Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids
Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylami...
Ausführliche Beschreibung
Autor*in: |
Attia, Yasser A. [verfasserIn] Mohamed, Yasser M.A. [verfasserIn] Awad, Mohamed M. [verfasserIn] Alexeree, Shaimaa [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Journal of organometallic chemistry - New York, NY [u.a.] : Elsevier, 1963, 919 |
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Übergeordnetes Werk: |
volume:919 |
DOI / URN: |
10.1016/j.jorganchem.2020.121320 |
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Katalog-ID: |
ELV004319109 |
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520 | |a Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. | ||
650 | 4 | |a ZnO nanorods | |
650 | 4 | |a Ag/ZnO nanocomposites | |
650 | 4 | |a Photocatalysis | |
650 | 4 | |a Photosynthesis | |
650 | 4 | |a Tetrazoles | |
650 | 4 | |a Toxicity | |
700 | 1 | |a Mohamed, Yasser M.A. |e verfasserin |0 (orcid)0000-0003-4678-9767 |4 aut | |
700 | 1 | |a Awad, Mohamed M. |e verfasserin |4 aut | |
700 | 1 | |a Alexeree, Shaimaa |e verfasserin |4 aut | |
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10.1016/j.jorganchem.2020.121320 doi (DE-627)ELV004319109 (ELSEVIER)S0022-328X(20)30222-9 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Attia, Yasser A. verfasserin (orcid)0000-0002-5830-2250 aut Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. ZnO nanorods Ag/ZnO nanocomposites Photocatalysis Photosynthesis Tetrazoles Toxicity Mohamed, Yasser M.A. verfasserin (orcid)0000-0003-4678-9767 aut Awad, Mohamed M. verfasserin aut Alexeree, Shaimaa verfasserin aut Enthalten in Journal of organometallic chemistry New York, NY [u.a.] : Elsevier, 1963 919 Online-Ressource (DE-627)302469990 (DE-600)1491530-3 (DE-576)094950318 1872-8561 nnns volume:919 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 919 |
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10.1016/j.jorganchem.2020.121320 doi (DE-627)ELV004319109 (ELSEVIER)S0022-328X(20)30222-9 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Attia, Yasser A. verfasserin (orcid)0000-0002-5830-2250 aut Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. ZnO nanorods Ag/ZnO nanocomposites Photocatalysis Photosynthesis Tetrazoles Toxicity Mohamed, Yasser M.A. verfasserin (orcid)0000-0003-4678-9767 aut Awad, Mohamed M. verfasserin aut Alexeree, Shaimaa verfasserin aut Enthalten in Journal of organometallic chemistry New York, NY [u.a.] : Elsevier, 1963 919 Online-Ressource (DE-627)302469990 (DE-600)1491530-3 (DE-576)094950318 1872-8561 nnns volume:919 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 919 |
allfields_unstemmed |
10.1016/j.jorganchem.2020.121320 doi (DE-627)ELV004319109 (ELSEVIER)S0022-328X(20)30222-9 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Attia, Yasser A. verfasserin (orcid)0000-0002-5830-2250 aut Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. ZnO nanorods Ag/ZnO nanocomposites Photocatalysis Photosynthesis Tetrazoles Toxicity Mohamed, Yasser M.A. verfasserin (orcid)0000-0003-4678-9767 aut Awad, Mohamed M. verfasserin aut Alexeree, Shaimaa verfasserin aut Enthalten in Journal of organometallic chemistry New York, NY [u.a.] : Elsevier, 1963 919 Online-Ressource (DE-627)302469990 (DE-600)1491530-3 (DE-576)094950318 1872-8561 nnns volume:919 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 919 |
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10.1016/j.jorganchem.2020.121320 doi (DE-627)ELV004319109 (ELSEVIER)S0022-328X(20)30222-9 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Attia, Yasser A. verfasserin (orcid)0000-0002-5830-2250 aut Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. ZnO nanorods Ag/ZnO nanocomposites Photocatalysis Photosynthesis Tetrazoles Toxicity Mohamed, Yasser M.A. verfasserin (orcid)0000-0003-4678-9767 aut Awad, Mohamed M. verfasserin aut Alexeree, Shaimaa verfasserin aut Enthalten in Journal of organometallic chemistry New York, NY [u.a.] : Elsevier, 1963 919 Online-Ressource (DE-627)302469990 (DE-600)1491530-3 (DE-576)094950318 1872-8561 nnns volume:919 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 919 |
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10.1016/j.jorganchem.2020.121320 doi (DE-627)ELV004319109 (ELSEVIER)S0022-328X(20)30222-9 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Attia, Yasser A. verfasserin (orcid)0000-0002-5830-2250 aut Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. ZnO nanorods Ag/ZnO nanocomposites Photocatalysis Photosynthesis Tetrazoles Toxicity Mohamed, Yasser M.A. verfasserin (orcid)0000-0003-4678-9767 aut Awad, Mohamed M. verfasserin aut Alexeree, Shaimaa verfasserin aut Enthalten in Journal of organometallic chemistry New York, NY [u.a.] : Elsevier, 1963 919 Online-Ressource (DE-627)302469990 (DE-600)1491530-3 (DE-576)094950318 1872-8561 nnns volume:919 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 919 |
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Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids |
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title_full |
Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids |
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Attia, Yasser A. |
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Journal of organometallic chemistry |
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Attia, Yasser A. Mohamed, Yasser M.A. Awad, Mohamed M. Alexeree, Shaimaa |
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Attia, Yasser A. |
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10.1016/j.jorganchem.2020.121320 |
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title_sort |
ag doped zno nanorods catalyzed photo-triggered synthesis of some novel (1h-tetrazol-5-yl)-coumarin hybrids |
title_auth |
Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids |
abstract |
Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. |
abstractGer |
Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. |
abstract_unstemmed |
Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. |
collection_details |
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title_short |
Ag doped ZnO nanorods catalyzed photo-triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids |
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author2 |
Mohamed, Yasser M.A. Awad, Mohamed M. Alexeree, Shaimaa |
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up_date |
2024-07-06T22:35:35.820Z |
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