Hepatoprotective lignans and triterpenoids from the roots of

Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shao, Si-Yuan [verfasserIn] Qi, Xin-Zhu [verfasserIn] Sun, Hua [verfasserIn] Li, Shuai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity

Übergeordnetes Werk:	Enthalten in: Fitoterapia - Amsterdam [u.a.] : Elsevier Science, 1999, 142
Übergeordnetes Werk:	volume:142

DOI / URN:	10.1016/j.fitote.2020.104487

Katalog-ID:	ELV003870588

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allfields	10.1016/j.fitote.2020.104487 doi (DE-627)ELV003870588 (ELSEVIER)S0367-326X(20)30069-1 DE-627 ger DE-627 rda eng 570 DE-600 Shao, Si-Yuan verfasserin aut Hepatoprotective lignans and triterpenoids from the roots of 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%. Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity Qi, Xin-Zhu verfasserin aut Sun, Hua verfasserin aut Li, Shuai verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 142 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 142
spelling	10.1016/j.fitote.2020.104487 doi (DE-627)ELV003870588 (ELSEVIER)S0367-326X(20)30069-1 DE-627 ger DE-627 rda eng 570 DE-600 Shao, Si-Yuan verfasserin aut Hepatoprotective lignans and triterpenoids from the roots of 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%. Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity Qi, Xin-Zhu verfasserin aut Sun, Hua verfasserin aut Li, Shuai verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 142 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 142
allfields_unstemmed	10.1016/j.fitote.2020.104487 doi (DE-627)ELV003870588 (ELSEVIER)S0367-326X(20)30069-1 DE-627 ger DE-627 rda eng 570 DE-600 Shao, Si-Yuan verfasserin aut Hepatoprotective lignans and triterpenoids from the roots of 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%. Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity Qi, Xin-Zhu verfasserin aut Sun, Hua verfasserin aut Li, Shuai verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 142 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 142
allfieldsGer	10.1016/j.fitote.2020.104487 doi (DE-627)ELV003870588 (ELSEVIER)S0367-326X(20)30069-1 DE-627 ger DE-627 rda eng 570 DE-600 Shao, Si-Yuan verfasserin aut Hepatoprotective lignans and triterpenoids from the roots of 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%. Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity Qi, Xin-Zhu verfasserin aut Sun, Hua verfasserin aut Li, Shuai verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 142 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 142
allfieldsSound	10.1016/j.fitote.2020.104487 doi (DE-627)ELV003870588 (ELSEVIER)S0367-326X(20)30069-1 DE-627 ger DE-627 rda eng 570 DE-600 Shao, Si-Yuan verfasserin aut Hepatoprotective lignans and triterpenoids from the roots of 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%. Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity Qi, Xin-Zhu verfasserin aut Sun, Hua verfasserin aut Li, Shuai verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 142 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 142
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topic_facet	Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity
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author	Shao, Si-Yuan
spellingShingle	Shao, Si-Yuan ddc 570 misc Tetrahydrobenzocyclooctabenzofuranone lignan misc Dibenzocyclooctadiene lignan misc Schiartane-type triterpenoid misc Hepatoprotective activity Hepatoprotective lignans and triterpenoids from the roots of
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topic_title	570 DE-600 Hepatoprotective lignans and triterpenoids from the roots of Tetrahydrobenzocyclooctabenzofuranone lignan Dibenzocyclooctadiene lignan Schiartane-type triterpenoid Hepatoprotective activity
topic	ddc 570 misc Tetrahydrobenzocyclooctabenzofuranone lignan misc Dibenzocyclooctadiene lignan misc Schiartane-type triterpenoid misc Hepatoprotective activity
topic_unstemmed	ddc 570 misc Tetrahydrobenzocyclooctabenzofuranone lignan misc Dibenzocyclooctadiene lignan misc Schiartane-type triterpenoid misc Hepatoprotective activity
topic_browse	ddc 570 misc Tetrahydrobenzocyclooctabenzofuranone lignan misc Dibenzocyclooctadiene lignan misc Schiartane-type triterpenoid misc Hepatoprotective activity
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title	Hepatoprotective lignans and triterpenoids from the roots of
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title_full	Hepatoprotective lignans and triterpenoids from the roots of
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title_sort	hepatoprotective lignans and triterpenoids from the roots of
title_auth	Hepatoprotective lignans and triterpenoids from the roots of
abstract	Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%.
abstractGer	Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%.
abstract_unstemmed	Two new tetrahydrobenzocyclooctabenzofuranone lignans (1–2), a new dibenzocyclooctadiene lignan (3) and three new schiartane-type triterpenoids (4–6), together with six known compounds (7–12), were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. Compound 12 exhibited moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 53.04%.
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title_short	Hepatoprotective lignans and triterpenoids from the roots of
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author2	Qi, Xin-Zhu Sun, Hua Li, Shuai
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doi_str	10.1016/j.fitote.2020.104487
up_date	2024-07-06T21:04:22.625Z
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Their structures were elucidated by extensive NMR and HRESIMS spectroscopic data analysis. The absolute configurations of these compounds were determined by comparison of the experimental and calculated ECD spectra. 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