Dissemination of a ‘rare’ extended-spectrum β-lactamase gene

An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Ent...
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Autor*in:	Zhou, Kai [verfasserIn] Zhou, Yanzi [verfasserIn] Zhang, Chuqiu [verfasserIn] Song, Jingjie [verfasserIn] Cao, Xiaoli [verfasserIn] Yu, Xiao [verfasserIn] Shen, Ping [verfasserIn] Xiao, Yonghong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SFO-1 Carbapenemase Epidemic clone

Übergeordnetes Werk:	Enthalten in: International journal of antimicrobial agents - Amsterdam [u.a.] : Elsevier Science, 1991, 56
Übergeordnetes Werk:	volume:56

DOI / URN:	10.1016/j.ijantimicag.2020.106079

Katalog-ID:	ELV004587723

Internformat


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520			\|a An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes.
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700	1		\|a Shen, Ping \|e verfasserin \|4 aut
700	1		\|a Xiao, Yonghong \|e verfasserin \|4 aut
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936	b	k	\|a 44.38 \|j Pharmakologie \|q VZ
951			\|a AR
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publishDate	2020
allfields	10.1016/j.ijantimicag.2020.106079 doi (DE-627)ELV004587723 (ELSEVIER)S0924-8579(20)30249-1 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Zhou, Kai verfasserin aut Dissemination of a ‘rare’ extended-spectrum β-lactamase gene 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes. SFO-1 Carbapenemase Epidemic clone Zhou, Yanzi verfasserin aut Zhang, Chuqiu verfasserin (orcid)0000-0001-6521-9693 aut Song, Jingjie verfasserin aut Cao, Xiaoli verfasserin aut Yu, Xiao verfasserin aut Shen, Ping verfasserin aut Xiao, Yonghong verfasserin aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 56 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:56 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie VZ AR 56
spelling	10.1016/j.ijantimicag.2020.106079 doi (DE-627)ELV004587723 (ELSEVIER)S0924-8579(20)30249-1 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Zhou, Kai verfasserin aut Dissemination of a ‘rare’ extended-spectrum β-lactamase gene 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes. SFO-1 Carbapenemase Epidemic clone Zhou, Yanzi verfasserin aut Zhang, Chuqiu verfasserin (orcid)0000-0001-6521-9693 aut Song, Jingjie verfasserin aut Cao, Xiaoli verfasserin aut Yu, Xiao verfasserin aut Shen, Ping verfasserin aut Xiao, Yonghong verfasserin aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 56 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:56 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie VZ AR 56
allfields_unstemmed	10.1016/j.ijantimicag.2020.106079 doi (DE-627)ELV004587723 (ELSEVIER)S0924-8579(20)30249-1 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Zhou, Kai verfasserin aut Dissemination of a ‘rare’ extended-spectrum β-lactamase gene 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes. SFO-1 Carbapenemase Epidemic clone Zhou, Yanzi verfasserin aut Zhang, Chuqiu verfasserin (orcid)0000-0001-6521-9693 aut Song, Jingjie verfasserin aut Cao, Xiaoli verfasserin aut Yu, Xiao verfasserin aut Shen, Ping verfasserin aut Xiao, Yonghong verfasserin aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 56 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:56 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie VZ AR 56
allfieldsGer	10.1016/j.ijantimicag.2020.106079 doi (DE-627)ELV004587723 (ELSEVIER)S0924-8579(20)30249-1 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Zhou, Kai verfasserin aut Dissemination of a ‘rare’ extended-spectrum β-lactamase gene 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes. SFO-1 Carbapenemase Epidemic clone Zhou, Yanzi verfasserin aut Zhang, Chuqiu verfasserin (orcid)0000-0001-6521-9693 aut Song, Jingjie verfasserin aut Cao, Xiaoli verfasserin aut Yu, Xiao verfasserin aut Shen, Ping verfasserin aut Xiao, Yonghong verfasserin aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 56 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:56 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie VZ AR 56
allfieldsSound	10.1016/j.ijantimicag.2020.106079 doi (DE-627)ELV004587723 (ELSEVIER)S0924-8579(20)30249-1 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Zhou, Kai verfasserin aut Dissemination of a ‘rare’ extended-spectrum β-lactamase gene 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes. SFO-1 Carbapenemase Epidemic clone Zhou, Yanzi verfasserin aut Zhang, Chuqiu verfasserin (orcid)0000-0001-6521-9693 aut Song, Jingjie verfasserin aut Cao, Xiaoli verfasserin aut Yu, Xiao verfasserin aut Shen, Ping verfasserin aut Xiao, Yonghong verfasserin aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 56 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:56 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie VZ AR 56
language	English
source	Enthalten in International journal of antimicrobial agents 56 volume:56
sourceStr	Enthalten in International journal of antimicrobial agents 56 volume:56
format_phy_str_mv	Article
bklname	Pharmakologie
institution	findex.gbv.de
topic_facet	SFO-1 Carbapenemase Epidemic clone
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of antimicrobial agents
authorswithroles_txt_mv	Zhou, Kai @@aut@@ Zhou, Yanzi @@aut@@ Zhang, Chuqiu @@aut@@ Song, Jingjie @@aut@@ Cao, Xiaoli @@aut@@ Yu, Xiao @@aut@@ Shen, Ping @@aut@@ Xiao, Yonghong @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	32049781X
dewey-sort	3610
id	ELV004587723
language_de	englisch
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author	Zhou, Kai
spellingShingle	Zhou, Kai ddc 610 ssgn 15,3 fid PHARM bkl 44.38 misc SFO-1 misc Carbapenemase misc Epidemic clone Dissemination of a ‘rare’ extended-spectrum β-lactamase gene
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topic_title	610 VZ 15,3 ssgn PHARM DE-84 fid 44.38 bkl Dissemination of a ‘rare’ extended-spectrum β-lactamase gene SFO-1 Carbapenemase Epidemic clone
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title	Dissemination of a ‘rare’ extended-spectrum β-lactamase gene
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title_full	Dissemination of a ‘rare’ extended-spectrum β-lactamase gene
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title_sort	dissemination of a ‘rare’ extended-spectrum β-lactamase gene
title_auth	Dissemination of a ‘rare’ extended-spectrum β-lactamase gene
abstract	An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes.
abstractGer	An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes.
abstract_unstemmed	An increasing trend of the coexistence of a rare extended-spectrum β-lactamase gene bla SFO-1 and carbapenemase genes in Enterobacteriaceae has recently been noted. This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. These findings highlight the potential of wide dissemination of low-prevalence antimicrobial resistance genes.
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title_short	Dissemination of a ‘rare’ extended-spectrum β-lactamase gene
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author2	Zhou, Yanzi Zhang, Chuqiu Song, Jingjie Cao, Xiaoli Yu, Xiao Shen, Ping Xiao, Yonghong
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doi_str	10.1016/j.ijantimicag.2020.106079
up_date	2024-07-06T23:29:46.232Z
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This study aimed to determine the epidemiological and genetic characterisation of SFO-1-positive carbapenem-resistant Enterobacter cloacae complex (CREC) isolates. A total of 61 CREC clinical isolates were collected in the framework of a national surveillance for carbapenem-resistant Enterobacteriaceae during 2011–2015 in China. Seven SFO-1-positive CREC isolates (11.5%) were identified in four provinces, suggesting a wide dissemination of the bla SFO-1 gene among the CREC population in China. Five SFO-1-positive CREC isolates were further identified by screening 1625 genomes of E. cloacae complex strains retrieved from GenBank. The 12 SFO-1-positive CREC isolates were further identified as Enterobacter hormaechei, of which 10 belonged to epidemic clones (ST93, ST114 and ST418), indicating that these clones might largely contribute to the dissemination of bla SFO-1. Phylogenomics analysis further identified the occurrence of clonal dissemination in the community setting. The bla SFO-1-bearing plasmids were assigned to various incompatibility groups with highly diverse sizes (~104–370 kb), suggesting a wide vector range of bla SFO-1. Two types of genetic context, with and without insertion sequence IS26, were identified for the bla SFO-1 gene. The genetic context flanked by IS26 was more prevalent, thus largely facilitating the mobility of bla SFO-1. This study revealed that the bla SFO-1 gene is not as rare as previously found and that epidemic clones of CREC are responsible for its dissemination in China. 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Dissemination of a ‘rare’ extended-spectrum β-lactamase gene

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