Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and micr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hamatani, Mio [verfasserIn] Yamashita, Hirofumi [verfasserIn] Ochi, Hirofumi [verfasserIn] Ashida, Shinji [verfasserIn] Hashi, Yuichiro [verfasserIn] Okada, Yoichiro [verfasserIn] Fujii, Chihiro [verfasserIn] Kawamura, Kazuyuki [verfasserIn] Kitazawa, Riko [verfasserIn] Nakagawa, Masanori [verfasserIn] Mizuno, Toshiki [verfasserIn] Takahashi, Ryosuke [verfasserIn] Kondo, Takayuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia |
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| Übergeordnetes Werk: |
Enthalten in: Neurobiology of disease - [Amsterdam] : Elsevier, 1994, 140 |
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| Übergeordnetes Werk: |
volume:140 |
| DOI / URN: |
10.1016/j.nbd.2020.104867 |
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| 245 | 1 | 0 | |a Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis |
| 264 | 1 | |c 2020 | |
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| 520 | |a Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. | ||
| 650 | 4 | |a Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia | |
| 650 | 4 | |a Colony stimulating factor 1 receptor | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a Leukodystrophy | |
| 650 | 4 | |a Microglia | |
| 650 | 4 | |a Peripheral blood monocytes | |
| 700 | 1 | |a Yamashita, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Ochi, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Ashida, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Hashi, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Yoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Chihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamura, Kazuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kitazawa, Riko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, Masanori |e verfasserin |4 aut | |
| 700 | 1 | |a Mizuno, Toshiki |e verfasserin |0 (orcid)0000-0002-7907-8243 |4 aut | |
| 700 | 1 | |a Takahashi, Ryosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Takayuki |e verfasserin |4 aut | |
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10.1016/j.nbd.2020.104867 doi (DE-627)ELV004132521 (ELSEVIER)S0969-9961(20)30142-X DE-627 ger DE-627 rda eng 610 570 DE-600 44.90 bkl Hamatani, Mio verfasserin aut Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Colony stimulating factor 1 receptor Flow cytometry Leukodystrophy Microglia Peripheral blood monocytes Yamashita, Hirofumi verfasserin aut Ochi, Hirofumi verfasserin aut Ashida, Shinji verfasserin aut Hashi, Yuichiro verfasserin aut Okada, Yoichiro verfasserin aut Fujii, Chihiro verfasserin aut Kawamura, Kazuyuki verfasserin aut Kitazawa, Riko verfasserin aut Nakagawa, Masanori verfasserin aut Mizuno, Toshiki verfasserin (orcid)0000-0002-7907-8243 aut Takahashi, Ryosuke verfasserin aut Kondo, Takayuki verfasserin aut Enthalten in Neurobiology of disease [Amsterdam] : Elsevier, 1994 140 Online-Ressource (DE-627)268125414 (DE-600)1471408-5 (DE-576)27234947X 1095-953X nnns volume:140 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie AR 140 |
| spelling |
10.1016/j.nbd.2020.104867 doi (DE-627)ELV004132521 (ELSEVIER)S0969-9961(20)30142-X DE-627 ger DE-627 rda eng 610 570 DE-600 44.90 bkl Hamatani, Mio verfasserin aut Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Colony stimulating factor 1 receptor Flow cytometry Leukodystrophy Microglia Peripheral blood monocytes Yamashita, Hirofumi verfasserin aut Ochi, Hirofumi verfasserin aut Ashida, Shinji verfasserin aut Hashi, Yuichiro verfasserin aut Okada, Yoichiro verfasserin aut Fujii, Chihiro verfasserin aut Kawamura, Kazuyuki verfasserin aut Kitazawa, Riko verfasserin aut Nakagawa, Masanori verfasserin aut Mizuno, Toshiki verfasserin (orcid)0000-0002-7907-8243 aut Takahashi, Ryosuke verfasserin aut Kondo, Takayuki verfasserin aut Enthalten in Neurobiology of disease [Amsterdam] : Elsevier, 1994 140 Online-Ressource (DE-627)268125414 (DE-600)1471408-5 (DE-576)27234947X 1095-953X nnns volume:140 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie AR 140 |
| allfields_unstemmed |
10.1016/j.nbd.2020.104867 doi (DE-627)ELV004132521 (ELSEVIER)S0969-9961(20)30142-X DE-627 ger DE-627 rda eng 610 570 DE-600 44.90 bkl Hamatani, Mio verfasserin aut Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Colony stimulating factor 1 receptor Flow cytometry Leukodystrophy Microglia Peripheral blood monocytes Yamashita, Hirofumi verfasserin aut Ochi, Hirofumi verfasserin aut Ashida, Shinji verfasserin aut Hashi, Yuichiro verfasserin aut Okada, Yoichiro verfasserin aut Fujii, Chihiro verfasserin aut Kawamura, Kazuyuki verfasserin aut Kitazawa, Riko verfasserin aut Nakagawa, Masanori verfasserin aut Mizuno, Toshiki verfasserin (orcid)0000-0002-7907-8243 aut Takahashi, Ryosuke verfasserin aut Kondo, Takayuki verfasserin aut Enthalten in Neurobiology of disease [Amsterdam] : Elsevier, 1994 140 Online-Ressource (DE-627)268125414 (DE-600)1471408-5 (DE-576)27234947X 1095-953X nnns volume:140 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie AR 140 |
| allfieldsGer |
10.1016/j.nbd.2020.104867 doi (DE-627)ELV004132521 (ELSEVIER)S0969-9961(20)30142-X DE-627 ger DE-627 rda eng 610 570 DE-600 44.90 bkl Hamatani, Mio verfasserin aut Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Colony stimulating factor 1 receptor Flow cytometry Leukodystrophy Microglia Peripheral blood monocytes Yamashita, Hirofumi verfasserin aut Ochi, Hirofumi verfasserin aut Ashida, Shinji verfasserin aut Hashi, Yuichiro verfasserin aut Okada, Yoichiro verfasserin aut Fujii, Chihiro verfasserin aut Kawamura, Kazuyuki verfasserin aut Kitazawa, Riko verfasserin aut Nakagawa, Masanori verfasserin aut Mizuno, Toshiki verfasserin (orcid)0000-0002-7907-8243 aut Takahashi, Ryosuke verfasserin aut Kondo, Takayuki verfasserin aut Enthalten in Neurobiology of disease [Amsterdam] : Elsevier, 1994 140 Online-Ressource (DE-627)268125414 (DE-600)1471408-5 (DE-576)27234947X 1095-953X nnns volume:140 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie AR 140 |
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Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis |
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Hamatani, Mio |
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Neurobiology of disease |
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Hamatani, Mio Yamashita, Hirofumi Ochi, Hirofumi Ashida, Shinji Hashi, Yuichiro Okada, Yoichiro Fujii, Chihiro Kawamura, Kazuyuki Kitazawa, Riko Nakagawa, Masanori Mizuno, Toshiki Takahashi, Ryosuke Kondo, Takayuki |
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Hamatani, Mio |
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10.1016/j.nbd.2020.104867 |
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altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: a clue to the pathomechanism of microglial dyshomeostasis |
| title_auth |
Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis |
| abstract |
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. |
| abstractGer |
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. |
| abstract_unstemmed |
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and microglia in the brain. Hence, microglial dysfunction is regarded as critical in the pathogenesis of ALSP. However, functional changes in these cells have not been elucidated. In this study, we report the phenotypic and functional alterations of monocytes in four patients with ALSP. Flow cytometric analysis revealed altered expression of antigen presentation- and migration-related molecules, an inflammatory shift in cytokine production and phagocytic impairment in ALSP monocytes. We speculate that the observed altered features of monocytes are mostly shared by microglial cells, leading to the clinical history and pathological characteristics of ALSP. Our analysis of PB monocytes provides novel insights into the pathogenesis of ALSP. |
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| title_short |
Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis |
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| author2 |
Yamashita, Hirofumi Ochi, Hirofumi Ashida, Shinji Hashi, Yuichiro Okada, Yoichiro Fujii, Chihiro Kawamura, Kazuyuki Kitazawa, Riko Nakagawa, Masanori Mizuno, Toshiki Takahashi, Ryosuke Kondo, Takayuki |
| author2Str |
Yamashita, Hirofumi Ochi, Hirofumi Ashida, Shinji Hashi, Yuichiro Okada, Yoichiro Fujii, Chihiro Kawamura, Kazuyuki Kitazawa, Riko Nakagawa, Masanori Mizuno, Toshiki Takahashi, Ryosuke Kondo, Takayuki |
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| doi_str |
10.1016/j.nbd.2020.104867 |
| up_date |
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