Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction
Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Meister, Sarah [verfasserIn] Kolben, Thomas [verfasserIn] Beyer, Susanne [verfasserIn] Hutter, Stefan [verfasserIn] Hofmann, Simone [verfasserIn] Kuhn, Christina [verfasserIn] Messner, Julia [verfasserIn] Mayr, Doris [verfasserIn] Solano, Maria Emilia [verfasserIn] Jegen, Magdalena [verfasserIn] Obermeier, Viola [verfasserIn] Mahner, Sven [verfasserIn] Arck, Petra [verfasserIn] Jeschke, Udo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of reproductive immunology - Oxford : Oxford University Press, 1979, 139 |
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| Übergeordnetes Werk: |
volume:139 |
| DOI / URN: |
10.1016/j.jri.2020.103124 |
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| Katalog-ID: |
ELV004064402 |
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| 100 | 1 | |a Meister, Sarah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
| 264 | 1 | |c 2020 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
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| 520 | |a Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. | ||
| 650 | 4 | |a Histone modification | |
| 650 | 4 | |a H3K4me3 | |
| 650 | 4 | |a H3K9ac | |
| 700 | 1 | |a Kolben, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Beyer, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Hutter, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Hofmann, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Kuhn, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Messner, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Mayr, Doris |e verfasserin |4 aut | |
| 700 | 1 | |a Solano, Maria Emilia |e verfasserin |4 aut | |
| 700 | 1 | |a Jegen, Magdalena |e verfasserin |4 aut | |
| 700 | 1 | |a Obermeier, Viola |e verfasserin |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Arck, Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Jeschke, Udo |e verfasserin |4 aut | |
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2020 |
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2020 |
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10.1016/j.jri.2020.103124 doi (DE-627)ELV004064402 (ELSEVIER)S0165-0378(20)30045-0 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Meister, Sarah verfasserin aut Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. Histone modification H3K4me3 H3K9ac Kolben, Thomas verfasserin aut Beyer, Susanne verfasserin aut Hutter, Stefan verfasserin aut Hofmann, Simone verfasserin aut Kuhn, Christina verfasserin aut Messner, Julia verfasserin aut Mayr, Doris verfasserin aut Solano, Maria Emilia verfasserin aut Jegen, Magdalena verfasserin aut Obermeier, Viola verfasserin aut Mahner, Sven verfasserin aut Arck, Petra verfasserin aut Jeschke, Udo verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 139 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:139 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 139 |
| spelling |
10.1016/j.jri.2020.103124 doi (DE-627)ELV004064402 (ELSEVIER)S0165-0378(20)30045-0 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Meister, Sarah verfasserin aut Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. Histone modification H3K4me3 H3K9ac Kolben, Thomas verfasserin aut Beyer, Susanne verfasserin aut Hutter, Stefan verfasserin aut Hofmann, Simone verfasserin aut Kuhn, Christina verfasserin aut Messner, Julia verfasserin aut Mayr, Doris verfasserin aut Solano, Maria Emilia verfasserin aut Jegen, Magdalena verfasserin aut Obermeier, Viola verfasserin aut Mahner, Sven verfasserin aut Arck, Petra verfasserin aut Jeschke, Udo verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 139 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:139 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 139 |
| allfields_unstemmed |
10.1016/j.jri.2020.103124 doi (DE-627)ELV004064402 (ELSEVIER)S0165-0378(20)30045-0 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Meister, Sarah verfasserin aut Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. Histone modification H3K4me3 H3K9ac Kolben, Thomas verfasserin aut Beyer, Susanne verfasserin aut Hutter, Stefan verfasserin aut Hofmann, Simone verfasserin aut Kuhn, Christina verfasserin aut Messner, Julia verfasserin aut Mayr, Doris verfasserin aut Solano, Maria Emilia verfasserin aut Jegen, Magdalena verfasserin aut Obermeier, Viola verfasserin aut Mahner, Sven verfasserin aut Arck, Petra verfasserin aut Jeschke, Udo verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 139 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:139 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 139 |
| allfieldsGer |
10.1016/j.jri.2020.103124 doi (DE-627)ELV004064402 (ELSEVIER)S0165-0378(20)30045-0 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Meister, Sarah verfasserin aut Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. Histone modification H3K4me3 H3K9ac Kolben, Thomas verfasserin aut Beyer, Susanne verfasserin aut Hutter, Stefan verfasserin aut Hofmann, Simone verfasserin aut Kuhn, Christina verfasserin aut Messner, Julia verfasserin aut Mayr, Doris verfasserin aut Solano, Maria Emilia verfasserin aut Jegen, Magdalena verfasserin aut Obermeier, Viola verfasserin aut Mahner, Sven verfasserin aut Arck, Petra verfasserin aut Jeschke, Udo verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 139 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:139 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 139 |
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10.1016/j.jri.2020.103124 doi (DE-627)ELV004064402 (ELSEVIER)S0165-0378(20)30045-0 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Meister, Sarah verfasserin aut Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. Histone modification H3K4me3 H3K9ac Kolben, Thomas verfasserin aut Beyer, Susanne verfasserin aut Hutter, Stefan verfasserin aut Hofmann, Simone verfasserin aut Kuhn, Christina verfasserin aut Messner, Julia verfasserin aut Mayr, Doris verfasserin aut Solano, Maria Emilia verfasserin aut Jegen, Magdalena verfasserin aut Obermeier, Viola verfasserin aut Mahner, Sven verfasserin aut Arck, Petra verfasserin aut Jeschke, Udo verfasserin aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 139 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:139 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 139 |
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610 DE-600 44.45 bkl Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction Histone modification H3K4me3 H3K9ac |
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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
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Meister, Sarah Kolben, Thomas Beyer, Susanne Hutter, Stefan Hofmann, Simone Kuhn, Christina Messner, Julia Mayr, Doris Solano, Maria Emilia Jegen, Magdalena Obermeier, Viola Mahner, Sven Arck, Petra Jeschke, Udo |
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sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
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Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. |
| abstractGer |
Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. |
| abstract_unstemmed |
Background: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.Patients and Methods: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.Results: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.Conclusion: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas. |
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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction |
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Kolben, Thomas Beyer, Susanne Hutter, Stefan Hofmann, Simone Kuhn, Christina Messner, Julia Mayr, Doris Solano, Maria Emilia Jegen, Magdalena Obermeier, Viola Mahner, Sven Arck, Petra Jeschke, Udo |
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