Schizophrenia polygenic risk score influence on white matter microstructure
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Simões, Beatriz [verfasserIn] Vassos, Evangelos [verfasserIn] Shergill, Sukhi [verfasserIn] McDonald, Colm [verfasserIn] Toulopoulou, Timothea [verfasserIn] Kalidindi, Sridevi [verfasserIn] Kane, Fergus [verfasserIn] Murray, Robin [verfasserIn] Bramon, Elvira [verfasserIn] Ferreira, Hugo [verfasserIn] Prata, Diana [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of psychiatric research - Amsterdam [u.a.] : Elsevier Science, 1961, 121, Seite 62-67 |
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| Übergeordnetes Werk: |
volume:121 ; pages:62-67 |
| DOI / URN: |
10.1016/j.jpsychires.2019.11.011 |
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| Katalog-ID: |
ELV003384128 |
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| 245 | 1 | 0 | |a Schizophrenia polygenic risk score influence on white matter microstructure |
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| 520 | |a Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. | ||
| 650 | 4 | |a Polygenic risk score | |
| 650 | 4 | |a PRS | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Bipolar disorder | |
| 650 | 4 | |a White matter | |
| 650 | 4 | |a Diffusion tensor imaging | |
| 650 | 4 | |a Psychosis | |
| 650 | 4 | |a Fractional anisotropy | |
| 650 | 4 | |a Mean diffusivity | |
| 650 | 4 | |a GWA | |
| 650 | 4 | |a Genome-wide association | |
| 700 | 1 | |a Vassos, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Shergill, Sukhi |e verfasserin |4 aut | |
| 700 | 1 | |a McDonald, Colm |e verfasserin |4 aut | |
| 700 | 1 | |a Toulopoulou, Timothea |e verfasserin |4 aut | |
| 700 | 1 | |a Kalidindi, Sridevi |e verfasserin |4 aut | |
| 700 | 1 | |a Kane, Fergus |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Robin |e verfasserin |4 aut | |
| 700 | 1 | |a Bramon, Elvira |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Hugo |e verfasserin |4 aut | |
| 700 | 1 | |a Prata, Diana |e verfasserin |4 aut | |
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10.1016/j.jpsychires.2019.11.011 doi (DE-627)ELV003384128 (ELSEVIER)S0022-3956(19)30713-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Simões, Beatriz verfasserin aut Schizophrenia polygenic risk score influence on white matter microstructure 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association Vassos, Evangelos verfasserin aut Shergill, Sukhi verfasserin aut McDonald, Colm verfasserin aut Toulopoulou, Timothea verfasserin aut Kalidindi, Sridevi verfasserin aut Kane, Fergus verfasserin aut Murray, Robin verfasserin aut Bramon, Elvira verfasserin aut Ferreira, Hugo verfasserin aut Prata, Diana verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 121, Seite 62-67 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:121 pages:62-67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 121 62-67 |
| spelling |
10.1016/j.jpsychires.2019.11.011 doi (DE-627)ELV003384128 (ELSEVIER)S0022-3956(19)30713-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Simões, Beatriz verfasserin aut Schizophrenia polygenic risk score influence on white matter microstructure 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association Vassos, Evangelos verfasserin aut Shergill, Sukhi verfasserin aut McDonald, Colm verfasserin aut Toulopoulou, Timothea verfasserin aut Kalidindi, Sridevi verfasserin aut Kane, Fergus verfasserin aut Murray, Robin verfasserin aut Bramon, Elvira verfasserin aut Ferreira, Hugo verfasserin aut Prata, Diana verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 121, Seite 62-67 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:121 pages:62-67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 121 62-67 |
| allfields_unstemmed |
10.1016/j.jpsychires.2019.11.011 doi (DE-627)ELV003384128 (ELSEVIER)S0022-3956(19)30713-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Simões, Beatriz verfasserin aut Schizophrenia polygenic risk score influence on white matter microstructure 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association Vassos, Evangelos verfasserin aut Shergill, Sukhi verfasserin aut McDonald, Colm verfasserin aut Toulopoulou, Timothea verfasserin aut Kalidindi, Sridevi verfasserin aut Kane, Fergus verfasserin aut Murray, Robin verfasserin aut Bramon, Elvira verfasserin aut Ferreira, Hugo verfasserin aut Prata, Diana verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 121, Seite 62-67 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:121 pages:62-67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 121 62-67 |
| allfieldsGer |
10.1016/j.jpsychires.2019.11.011 doi (DE-627)ELV003384128 (ELSEVIER)S0022-3956(19)30713-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Simões, Beatriz verfasserin aut Schizophrenia polygenic risk score influence on white matter microstructure 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association Vassos, Evangelos verfasserin aut Shergill, Sukhi verfasserin aut McDonald, Colm verfasserin aut Toulopoulou, Timothea verfasserin aut Kalidindi, Sridevi verfasserin aut Kane, Fergus verfasserin aut Murray, Robin verfasserin aut Bramon, Elvira verfasserin aut Ferreira, Hugo verfasserin aut Prata, Diana verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 121, Seite 62-67 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:121 pages:62-67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 121 62-67 |
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10.1016/j.jpsychires.2019.11.011 doi (DE-627)ELV003384128 (ELSEVIER)S0022-3956(19)30713-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Simões, Beatriz verfasserin aut Schizophrenia polygenic risk score influence on white matter microstructure 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association Vassos, Evangelos verfasserin aut Shergill, Sukhi verfasserin aut McDonald, Colm verfasserin aut Toulopoulou, Timothea verfasserin aut Kalidindi, Sridevi verfasserin aut Kane, Fergus verfasserin aut Murray, Robin verfasserin aut Bramon, Elvira verfasserin aut Ferreira, Hugo verfasserin aut Prata, Diana verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 121, Seite 62-67 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:121 pages:62-67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 121 62-67 |
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| author |
Simões, Beatriz |
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Simões, Beatriz ddc 610 bkl 44.91 misc Polygenic risk score misc PRS misc Schizophrenia misc Bipolar disorder misc White matter misc Diffusion tensor imaging misc Psychosis misc Fractional anisotropy misc Mean diffusivity misc GWA misc Genome-wide association Schizophrenia polygenic risk score influence on white matter microstructure |
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610 DE-600 44.91 bkl Schizophrenia polygenic risk score influence on white matter microstructure Polygenic risk score PRS Schizophrenia Bipolar disorder White matter Diffusion tensor imaging Psychosis Fractional anisotropy Mean diffusivity GWA Genome-wide association |
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Schizophrenia polygenic risk score influence on white matter microstructure |
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Simões, Beatriz Vassos, Evangelos Shergill, Sukhi McDonald, Colm Toulopoulou, Timothea Kalidindi, Sridevi Kane, Fergus Murray, Robin Bramon, Elvira Ferreira, Hugo Prata, Diana |
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schizophrenia polygenic risk score influence on white matter microstructure |
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Schizophrenia polygenic risk score influence on white matter microstructure |
| abstract |
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. |
| abstractGer |
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. |
| abstract_unstemmed |
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. |
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Vassos, Evangelos Shergill, Sukhi McDonald, Colm Toulopoulou, Timothea Kalidindi, Sridevi Kane, Fergus Murray, Robin Bramon, Elvira Ferreira, Hugo Prata, Diana |
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