Endpoints for tricuspid regurgitation trans-catheter therapy trials

Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricusp...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hahn, Rebecca T. [verfasserIn] Ben-Yehuda, Ori [verfasserIn] Leon, Martin B. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials

Übergeordnetes Werk:	Enthalten in: Progress in cardiovascular diseases - Orlando, Fla. : Elsevier, 1958, 62, Seite 479-481
Übergeordnetes Werk:	volume:62 ; pages:479-481

DOI / URN:	10.1016/j.pcad.2019.11.019

Katalog-ID:	ELV003665291

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520			\|a Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies.
650		4	\|a Tricuspid regurgitation
650		4	\|a Trans-catheter therapy
650		4	\|a Endpoints
650		4	\|a Clinical trials
700	1		\|a Ben-Yehuda, Ori \|e verfasserin \|4 aut
700	1		\|a Leon, Martin B. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Progress in cardiovascular diseases \|d Orlando, Fla. : Elsevier, 1958 \|g 62, Seite 479-481 \|h Online-Ressource \|w (DE-627)326646035 \|w (DE-600)2041627-1 \|w (DE-576)09450573X \|x 1532-8643 \|7 nnns
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936	b	k	\|a 44.85 \|j Kardiologie \|j Angiologie
951			\|a AR
952			\|d 62 \|h 479-481

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allfields	10.1016/j.pcad.2019.11.019 doi (DE-627)ELV003665291 (ELSEVIER)S0033-0620(19)30160-4 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Hahn, Rebecca T. verfasserin aut Endpoints for tricuspid regurgitation trans-catheter therapy trials 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies. Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials Ben-Yehuda, Ori verfasserin aut Leon, Martin B. verfasserin aut Enthalten in Progress in cardiovascular diseases Orlando, Fla. : Elsevier, 1958 62, Seite 479-481 Online-Ressource (DE-627)326646035 (DE-600)2041627-1 (DE-576)09450573X 1532-8643 nnns volume:62 pages:479-481 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.85 Kardiologie Angiologie AR 62 479-481
spelling	10.1016/j.pcad.2019.11.019 doi (DE-627)ELV003665291 (ELSEVIER)S0033-0620(19)30160-4 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Hahn, Rebecca T. verfasserin aut Endpoints for tricuspid regurgitation trans-catheter therapy trials 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies. Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials Ben-Yehuda, Ori verfasserin aut Leon, Martin B. verfasserin aut Enthalten in Progress in cardiovascular diseases Orlando, Fla. : Elsevier, 1958 62, Seite 479-481 Online-Ressource (DE-627)326646035 (DE-600)2041627-1 (DE-576)09450573X 1532-8643 nnns volume:62 pages:479-481 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.85 Kardiologie Angiologie AR 62 479-481
allfields_unstemmed	10.1016/j.pcad.2019.11.019 doi (DE-627)ELV003665291 (ELSEVIER)S0033-0620(19)30160-4 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Hahn, Rebecca T. verfasserin aut Endpoints for tricuspid regurgitation trans-catheter therapy trials 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies. Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials Ben-Yehuda, Ori verfasserin aut Leon, Martin B. verfasserin aut Enthalten in Progress in cardiovascular diseases Orlando, Fla. : Elsevier, 1958 62, Seite 479-481 Online-Ressource (DE-627)326646035 (DE-600)2041627-1 (DE-576)09450573X 1532-8643 nnns volume:62 pages:479-481 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.85 Kardiologie Angiologie AR 62 479-481
allfieldsGer	10.1016/j.pcad.2019.11.019 doi (DE-627)ELV003665291 (ELSEVIER)S0033-0620(19)30160-4 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Hahn, Rebecca T. verfasserin aut Endpoints for tricuspid regurgitation trans-catheter therapy trials 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies. Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials Ben-Yehuda, Ori verfasserin aut Leon, Martin B. verfasserin aut Enthalten in Progress in cardiovascular diseases Orlando, Fla. : Elsevier, 1958 62, Seite 479-481 Online-Ressource (DE-627)326646035 (DE-600)2041627-1 (DE-576)09450573X 1532-8643 nnns volume:62 pages:479-481 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.85 Kardiologie Angiologie AR 62 479-481
allfieldsSound	10.1016/j.pcad.2019.11.019 doi (DE-627)ELV003665291 (ELSEVIER)S0033-0620(19)30160-4 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Hahn, Rebecca T. verfasserin aut Endpoints for tricuspid regurgitation trans-catheter therapy trials 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies. Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials Ben-Yehuda, Ori verfasserin aut Leon, Martin B. verfasserin aut Enthalten in Progress in cardiovascular diseases Orlando, Fla. : Elsevier, 1958 62, Seite 479-481 Online-Ressource (DE-627)326646035 (DE-600)2041627-1 (DE-576)09450573X 1532-8643 nnns volume:62 pages:479-481 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.85 Kardiologie Angiologie AR 62 479-481
language	English
source	Enthalten in Progress in cardiovascular diseases 62, Seite 479-481 volume:62 pages:479-481
sourceStr	Enthalten in Progress in cardiovascular diseases 62, Seite 479-481 volume:62 pages:479-481
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bklname	Kardiologie Angiologie
institution	findex.gbv.de
topic_facet	Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials
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container_title	Progress in cardiovascular diseases
authorswithroles_txt_mv	Hahn, Rebecca T. @@aut@@ Ben-Yehuda, Ori @@aut@@ Leon, Martin B. @@aut@@
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author	Hahn, Rebecca T.
spellingShingle	Hahn, Rebecca T. ddc 610 bkl 44.85 misc Tricuspid regurgitation misc Trans-catheter therapy misc Endpoints misc Clinical trials Endpoints for tricuspid regurgitation trans-catheter therapy trials
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topic_title	610 DE-600 44.85 bkl Endpoints for tricuspid regurgitation trans-catheter therapy trials Tricuspid regurgitation Trans-catheter therapy Endpoints Clinical trials
topic	ddc 610 bkl 44.85 misc Tricuspid regurgitation misc Trans-catheter therapy misc Endpoints misc Clinical trials
topic_unstemmed	ddc 610 bkl 44.85 misc Tricuspid regurgitation misc Trans-catheter therapy misc Endpoints misc Clinical trials
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title	Endpoints for tricuspid regurgitation trans-catheter therapy trials
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title_full	Endpoints for tricuspid regurgitation trans-catheter therapy trials
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title_sort	endpoints for tricuspid regurgitation trans-catheter therapy trials
title_auth	Endpoints for tricuspid regurgitation trans-catheter therapy trials
abstract	Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies.
abstractGer	Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies.
abstract_unstemmed	Tricuspid regurgitation (TR), particularly functional or secondary TR, is increasingly recognized in clinical practice and when at least moderate in severity is associated with significant increase in mortality. In recent years multiple new trans-catheter devices have been developed to treat tricuspid regurgitation and are now undergoing clinical trial evaluations. The choice of appropriate endpoints in TR trials is particularly challenging as the disease is complex, often co-exists with left heart disease and pulmonary hypertension, and has not been extensively studied. Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials. Ultimately the development of TR specific endpoints may provide for more specific and robust assessment of these novel therapies.
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title_short	Endpoints for tricuspid regurgitation trans-catheter therapy trials
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author2	Ben-Yehuda, Ori Leon, Martin B.
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up_date	2024-07-06T20:23:27.590Z
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