Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system

Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR,...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	de Freitas Marques, Maria Betânia [verfasserIn] de Araujo, Bárbara Caroline Rodrigues [verfasserIn] de Cassia de Oliveira Sebastião, Rita [verfasserIn] da Nova Mussel, Wagner [verfasserIn] Yoshida, Maria Irene [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection

Übergeordnetes Werk:	Enthalten in: Thermochimica acta - Amsterdam [u.a.] : Elsevier Science, 1970, 682
Übergeordnetes Werk:	volume:682

DOI / URN:	10.1016/j.tca.2019.178408

Katalog-ID:	ELV00312780X

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520			\|a Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose.
650		4	\|a Disordered cardiovascular drugs
650		4	\|a Compatibility of fixed-dose formulation
650		4	\|a Thermal analysis
650		4	\|a Kinetics
650		4	\|a Electron density projection
700	1		\|a de Araujo, Bárbara Caroline Rodrigues \|e verfasserin \|4 aut
700	1		\|a de Cassia de Oliveira Sebastião, Rita \|e verfasserin \|4 aut
700	1		\|a da Nova Mussel, Wagner \|e verfasserin \|4 aut
700	1		\|a Yoshida, Maria Irene \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Thermochimica acta \|d Amsterdam [u.a.] : Elsevier Science, 1970 \|g 682 \|h Online-Ressource \|w (DE-627)306712628 \|w (DE-600)1500974-9 \|w (DE-576)251938166 \|7 nnns
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912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
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912			\|a GBV_ILN_73
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912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 35.00 \|j Chemie: Allgemeines
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matchkey_str	defreitasmarquesmariabetniadearaujobrbar:2019----:ieistdadisflsraenlssoaovsaiclimrh
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publishDate	2019
allfields	10.1016/j.tca.2019.178408 doi (DE-627)ELV00312780X (ELSEVIER)S0040-6031(19)30666-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl de Freitas Marques, Maria Betânia verfasserin aut Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose. Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection de Araujo, Bárbara Caroline Rodrigues verfasserin aut de Cassia de Oliveira Sebastião, Rita verfasserin aut da Nova Mussel, Wagner verfasserin aut Yoshida, Maria Irene verfasserin aut Enthalten in Thermochimica acta Amsterdam [u.a.] : Elsevier Science, 1970 682 Online-Ressource (DE-627)306712628 (DE-600)1500974-9 (DE-576)251938166 nnns volume:682 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 682
spelling	10.1016/j.tca.2019.178408 doi (DE-627)ELV00312780X (ELSEVIER)S0040-6031(19)30666-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl de Freitas Marques, Maria Betânia verfasserin aut Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose. Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection de Araujo, Bárbara Caroline Rodrigues verfasserin aut de Cassia de Oliveira Sebastião, Rita verfasserin aut da Nova Mussel, Wagner verfasserin aut Yoshida, Maria Irene verfasserin aut Enthalten in Thermochimica acta Amsterdam [u.a.] : Elsevier Science, 1970 682 Online-Ressource (DE-627)306712628 (DE-600)1500974-9 (DE-576)251938166 nnns volume:682 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 682
allfields_unstemmed	10.1016/j.tca.2019.178408 doi (DE-627)ELV00312780X (ELSEVIER)S0040-6031(19)30666-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl de Freitas Marques, Maria Betânia verfasserin aut Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose. Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection de Araujo, Bárbara Caroline Rodrigues verfasserin aut de Cassia de Oliveira Sebastião, Rita verfasserin aut da Nova Mussel, Wagner verfasserin aut Yoshida, Maria Irene verfasserin aut Enthalten in Thermochimica acta Amsterdam [u.a.] : Elsevier Science, 1970 682 Online-Ressource (DE-627)306712628 (DE-600)1500974-9 (DE-576)251938166 nnns volume:682 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 682
allfieldsGer	10.1016/j.tca.2019.178408 doi (DE-627)ELV00312780X (ELSEVIER)S0040-6031(19)30666-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl de Freitas Marques, Maria Betânia verfasserin aut Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose. Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection de Araujo, Bárbara Caroline Rodrigues verfasserin aut de Cassia de Oliveira Sebastião, Rita verfasserin aut da Nova Mussel, Wagner verfasserin aut Yoshida, Maria Irene verfasserin aut Enthalten in Thermochimica acta Amsterdam [u.a.] : Elsevier Science, 1970 682 Online-Ressource (DE-627)306712628 (DE-600)1500974-9 (DE-576)251938166 nnns volume:682 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 682
allfieldsSound	10.1016/j.tca.2019.178408 doi (DE-627)ELV00312780X (ELSEVIER)S0040-6031(19)30666-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl de Freitas Marques, Maria Betânia verfasserin aut Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose. Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection de Araujo, Bárbara Caroline Rodrigues verfasserin aut de Cassia de Oliveira Sebastião, Rita verfasserin aut da Nova Mussel, Wagner verfasserin aut Yoshida, Maria Irene verfasserin aut Enthalten in Thermochimica acta Amsterdam [u.a.] : Elsevier Science, 1970 682 Online-Ressource (DE-627)306712628 (DE-600)1500974-9 (DE-576)251938166 nnns volume:682 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 682
language	English
source	Enthalten in Thermochimica acta 682 volume:682
sourceStr	Enthalten in Thermochimica acta 682 volume:682
format_phy_str_mv	Article
bklname	Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection
dewey-raw	540
isfreeaccess_bool	false
container_title	Thermochimica acta
authorswithroles_txt_mv	de Freitas Marques, Maria Betânia @@aut@@ de Araujo, Bárbara Caroline Rodrigues @@aut@@ de Cassia de Oliveira Sebastião, Rita @@aut@@ da Nova Mussel, Wagner @@aut@@ Yoshida, Maria Irene @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	306712628
dewey-sort	3540
id	ELV00312780X
language_de	englisch
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author	de Freitas Marques, Maria Betânia
spellingShingle	de Freitas Marques, Maria Betânia ddc 540 bkl 35.00 misc Disordered cardiovascular drugs misc Compatibility of fixed-dose formulation misc Thermal analysis misc Kinetics misc Electron density projection Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
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topic_title	540 DE-600 35.00 bkl Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system Disordered cardiovascular drugs Compatibility of fixed-dose formulation Thermal analysis Kinetics Electron density projection
topic	ddc 540 bkl 35.00 misc Disordered cardiovascular drugs misc Compatibility of fixed-dose formulation misc Thermal analysis misc Kinetics misc Electron density projection
topic_unstemmed	ddc 540 bkl 35.00 misc Disordered cardiovascular drugs misc Compatibility of fixed-dose formulation misc Thermal analysis misc Kinetics misc Electron density projection
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title	Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
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title_full	Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
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title_sort	kinetics study and hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
title_auth	Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
abstract	Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose.
abstractGer	Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose.
abstract_unstemmed	Atorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose.
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title_short	Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
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author2	de Araujo, Bárbara Caroline Rodrigues de Cassia de Oliveira Sebastião, Rita da Nova Mussel, Wagner Yoshida, Maria Irene
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up_date	2024-07-06T18:35:03.343Z
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Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system

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