Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear?
This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma ce...
Ausführliche Beschreibung
Autor*in: |
Kokocinska-Kusiak, Agata [verfasserIn] Matalińska, Joanna [verfasserIn] Sacharczuk, Mariusz [verfasserIn] Sobczyńska, Magdalena [verfasserIn] Góral-Radziszewska, Katarzyna [verfasserIn] Wileńska, Beata [verfasserIn] Misicka, Aleksandra [verfasserIn] Jezierski, Tadeusz [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Journal of veterinary behavior - Amsterdam [u.a.] : Elsevier, 2006, 39, Seite 64-76 |
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Übergeordnetes Werk: |
volume:39 ; pages:64-76 |
DOI / URN: |
10.1016/j.jveb.2020.04.004 |
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Katalog-ID: |
ELV004744195 |
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520 | |a This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. | ||
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700 | 1 | |a Jezierski, Tadeusz |e verfasserin |4 aut | |
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2020 |
allfields |
10.1016/j.jveb.2020.04.004 doi (DE-627)ELV004744195 (ELSEVIER)S1558-7878(20)30036-8 DE-627 ger DE-627 rda eng 630 DE-600 46.00 bkl Kokocinska-Kusiak, Agata verfasserin aut Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. melanoma urine odor mice training volatile organic compounds Matalińska, Joanna verfasserin aut Sacharczuk, Mariusz verfasserin aut Sobczyńska, Magdalena verfasserin aut Góral-Radziszewska, Katarzyna verfasserin aut Wileńska, Beata verfasserin aut Misicka, Aleksandra verfasserin aut Jezierski, Tadeusz verfasserin aut Enthalten in Journal of veterinary behavior Amsterdam [u.a.] : Elsevier, 2006 39, Seite 64-76 Online-Ressource (DE-627)519763785 (DE-600)2256674-0 (DE-576)284926841 1558-7878 nnns volume:39 pages:64-76 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 46.00 Tiermedizin: Allgemeines AR 39 64-76 |
spelling |
10.1016/j.jveb.2020.04.004 doi (DE-627)ELV004744195 (ELSEVIER)S1558-7878(20)30036-8 DE-627 ger DE-627 rda eng 630 DE-600 46.00 bkl Kokocinska-Kusiak, Agata verfasserin aut Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. melanoma urine odor mice training volatile organic compounds Matalińska, Joanna verfasserin aut Sacharczuk, Mariusz verfasserin aut Sobczyńska, Magdalena verfasserin aut Góral-Radziszewska, Katarzyna verfasserin aut Wileńska, Beata verfasserin aut Misicka, Aleksandra verfasserin aut Jezierski, Tadeusz verfasserin aut Enthalten in Journal of veterinary behavior Amsterdam [u.a.] : Elsevier, 2006 39, Seite 64-76 Online-Ressource (DE-627)519763785 (DE-600)2256674-0 (DE-576)284926841 1558-7878 nnns volume:39 pages:64-76 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 46.00 Tiermedizin: Allgemeines AR 39 64-76 |
allfields_unstemmed |
10.1016/j.jveb.2020.04.004 doi (DE-627)ELV004744195 (ELSEVIER)S1558-7878(20)30036-8 DE-627 ger DE-627 rda eng 630 DE-600 46.00 bkl Kokocinska-Kusiak, Agata verfasserin aut Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. melanoma urine odor mice training volatile organic compounds Matalińska, Joanna verfasserin aut Sacharczuk, Mariusz verfasserin aut Sobczyńska, Magdalena verfasserin aut Góral-Radziszewska, Katarzyna verfasserin aut Wileńska, Beata verfasserin aut Misicka, Aleksandra verfasserin aut Jezierski, Tadeusz verfasserin aut Enthalten in Journal of veterinary behavior Amsterdam [u.a.] : Elsevier, 2006 39, Seite 64-76 Online-Ressource (DE-627)519763785 (DE-600)2256674-0 (DE-576)284926841 1558-7878 nnns volume:39 pages:64-76 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 46.00 Tiermedizin: Allgemeines AR 39 64-76 |
allfieldsGer |
10.1016/j.jveb.2020.04.004 doi (DE-627)ELV004744195 (ELSEVIER)S1558-7878(20)30036-8 DE-627 ger DE-627 rda eng 630 DE-600 46.00 bkl Kokocinska-Kusiak, Agata verfasserin aut Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. melanoma urine odor mice training volatile organic compounds Matalińska, Joanna verfasserin aut Sacharczuk, Mariusz verfasserin aut Sobczyńska, Magdalena verfasserin aut Góral-Radziszewska, Katarzyna verfasserin aut Wileńska, Beata verfasserin aut Misicka, Aleksandra verfasserin aut Jezierski, Tadeusz verfasserin aut Enthalten in Journal of veterinary behavior Amsterdam [u.a.] : Elsevier, 2006 39, Seite 64-76 Online-Ressource (DE-627)519763785 (DE-600)2256674-0 (DE-576)284926841 1558-7878 nnns volume:39 pages:64-76 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 46.00 Tiermedizin: Allgemeines AR 39 64-76 |
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10.1016/j.jveb.2020.04.004 doi (DE-627)ELV004744195 (ELSEVIER)S1558-7878(20)30036-8 DE-627 ger DE-627 rda eng 630 DE-600 46.00 bkl Kokocinska-Kusiak, Agata verfasserin aut Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. melanoma urine odor mice training volatile organic compounds Matalińska, Joanna verfasserin aut Sacharczuk, Mariusz verfasserin aut Sobczyńska, Magdalena verfasserin aut Góral-Radziszewska, Katarzyna verfasserin aut Wileńska, Beata verfasserin aut Misicka, Aleksandra verfasserin aut Jezierski, Tadeusz verfasserin aut Enthalten in Journal of veterinary behavior Amsterdam [u.a.] : Elsevier, 2006 39, Seite 64-76 Online-Ressource (DE-627)519763785 (DE-600)2256674-0 (DE-576)284926841 1558-7878 nnns volume:39 pages:64-76 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 46.00 Tiermedizin: Allgemeines AR 39 64-76 |
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Kokocinska-Kusiak, Agata @@aut@@ Matalińska, Joanna @@aut@@ Sacharczuk, Mariusz @@aut@@ Sobczyńska, Magdalena @@aut@@ Góral-Radziszewska, Katarzyna @@aut@@ Wileńska, Beata @@aut@@ Misicka, Aleksandra @@aut@@ Jezierski, Tadeusz @@aut@@ |
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Kokocinska-Kusiak, Agata ddc 630 bkl 46.00 misc melanoma misc urine odor misc mice misc training misc volatile organic compounds Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
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630 DE-600 46.00 bkl Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? melanoma urine odor mice training volatile organic compounds |
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Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
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Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
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Kokocinska-Kusiak, Agata Matalińska, Joanna Sacharczuk, Mariusz Sobczyńska, Magdalena Góral-Radziszewska, Katarzyna Wileńska, Beata Misicka, Aleksandra Jezierski, Tadeusz |
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10.1016/j.jveb.2020.04.004 |
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can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
title_auth |
Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
abstract |
This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. |
abstractGer |
This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. |
abstract_unstemmed |
This study sought to determine whether mice can differentiate, through urine odors, conspecifics with melanoma in early stages, when no clinical signs are detectable, from healthy animals. Forty male mice of the B57BL6 strain were urine donors before and after orthotopic inoculation with melanoma cells. Another group (35 males and 31 females), divided into two subgroups were either tested for spontaneous preference for urine odor from donors with melanoma against urine odor of healthy conspecifics, or underwent operant conditioning training to discriminate between the two kinds of urine samples. Open-field and Y-maze tests were used initially to assess any spontaneous preference for urine of either type of donor, and subsequently a Y-maze test was used in discrimination training. During 5-minute tests, it was recorded which sample the mouse approached first, the latency to the first sniffing, the frequency of approaching, and the total duration of sniffing of each urine sample. |
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Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear? |
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Matalińska, Joanna Sacharczuk, Mariusz Sobczyńska, Magdalena Góral-Radziszewska, Katarzyna Wileńska, Beata Misicka, Aleksandra Jezierski, Tadeusz |
author2Str |
Matalińska, Joanna Sacharczuk, Mariusz Sobczyńska, Magdalena Góral-Radziszewska, Katarzyna Wileńska, Beata Misicka, Aleksandra Jezierski, Tadeusz |
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up_date |
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