Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies

Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to Novem...
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Autor*in:	Movahedian, Mina [verfasserIn] Rahmani, Jamal [verfasserIn] Hashemi Nazari, Seyed Saeed [verfasserIn] Mohamadi, Susan [verfasserIn] Naik, Gurudatta [verfasserIn] Hekmatdoost, Azita [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Fatty liver Diabetes Dose-response FLI FLD

Übergeordnetes Werk:	Enthalten in: Primary care diabetes - Amsterdam [u.a.] : Elsevier, 2007, 14, Seite 577-583
Übergeordnetes Werk:	volume:14 ; pages:577-583

DOI / URN:	10.1016/j.pcd.2020.02.011

Katalog-ID:	ELV005041627

Internformat


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100	1		\|a Movahedian, Mina \|e verfasserin \|4 aut
245	1	0	\|a Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
264		1	\|c 2020
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence.
650		4	\|a Fatty liver
650		4	\|a Diabetes
650		4	\|a Dose-response
650		4	\|a FLI
650		4	\|a FLD
700	1		\|a Rahmani, Jamal \|e verfasserin \|4 aut
700	1		\|a Hashemi Nazari, Seyed Saeed \|e verfasserin \|4 aut
700	1		\|a Mohamadi, Susan \|e verfasserin \|4 aut
700	1		\|a Naik, Gurudatta \|e verfasserin \|4 aut
700	1		\|a Hekmatdoost, Azita \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Primary care diabetes \|d Amsterdam [u.a.] : Elsevier, 2007 \|g 14, Seite 577-583 \|h Online-Ressource \|w (DE-627)52587674X \|w (DE-600)2273997-X \|w (DE-576)272351202 \|x 1878-0210 \|7 nnns
773	1	8	\|g volume:14 \|g pages:577-583
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912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
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912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.89 \|j Endokrinologie
951			\|a AR
952			\|d 14 \|h 577-583

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publishDate	2020
allfields	10.1016/j.pcd.2020.02.011 doi (DE-627)ELV005041627 (ELSEVIER)S1751-9918(19)30526-1 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Movahedian, Mina verfasserin aut Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence. Fatty liver Diabetes Dose-response FLI FLD Rahmani, Jamal verfasserin aut Hashemi Nazari, Seyed Saeed verfasserin aut Mohamadi, Susan verfasserin aut Naik, Gurudatta verfasserin aut Hekmatdoost, Azita verfasserin aut Enthalten in Primary care diabetes Amsterdam [u.a.] : Elsevier, 2007 14, Seite 577-583 Online-Ressource (DE-627)52587674X (DE-600)2273997-X (DE-576)272351202 1878-0210 nnns volume:14 pages:577-583 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 577-583
spelling	10.1016/j.pcd.2020.02.011 doi (DE-627)ELV005041627 (ELSEVIER)S1751-9918(19)30526-1 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Movahedian, Mina verfasserin aut Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence. Fatty liver Diabetes Dose-response FLI FLD Rahmani, Jamal verfasserin aut Hashemi Nazari, Seyed Saeed verfasserin aut Mohamadi, Susan verfasserin aut Naik, Gurudatta verfasserin aut Hekmatdoost, Azita verfasserin aut Enthalten in Primary care diabetes Amsterdam [u.a.] : Elsevier, 2007 14, Seite 577-583 Online-Ressource (DE-627)52587674X (DE-600)2273997-X (DE-576)272351202 1878-0210 nnns volume:14 pages:577-583 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 577-583
allfields_unstemmed	10.1016/j.pcd.2020.02.011 doi (DE-627)ELV005041627 (ELSEVIER)S1751-9918(19)30526-1 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Movahedian, Mina verfasserin aut Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence. Fatty liver Diabetes Dose-response FLI FLD Rahmani, Jamal verfasserin aut Hashemi Nazari, Seyed Saeed verfasserin aut Mohamadi, Susan verfasserin aut Naik, Gurudatta verfasserin aut Hekmatdoost, Azita verfasserin aut Enthalten in Primary care diabetes Amsterdam [u.a.] : Elsevier, 2007 14, Seite 577-583 Online-Ressource (DE-627)52587674X (DE-600)2273997-X (DE-576)272351202 1878-0210 nnns volume:14 pages:577-583 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 577-583
allfieldsGer	10.1016/j.pcd.2020.02.011 doi (DE-627)ELV005041627 (ELSEVIER)S1751-9918(19)30526-1 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Movahedian, Mina verfasserin aut Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence. Fatty liver Diabetes Dose-response FLI FLD Rahmani, Jamal verfasserin aut Hashemi Nazari, Seyed Saeed verfasserin aut Mohamadi, Susan verfasserin aut Naik, Gurudatta verfasserin aut Hekmatdoost, Azita verfasserin aut Enthalten in Primary care diabetes Amsterdam [u.a.] : Elsevier, 2007 14, Seite 577-583 Online-Ressource (DE-627)52587674X (DE-600)2273997-X (DE-576)272351202 1878-0210 nnns volume:14 pages:577-583 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 577-583
allfieldsSound	10.1016/j.pcd.2020.02.011 doi (DE-627)ELV005041627 (ELSEVIER)S1751-9918(19)30526-1 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Movahedian, Mina verfasserin aut Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence. Fatty liver Diabetes Dose-response FLI FLD Rahmani, Jamal verfasserin aut Hashemi Nazari, Seyed Saeed verfasserin aut Mohamadi, Susan verfasserin aut Naik, Gurudatta verfasserin aut Hekmatdoost, Azita verfasserin aut Enthalten in Primary care diabetes Amsterdam [u.a.] : Elsevier, 2007 14, Seite 577-583 Online-Ressource (DE-627)52587674X (DE-600)2273997-X (DE-576)272351202 1878-0210 nnns volume:14 pages:577-583 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 14 577-583
language	English
source	Enthalten in Primary care diabetes 14, Seite 577-583 volume:14 pages:577-583
sourceStr	Enthalten in Primary care diabetes 14, Seite 577-583 volume:14 pages:577-583
format_phy_str_mv	Article
bklname	Endokrinologie
institution	findex.gbv.de
topic_facet	Fatty liver Diabetes Dose-response FLI FLD
dewey-raw	610
isfreeaccess_bool	false
container_title	Primary care diabetes
authorswithroles_txt_mv	Movahedian, Mina @@aut@@ Rahmani, Jamal @@aut@@ Hashemi Nazari, Seyed Saeed @@aut@@ Mohamadi, Susan @@aut@@ Naik, Gurudatta @@aut@@ Hekmatdoost, Azita @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	52587674X
dewey-sort	3610
id	ELV005041627
language_de	englisch
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author	Movahedian, Mina
spellingShingle	Movahedian, Mina ddc 610 bkl 44.89 misc Fatty liver misc Diabetes misc Dose-response misc FLI misc FLD Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
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topic_title	610 DE-600 44.89 bkl Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies Fatty liver Diabetes Dose-response FLI FLD
topic	ddc 610 bkl 44.89 misc Fatty liver misc Diabetes misc Dose-response misc FLI misc FLD
topic_unstemmed	ddc 610 bkl 44.89 misc Fatty liver misc Diabetes misc Dose-response misc FLI misc FLD
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title	Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
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title_full	Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
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author_browse	Movahedian, Mina Rahmani, Jamal Hashemi Nazari, Seyed Saeed Mohamadi, Susan Naik, Gurudatta Hekmatdoost, Azita
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author-letter	Movahedian, Mina
doi_str_mv	10.1016/j.pcd.2020.02.011
dewey-full	610
author2-role	verfasserin
title_sort	fatty liver index and risk of diabetes incidence: a systematic review and dose-response meta-analysis of cohort studies
title_auth	Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
abstract	Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence.
abstractGer	Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence.
abstract_unstemmed	Aims: Fatty Liver Index (FLI) is a surrogate index for diagnosis of Fatty Liver Disease (FLD). We performed a dose-response meta-analysis to investigate the relationship between FLI and diabetes incidence in prospective cohort studies.Methods: We conducted a systematic search of articles up to November 2019 in PubMed, SCOPUS, Cochrane library, and Embase. Hazard Ratios (HRs) with corresponding 95% confidence intervals (CIs) of studies were pooled using meta-analysis with DerSimonian and Laird random-effects models to find combined HRs. Dose-response effect of this relationship was also assessed.Results: Twenty-seven studies providing 70,918 participants were included in the meta-analysis. Pooled results showed that the highest category of FLI was associated with an increased incidence of diabetes [HR: 2.88, 95% CI: 2.18–3.81; P for heterogeneity: 0.001]. Subgroup analysis based on sex, continent, and the quality of study could not explain the source of heterogeneity. The pooled HR from the random-effects dose-response model indicated a significant association between FLI level and risk of diabetes incidence (Coef=0.0239, p=0.001).Conclusion: Our dose-response meta-analysis revealed a direct relationship between FLI and HR of diabetes incidence.
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title_short	Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies
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author2	Rahmani, Jamal Hashemi Nazari, Seyed Saeed Mohamadi, Susan Naik, Gurudatta Hekmatdoost, Azita
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doi_str	10.1016/j.pcd.2020.02.011
up_date	2024-07-06T16:37:18.149Z
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Fatty liver index and risk of diabetes incidence: A systematic review and dose-response meta-analysis of cohort studies

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