BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank

Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised...
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Autor*in:	Sattar, Naveed [verfasserIn] Ho, Frederick K. [verfasserIn] Gill, Jason MR. [verfasserIn] Ghouri, Nazim [verfasserIn] Gray, Stuart R. [verfasserIn] Celis-Morales, Carlos A. [verfasserIn] Katikireddi, S. Vittal [verfasserIn] Berry, Colin [verfasserIn] Pell, Jill P. [verfasserIn] McMurray, John JV. [verfasserIn] Welsh, Paul [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Body mass index COVID-19 Obesity

Übergeordnetes Werk:	Enthalten in: Diabetes & metabolic syndrome - Amsterdam [u.a.] : Elsevier, 2007, 14, Seite 1149-1151
Übergeordnetes Werk:	volume:14 ; pages:1149-1151

DOI / URN:	10.1016/j.dsx.2020.06.060

Katalog-ID:	ELV004674049

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100	1		\|a Sattar, Naveed \|e verfasserin \|0 (orcid)0000-0002-1604-2593 \|4 aut
245	1	0	\|a BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
264		1	\|c 2020
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.
650		4	\|a Body mass index
650		4	\|a COVID-19
650		4	\|a Obesity
700	1		\|a Ho, Frederick K. \|e verfasserin \|0 (orcid)0000-0001-7190-9025 \|4 aut
700	1		\|a Gill, Jason MR. \|e verfasserin \|0 (orcid)0000-0003-3615-0986 \|4 aut
700	1		\|a Ghouri, Nazim \|e verfasserin \|4 aut
700	1		\|a Gray, Stuart R. \|e verfasserin \|4 aut
700	1		\|a Celis-Morales, Carlos A. \|e verfasserin \|4 aut
700	1		\|a Katikireddi, S. Vittal \|e verfasserin \|0 (orcid)0000-0001-6593-9092 \|4 aut
700	1		\|a Berry, Colin \|e verfasserin \|4 aut
700	1		\|a Pell, Jill P. \|e verfasserin \|4 aut
700	1		\|a McMurray, John JV. \|e verfasserin \|4 aut
700	1		\|a Welsh, Paul \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Diabetes & metabolic syndrome \|d Amsterdam [u.a.] : Elsevier, 2007 \|g 14, Seite 1149-1151 \|h Online-Ressource \|w (DE-627)525874976 \|w (DE-600)2273766-2 \|w (DE-576)267763328 \|x 1878-0334 \|7 nnns
773	1	8	\|g volume:14 \|g pages:1149-1151
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912			\|a GBV_ILN_70
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912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
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912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
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912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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936	b	k	\|a 44.89 \|j Endokrinologie
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publishDate	2020
allfields	10.1016/j.dsx.2020.06.060 doi (DE-627)ELV004674049 (ELSEVIER)S1871-4021(20)30230-7 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Sattar, Naveed verfasserin (orcid)0000-0002-1604-2593 aut BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. Body mass index COVID-19 Obesity Ho, Frederick K. verfasserin (orcid)0000-0001-7190-9025 aut Gill, Jason MR. verfasserin (orcid)0000-0003-3615-0986 aut Ghouri, Nazim verfasserin aut Gray, Stuart R. verfasserin aut Celis-Morales, Carlos A. verfasserin aut Katikireddi, S. Vittal verfasserin (orcid)0000-0001-6593-9092 aut Berry, Colin verfasserin aut Pell, Jill P. verfasserin aut McMurray, John JV. verfasserin aut Welsh, Paul verfasserin aut Enthalten in Diabetes & metabolic syndrome Amsterdam [u.a.] : Elsevier, 2007 14, Seite 1149-1151 Online-Ressource (DE-627)525874976 (DE-600)2273766-2 (DE-576)267763328 1878-0334 nnns volume:14 pages:1149-1151 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 1149-1151
spelling	10.1016/j.dsx.2020.06.060 doi (DE-627)ELV004674049 (ELSEVIER)S1871-4021(20)30230-7 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Sattar, Naveed verfasserin (orcid)0000-0002-1604-2593 aut BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. Body mass index COVID-19 Obesity Ho, Frederick K. verfasserin (orcid)0000-0001-7190-9025 aut Gill, Jason MR. verfasserin (orcid)0000-0003-3615-0986 aut Ghouri, Nazim verfasserin aut Gray, Stuart R. verfasserin aut Celis-Morales, Carlos A. verfasserin aut Katikireddi, S. Vittal verfasserin (orcid)0000-0001-6593-9092 aut Berry, Colin verfasserin aut Pell, Jill P. verfasserin aut McMurray, John JV. verfasserin aut Welsh, Paul verfasserin aut Enthalten in Diabetes & metabolic syndrome Amsterdam [u.a.] : Elsevier, 2007 14, Seite 1149-1151 Online-Ressource (DE-627)525874976 (DE-600)2273766-2 (DE-576)267763328 1878-0334 nnns volume:14 pages:1149-1151 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 1149-1151
allfields_unstemmed	10.1016/j.dsx.2020.06.060 doi (DE-627)ELV004674049 (ELSEVIER)S1871-4021(20)30230-7 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Sattar, Naveed verfasserin (orcid)0000-0002-1604-2593 aut BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. Body mass index COVID-19 Obesity Ho, Frederick K. verfasserin (orcid)0000-0001-7190-9025 aut Gill, Jason MR. verfasserin (orcid)0000-0003-3615-0986 aut Ghouri, Nazim verfasserin aut Gray, Stuart R. verfasserin aut Celis-Morales, Carlos A. verfasserin aut Katikireddi, S. Vittal verfasserin (orcid)0000-0001-6593-9092 aut Berry, Colin verfasserin aut Pell, Jill P. verfasserin aut McMurray, John JV. verfasserin aut Welsh, Paul verfasserin aut Enthalten in Diabetes & metabolic syndrome Amsterdam [u.a.] : Elsevier, 2007 14, Seite 1149-1151 Online-Ressource (DE-627)525874976 (DE-600)2273766-2 (DE-576)267763328 1878-0334 nnns volume:14 pages:1149-1151 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 1149-1151
allfieldsGer	10.1016/j.dsx.2020.06.060 doi (DE-627)ELV004674049 (ELSEVIER)S1871-4021(20)30230-7 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Sattar, Naveed verfasserin (orcid)0000-0002-1604-2593 aut BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. Body mass index COVID-19 Obesity Ho, Frederick K. verfasserin (orcid)0000-0001-7190-9025 aut Gill, Jason MR. verfasserin (orcid)0000-0003-3615-0986 aut Ghouri, Nazim verfasserin aut Gray, Stuart R. verfasserin aut Celis-Morales, Carlos A. verfasserin aut Katikireddi, S. Vittal verfasserin (orcid)0000-0001-6593-9092 aut Berry, Colin verfasserin aut Pell, Jill P. verfasserin aut McMurray, John JV. verfasserin aut Welsh, Paul verfasserin aut Enthalten in Diabetes & metabolic syndrome Amsterdam [u.a.] : Elsevier, 2007 14, Seite 1149-1151 Online-Ressource (DE-627)525874976 (DE-600)2273766-2 (DE-576)267763328 1878-0334 nnns volume:14 pages:1149-1151 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 1149-1151
allfieldsSound	10.1016/j.dsx.2020.06.060 doi (DE-627)ELV004674049 (ELSEVIER)S1871-4021(20)30230-7 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Sattar, Naveed verfasserin (orcid)0000-0002-1604-2593 aut BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. Body mass index COVID-19 Obesity Ho, Frederick K. verfasserin (orcid)0000-0001-7190-9025 aut Gill, Jason MR. verfasserin (orcid)0000-0003-3615-0986 aut Ghouri, Nazim verfasserin aut Gray, Stuart R. verfasserin aut Celis-Morales, Carlos A. verfasserin aut Katikireddi, S. Vittal verfasserin (orcid)0000-0001-6593-9092 aut Berry, Colin verfasserin aut Pell, Jill P. verfasserin aut McMurray, John JV. verfasserin aut Welsh, Paul verfasserin aut Enthalten in Diabetes & metabolic syndrome Amsterdam [u.a.] : Elsevier, 2007 14, Seite 1149-1151 Online-Ressource (DE-627)525874976 (DE-600)2273766-2 (DE-576)267763328 1878-0334 nnns volume:14 pages:1149-1151 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 1149-1151
language	English
source	Enthalten in Diabetes & metabolic syndrome 14, Seite 1149-1151 volume:14 pages:1149-1151
sourceStr	Enthalten in Diabetes & metabolic syndrome 14, Seite 1149-1151 volume:14 pages:1149-1151
format_phy_str_mv	Article
bklname	Endokrinologie
institution	findex.gbv.de
topic_facet	Body mass index COVID-19 Obesity
dewey-raw	610
isfreeaccess_bool	false
container_title	Diabetes & metabolic syndrome
authorswithroles_txt_mv	Sattar, Naveed @@aut@@ Ho, Frederick K. @@aut@@ Gill, Jason MR. @@aut@@ Ghouri, Nazim @@aut@@ Gray, Stuart R. @@aut@@ Celis-Morales, Carlos A. @@aut@@ Katikireddi, S. Vittal @@aut@@ Berry, Colin @@aut@@ Pell, Jill P. @@aut@@ McMurray, John JV. @@aut@@ Welsh, Paul @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	525874976
dewey-sort	3610
id	ELV004674049
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV004674049</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524150122.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230503s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.dsx.2020.06.060</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV004674049</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1871-4021(20)30230-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.89</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sattar, Naveed</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-1604-2593</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. 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author	Sattar, Naveed
spellingShingle	Sattar, Naveed ddc 610 bkl 44.89 misc Body mass index misc COVID-19 misc Obesity BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
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title	BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
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title_full	BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
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author_browse	Sattar, Naveed Ho, Frederick K. Gill, Jason MR. Ghouri, Nazim Gray, Stuart R. Celis-Morales, Carlos A. Katikireddi, S. Vittal Berry, Colin Pell, Jill P. McMurray, John JV. Welsh, Paul
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title_sort	bmi and future risk for covid-19 infection and death across sex, age and ethnicity: preliminary findings from uk biobank
title_auth	BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
abstract	Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.
abstractGer	Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.
abstract_unstemmed	Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.
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title_short	BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank
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author2	Ho, Frederick K. Gill, Jason MR Ghouri, Nazim Gray, Stuart R. Celis-Morales, Carlos A. Katikireddi, S. Vittal Berry, Colin Pell, Jill P. McMurray, John JV Welsh, Paul
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doi_str	10.1016/j.dsx.2020.06.060
up_date	2024-07-06T23:46:58.362Z
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Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Body mass index</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obesity</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ho, Frederick K.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-7190-9025</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gill, Jason MR.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0003-3615-0986</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ghouri, Nazim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gray, Stuart R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Celis-Morales, Carlos A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Katikireddi, S. 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BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank

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