Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor
Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Maillet, Thibault [verfasserIn] Goletto, Tiphaine [verfasserIn] Beltramo, Guillaume [verfasserIn] Dupuy, Henry [verfasserIn] Jouneau, Stéphane [verfasserIn] Borie, Raphael [verfasserIn] Crestani, Bruno [verfasserIn] Cottin, Vincent [verfasserIn] Blockmans, Daniel [verfasserIn] Lazaro, Estibaliz [verfasserIn] Naccache, Jean-Marc [verfasserIn] Pugnet, Grégory [verfasserIn] Nunes, Hilario [verfasserIn] de Menthon, Mathilde [verfasserIn] Devilliers, Hervé [verfasserIn] Bonniaud, Philippe [verfasserIn] Puéchal, Xavier [verfasserIn] Mouthon, Luc [verfasserIn] Bonnotte, Bernard [verfasserIn] Guillevin, Loïc [verfasserIn] Terrier, Benjamin [verfasserIn] Samson, Maxime [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of autoimmunity - London : Academic Press, 1988, 106 |
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| Übergeordnetes Werk: |
volume:106 |
| DOI / URN: |
10.1016/j.jaut.2019.102338 |
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| Katalog-ID: |
ELV003337502 |
|---|
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| 024 | 7 | |a 10.1016/j.jaut.2019.102338 |2 doi | |
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| 100 | 1 | |a Maillet, Thibault |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
| 264 | 1 | |c 2019 | |
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| 520 | |a Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. | ||
| 650 | 4 | |a ANCA-Associated vasculitis | |
| 650 | 4 | |a Interstitial lung disease | |
| 650 | 4 | |a Usual interstitial pneumonia | |
| 650 | 4 | |a Non-specific interstitial pneumonia | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Prognosis | |
| 700 | 1 | |a Goletto, Tiphaine |e verfasserin |4 aut | |
| 700 | 1 | |a Beltramo, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Dupuy, Henry |e verfasserin |4 aut | |
| 700 | 1 | |a Jouneau, Stéphane |e verfasserin |4 aut | |
| 700 | 1 | |a Borie, Raphael |e verfasserin |4 aut | |
| 700 | 1 | |a Crestani, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Cottin, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Blockmans, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Lazaro, Estibaliz |e verfasserin |4 aut | |
| 700 | 1 | |a Naccache, Jean-Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Pugnet, Grégory |e verfasserin |4 aut | |
| 700 | 1 | |a Nunes, Hilario |e verfasserin |4 aut | |
| 700 | 1 | |a de Menthon, Mathilde |e verfasserin |4 aut | |
| 700 | 1 | |a Devilliers, Hervé |e verfasserin |4 aut | |
| 700 | 1 | |a Bonniaud, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Puéchal, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Mouthon, Luc |e verfasserin |4 aut | |
| 700 | 1 | |a Bonnotte, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Guillevin, Loïc |e verfasserin |4 aut | |
| 700 | 1 | |a Terrier, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Samson, Maxime |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of autoimmunity |d London : Academic Press, 1988 |g 106 |h Online-Ressource |w (DE-627)266890822 |w (DE-600)1468989-3 |w (DE-576)104193786 |x 1095-9157 |7 nnns |
| 773 | 1 | 8 | |g volume:106 |
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| 936 | b | k | |a 44.45 |j Immunologie |
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2019 |
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2019 |
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10.1016/j.jaut.2019.102338 doi (DE-627)ELV003337502 (ELSEVIER)S0896-8411(19)30461-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Maillet, Thibault verfasserin aut Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis Goletto, Tiphaine verfasserin aut Beltramo, Guillaume verfasserin aut Dupuy, Henry verfasserin aut Jouneau, Stéphane verfasserin aut Borie, Raphael verfasserin aut Crestani, Bruno verfasserin aut Cottin, Vincent verfasserin aut Blockmans, Daniel verfasserin aut Lazaro, Estibaliz verfasserin aut Naccache, Jean-Marc verfasserin aut Pugnet, Grégory verfasserin aut Nunes, Hilario verfasserin aut de Menthon, Mathilde verfasserin aut Devilliers, Hervé verfasserin aut Bonniaud, Philippe verfasserin aut Puéchal, Xavier verfasserin aut Mouthon, Luc verfasserin aut Bonnotte, Bernard verfasserin aut Guillevin, Loïc verfasserin aut Terrier, Benjamin verfasserin aut Samson, Maxime verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 106 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:106 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 106 |
| spelling |
10.1016/j.jaut.2019.102338 doi (DE-627)ELV003337502 (ELSEVIER)S0896-8411(19)30461-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Maillet, Thibault verfasserin aut Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis Goletto, Tiphaine verfasserin aut Beltramo, Guillaume verfasserin aut Dupuy, Henry verfasserin aut Jouneau, Stéphane verfasserin aut Borie, Raphael verfasserin aut Crestani, Bruno verfasserin aut Cottin, Vincent verfasserin aut Blockmans, Daniel verfasserin aut Lazaro, Estibaliz verfasserin aut Naccache, Jean-Marc verfasserin aut Pugnet, Grégory verfasserin aut Nunes, Hilario verfasserin aut de Menthon, Mathilde verfasserin aut Devilliers, Hervé verfasserin aut Bonniaud, Philippe verfasserin aut Puéchal, Xavier verfasserin aut Mouthon, Luc verfasserin aut Bonnotte, Bernard verfasserin aut Guillevin, Loïc verfasserin aut Terrier, Benjamin verfasserin aut Samson, Maxime verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 106 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:106 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 106 |
| allfields_unstemmed |
10.1016/j.jaut.2019.102338 doi (DE-627)ELV003337502 (ELSEVIER)S0896-8411(19)30461-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Maillet, Thibault verfasserin aut Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis Goletto, Tiphaine verfasserin aut Beltramo, Guillaume verfasserin aut Dupuy, Henry verfasserin aut Jouneau, Stéphane verfasserin aut Borie, Raphael verfasserin aut Crestani, Bruno verfasserin aut Cottin, Vincent verfasserin aut Blockmans, Daniel verfasserin aut Lazaro, Estibaliz verfasserin aut Naccache, Jean-Marc verfasserin aut Pugnet, Grégory verfasserin aut Nunes, Hilario verfasserin aut de Menthon, Mathilde verfasserin aut Devilliers, Hervé verfasserin aut Bonniaud, Philippe verfasserin aut Puéchal, Xavier verfasserin aut Mouthon, Luc verfasserin aut Bonnotte, Bernard verfasserin aut Guillevin, Loïc verfasserin aut Terrier, Benjamin verfasserin aut Samson, Maxime verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 106 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:106 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 106 |
| allfieldsGer |
10.1016/j.jaut.2019.102338 doi (DE-627)ELV003337502 (ELSEVIER)S0896-8411(19)30461-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Maillet, Thibault verfasserin aut Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis Goletto, Tiphaine verfasserin aut Beltramo, Guillaume verfasserin aut Dupuy, Henry verfasserin aut Jouneau, Stéphane verfasserin aut Borie, Raphael verfasserin aut Crestani, Bruno verfasserin aut Cottin, Vincent verfasserin aut Blockmans, Daniel verfasserin aut Lazaro, Estibaliz verfasserin aut Naccache, Jean-Marc verfasserin aut Pugnet, Grégory verfasserin aut Nunes, Hilario verfasserin aut de Menthon, Mathilde verfasserin aut Devilliers, Hervé verfasserin aut Bonniaud, Philippe verfasserin aut Puéchal, Xavier verfasserin aut Mouthon, Luc verfasserin aut Bonnotte, Bernard verfasserin aut Guillevin, Loïc verfasserin aut Terrier, Benjamin verfasserin aut Samson, Maxime verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 106 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:106 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 106 |
| allfieldsSound |
10.1016/j.jaut.2019.102338 doi (DE-627)ELV003337502 (ELSEVIER)S0896-8411(19)30461-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Maillet, Thibault verfasserin aut Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis Goletto, Tiphaine verfasserin aut Beltramo, Guillaume verfasserin aut Dupuy, Henry verfasserin aut Jouneau, Stéphane verfasserin aut Borie, Raphael verfasserin aut Crestani, Bruno verfasserin aut Cottin, Vincent verfasserin aut Blockmans, Daniel verfasserin aut Lazaro, Estibaliz verfasserin aut Naccache, Jean-Marc verfasserin aut Pugnet, Grégory verfasserin aut Nunes, Hilario verfasserin aut de Menthon, Mathilde verfasserin aut Devilliers, Hervé verfasserin aut Bonniaud, Philippe verfasserin aut Puéchal, Xavier verfasserin aut Mouthon, Luc verfasserin aut Bonnotte, Bernard verfasserin aut Guillevin, Loïc verfasserin aut Terrier, Benjamin verfasserin aut Samson, Maxime verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 106 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:106 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 106 |
| language |
English |
| source |
Enthalten in Journal of autoimmunity 106 volume:106 |
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Enthalten in Journal of autoimmunity 106 volume:106 |
| format_phy_str_mv |
Article |
| bklname |
Immunologie |
| institution |
findex.gbv.de |
| topic_facet |
ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Journal of autoimmunity |
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Maillet, Thibault @@aut@@ Goletto, Tiphaine @@aut@@ Beltramo, Guillaume @@aut@@ Dupuy, Henry @@aut@@ Jouneau, Stéphane @@aut@@ Borie, Raphael @@aut@@ Crestani, Bruno @@aut@@ Cottin, Vincent @@aut@@ Blockmans, Daniel @@aut@@ Lazaro, Estibaliz @@aut@@ Naccache, Jean-Marc @@aut@@ Pugnet, Grégory @@aut@@ Nunes, Hilario @@aut@@ de Menthon, Mathilde @@aut@@ Devilliers, Hervé @@aut@@ Bonniaud, Philippe @@aut@@ Puéchal, Xavier @@aut@@ Mouthon, Luc @@aut@@ Bonnotte, Bernard @@aut@@ Guillevin, Loïc @@aut@@ Terrier, Benjamin @@aut@@ Samson, Maxime @@aut@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
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266890822 |
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3610 |
| id |
ELV003337502 |
| language_de |
englisch |
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This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). 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Maillet, Thibault |
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Maillet, Thibault ddc 610 bkl 44.45 misc ANCA-Associated vasculitis misc Interstitial lung disease misc Usual interstitial pneumonia misc Non-specific interstitial pneumonia misc Survival misc Prognosis Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
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610 DE-600 44.45 bkl Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor ANCA-Associated vasculitis Interstitial lung disease Usual interstitial pneumonia Non-specific interstitial pneumonia Survival Prognosis |
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ddc 610 bkl 44.45 misc ANCA-Associated vasculitis misc Interstitial lung disease misc Usual interstitial pneumonia misc Non-specific interstitial pneumonia misc Survival misc Prognosis |
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ddc 610 bkl 44.45 misc ANCA-Associated vasculitis misc Interstitial lung disease misc Usual interstitial pneumonia misc Non-specific interstitial pneumonia misc Survival misc Prognosis |
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ddc 610 bkl 44.45 misc ANCA-Associated vasculitis misc Interstitial lung disease misc Usual interstitial pneumonia misc Non-specific interstitial pneumonia misc Survival misc Prognosis |
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Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
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Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
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Maillet, Thibault |
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Journal of autoimmunity |
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Maillet, Thibault Goletto, Tiphaine Beltramo, Guillaume Dupuy, Henry Jouneau, Stéphane Borie, Raphael Crestani, Bruno Cottin, Vincent Blockmans, Daniel Lazaro, Estibaliz Naccache, Jean-Marc Pugnet, Grégory Nunes, Hilario de Menthon, Mathilde Devilliers, Hervé Bonniaud, Philippe Puéchal, Xavier Mouthon, Luc Bonnotte, Bernard Guillevin, Loïc Terrier, Benjamin Samson, Maxime |
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10.1016/j.jaut.2019.102338 |
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usual interstitial pneumonia in anca-associated vasculitis: a poor prognostic factor |
| title_auth |
Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
| abstract |
Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. |
| abstractGer |
Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. |
| abstract_unstemmed |
Background: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). Multivariate analyses retained age >65 years (hazard ratio (HR) 4.54; p < 0.001), alveolar haemorrhage (HR 2.25; p = 0.019) and UIP (HR 2.73; p = 0.002), but not immunosuppressant use, as factors independently associated with shorter survival.Conclusion: For AAV–ILD patients, only UIP was associated with poorer prognosis. Immunosuppressants did not improve the AAV–ILD prognosis. But in analogy to idiopathic pulmonary fibrosis, anti-fibrosing agents might be useful and should be assessed in AAV–ILD patients with a UIP pattern. |
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Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor |
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Goletto, Tiphaine Beltramo, Guillaume Dupuy, Henry Jouneau, Stéphane Borie, Raphael Crestani, Bruno Cottin, Vincent Blockmans, Daniel Lazaro, Estibaliz Naccache, Jean-Marc Pugnet, Grégory Nunes, Hilario de Menthon, Mathilde Devilliers, Hervé Bonniaud, Philippe Puéchal, Xavier Mouthon, Luc Bonnotte, Bernard Guillevin, Loïc Terrier, Benjamin Samson, Maxime |
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Goletto, Tiphaine Beltramo, Guillaume Dupuy, Henry Jouneau, Stéphane Borie, Raphael Crestani, Bruno Cottin, Vincent Blockmans, Daniel Lazaro, Estibaliz Naccache, Jean-Marc Pugnet, Grégory Nunes, Hilario de Menthon, Mathilde Devilliers, Hervé Bonniaud, Philippe Puéchal, Xavier Mouthon, Luc Bonnotte, Bernard Guillevin, Loïc Terrier, Benjamin Samson, Maxime |
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| doi_str |
10.1016/j.jaut.2019.102338 |
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2024-07-06T19:17:06.217Z |
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This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD).Methods: AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or <150 μmol/L).Results: Sixty-two cases (89% MPO-ANCA+) were included. Median age at AAV diagnosis was 66 years. ILD (63% UIP), was diagnosed before (52%) or simultaneously (39%) with AAV. Cases versus 124 controls less frequently had systemic vasculitis symptoms. One-, 3- and 5-year overall survival rates, respectively, were: 96.7%, 80% and 66% for cases versus 93.5%, 89.6% and 83.8% for controls (p = 0.008). 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