Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study
Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB wat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wengler, Kenneth [verfasserIn] Ha, Jason [verfasserIn] Syritsyna, Olga [verfasserIn] Bangiyev, Lev [verfasserIn] Coyle, Patricia K. [verfasserIn] Duong, Tim Q. [verfasserIn] Schweitzer, Mark E. [verfasserIn] He, Xiang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
Water permeability surface area product |
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| Übergeordnetes Werk: |
Enthalten in: Magnetic resonance imaging - Amsterdam [u.a.] : Elsevier Science, 1982, 70, Seite 126-133 |
|---|---|
| Übergeordnetes Werk: |
volume:70 ; pages:126-133 |
| DOI / URN: |
10.1016/j.mri.2020.04.017 |
|---|
| Katalog-ID: |
ELV004320506 |
|---|
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| 245 | 1 | 0 | |a Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study |
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| 520 | |a Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. | ||
| 650 | 4 | |a Blood-brain barrier (BBB) | |
| 650 | 4 | |a Water permeability surface area product | |
| 650 | 4 | |a Water extraction fraction | |
| 650 | 4 | |a Relapsing-remitting multiple sclerosis (RRMS) | |
| 650 | 4 | |a IDEALS | |
| 700 | 1 | |a Ha, Jason |e verfasserin |4 aut | |
| 700 | 1 | |a Syritsyna, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Bangiyev, Lev |e verfasserin |4 aut | |
| 700 | 1 | |a Coyle, Patricia K. |e verfasserin |4 aut | |
| 700 | 1 | |a Duong, Tim Q. |e verfasserin |4 aut | |
| 700 | 1 | |a Schweitzer, Mark E. |e verfasserin |4 aut | |
| 700 | 1 | |a He, Xiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Magnetic resonance imaging |d Amsterdam [u.a.] : Elsevier Science, 1982 |g 70, Seite 126-133 |h Online-Ressource |w (DE-627)306661160 |w (DE-600)1500646-3 |w (DE-576)081986750 |x 1873-5894 |7 nnns |
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10.1016/j.mri.2020.04.017 doi (DE-627)ELV004320506 (ELSEVIER)S0730-725X(20)30075-8 DE-627 ger DE-627 rda eng 610 DE-600 44.64 bkl Wengler, Kenneth verfasserin aut Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS Ha, Jason verfasserin aut Syritsyna, Olga verfasserin aut Bangiyev, Lev verfasserin aut Coyle, Patricia K. verfasserin aut Duong, Tim Q. verfasserin aut Schweitzer, Mark E. verfasserin aut He, Xiang verfasserin aut Enthalten in Magnetic resonance imaging Amsterdam [u.a.] : Elsevier Science, 1982 70, Seite 126-133 Online-Ressource (DE-627)306661160 (DE-600)1500646-3 (DE-576)081986750 1873-5894 nnns volume:70 pages:126-133 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.64 Radiologie AR 70 126-133 |
| spelling |
10.1016/j.mri.2020.04.017 doi (DE-627)ELV004320506 (ELSEVIER)S0730-725X(20)30075-8 DE-627 ger DE-627 rda eng 610 DE-600 44.64 bkl Wengler, Kenneth verfasserin aut Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS Ha, Jason verfasserin aut Syritsyna, Olga verfasserin aut Bangiyev, Lev verfasserin aut Coyle, Patricia K. verfasserin aut Duong, Tim Q. verfasserin aut Schweitzer, Mark E. verfasserin aut He, Xiang verfasserin aut Enthalten in Magnetic resonance imaging Amsterdam [u.a.] : Elsevier Science, 1982 70, Seite 126-133 Online-Ressource (DE-627)306661160 (DE-600)1500646-3 (DE-576)081986750 1873-5894 nnns volume:70 pages:126-133 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.64 Radiologie AR 70 126-133 |
| allfields_unstemmed |
10.1016/j.mri.2020.04.017 doi (DE-627)ELV004320506 (ELSEVIER)S0730-725X(20)30075-8 DE-627 ger DE-627 rda eng 610 DE-600 44.64 bkl Wengler, Kenneth verfasserin aut Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS Ha, Jason verfasserin aut Syritsyna, Olga verfasserin aut Bangiyev, Lev verfasserin aut Coyle, Patricia K. verfasserin aut Duong, Tim Q. verfasserin aut Schweitzer, Mark E. verfasserin aut He, Xiang verfasserin aut Enthalten in Magnetic resonance imaging Amsterdam [u.a.] : Elsevier Science, 1982 70, Seite 126-133 Online-Ressource (DE-627)306661160 (DE-600)1500646-3 (DE-576)081986750 1873-5894 nnns volume:70 pages:126-133 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.64 Radiologie AR 70 126-133 |
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10.1016/j.mri.2020.04.017 doi (DE-627)ELV004320506 (ELSEVIER)S0730-725X(20)30075-8 DE-627 ger DE-627 rda eng 610 DE-600 44.64 bkl Wengler, Kenneth verfasserin aut Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS Ha, Jason verfasserin aut Syritsyna, Olga verfasserin aut Bangiyev, Lev verfasserin aut Coyle, Patricia K. verfasserin aut Duong, Tim Q. verfasserin aut Schweitzer, Mark E. verfasserin aut He, Xiang verfasserin aut Enthalten in Magnetic resonance imaging Amsterdam [u.a.] : Elsevier Science, 1982 70, Seite 126-133 Online-Ressource (DE-627)306661160 (DE-600)1500646-3 (DE-576)081986750 1873-5894 nnns volume:70 pages:126-133 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.64 Radiologie AR 70 126-133 |
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10.1016/j.mri.2020.04.017 doi (DE-627)ELV004320506 (ELSEVIER)S0730-725X(20)30075-8 DE-627 ger DE-627 rda eng 610 DE-600 44.64 bkl Wengler, Kenneth verfasserin aut Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS Ha, Jason verfasserin aut Syritsyna, Olga verfasserin aut Bangiyev, Lev verfasserin aut Coyle, Patricia K. verfasserin aut Duong, Tim Q. verfasserin aut Schweitzer, Mark E. verfasserin aut He, Xiang verfasserin aut Enthalten in Magnetic resonance imaging Amsterdam [u.a.] : Elsevier Science, 1982 70, Seite 126-133 Online-Ressource (DE-627)306661160 (DE-600)1500646-3 (DE-576)081986750 1873-5894 nnns volume:70 pages:126-133 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.64 Radiologie AR 70 126-133 |
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Wengler, Kenneth |
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Wengler, Kenneth ddc 610 bkl 44.64 misc Blood-brain barrier (BBB) misc Water permeability surface area product misc Water extraction fraction misc Relapsing-remitting multiple sclerosis (RRMS) misc IDEALS Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study |
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610 DE-600 44.64 bkl Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study Blood-brain barrier (BBB) Water permeability surface area product Water extraction fraction Relapsing-remitting multiple sclerosis (RRMS) IDEALS |
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Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study |
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Wengler, Kenneth Ha, Jason Syritsyna, Olga Bangiyev, Lev Coyle, Patricia K. Duong, Tim Q. Schweitzer, Mark E. He, Xiang |
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abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: a preliminary study |
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Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study |
| abstract |
Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. |
| abstractGer |
Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. |
| abstract_unstemmed |
Relapsing-remitting multiple sclerosis (RRMS) is associated with persistent blood-brain barrier (BBB) dysfunction. The impact of this persistent dysfunction in both active and chronic MS lesions has yet to be investigated due to technological challenges associated with invasive assessment of BBB water transportation (e.g. 15O-PET). The purpose of this study was to test if persistent BBB dysfunction in RRMS manifests as lower BBB water exchange in chronic lesions using a recently developed noninvasive MRI paradigm. Patients with relapsing-remitting MS and healthy subjects were recruited for this prospective study. The novel Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) MRI method was used to map BBB water extraction fraction (E w ) and water permeability surface area product (PS w ), as well as cerebral blood flow (CBF). Regional differences in BBB water exchange were evaluated between MS patients (normal appearing white matter [NAWM] and normal appearing gray matter [NAGM]) and healthy subjects (white matter [WM] and gray matter [GM]) and within MS subjects in non gadolinium-based contrast-agent (GBCA) enhancing chronic lesions, perilesional areas, and NAWM. Significantly lower PS w and E w were observed in NAWM compared to WM (ΔPS w : −11.9 mL/100 g/min, p < .05; ΔE w : −4.3%, p < .01). Significantly lower E w was observed in NAGM compared to GM (ΔE w : −12.1%, p < .01). Significantly lower PS w and CBF were observed in non-GBCA contrast enhancing lesions compared to NAWM (ΔPS w = −11.5 mL/100 g/min, p < .05; ΔCBF = −8.1 mL/100 g/min, p < .05). E w was significantly higher in non-GBCA enhancing chronic MS lesions compared to NAWM (ΔE w = 1.6%, p < .05). The lower BBB water exchange in chronic MS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS. |
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