Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase

Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration...
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Autor*in:	Hebert, Solène [verfasserIn] Clavel, Pierre [verfasserIn] Maier, Benjamin [verfasserIn] Mizutani, Katsuhiro [verfasserIn] Delvoye, François [verfasserIn] Lapergue, Bertrand [verfasserIn] Maacha, Malek Ben [verfasserIn] Fahed, Robert [verfasserIn] Escalard, Simon [verfasserIn] Desilles, Jean-Philippe [verfasserIn] Redjem, Hocine [verfasserIn] Ciccio, Gabriele [verfasserIn] Smajda, Stanislas [verfasserIn] Blanc, Raphael [verfasserIn] Piotin, Michel [verfasserIn] Mazighi, Mikael [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic

Übergeordnetes Werk:	Enthalten in: Journal of stroke and cerebrovascular diseases - New York, NY : Elsevier, 1991, 29
Übergeordnetes Werk:	volume:29

DOI / URN:	10.1016/j.jstrokecerebrovasdis.2020.105052

Katalog-ID:	ELV004633970

Internformat


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100	1		\|a Hebert, Solène \|e verfasserin \|4 aut
245	1	0	\|a Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
264		1	\|c 2020
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management.
650		4	\|a Stroke
650		4	\|a Heparin
650		4	\|a Mechanical thrombectomy
650		4	\|a Endovascular treatment
650		4	\|a Antithrombotic
700	1		\|a Clavel, Pierre \|e verfasserin \|4 aut
700	1		\|a Maier, Benjamin \|e verfasserin \|4 aut
700	1		\|a Mizutani, Katsuhiro \|e verfasserin \|0 (orcid)0000-0002-3158-0189 \|4 aut
700	1		\|a Delvoye, François \|e verfasserin \|0 (orcid)0000-0002-0697-2156 \|4 aut
700	1		\|a Lapergue, Bertrand \|e verfasserin \|4 aut
700	1		\|a Maacha, Malek Ben \|e verfasserin \|4 aut
700	1		\|a Fahed, Robert \|e verfasserin \|4 aut
700	1		\|a Escalard, Simon \|e verfasserin \|0 (orcid)0000-0003-1306-1008 \|4 aut
700	1		\|a Desilles, Jean-Philippe \|e verfasserin \|4 aut
700	1		\|a Redjem, Hocine \|e verfasserin \|4 aut
700	1		\|a Ciccio, Gabriele \|e verfasserin \|4 aut
700	1		\|a Smajda, Stanislas \|e verfasserin \|4 aut
700	1		\|a Blanc, Raphael \|e verfasserin \|4 aut
700	1		\|a Piotin, Michel \|e verfasserin \|4 aut
700	1		\|a Mazighi, Mikael \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Journal of stroke and cerebrovascular diseases \|d New York, NY : Elsevier, 1991 \|g 29 \|h Online-Ressource \|w (DE-627)332166503 \|w (DE-600)2052957-0 \|w (DE-576)271585501 \|x 1532-8511 \|7 nnns
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
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912			\|a GBV_ILN_2059
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912			\|a GBV_ILN_2065
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912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
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912			\|a GBV_ILN_4242
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912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
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936	b	k	\|a 44.90 \|j Neurologie
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Indexfelder

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hierarchy_sort_str	2020
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publishDate	2020
allfields	10.1016/j.jstrokecerebrovasdis.2020.105052 doi (DE-627)ELV004633970 (ELSEVIER)S1052-3057(20)30470-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hebert, Solène verfasserin aut Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management. Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic Clavel, Pierre verfasserin aut Maier, Benjamin verfasserin aut Mizutani, Katsuhiro verfasserin (orcid)0000-0002-3158-0189 aut Delvoye, François verfasserin (orcid)0000-0002-0697-2156 aut Lapergue, Bertrand verfasserin aut Maacha, Malek Ben verfasserin aut Fahed, Robert verfasserin aut Escalard, Simon verfasserin (orcid)0000-0003-1306-1008 aut Desilles, Jean-Philippe verfasserin aut Redjem, Hocine verfasserin aut Ciccio, Gabriele verfasserin aut Smajda, Stanislas verfasserin aut Blanc, Raphael verfasserin aut Piotin, Michel verfasserin aut Mazighi, Mikael verfasserin aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29 Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 29
spelling	10.1016/j.jstrokecerebrovasdis.2020.105052 doi (DE-627)ELV004633970 (ELSEVIER)S1052-3057(20)30470-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hebert, Solène verfasserin aut Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management. Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic Clavel, Pierre verfasserin aut Maier, Benjamin verfasserin aut Mizutani, Katsuhiro verfasserin (orcid)0000-0002-3158-0189 aut Delvoye, François verfasserin (orcid)0000-0002-0697-2156 aut Lapergue, Bertrand verfasserin aut Maacha, Malek Ben verfasserin aut Fahed, Robert verfasserin aut Escalard, Simon verfasserin (orcid)0000-0003-1306-1008 aut Desilles, Jean-Philippe verfasserin aut Redjem, Hocine verfasserin aut Ciccio, Gabriele verfasserin aut Smajda, Stanislas verfasserin aut Blanc, Raphael verfasserin aut Piotin, Michel verfasserin aut Mazighi, Mikael verfasserin aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29 Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 29
allfields_unstemmed	10.1016/j.jstrokecerebrovasdis.2020.105052 doi (DE-627)ELV004633970 (ELSEVIER)S1052-3057(20)30470-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hebert, Solène verfasserin aut Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management. Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic Clavel, Pierre verfasserin aut Maier, Benjamin verfasserin aut Mizutani, Katsuhiro verfasserin (orcid)0000-0002-3158-0189 aut Delvoye, François verfasserin (orcid)0000-0002-0697-2156 aut Lapergue, Bertrand verfasserin aut Maacha, Malek Ben verfasserin aut Fahed, Robert verfasserin aut Escalard, Simon verfasserin (orcid)0000-0003-1306-1008 aut Desilles, Jean-Philippe verfasserin aut Redjem, Hocine verfasserin aut Ciccio, Gabriele verfasserin aut Smajda, Stanislas verfasserin aut Blanc, Raphael verfasserin aut Piotin, Michel verfasserin aut Mazighi, Mikael verfasserin aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29 Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 29
allfieldsGer	10.1016/j.jstrokecerebrovasdis.2020.105052 doi (DE-627)ELV004633970 (ELSEVIER)S1052-3057(20)30470-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hebert, Solène verfasserin aut Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management. Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic Clavel, Pierre verfasserin aut Maier, Benjamin verfasserin aut Mizutani, Katsuhiro verfasserin (orcid)0000-0002-3158-0189 aut Delvoye, François verfasserin (orcid)0000-0002-0697-2156 aut Lapergue, Bertrand verfasserin aut Maacha, Malek Ben verfasserin aut Fahed, Robert verfasserin aut Escalard, Simon verfasserin (orcid)0000-0003-1306-1008 aut Desilles, Jean-Philippe verfasserin aut Redjem, Hocine verfasserin aut Ciccio, Gabriele verfasserin aut Smajda, Stanislas verfasserin aut Blanc, Raphael verfasserin aut Piotin, Michel verfasserin aut Mazighi, Mikael verfasserin aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29 Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 29
allfieldsSound	10.1016/j.jstrokecerebrovasdis.2020.105052 doi (DE-627)ELV004633970 (ELSEVIER)S1052-3057(20)30470-5 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hebert, Solène verfasserin aut Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management. Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic Clavel, Pierre verfasserin aut Maier, Benjamin verfasserin aut Mizutani, Katsuhiro verfasserin (orcid)0000-0002-3158-0189 aut Delvoye, François verfasserin (orcid)0000-0002-0697-2156 aut Lapergue, Bertrand verfasserin aut Maacha, Malek Ben verfasserin aut Fahed, Robert verfasserin aut Escalard, Simon verfasserin (orcid)0000-0003-1306-1008 aut Desilles, Jean-Philippe verfasserin aut Redjem, Hocine verfasserin aut Ciccio, Gabriele verfasserin aut Smajda, Stanislas verfasserin aut Blanc, Raphael verfasserin aut Piotin, Michel verfasserin aut Mazighi, Mikael verfasserin aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29 Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 29
language	English
source	Enthalten in Journal of stroke and cerebrovascular diseases 29 volume:29
sourceStr	Enthalten in Journal of stroke and cerebrovascular diseases 29 volume:29
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of stroke and cerebrovascular diseases
authorswithroles_txt_mv	Hebert, Solène @@aut@@ Clavel, Pierre @@aut@@ Maier, Benjamin @@aut@@ Mizutani, Katsuhiro @@aut@@ Delvoye, François @@aut@@ Lapergue, Bertrand @@aut@@ Maacha, Malek Ben @@aut@@ Fahed, Robert @@aut@@ Escalard, Simon @@aut@@ Desilles, Jean-Philippe @@aut@@ Redjem, Hocine @@aut@@ Ciccio, Gabriele @@aut@@ Smajda, Stanislas @@aut@@ Blanc, Raphael @@aut@@ Piotin, Michel @@aut@@ Mazighi, Mikael @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	332166503
dewey-sort	3610
id	ELV004633970
language_de	englisch
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Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. 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author	Hebert, Solène
spellingShingle	Hebert, Solène ddc 610 bkl 44.90 misc Stroke misc Heparin misc Mechanical thrombectomy misc Endovascular treatment misc Antithrombotic Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
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topic_title	610 DE-600 44.90 bkl Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase Stroke Heparin Mechanical thrombectomy Endovascular treatment Antithrombotic
topic	ddc 610 bkl 44.90 misc Stroke misc Heparin misc Mechanical thrombectomy misc Endovascular treatment misc Antithrombotic
topic_unstemmed	ddc 610 bkl 44.90 misc Stroke misc Heparin misc Mechanical thrombectomy misc Endovascular treatment misc Antithrombotic
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title	Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
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title_full	Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
author_sort	Hebert, Solène
journal	Journal of stroke and cerebrovascular diseases
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author_browse	Hebert, Solène Clavel, Pierre Maier, Benjamin Mizutani, Katsuhiro Delvoye, François Lapergue, Bertrand Maacha, Malek Ben Fahed, Robert Escalard, Simon Desilles, Jean-Philippe Redjem, Hocine Ciccio, Gabriele Smajda, Stanislas Blanc, Raphael Piotin, Michel Mazighi, Mikael
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author-letter	Hebert, Solène
doi_str_mv	10.1016/j.jstrokecerebrovasdis.2020.105052
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title_sort	benefits and safety of periprocedural heparin during thrombectomy in patients contra-indicated for alteplase
title_auth	Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
abstract	Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management.
abstractGer	Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management.
abstract_unstemmed	Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management.
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title_short	Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase
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author2	Clavel, Pierre Maier, Benjamin Mizutani, Katsuhiro Delvoye, François Lapergue, Bertrand Maacha, Malek Ben Fahed, Robert Escalard, Simon Desilles, Jean-Philippe Redjem, Hocine Ciccio, Gabriele Smajda, Stanislas Blanc, Raphael Piotin, Michel Mazighi, Mikael
author2Str	Clavel, Pierre Maier, Benjamin Mizutani, Katsuhiro Delvoye, François Lapergue, Bertrand Maacha, Malek Ben Fahed, Robert Escalard, Simon Desilles, Jean-Philippe Redjem, Hocine Ciccio, Gabriele Smajda, Stanislas Blanc, Raphael Piotin, Michel Mazighi, Mikael
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doi_str	10.1016/j.jstrokecerebrovasdis.2020.105052
up_date	2024-07-06T23:39:05.510Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV004633970</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524160945.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230503s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jstrokecerebrovasdis.2020.105052</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV004633970</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1052-3057(20)30470-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hebert, Solène</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Backround and Purpose: Role of peri-procedural heparin as an adjuvant treatment during mechanical thrombectomy (MT) for patients contra-indicated for alteplase remains a source of debate.Methods: We included patients from the multicenter French register ETIS that underwent MT without administration of alteplase, and compared patients who received heparin during MT with patients who did not. Heparin impact on outcome were analyzed regarding final TICI score, NIHSS at day one, modified rankin scale (mRS) and intracranial hemorrhagic transformation on imaging at day one.Results: Over 1031 patients, 751 were included between January 2015 and June 2018 in 6 different centers, and 223 (26.69%) received heparin. Heparin administration was associated with a significant deleterious effect on NIHSS at 24h [adjusted OR = 1.2; p = 0.02], mRS at 3 months [adjusted OR 1.58; p = 0.03], and on complete reperfusion [TICI 3 adjusted OR 0.68; p = 0.02]. Heparin administration was associated with a significant reduction of hemorrhagic transformation [adjusted OR 0.48; p = 0.00005].Conclusions: Heparin administration during MT seems deleterious for reperfusion and functional outcome. Randomized trials are needed to identify the role of antithrombotic treatments, such as heparin, in the setting of acute ischemic stroke management.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stroke</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heparin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mechanical thrombectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endovascular treatment</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antithrombotic</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clavel, Pierre</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maier, Benjamin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield 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Benefits and Safety of Periprocedural Heparin During Thrombectomy in Patients Contra-Indicated for Alteplase

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