Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges
The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Beddok, Arnaud [verfasserIn] Vela, Anthony [verfasserIn] Calugaru, Valentin [verfasserIn] Tessonnier, Thomas [verfasserIn] Kubes, Jiri [verfasserIn] Dutheil, Pauline [verfasserIn] Gerard, Anais [verfasserIn] Vidal, Marie [verfasserIn] Goudjil, Farid [verfasserIn] Florescu, Carmen [verfasserIn] Kammerer, Emmanuel [verfasserIn] Benezery, Karen [verfasserIn] Herault, Joel [verfasserIn] Poortmans, Philip [verfasserIn] Bourhis, Jean [verfasserIn] Thariat, Juliette [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Radiotherapy and oncology - Amsterdam [u.a.] : Elsevier Science, 1983, 147, Seite 30-39 |
|---|---|
| Übergeordnetes Werk: |
volume:147 ; pages:30-39 |
| DOI / URN: |
10.1016/j.radonc.2020.03.006 |
|---|
| Katalog-ID: |
ELV004319826 |
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| 245 | 1 | 0 | |a Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges |
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| 520 | |a The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. | ||
| 650 | 4 | |a Proton therapy | |
| 650 | 4 | |a Squamous Cell Carcinoma of Head and Neck | |
| 650 | 4 | |a Radiation therapy planning | |
| 650 | 4 | |a Computer-assisted | |
| 650 | 4 | |a Radiation tolerance | |
| 700 | 1 | |a Vela, Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a Calugaru, Valentin |e verfasserin |4 aut | |
| 700 | 1 | |a Tessonnier, Thomas |e verfasserin |0 (orcid)0000-0002-8919-4299 |4 aut | |
| 700 | 1 | |a Kubes, Jiri |e verfasserin |4 aut | |
| 700 | 1 | |a Dutheil, Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Gerard, Anais |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Goudjil, Farid |e verfasserin |4 aut | |
| 700 | 1 | |a Florescu, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Kammerer, Emmanuel |e verfasserin |0 (orcid)0000-0002-7386-9669 |4 aut | |
| 700 | 1 | |a Benezery, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Herault, Joel |e verfasserin |4 aut | |
| 700 | 1 | |a Poortmans, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Bourhis, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Thariat, Juliette |e verfasserin |4 aut | |
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10.1016/j.radonc.2020.03.006 doi (DE-627)ELV004319826 (ELSEVIER)S0167-8140(20)30115-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.64 bkl Beddok, Arnaud verfasserin aut Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance Vela, Anthony verfasserin aut Calugaru, Valentin verfasserin aut Tessonnier, Thomas verfasserin (orcid)0000-0002-8919-4299 aut Kubes, Jiri verfasserin aut Dutheil, Pauline verfasserin aut Gerard, Anais verfasserin aut Vidal, Marie verfasserin aut Goudjil, Farid verfasserin aut Florescu, Carmen verfasserin aut Kammerer, Emmanuel verfasserin (orcid)0000-0002-7386-9669 aut Benezery, Karen verfasserin aut Herault, Joel verfasserin aut Poortmans, Philip verfasserin aut Bourhis, Jean verfasserin aut Thariat, Juliette verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 147, Seite 30-39 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:147 pages:30-39 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.64 Radiologie AR 147 30-39 |
| spelling |
10.1016/j.radonc.2020.03.006 doi (DE-627)ELV004319826 (ELSEVIER)S0167-8140(20)30115-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.64 bkl Beddok, Arnaud verfasserin aut Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance Vela, Anthony verfasserin aut Calugaru, Valentin verfasserin aut Tessonnier, Thomas verfasserin (orcid)0000-0002-8919-4299 aut Kubes, Jiri verfasserin aut Dutheil, Pauline verfasserin aut Gerard, Anais verfasserin aut Vidal, Marie verfasserin aut Goudjil, Farid verfasserin aut Florescu, Carmen verfasserin aut Kammerer, Emmanuel verfasserin (orcid)0000-0002-7386-9669 aut Benezery, Karen verfasserin aut Herault, Joel verfasserin aut Poortmans, Philip verfasserin aut Bourhis, Jean verfasserin aut Thariat, Juliette verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 147, Seite 30-39 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:147 pages:30-39 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.64 Radiologie AR 147 30-39 |
| allfields_unstemmed |
10.1016/j.radonc.2020.03.006 doi (DE-627)ELV004319826 (ELSEVIER)S0167-8140(20)30115-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.64 bkl Beddok, Arnaud verfasserin aut Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance Vela, Anthony verfasserin aut Calugaru, Valentin verfasserin aut Tessonnier, Thomas verfasserin (orcid)0000-0002-8919-4299 aut Kubes, Jiri verfasserin aut Dutheil, Pauline verfasserin aut Gerard, Anais verfasserin aut Vidal, Marie verfasserin aut Goudjil, Farid verfasserin aut Florescu, Carmen verfasserin aut Kammerer, Emmanuel verfasserin (orcid)0000-0002-7386-9669 aut Benezery, Karen verfasserin aut Herault, Joel verfasserin aut Poortmans, Philip verfasserin aut Bourhis, Jean verfasserin aut Thariat, Juliette verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 147, Seite 30-39 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:147 pages:30-39 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.64 Radiologie AR 147 30-39 |
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10.1016/j.radonc.2020.03.006 doi (DE-627)ELV004319826 (ELSEVIER)S0167-8140(20)30115-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.64 bkl Beddok, Arnaud verfasserin aut Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance Vela, Anthony verfasserin aut Calugaru, Valentin verfasserin aut Tessonnier, Thomas verfasserin (orcid)0000-0002-8919-4299 aut Kubes, Jiri verfasserin aut Dutheil, Pauline verfasserin aut Gerard, Anais verfasserin aut Vidal, Marie verfasserin aut Goudjil, Farid verfasserin aut Florescu, Carmen verfasserin aut Kammerer, Emmanuel verfasserin (orcid)0000-0002-7386-9669 aut Benezery, Karen verfasserin aut Herault, Joel verfasserin aut Poortmans, Philip verfasserin aut Bourhis, Jean verfasserin aut Thariat, Juliette verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 147, Seite 30-39 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:147 pages:30-39 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.64 Radiologie AR 147 30-39 |
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10.1016/j.radonc.2020.03.006 doi (DE-627)ELV004319826 (ELSEVIER)S0167-8140(20)30115-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.64 bkl Beddok, Arnaud verfasserin aut Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance Vela, Anthony verfasserin aut Calugaru, Valentin verfasserin aut Tessonnier, Thomas verfasserin (orcid)0000-0002-8919-4299 aut Kubes, Jiri verfasserin aut Dutheil, Pauline verfasserin aut Gerard, Anais verfasserin aut Vidal, Marie verfasserin aut Goudjil, Farid verfasserin aut Florescu, Carmen verfasserin aut Kammerer, Emmanuel verfasserin (orcid)0000-0002-7386-9669 aut Benezery, Karen verfasserin aut Herault, Joel verfasserin aut Poortmans, Philip verfasserin aut Bourhis, Jean verfasserin aut Thariat, Juliette verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 147, Seite 30-39 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:147 pages:30-39 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.64 Radiologie AR 147 30-39 |
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Beddok, Arnaud @@aut@@ Vela, Anthony @@aut@@ Calugaru, Valentin @@aut@@ Tessonnier, Thomas @@aut@@ Kubes, Jiri @@aut@@ Dutheil, Pauline @@aut@@ Gerard, Anais @@aut@@ Vidal, Marie @@aut@@ Goudjil, Farid @@aut@@ Florescu, Carmen @@aut@@ Kammerer, Emmanuel @@aut@@ Benezery, Karen @@aut@@ Herault, Joel @@aut@@ Poortmans, Philip @@aut@@ Bourhis, Jean @@aut@@ Thariat, Juliette @@aut@@ |
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610 DE-600 44.81 bkl 44.64 bkl Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges Proton therapy Squamous Cell Carcinoma of Head and Neck Radiation therapy planning Computer-assisted Radiation tolerance |
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Beddok, Arnaud Vela, Anthony Calugaru, Valentin Tessonnier, Thomas Kubes, Jiri Dutheil, Pauline Gerard, Anais Vidal, Marie Goudjil, Farid Florescu, Carmen Kammerer, Emmanuel Benezery, Karen Herault, Joel Poortmans, Philip Bourhis, Jean Thariat, Juliette |
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proton therapy for head and neck squamous cell carcinomas: a review of the physical and clinical challenges |
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Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges |
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The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. |
| abstractGer |
The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. |
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The quality of radiation therapy has been shown to significantly influence the outcomes for head and neck squamous cell carcinoma (HNSCC) patients. The results of dosimetric studies suggest that intensity-modulated proton therapy (IMPT) could be of added value for HNSCC by being more effective than intensity-modulated (photon) radiation therapy (IMRT) for reducing side effects of radiation therapy. However, the physical properties of protons make IMPT more sensitive than photons to planning uncertainties. This could potentially have a negative effect on the quality of IMPT planning and delivery. For this review, the three French proton therapy centers collaborated to evaluate the differences between IMRT and IMPT. The review explored the effects of these uncertainties and their management for developing a robust and optimized IMPT treatment delivery plan to achieve clinical outcomes that are superior to those for IMRT. We also provide practical suggestions for the management of HNSCC carcinoma with IMPT. Because metallic dental implants can increase range uncertainties (3–10%), patient preparation for IMPT may require more systematic removal of in-field alien material than is done for IMRT. Multi-energy CT may be an alternative to calculate more accurately the dose distribution. The practical aspects that we describe are essential to guarantee optimal quality in radiation therapy in both model-based and randomized clinical trials. |
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