:26.816Z
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Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis

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