Concurrent use of aspirin with osimertinib is associated with improved survival in advanced
Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, Xiaoke [verfasserIn] Hong, Lingzhi [verfasserIn] Nilsson, Monique [verfasserIn] Hubert, Shawna Marie [verfasserIn] Wu, Shuhong [verfasserIn] Rinsurongkawong, Waree [verfasserIn] Lewis, Jeffery [verfasserIn] Spelman, Amy [verfasserIn] Roth, Jack [verfasserIn] Swisher, Steven [verfasserIn] He, Yong [verfasserIn] Jack Lee, J. [verfasserIn] Fang, Bingliang [verfasserIn] Heymach, John V. [verfasserIn] Zhang, Jianjun [verfasserIn] Le, Xiuning [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Lung cancer - Amsterdam [u.a.] : Elsevier, 1985, 149, Seite 33-40 |
|---|---|
| Übergeordnetes Werk: |
volume:149 ; pages:33-40 |
| DOI / URN: |
10.1016/j.lungcan.2020.08.023 |
|---|
| Katalog-ID: |
ELV004826531 |
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| 100 | 1 | |a Liu, Xiaoke |e verfasserin |0 (orcid)0000-0002-7800-6934 |4 aut | |
| 245 | 1 | 0 | |a Concurrent use of aspirin with osimertinib is associated with improved survival in advanced |
| 264 | 1 | |c 2020 | |
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| 520 | |a Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. | ||
| 650 | 4 | |a Non-small cell lung cancer | |
| 650 | 4 | |a Aspirin | |
| 650 | 4 | |a Osimertinib | |
| 650 | 4 | |a PD-L1 | |
| 700 | 1 | |a Hong, Lingzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Nilsson, Monique |e verfasserin |4 aut | |
| 700 | 1 | |a Hubert, Shawna Marie |e verfasserin |0 (orcid)0000-0002-7907-9609 |4 aut | |
| 700 | 1 | |a Wu, Shuhong |e verfasserin |0 (orcid)0000-0001-8476-4179 |4 aut | |
| 700 | 1 | |a Rinsurongkawong, Waree |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Jeffery |e verfasserin |4 aut | |
| 700 | 1 | |a Spelman, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Roth, Jack |e verfasserin |0 (orcid)0000-0002-8955-1313 |4 aut | |
| 700 | 1 | |a Swisher, Steven |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Jack Lee, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Bingliang |e verfasserin |4 aut | |
| 700 | 1 | |a Heymach, John V. |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jianjun |e verfasserin |4 aut | |
| 700 | 1 | |a Le, Xiuning |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Lung cancer |d Amsterdam [u.a.] : Elsevier, 1985 |g 149, Seite 33-40 |h Online-Ressource |w (DE-627)320649733 |w (DE-600)2025812-4 |w (DE-576)264627539 |x 1872-8332 |7 nnns |
| 773 | 1 | 8 | |g volume:149 |g pages:33-40 |
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10.1016/j.lungcan.2020.08.023 doi (DE-627)ELV004826531 (ELSEVIER)S0169-5002(20)30599-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Liu, Xiaoke verfasserin (orcid)0000-0002-7800-6934 aut Concurrent use of aspirin with osimertinib is associated with improved survival in advanced 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. Non-small cell lung cancer Aspirin Osimertinib PD-L1 Hong, Lingzhi verfasserin aut Nilsson, Monique verfasserin aut Hubert, Shawna Marie verfasserin (orcid)0000-0002-7907-9609 aut Wu, Shuhong verfasserin (orcid)0000-0001-8476-4179 aut Rinsurongkawong, Waree verfasserin aut Lewis, Jeffery verfasserin aut Spelman, Amy verfasserin aut Roth, Jack verfasserin (orcid)0000-0002-8955-1313 aut Swisher, Steven verfasserin aut He, Yong verfasserin aut Jack Lee, J. verfasserin aut Fang, Bingliang verfasserin aut Heymach, John V. verfasserin aut Zhang, Jianjun verfasserin aut Le, Xiuning verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 149, Seite 33-40 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:149 pages:33-40 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 149 33-40 |
| spelling |
10.1016/j.lungcan.2020.08.023 doi (DE-627)ELV004826531 (ELSEVIER)S0169-5002(20)30599-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Liu, Xiaoke verfasserin (orcid)0000-0002-7800-6934 aut Concurrent use of aspirin with osimertinib is associated with improved survival in advanced 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. Non-small cell lung cancer Aspirin Osimertinib PD-L1 Hong, Lingzhi verfasserin aut Nilsson, Monique verfasserin aut Hubert, Shawna Marie verfasserin (orcid)0000-0002-7907-9609 aut Wu, Shuhong verfasserin (orcid)0000-0001-8476-4179 aut Rinsurongkawong, Waree verfasserin aut Lewis, Jeffery verfasserin aut Spelman, Amy verfasserin aut Roth, Jack verfasserin (orcid)0000-0002-8955-1313 aut Swisher, Steven verfasserin aut He, Yong verfasserin aut Jack Lee, J. verfasserin aut Fang, Bingliang verfasserin aut Heymach, John V. verfasserin aut Zhang, Jianjun verfasserin aut Le, Xiuning verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 149, Seite 33-40 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:149 pages:33-40 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 149 33-40 |
| allfields_unstemmed |
10.1016/j.lungcan.2020.08.023 doi (DE-627)ELV004826531 (ELSEVIER)S0169-5002(20)30599-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Liu, Xiaoke verfasserin (orcid)0000-0002-7800-6934 aut Concurrent use of aspirin with osimertinib is associated with improved survival in advanced 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. Non-small cell lung cancer Aspirin Osimertinib PD-L1 Hong, Lingzhi verfasserin aut Nilsson, Monique verfasserin aut Hubert, Shawna Marie verfasserin (orcid)0000-0002-7907-9609 aut Wu, Shuhong verfasserin (orcid)0000-0001-8476-4179 aut Rinsurongkawong, Waree verfasserin aut Lewis, Jeffery verfasserin aut Spelman, Amy verfasserin aut Roth, Jack verfasserin (orcid)0000-0002-8955-1313 aut Swisher, Steven verfasserin aut He, Yong verfasserin aut Jack Lee, J. verfasserin aut Fang, Bingliang verfasserin aut Heymach, John V. verfasserin aut Zhang, Jianjun verfasserin aut Le, Xiuning verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 149, Seite 33-40 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:149 pages:33-40 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 149 33-40 |
| allfieldsGer |
10.1016/j.lungcan.2020.08.023 doi (DE-627)ELV004826531 (ELSEVIER)S0169-5002(20)30599-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Liu, Xiaoke verfasserin (orcid)0000-0002-7800-6934 aut Concurrent use of aspirin with osimertinib is associated with improved survival in advanced 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. Non-small cell lung cancer Aspirin Osimertinib PD-L1 Hong, Lingzhi verfasserin aut Nilsson, Monique verfasserin aut Hubert, Shawna Marie verfasserin (orcid)0000-0002-7907-9609 aut Wu, Shuhong verfasserin (orcid)0000-0001-8476-4179 aut Rinsurongkawong, Waree verfasserin aut Lewis, Jeffery verfasserin aut Spelman, Amy verfasserin aut Roth, Jack verfasserin (orcid)0000-0002-8955-1313 aut Swisher, Steven verfasserin aut He, Yong verfasserin aut Jack Lee, J. verfasserin aut Fang, Bingliang verfasserin aut Heymach, John V. verfasserin aut Zhang, Jianjun verfasserin aut Le, Xiuning verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 149, Seite 33-40 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:149 pages:33-40 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 149 33-40 |
| allfieldsSound |
10.1016/j.lungcan.2020.08.023 doi (DE-627)ELV004826531 (ELSEVIER)S0169-5002(20)30599-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Liu, Xiaoke verfasserin (orcid)0000-0002-7800-6934 aut Concurrent use of aspirin with osimertinib is associated with improved survival in advanced 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. Non-small cell lung cancer Aspirin Osimertinib PD-L1 Hong, Lingzhi verfasserin aut Nilsson, Monique verfasserin aut Hubert, Shawna Marie verfasserin (orcid)0000-0002-7907-9609 aut Wu, Shuhong verfasserin (orcid)0000-0001-8476-4179 aut Rinsurongkawong, Waree verfasserin aut Lewis, Jeffery verfasserin aut Spelman, Amy verfasserin aut Roth, Jack verfasserin (orcid)0000-0002-8955-1313 aut Swisher, Steven verfasserin aut He, Yong verfasserin aut Jack Lee, J. verfasserin aut Fang, Bingliang verfasserin aut Heymach, John V. verfasserin aut Zhang, Jianjun verfasserin aut Le, Xiuning verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 149, Seite 33-40 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:149 pages:33-40 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 149 33-40 |
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Enthalten in Lung cancer 149, Seite 33-40 volume:149 pages:33-40 |
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Enthalten in Lung cancer 149, Seite 33-40 volume:149 pages:33-40 |
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Rheumatologie Orthopädie |
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Non-small cell lung cancer Aspirin Osimertinib PD-L1 |
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Liu, Xiaoke @@aut@@ Hong, Lingzhi @@aut@@ Nilsson, Monique @@aut@@ Hubert, Shawna Marie @@aut@@ Wu, Shuhong @@aut@@ Rinsurongkawong, Waree @@aut@@ Lewis, Jeffery @@aut@@ Spelman, Amy @@aut@@ Roth, Jack @@aut@@ Swisher, Steven @@aut@@ He, Yong @@aut@@ Jack Lee, J. @@aut@@ Fang, Bingliang @@aut@@ Heymach, John V. @@aut@@ Zhang, Jianjun @@aut@@ Le, Xiuning @@aut@@ |
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2020-01-01T00:00:00Z |
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englisch |
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Liu, Xiaoke |
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Liu, Xiaoke ddc 610 bkl 44.83 misc Non-small cell lung cancer misc Aspirin misc Osimertinib misc PD-L1 Concurrent use of aspirin with osimertinib is associated with improved survival in advanced |
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610 DE-600 44.83 bkl Concurrent use of aspirin with osimertinib is associated with improved survival in advanced Non-small cell lung cancer Aspirin Osimertinib PD-L1 |
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ddc 610 bkl 44.83 misc Non-small cell lung cancer misc Aspirin misc Osimertinib misc PD-L1 |
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Liu, Xiaoke Hong, Lingzhi Nilsson, Monique Hubert, Shawna Marie Wu, Shuhong Rinsurongkawong, Waree Lewis, Jeffery Spelman, Amy Roth, Jack Swisher, Steven He, Yong Jack Lee, J. Fang, Bingliang Heymach, John V. Zhang, Jianjun Le, Xiuning |
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concurrent use of aspirin with osimertinib is associated with improved survival in advanced |
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Concurrent use of aspirin with osimertinib is associated with improved survival in advanced |
| abstract |
Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. |
| abstractGer |
Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. |
| abstract_unstemmed |
Background: Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes.Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR-mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS).Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity.Conclusion: Concurrent aspirin use with osimertinib in EGFR-mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status. |
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Hong, Lingzhi Nilsson, Monique Hubert, Shawna Marie Wu, Shuhong Rinsurongkawong, Waree Lewis, Jeffery Spelman, Amy Roth, Jack Swisher, Steven He, Yong Jack Lee, J. Fang, Bingliang Heymach, John V. Zhang, Jianjun Le, Xiuning |
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In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. 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ind2=" "><subfield code="a">Heymach, John V.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Jianjun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Le, Xiuning</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Lung cancer</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 1985</subfield><subfield code="g">149, Seite 33-40</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)320649733</subfield><subfield code="w">(DE-600)2025812-4</subfield><subfield code="w">(DE-576)264627539</subfield><subfield code="x">1872-8332</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" 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