Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome

Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie,...
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Autor*in:	Bokov, Plamen [verfasserIn] Matrot, Boris [verfasserIn] Medjahdi, Noria [verfasserIn] Boureghda, Souham [verfasserIn] Essalhi, Mohamed [verfasserIn] Konofal, Eric [verfasserIn] Lecendreux, Michel [verfasserIn] Gallego, Jorge [verfasserIn] Delclaux, Christophe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Sleep apnea Childhood Ventilatory control Loop gain

Übergeordnetes Werk:	Enthalten in: Sleep medicine - Amsterdam [u.a.] : Elsevier, 2000, 69, Seite 172-178
Übergeordnetes Werk:	volume:69 ; pages:172-178

DOI / URN:	10.1016/j.sleep.2020.01.023

Katalog-ID:	ELV004036964

Internformat


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100	1		\|a Bokov, Plamen \|e verfasserin \|4 aut
245	1	0	\|a Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
264		1	\|c 2020
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.
650		4	\|a Sleep apnea
650		4	\|a Childhood
650		4	\|a Ventilatory control
650		4	\|a Loop gain
700	1		\|a Matrot, Boris \|e verfasserin \|4 aut
700	1		\|a Medjahdi, Noria \|e verfasserin \|4 aut
700	1		\|a Boureghda, Souham \|e verfasserin \|4 aut
700	1		\|a Essalhi, Mohamed \|e verfasserin \|4 aut
700	1		\|a Konofal, Eric \|e verfasserin \|0 (orcid)0000-0002-7284-0987 \|4 aut
700	1		\|a Lecendreux, Michel \|e verfasserin \|4 aut
700	1		\|a Gallego, Jorge \|e verfasserin \|4 aut
700	1		\|a Delclaux, Christophe \|e verfasserin \|0 (orcid)0000-0003-2786-0812 \|4 aut
773	0	8	\|i Enthalten in \|t Sleep medicine \|d Amsterdam [u.a.] : Elsevier, 2000 \|g 69, Seite 172-178 \|h Online-Ressource \|w (DE-627)326646949 \|w (DE-600)2041737-8 \|w (DE-576)105536768 \|x 1878-5506 \|7 nnns
773	1	8	\|g volume:69 \|g pages:172-178
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
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912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.90 \|j Neurologie
951			\|a AR
952			\|d 69 \|h 172-178

Indexfelder

author_variant	p b pb b m bm n m nm s b sb m e me e k ek m l ml j g jg c d cd
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publishDate	2020
allfields	10.1016/j.sleep.2020.01.023 doi (DE-627)ELV004036964 (ELSEVIER)S1389-9457(20)30057-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Bokov, Plamen verfasserin aut Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested. Sleep apnea Childhood Ventilatory control Loop gain Matrot, Boris verfasserin aut Medjahdi, Noria verfasserin aut Boureghda, Souham verfasserin aut Essalhi, Mohamed verfasserin aut Konofal, Eric verfasserin (orcid)0000-0002-7284-0987 aut Lecendreux, Michel verfasserin aut Gallego, Jorge verfasserin aut Delclaux, Christophe verfasserin (orcid)0000-0003-2786-0812 aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 69, Seite 172-178 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:69 pages:172-178 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 69 172-178
spelling	10.1016/j.sleep.2020.01.023 doi (DE-627)ELV004036964 (ELSEVIER)S1389-9457(20)30057-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Bokov, Plamen verfasserin aut Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested. Sleep apnea Childhood Ventilatory control Loop gain Matrot, Boris verfasserin aut Medjahdi, Noria verfasserin aut Boureghda, Souham verfasserin aut Essalhi, Mohamed verfasserin aut Konofal, Eric verfasserin (orcid)0000-0002-7284-0987 aut Lecendreux, Michel verfasserin aut Gallego, Jorge verfasserin aut Delclaux, Christophe verfasserin (orcid)0000-0003-2786-0812 aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 69, Seite 172-178 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:69 pages:172-178 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 69 172-178
allfields_unstemmed	10.1016/j.sleep.2020.01.023 doi (DE-627)ELV004036964 (ELSEVIER)S1389-9457(20)30057-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Bokov, Plamen verfasserin aut Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested. Sleep apnea Childhood Ventilatory control Loop gain Matrot, Boris verfasserin aut Medjahdi, Noria verfasserin aut Boureghda, Souham verfasserin aut Essalhi, Mohamed verfasserin aut Konofal, Eric verfasserin (orcid)0000-0002-7284-0987 aut Lecendreux, Michel verfasserin aut Gallego, Jorge verfasserin aut Delclaux, Christophe verfasserin (orcid)0000-0003-2786-0812 aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 69, Seite 172-178 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:69 pages:172-178 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 69 172-178
allfieldsGer	10.1016/j.sleep.2020.01.023 doi (DE-627)ELV004036964 (ELSEVIER)S1389-9457(20)30057-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Bokov, Plamen verfasserin aut Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested. Sleep apnea Childhood Ventilatory control Loop gain Matrot, Boris verfasserin aut Medjahdi, Noria verfasserin aut Boureghda, Souham verfasserin aut Essalhi, Mohamed verfasserin aut Konofal, Eric verfasserin (orcid)0000-0002-7284-0987 aut Lecendreux, Michel verfasserin aut Gallego, Jorge verfasserin aut Delclaux, Christophe verfasserin (orcid)0000-0003-2786-0812 aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 69, Seite 172-178 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:69 pages:172-178 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 69 172-178
allfieldsSound	10.1016/j.sleep.2020.01.023 doi (DE-627)ELV004036964 (ELSEVIER)S1389-9457(20)30057-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Bokov, Plamen verfasserin aut Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested. Sleep apnea Childhood Ventilatory control Loop gain Matrot, Boris verfasserin aut Medjahdi, Noria verfasserin aut Boureghda, Souham verfasserin aut Essalhi, Mohamed verfasserin aut Konofal, Eric verfasserin (orcid)0000-0002-7284-0987 aut Lecendreux, Michel verfasserin aut Gallego, Jorge verfasserin aut Delclaux, Christophe verfasserin (orcid)0000-0003-2786-0812 aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 69, Seite 172-178 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:69 pages:172-178 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 69 172-178
language	English
source	Enthalten in Sleep medicine 69, Seite 172-178 volume:69 pages:172-178
sourceStr	Enthalten in Sleep medicine 69, Seite 172-178 volume:69 pages:172-178
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Sleep apnea Childhood Ventilatory control Loop gain
dewey-raw	610
isfreeaccess_bool	false
container_title	Sleep medicine
authorswithroles_txt_mv	Bokov, Plamen @@aut@@ Matrot, Boris @@aut@@ Medjahdi, Noria @@aut@@ Boureghda, Souham @@aut@@ Essalhi, Mohamed @@aut@@ Konofal, Eric @@aut@@ Lecendreux, Michel @@aut@@ Gallego, Jorge @@aut@@ Delclaux, Christophe @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	326646949
dewey-sort	3610
id	ELV004036964
language_de	englisch
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In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sleep apnea</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Childhood</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventilatory control</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Loop gain</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matrot, Boris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Medjahdi, Noria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" 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author	Bokov, Plamen
spellingShingle	Bokov, Plamen ddc 610 bkl 44.90 misc Sleep apnea misc Childhood misc Ventilatory control misc Loop gain Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
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topic_title	610 DE-600 44.90 bkl Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome Sleep apnea Childhood Ventilatory control Loop gain
topic	ddc 610 bkl 44.90 misc Sleep apnea misc Childhood misc Ventilatory control misc Loop gain
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title	Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
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title_full	Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
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author_browse	Bokov, Plamen Matrot, Boris Medjahdi, Noria Boureghda, Souham Essalhi, Mohamed Konofal, Eric Lecendreux, Michel Gallego, Jorge Delclaux, Christophe
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title_sort	cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
title_auth	Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
abstract	Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.
abstractGer	Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.
abstract_unstemmed	Study objectives: We aimed to assess ventilatory control in typically developing children with and without obstructive sleep apnea (OSA).Methods: Otherwise healthy children referred for suspicion of OSA were recruited. In addition to polysomnography, we analyzed loop, controller and plant gains (ie, LG, CG, and PG), which reflect the stability of control, chemoreceptor sensitivity and the pulmonary control of blood gases in response to changes in ventilation, respectively, from tidal breathing recordings during wakefulness. Two bivariate (ventilation, end-tidal CO2: one unconstrained and one constrained) and one trivariate (plus end-tidal oxygen) unconstrained model were used to assess model consistency and oxygen chemosensitivity.Results: In sum, 54 children (median age 11.6 years) were included. Children with OSA (n = 19, [obstructive apnea-hypopnea index] OAHI ≥2.h−1) had a higher plant gain compared with those without OSA (n = 35), and it was positively correlated with apnea hypopnea index (AHI) (r2 = 0.10, p < 0.020). The two models showed consistent results. The bivariate constrained model showed that children with OAHI ≥5.h−1 showed an increased steady-state plant gain compared with children with OAHI <5.h−1. The trivariate model did not show evidence of any abnormality of oxygen chemosensitivity.Conclusion: Plant gain may contribute to OSA pathophysiology in children, and therapies directed at its reduction should be tested.
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title_short	Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
remote_bool	true
author2	Matrot, Boris Medjahdi, Noria Boureghda, Souham Essalhi, Mohamed Konofal, Eric Lecendreux, Michel Gallego, Jorge Delclaux, Christophe
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doi_str	10.1016/j.sleep.2020.01.023
up_date	2024-07-06T21:38:10.463Z
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Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome

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