Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging
Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotem...
Ausführliche Beschreibung
Autor*in: |
Zou, Zhen [verfasserIn] Luo, Ziling [verfasserIn] Xu, Xuan [verfasserIn] Yang, Sheng [verfasserIn] Qing, Zhihe [verfasserIn] Liu, Juewen [verfasserIn] Yang, Ronghua [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Trends in analytical chemistry - Amsterdam : Elsevier, 1981, 125 |
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Übergeordnetes Werk: |
volume:125 |
DOI / URN: |
10.1016/j.trac.2020.115811 |
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Katalog-ID: |
ELV003895785 |
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520 | |a Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. | ||
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2020 |
allfields |
10.1016/j.trac.2020.115811 doi (DE-627)ELV003895785 (ELSEVIER)S0165-9936(19)30543-6 DE-627 ger DE-627 rda eng 540 DE-600 35.23 bkl Zou, Zhen verfasserin aut Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. Photoactivatable Spatiotemporal-control Organic small-molecular probes Nucleic acid probes Biosensing and imaging Luo, Ziling verfasserin aut Xu, Xuan verfasserin aut Yang, Sheng verfasserin aut Qing, Zhihe verfasserin aut Liu, Juewen verfasserin aut Yang, Ronghua verfasserin aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 125 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:125 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.23 Analytische Chemie: Allgemeines AR 125 |
spelling |
10.1016/j.trac.2020.115811 doi (DE-627)ELV003895785 (ELSEVIER)S0165-9936(19)30543-6 DE-627 ger DE-627 rda eng 540 DE-600 35.23 bkl Zou, Zhen verfasserin aut Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. Photoactivatable Spatiotemporal-control Organic small-molecular probes Nucleic acid probes Biosensing and imaging Luo, Ziling verfasserin aut Xu, Xuan verfasserin aut Yang, Sheng verfasserin aut Qing, Zhihe verfasserin aut Liu, Juewen verfasserin aut Yang, Ronghua verfasserin aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 125 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:125 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.23 Analytische Chemie: Allgemeines AR 125 |
allfields_unstemmed |
10.1016/j.trac.2020.115811 doi (DE-627)ELV003895785 (ELSEVIER)S0165-9936(19)30543-6 DE-627 ger DE-627 rda eng 540 DE-600 35.23 bkl Zou, Zhen verfasserin aut Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. Photoactivatable Spatiotemporal-control Organic small-molecular probes Nucleic acid probes Biosensing and imaging Luo, Ziling verfasserin aut Xu, Xuan verfasserin aut Yang, Sheng verfasserin aut Qing, Zhihe verfasserin aut Liu, Juewen verfasserin aut Yang, Ronghua verfasserin aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 125 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:125 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.23 Analytische Chemie: Allgemeines AR 125 |
allfieldsGer |
10.1016/j.trac.2020.115811 doi (DE-627)ELV003895785 (ELSEVIER)S0165-9936(19)30543-6 DE-627 ger DE-627 rda eng 540 DE-600 35.23 bkl Zou, Zhen verfasserin aut Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. Photoactivatable Spatiotemporal-control Organic small-molecular probes Nucleic acid probes Biosensing and imaging Luo, Ziling verfasserin aut Xu, Xuan verfasserin aut Yang, Sheng verfasserin aut Qing, Zhihe verfasserin aut Liu, Juewen verfasserin aut Yang, Ronghua verfasserin aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 125 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:125 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.23 Analytische Chemie: Allgemeines AR 125 |
allfieldsSound |
10.1016/j.trac.2020.115811 doi (DE-627)ELV003895785 (ELSEVIER)S0165-9936(19)30543-6 DE-627 ger DE-627 rda eng 540 DE-600 35.23 bkl Zou, Zhen verfasserin aut Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. Photoactivatable Spatiotemporal-control Organic small-molecular probes Nucleic acid probes Biosensing and imaging Luo, Ziling verfasserin aut Xu, Xuan verfasserin aut Yang, Sheng verfasserin aut Qing, Zhihe verfasserin aut Liu, Juewen verfasserin aut Yang, Ronghua verfasserin aut Enthalten in Trends in analytical chemistry Amsterdam : Elsevier, 1981 125 Online-Ressource (DE-627)320516601 (DE-600)2014041-1 (DE-576)098253344 nnns volume:125 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.23 Analytische Chemie: Allgemeines AR 125 |
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Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging |
abstract |
Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. |
abstractGer |
Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. |
abstract_unstemmed |
Designing fluorescent probes for accurately analyzing target molecules of interest become fascinating and vital in the view of biology and biomedicine. Conventional fluorescent probes are often obscured by the interference from biological autofluorescence, off-target effects, and a lack of spatiotemporal control. As a newly developed paradigm, photoactivatable fluorescent probes (PFPs), whose sensing or imaging behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Over the past decades, substantial progress has been made in designing PFPs for sensing and imaging of biologically active molecules. In this review, we display an overview of current representative strategies and their underlying mechanisms, including light-inducible target recognition, light-controlled enzymatic activity, and photoactivatable fluorophores. Finally, the challenges and prospects in this promising field are featured on the basis of its current development. |
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title_short |
Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging |
remote_bool |
true |
author2 |
Luo, Ziling Xu, Xuan Yang, Sheng Qing, Zhihe Liu, Juewen Yang, Ronghua |
author2Str |
Luo, Ziling Xu, Xuan Yang, Sheng Qing, Zhihe Liu, Juewen Yang, Ronghua |
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320516601 |
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c |
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doi_str |
10.1016/j.trac.2020.115811 |
up_date |
2024-07-06T21:09:23.046Z |
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