Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation
The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Magro, Massimiliano [verfasserIn] Cozza, Giorgio [verfasserIn] Molinari, Simone [verfasserIn] Venerando, Andrea [verfasserIn] Baratella, Davide [verfasserIn] Miotto, Giovanni [verfasserIn] Zennaro, Lucio [verfasserIn] Rossetto, Monica [verfasserIn] Frömmel, Jan [verfasserIn] Kopečná, Martina [verfasserIn] Šebela, Marek [verfasserIn] Salviulo, Gabriella [verfasserIn] Vianello, Fabio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of biological macromolecules - New York, NY [u.a.] : Elsevier, 1979, 164, Seite 1715-1728 |
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| Übergeordnetes Werk: |
volume:164 ; pages:1715-1728 |
| DOI / URN: |
10.1016/j.ijbiomac.2020.07.295 |
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| 245 | 1 | 0 | |a Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
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| 520 | |a The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. | ||
| 650 | 4 | |a Protein binding | |
| 650 | 4 | |a Nanoparticle recognition | |
| 650 | 4 | |a Protein corona | |
| 650 | 4 | |a Nanomaterial surface | |
| 650 | 4 | |a Iron oxide nanoparticles | |
| 700 | 1 | |a Cozza, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Molinari, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Venerando, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Baratella, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Miotto, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Zennaro, Lucio |e verfasserin |4 aut | |
| 700 | 1 | |a Rossetto, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Frömmel, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Kopečná, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Šebela, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Salviulo, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Vianello, Fabio |e verfasserin |4 aut | |
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10.1016/j.ijbiomac.2020.07.295 doi (DE-627)ELV004930177 (ELSEVIER)S0141-8130(20)34054-X DE-627 ger DE-627 rda eng 540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Magro, Massimiliano verfasserin aut Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles Cozza, Giorgio verfasserin aut Molinari, Simone verfasserin aut Venerando, Andrea verfasserin aut Baratella, Davide verfasserin aut Miotto, Giovanni verfasserin aut Zennaro, Lucio verfasserin aut Rossetto, Monica verfasserin aut Frömmel, Jan verfasserin aut Kopečná, Martina verfasserin aut Šebela, Marek verfasserin aut Salviulo, Gabriella verfasserin aut Vianello, Fabio verfasserin aut Enthalten in International journal of biological macromolecules New York, NY [u.a.] : Elsevier, 1979 164, Seite 1715-1728 Online-Ressource (DE-627)30089502X (DE-600)1483284-7 (DE-576)259270814 1879-0003 nnns volume:164 pages:1715-1728 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 58.30 Biotechnologie AR 164 1715-1728 |
| spelling |
10.1016/j.ijbiomac.2020.07.295 doi (DE-627)ELV004930177 (ELSEVIER)S0141-8130(20)34054-X DE-627 ger DE-627 rda eng 540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Magro, Massimiliano verfasserin aut Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles Cozza, Giorgio verfasserin aut Molinari, Simone verfasserin aut Venerando, Andrea verfasserin aut Baratella, Davide verfasserin aut Miotto, Giovanni verfasserin aut Zennaro, Lucio verfasserin aut Rossetto, Monica verfasserin aut Frömmel, Jan verfasserin aut Kopečná, Martina verfasserin aut Šebela, Marek verfasserin aut Salviulo, Gabriella verfasserin aut Vianello, Fabio verfasserin aut Enthalten in International journal of biological macromolecules New York, NY [u.a.] : Elsevier, 1979 164, Seite 1715-1728 Online-Ressource (DE-627)30089502X (DE-600)1483284-7 (DE-576)259270814 1879-0003 nnns volume:164 pages:1715-1728 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 58.30 Biotechnologie AR 164 1715-1728 |
| allfields_unstemmed |
10.1016/j.ijbiomac.2020.07.295 doi (DE-627)ELV004930177 (ELSEVIER)S0141-8130(20)34054-X DE-627 ger DE-627 rda eng 540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Magro, Massimiliano verfasserin aut Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles Cozza, Giorgio verfasserin aut Molinari, Simone verfasserin aut Venerando, Andrea verfasserin aut Baratella, Davide verfasserin aut Miotto, Giovanni verfasserin aut Zennaro, Lucio verfasserin aut Rossetto, Monica verfasserin aut Frömmel, Jan verfasserin aut Kopečná, Martina verfasserin aut Šebela, Marek verfasserin aut Salviulo, Gabriella verfasserin aut Vianello, Fabio verfasserin aut Enthalten in International journal of biological macromolecules New York, NY [u.a.] : Elsevier, 1979 164, Seite 1715-1728 Online-Ressource (DE-627)30089502X (DE-600)1483284-7 (DE-576)259270814 1879-0003 nnns volume:164 pages:1715-1728 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 58.30 Biotechnologie AR 164 1715-1728 |
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10.1016/j.ijbiomac.2020.07.295 doi (DE-627)ELV004930177 (ELSEVIER)S0141-8130(20)34054-X DE-627 ger DE-627 rda eng 540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Magro, Massimiliano verfasserin aut Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles Cozza, Giorgio verfasserin aut Molinari, Simone verfasserin aut Venerando, Andrea verfasserin aut Baratella, Davide verfasserin aut Miotto, Giovanni verfasserin aut Zennaro, Lucio verfasserin aut Rossetto, Monica verfasserin aut Frömmel, Jan verfasserin aut Kopečná, Martina verfasserin aut Šebela, Marek verfasserin aut Salviulo, Gabriella verfasserin aut Vianello, Fabio verfasserin aut Enthalten in International journal of biological macromolecules New York, NY [u.a.] : Elsevier, 1979 164, Seite 1715-1728 Online-Ressource (DE-627)30089502X (DE-600)1483284-7 (DE-576)259270814 1879-0003 nnns volume:164 pages:1715-1728 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 58.30 Biotechnologie AR 164 1715-1728 |
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10.1016/j.ijbiomac.2020.07.295 doi (DE-627)ELV004930177 (ELSEVIER)S0141-8130(20)34054-X DE-627 ger DE-627 rda eng 540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Magro, Massimiliano verfasserin aut Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles Cozza, Giorgio verfasserin aut Molinari, Simone verfasserin aut Venerando, Andrea verfasserin aut Baratella, Davide verfasserin aut Miotto, Giovanni verfasserin aut Zennaro, Lucio verfasserin aut Rossetto, Monica verfasserin aut Frömmel, Jan verfasserin aut Kopečná, Martina verfasserin aut Šebela, Marek verfasserin aut Salviulo, Gabriella verfasserin aut Vianello, Fabio verfasserin aut Enthalten in International journal of biological macromolecules New York, NY [u.a.] : Elsevier, 1979 164, Seite 1715-1728 Online-Ressource (DE-627)30089502X (DE-600)1483284-7 (DE-576)259270814 1879-0003 nnns volume:164 pages:1715-1728 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 58.30 Biotechnologie AR 164 1715-1728 |
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Enthalten in International journal of biological macromolecules 164, Seite 1715-1728 volume:164 pages:1715-1728 |
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Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles |
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International journal of biological macromolecules |
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Magro, Massimiliano @@aut@@ Cozza, Giorgio @@aut@@ Molinari, Simone @@aut@@ Venerando, Andrea @@aut@@ Baratella, Davide @@aut@@ Miotto, Giovanni @@aut@@ Zennaro, Lucio @@aut@@ Rossetto, Monica @@aut@@ Frömmel, Jan @@aut@@ Kopečná, Martina @@aut@@ Šebela, Marek @@aut@@ Salviulo, Gabriella @@aut@@ Vianello, Fabio @@aut@@ |
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2020-01-01T00:00:00Z |
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Magro, Massimiliano |
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Magro, Massimiliano ddc 540 fid BIODIV bkl 35.80 bkl 58.30 misc Protein binding misc Nanoparticle recognition misc Protein corona misc Nanomaterial surface misc Iron oxide nanoparticles Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
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540 570 DE-600 BIODIV DE-30 fid 35.80 bkl 58.30 bkl Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation Protein binding Nanoparticle recognition Protein corona Nanomaterial surface Iron oxide nanoparticles |
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Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
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Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
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Magro, Massimiliano Cozza, Giorgio Molinari, Simone Venerando, Andrea Baratella, Davide Miotto, Giovanni Zennaro, Lucio Rossetto, Monica Frömmel, Jan Kopečná, Martina Šebela, Marek Salviulo, Gabriella Vianello, Fabio |
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role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: a key for protein corona formation |
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Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
| abstract |
The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. |
| abstractGer |
The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. |
| abstract_unstemmed |
The knowledge of protein-nanoparticle interplay is of crucial importance to predict the fate of nanomaterials in biological environments. Indeed, protein corona on nanomaterials is responsible for the physiological response of the organism, influencing cell processes, from transport to accumulation and toxicity. Herein, a comparison using four different proteins reveals the existence of patterned regions of carboxylic groups acting as recognition sites for naked iron oxide nanoparticles. Readily interacting proteins display a distinctive surface distribution of carboxylic groups, recalling the geometric shape of an ellipse. This is morphologically complementary to nanoparticles curvature and compatible with the topography of exposed FeIII sites laying on the nanomaterial surface. The recognition site, absent in non-interacting proteins, promotes the nanoparticle harboring and allows the formation of functional protein coronas. The present work envisages the possibility of predicting the composition and the biological properties of protein corona on metal oxide nanoparticles. |
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Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation |
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Cozza, Giorgio Molinari, Simone Venerando, Andrea Baratella, Davide Miotto, Giovanni Zennaro, Lucio Rossetto, Monica Frömmel, Jan Kopečná, Martina Šebela, Marek Salviulo, Gabriella Vianello, Fabio |
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