A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy
Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the lar...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ahn, Young Ha [verfasserIn] Ren, Long [verfasserIn] Kim, Seok Min [verfasserIn] Seo, Sang-Hwan [verfasserIn] Jung, Cho-Rok [verfasserIn] Kim, Da Seul [verfasserIn] Noh, Ji-Yoon [verfasserIn] Lee, Soo Yun [verfasserIn] Lee, Hyunseung [verfasserIn] Cho, Mi Young [verfasserIn] Jung, Haiyoung [verfasserIn] Yoon, Suk Ran [verfasserIn] Kim, Jung-Eun [verfasserIn] Lee, Sang Nam [verfasserIn] Kim, Sohyun [verfasserIn] Shin, Il Woo [verfasserIn] Shin, Hong Sik [verfasserIn] Hong, Kwan Soo [verfasserIn] Lim, Yong Taik [verfasserIn] Choi, Inpyo [verfasserIn] Kim, Tae-Don [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Biomaterials - Amsterdam [u.a.] : Elsevier Science, 1980, 247 |
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| Übergeordnetes Werk: |
volume:247 |
| DOI / URN: |
10.1016/j.biomaterials.2020.119960 |
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| Katalog-ID: |
ELV003938697 |
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| 245 | 1 | 0 | |a A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy |
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| 520 | |a Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. | ||
| 650 | 4 | |a Natural killer cells | |
| 650 | 4 | |a Three-dimensional culture | |
| 650 | 4 | |a Scaffold | |
| 650 | 4 | |a Cancer immunotherapy | |
| 650 | 4 | |a Adoptive cell transfer | |
| 700 | 1 | |a Ren, Long |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Seok Min |e verfasserin |4 aut | |
| 700 | 1 | |a Seo, Sang-Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Cho-Rok |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Da Seul |e verfasserin |4 aut | |
| 700 | 1 | |a Noh, Ji-Yoon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Soo Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hyunseung |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Mi Young |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Haiyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Suk Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jung-Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Sang Nam |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sohyun |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Il Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Hong Sik |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Kwan Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Yong Taik |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Inpyo |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Tae-Don |e verfasserin |4 aut | |
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10.1016/j.biomaterials.2020.119960 doi (DE-627)ELV003938697 (ELSEVIER)S0142-9612(20)30206-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.09 bkl Ahn, Young Ha verfasserin aut A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer Ren, Long verfasserin aut Kim, Seok Min verfasserin aut Seo, Sang-Hwan verfasserin aut Jung, Cho-Rok verfasserin aut Kim, Da Seul verfasserin aut Noh, Ji-Yoon verfasserin aut Lee, Soo Yun verfasserin aut Lee, Hyunseung verfasserin aut Cho, Mi Young verfasserin aut Jung, Haiyoung verfasserin aut Yoon, Suk Ran verfasserin aut Kim, Jung-Eun verfasserin aut Lee, Sang Nam verfasserin aut Kim, Sohyun verfasserin aut Shin, Il Woo verfasserin aut Shin, Hong Sik verfasserin aut Hong, Kwan Soo verfasserin aut Lim, Yong Taik verfasserin aut Choi, Inpyo verfasserin aut Kim, Tae-Don verfasserin aut Enthalten in Biomaterials Amsterdam [u.a.] : Elsevier Science, 1980 247 Online-Ressource (DE-627)32043320X (DE-600)2004010-6 (DE-576)098614932 0142-9612 nnns volume:247 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.09 Medizintechnik AR 247 |
| spelling |
10.1016/j.biomaterials.2020.119960 doi (DE-627)ELV003938697 (ELSEVIER)S0142-9612(20)30206-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.09 bkl Ahn, Young Ha verfasserin aut A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer Ren, Long verfasserin aut Kim, Seok Min verfasserin aut Seo, Sang-Hwan verfasserin aut Jung, Cho-Rok verfasserin aut Kim, Da Seul verfasserin aut Noh, Ji-Yoon verfasserin aut Lee, Soo Yun verfasserin aut Lee, Hyunseung verfasserin aut Cho, Mi Young verfasserin aut Jung, Haiyoung verfasserin aut Yoon, Suk Ran verfasserin aut Kim, Jung-Eun verfasserin aut Lee, Sang Nam verfasserin aut Kim, Sohyun verfasserin aut Shin, Il Woo verfasserin aut Shin, Hong Sik verfasserin aut Hong, Kwan Soo verfasserin aut Lim, Yong Taik verfasserin aut Choi, Inpyo verfasserin aut Kim, Tae-Don verfasserin aut Enthalten in Biomaterials Amsterdam [u.a.] : Elsevier Science, 1980 247 Online-Ressource (DE-627)32043320X (DE-600)2004010-6 (DE-576)098614932 0142-9612 nnns volume:247 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.09 Medizintechnik AR 247 |
| allfields_unstemmed |
10.1016/j.biomaterials.2020.119960 doi (DE-627)ELV003938697 (ELSEVIER)S0142-9612(20)30206-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.09 bkl Ahn, Young Ha verfasserin aut A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer Ren, Long verfasserin aut Kim, Seok Min verfasserin aut Seo, Sang-Hwan verfasserin aut Jung, Cho-Rok verfasserin aut Kim, Da Seul verfasserin aut Noh, Ji-Yoon verfasserin aut Lee, Soo Yun verfasserin aut Lee, Hyunseung verfasserin aut Cho, Mi Young verfasserin aut Jung, Haiyoung verfasserin aut Yoon, Suk Ran verfasserin aut Kim, Jung-Eun verfasserin aut Lee, Sang Nam verfasserin aut Kim, Sohyun verfasserin aut Shin, Il Woo verfasserin aut Shin, Hong Sik verfasserin aut Hong, Kwan Soo verfasserin aut Lim, Yong Taik verfasserin aut Choi, Inpyo verfasserin aut Kim, Tae-Don verfasserin aut Enthalten in Biomaterials Amsterdam [u.a.] : Elsevier Science, 1980 247 Online-Ressource (DE-627)32043320X (DE-600)2004010-6 (DE-576)098614932 0142-9612 nnns volume:247 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.09 Medizintechnik AR 247 |
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10.1016/j.biomaterials.2020.119960 doi (DE-627)ELV003938697 (ELSEVIER)S0142-9612(20)30206-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.09 bkl Ahn, Young Ha verfasserin aut A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer Ren, Long verfasserin aut Kim, Seok Min verfasserin aut Seo, Sang-Hwan verfasserin aut Jung, Cho-Rok verfasserin aut Kim, Da Seul verfasserin aut Noh, Ji-Yoon verfasserin aut Lee, Soo Yun verfasserin aut Lee, Hyunseung verfasserin aut Cho, Mi Young verfasserin aut Jung, Haiyoung verfasserin aut Yoon, Suk Ran verfasserin aut Kim, Jung-Eun verfasserin aut Lee, Sang Nam verfasserin aut Kim, Sohyun verfasserin aut Shin, Il Woo verfasserin aut Shin, Hong Sik verfasserin aut Hong, Kwan Soo verfasserin aut Lim, Yong Taik verfasserin aut Choi, Inpyo verfasserin aut Kim, Tae-Don verfasserin aut Enthalten in Biomaterials Amsterdam [u.a.] : Elsevier Science, 1980 247 Online-Ressource (DE-627)32043320X (DE-600)2004010-6 (DE-576)098614932 0142-9612 nnns volume:247 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.09 Medizintechnik AR 247 |
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10.1016/j.biomaterials.2020.119960 doi (DE-627)ELV003938697 (ELSEVIER)S0142-9612(20)30206-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.09 bkl Ahn, Young Ha verfasserin aut A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer Ren, Long verfasserin aut Kim, Seok Min verfasserin aut Seo, Sang-Hwan verfasserin aut Jung, Cho-Rok verfasserin aut Kim, Da Seul verfasserin aut Noh, Ji-Yoon verfasserin aut Lee, Soo Yun verfasserin aut Lee, Hyunseung verfasserin aut Cho, Mi Young verfasserin aut Jung, Haiyoung verfasserin aut Yoon, Suk Ran verfasserin aut Kim, Jung-Eun verfasserin aut Lee, Sang Nam verfasserin aut Kim, Sohyun verfasserin aut Shin, Il Woo verfasserin aut Shin, Hong Sik verfasserin aut Hong, Kwan Soo verfasserin aut Lim, Yong Taik verfasserin aut Choi, Inpyo verfasserin aut Kim, Tae-Don verfasserin aut Enthalten in Biomaterials Amsterdam [u.a.] : Elsevier Science, 1980 247 Online-Ressource (DE-627)32043320X (DE-600)2004010-6 (DE-576)098614932 0142-9612 nnns volume:247 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.09 Medizintechnik AR 247 |
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Ahn, Young Ha @@aut@@ Ren, Long @@aut@@ Kim, Seok Min @@aut@@ Seo, Sang-Hwan @@aut@@ Jung, Cho-Rok @@aut@@ Kim, Da Seul @@aut@@ Noh, Ji-Yoon @@aut@@ Lee, Soo Yun @@aut@@ Lee, Hyunseung @@aut@@ Cho, Mi Young @@aut@@ Jung, Haiyoung @@aut@@ Yoon, Suk Ran @@aut@@ Kim, Jung-Eun @@aut@@ Lee, Sang Nam @@aut@@ Kim, Sohyun @@aut@@ Shin, Il Woo @@aut@@ Shin, Hong Sik @@aut@@ Hong, Kwan Soo @@aut@@ Lim, Yong Taik @@aut@@ Choi, Inpyo @@aut@@ Kim, Tae-Don @@aut@@ |
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2020-01-01T00:00:00Z |
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ELV003938697 |
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570 DE-600 BIODIV DE-30 fid 44.09 bkl A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy Natural killer cells Three-dimensional culture Scaffold Cancer immunotherapy Adoptive cell transfer |
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Ahn, Young Ha Ren, Long Kim, Seok Min Seo, Sang-Hwan Jung, Cho-Rok Kim, Da Seul Noh, Ji-Yoon Lee, Soo Yun Lee, Hyunseung Cho, Mi Young Jung, Haiyoung Yoon, Suk Ran Kim, Jung-Eun Lee, Sang Nam Kim, Sohyun Shin, Il Woo Shin, Hong Sik Hong, Kwan Soo Lim, Yong Taik Choi, Inpyo Kim, Tae-Don |
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a three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy |
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A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy |
| abstract |
Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. |
| abstractGer |
Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. |
| abstract_unstemmed |
Adoptive transfer of natural killer (NK) cells is becoming one of the most important parts of cancer immunotherapy. However, recent accomplishments have focused on the improvement of the targeting effects based on the engineering of chimeric antigen receptors (CARs) on cell surfaces. Despite the large quantity of therapeutic cells required for clinical applications, the technology for ex vivo expansion is not well developed. Herein, a three-dimensional (3D) engineered hyaluronic acid-based niche for cell expansion (3D-ENHANCE) is introduced. Compared with the conventional two-dimensional (2D) method, NK-92 cell lines and human EGFR-specific (CAR)–NK cells cultured in 3D-ENHANCE yield favorable mRNA expressions, elevated cytokine release, upregulated proliferative and tumor-lytic abilities, and result in enhanced antitumor efficacy. Furthermore, controllable degradation rates can be realized by tuning the formulation of 3D-ENHANCE so that it can be applied as an implantable cell reservoir at surgical sites. In vivo results with the incompletely resected MDA-MB-231 model confirm that the peri-operative implantation of 3D-ENHANCE prevents the relapse and metastases after surgery. Overall, 3D-ENHANCE presents an effective cytokine-free niche for ex vivo expansion and postsurgical treatment that enhances the low-therapeutic efficacy of human NK cells. |
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Ren, Long Kim, Seok Min Seo, Sang-Hwan Jung, Cho-Rok Kim, Da Seul Noh, Ji-Yoon Lee, Soo Yun Lee, Hyunseung Cho, Mi Young Jung, Haiyoung Yoon, Suk Ran Kim, Jung-Eun Lee, Sang Nam Kim, Sohyun Shin, Il Woo Shin, Hong Sik Hong, Kwan Soo Lim, Yong Taik Choi, Inpyo Kim, Tae-Don |
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| score |
7.399952 |