Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f
We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ravera, Silvia [verfasserIn] Esposito, Alfonso [verfasserIn] Degan, Paolo [verfasserIn] Caicci, Federico [verfasserIn] Calzia, Daniela [verfasserIn] Perrotta, Eleonora [verfasserIn] Manni, Lucia [verfasserIn] Bisio, Angela [verfasserIn] Iobbi, Valeria [verfasserIn] Schito, Anna [verfasserIn] Traverso, Carlo Enrico [verfasserIn] Panfoli, Isabella [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Free radical biology and medicine - New York, NY [u.a.] : Elsevier, 1987, 160, Seite 368-375 |
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| Übergeordnetes Werk: |
volume:160 ; pages:368-375 |
| DOI / URN: |
10.1016/j.freeradbiomed.2020.08.014 |
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| 245 | 1 | 0 | |a Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f |
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| 520 | |a We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. | ||
| 650 | 4 | |a ATP synthase | |
| 650 | 4 | |a Aerobic metabolism | |
| 650 | 4 | |a Light | |
| 650 | 4 | |a Oxidative phosphorylation | |
| 650 | 4 | |a Respiratory chain complexes | |
| 650 | 4 | |a Rod outer segment | |
| 650 | 4 | |a Sclareol | |
| 650 | 4 | |a Transmission electron microscopy. | |
| 700 | 1 | |a Esposito, Alfonso |e verfasserin |0 (orcid)0000-0003-0726-5290 |4 aut | |
| 700 | 1 | |a Degan, Paolo |e verfasserin |0 (orcid)0000-0003-0855-8896 |4 aut | |
| 700 | 1 | |a Caicci, Federico |e verfasserin |0 (orcid)0000-0001-6981-449X |4 aut | |
| 700 | 1 | |a Calzia, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Perrotta, Eleonora |e verfasserin |0 (orcid)0000-0002-9262-2303 |4 aut | |
| 700 | 1 | |a Manni, Lucia |e verfasserin |0 (orcid)0000-0003-4257-8946 |4 aut | |
| 700 | 1 | |a Bisio, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Iobbi, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Schito, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Traverso, Carlo Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Panfoli, Isabella |e verfasserin |0 (orcid)0000-0002-6261-1128 |4 aut | |
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10.1016/j.freeradbiomed.2020.08.014 doi (DE-627)ELV00507178X (ELSEVIER)S0891-5849(20)31209-0 DE-627 ger DE-627 rda eng 570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Ravera, Silvia verfasserin aut Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. Esposito, Alfonso verfasserin (orcid)0000-0003-0726-5290 aut Degan, Paolo verfasserin (orcid)0000-0003-0855-8896 aut Caicci, Federico verfasserin (orcid)0000-0001-6981-449X aut Calzia, Daniela verfasserin aut Perrotta, Eleonora verfasserin (orcid)0000-0002-9262-2303 aut Manni, Lucia verfasserin (orcid)0000-0003-4257-8946 aut Bisio, Angela verfasserin aut Iobbi, Valeria verfasserin aut Schito, Anna verfasserin aut Traverso, Carlo Enrico verfasserin aut Panfoli, Isabella verfasserin (orcid)0000-0002-6261-1128 aut Enthalten in Free radical biology and medicine New York, NY [u.a.] : Elsevier, 1987 160, Seite 368-375 Online-Ressource (DE-627)300898568 (DE-600)1483653-1 (DE-576)098330233 1873-4596 nnns volume:160 pages:368-375 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.46 Klinische Pathologie 44.33 Physiologische Chemie 42.13 Molekularbiologie 44.39 Toxikologie AR 160 368-375 |
| spelling |
10.1016/j.freeradbiomed.2020.08.014 doi (DE-627)ELV00507178X (ELSEVIER)S0891-5849(20)31209-0 DE-627 ger DE-627 rda eng 570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Ravera, Silvia verfasserin aut Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. Esposito, Alfonso verfasserin (orcid)0000-0003-0726-5290 aut Degan, Paolo verfasserin (orcid)0000-0003-0855-8896 aut Caicci, Federico verfasserin (orcid)0000-0001-6981-449X aut Calzia, Daniela verfasserin aut Perrotta, Eleonora verfasserin (orcid)0000-0002-9262-2303 aut Manni, Lucia verfasserin (orcid)0000-0003-4257-8946 aut Bisio, Angela verfasserin aut Iobbi, Valeria verfasserin aut Schito, Anna verfasserin aut Traverso, Carlo Enrico verfasserin aut Panfoli, Isabella verfasserin (orcid)0000-0002-6261-1128 aut Enthalten in Free radical biology and medicine New York, NY [u.a.] : Elsevier, 1987 160, Seite 368-375 Online-Ressource (DE-627)300898568 (DE-600)1483653-1 (DE-576)098330233 1873-4596 nnns volume:160 pages:368-375 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.46 Klinische Pathologie 44.33 Physiologische Chemie 42.13 Molekularbiologie 44.39 Toxikologie AR 160 368-375 |
| allfields_unstemmed |
10.1016/j.freeradbiomed.2020.08.014 doi (DE-627)ELV00507178X (ELSEVIER)S0891-5849(20)31209-0 DE-627 ger DE-627 rda eng 570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Ravera, Silvia verfasserin aut Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. Esposito, Alfonso verfasserin (orcid)0000-0003-0726-5290 aut Degan, Paolo verfasserin (orcid)0000-0003-0855-8896 aut Caicci, Federico verfasserin (orcid)0000-0001-6981-449X aut Calzia, Daniela verfasserin aut Perrotta, Eleonora verfasserin (orcid)0000-0002-9262-2303 aut Manni, Lucia verfasserin (orcid)0000-0003-4257-8946 aut Bisio, Angela verfasserin aut Iobbi, Valeria verfasserin aut Schito, Anna verfasserin aut Traverso, Carlo Enrico verfasserin aut Panfoli, Isabella verfasserin (orcid)0000-0002-6261-1128 aut Enthalten in Free radical biology and medicine New York, NY [u.a.] : Elsevier, 1987 160, Seite 368-375 Online-Ressource (DE-627)300898568 (DE-600)1483653-1 (DE-576)098330233 1873-4596 nnns volume:160 pages:368-375 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.46 Klinische Pathologie 44.33 Physiologische Chemie 42.13 Molekularbiologie 44.39 Toxikologie AR 160 368-375 |
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10.1016/j.freeradbiomed.2020.08.014 doi (DE-627)ELV00507178X (ELSEVIER)S0891-5849(20)31209-0 DE-627 ger DE-627 rda eng 570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Ravera, Silvia verfasserin aut Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. Esposito, Alfonso verfasserin (orcid)0000-0003-0726-5290 aut Degan, Paolo verfasserin (orcid)0000-0003-0855-8896 aut Caicci, Federico verfasserin (orcid)0000-0001-6981-449X aut Calzia, Daniela verfasserin aut Perrotta, Eleonora verfasserin (orcid)0000-0002-9262-2303 aut Manni, Lucia verfasserin (orcid)0000-0003-4257-8946 aut Bisio, Angela verfasserin aut Iobbi, Valeria verfasserin aut Schito, Anna verfasserin aut Traverso, Carlo Enrico verfasserin aut Panfoli, Isabella verfasserin (orcid)0000-0002-6261-1128 aut Enthalten in Free radical biology and medicine New York, NY [u.a.] : Elsevier, 1987 160, Seite 368-375 Online-Ressource (DE-627)300898568 (DE-600)1483653-1 (DE-576)098330233 1873-4596 nnns volume:160 pages:368-375 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.46 Klinische Pathologie 44.33 Physiologische Chemie 42.13 Molekularbiologie 44.39 Toxikologie AR 160 368-375 |
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10.1016/j.freeradbiomed.2020.08.014 doi (DE-627)ELV00507178X (ELSEVIER)S0891-5849(20)31209-0 DE-627 ger DE-627 rda eng 570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Ravera, Silvia verfasserin aut Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. Esposito, Alfonso verfasserin (orcid)0000-0003-0726-5290 aut Degan, Paolo verfasserin (orcid)0000-0003-0855-8896 aut Caicci, Federico verfasserin (orcid)0000-0001-6981-449X aut Calzia, Daniela verfasserin aut Perrotta, Eleonora verfasserin (orcid)0000-0002-9262-2303 aut Manni, Lucia verfasserin (orcid)0000-0003-4257-8946 aut Bisio, Angela verfasserin aut Iobbi, Valeria verfasserin aut Schito, Anna verfasserin aut Traverso, Carlo Enrico verfasserin aut Panfoli, Isabella verfasserin (orcid)0000-0002-6261-1128 aut Enthalten in Free radical biology and medicine New York, NY [u.a.] : Elsevier, 1987 160, Seite 368-375 Online-Ressource (DE-627)300898568 (DE-600)1483653-1 (DE-576)098330233 1873-4596 nnns volume:160 pages:368-375 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.46 Klinische Pathologie 44.33 Physiologische Chemie 42.13 Molekularbiologie 44.39 Toxikologie AR 160 368-375 |
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Enthalten in Free radical biology and medicine 160, Seite 368-375 volume:160 pages:368-375 |
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Enthalten in Free radical biology and medicine 160, Seite 368-375 volume:160 pages:368-375 |
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Klinische Pathologie Physiologische Chemie Molekularbiologie Toxikologie |
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ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy. |
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Ravera, Silvia @@aut@@ Esposito, Alfonso @@aut@@ Degan, Paolo @@aut@@ Caicci, Federico @@aut@@ Calzia, Daniela @@aut@@ Perrotta, Eleonora @@aut@@ Manni, Lucia @@aut@@ Bisio, Angela @@aut@@ Iobbi, Valeria @@aut@@ Schito, Anna @@aut@@ Traverso, Carlo Enrico @@aut@@ Panfoli, Isabella @@aut@@ |
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2020-01-01T00:00:00Z |
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Ravera, Silvia ddc 570 bkl 44.46 bkl 44.33 bkl 42.13 bkl 44.39 misc ATP synthase misc Aerobic metabolism misc Light misc Oxidative phosphorylation misc Respiratory chain complexes misc Rod outer segment misc Sclareol misc Transmission electron microscopy. Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f |
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570 610 DE-600 44.46 bkl 44.33 bkl 42.13 bkl 44.39 bkl Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f ATP synthase Aerobic metabolism Light Oxidative phosphorylation Respiratory chain complexes Rod outer segment Sclareol Transmission electron microscopy |
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ddc 570 bkl 44.46 bkl 44.33 bkl 42.13 bkl 44.39 misc ATP synthase misc Aerobic metabolism misc Light misc Oxidative phosphorylation misc Respiratory chain complexes misc Rod outer segment misc Sclareol misc Transmission electron microscopy. |
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Ravera, Silvia Esposito, Alfonso Degan, Paolo Caicci, Federico Calzia, Daniela Perrotta, Eleonora Manni, Lucia Bisio, Angela Iobbi, Valeria Schito, Anna Traverso, Carlo Enrico Panfoli, Isabella |
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sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f |
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Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f |
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We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. |
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We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. |
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We have previously shown that the retinal rod outer segments (OS) produce reactive oxygen species in the function of illumination in vitro, establishing a relationship among the extra-mitochondrial oxidative phosphorylation and phototransduction. This source of oxidative stress in the OS can be modulated by polyphenols, acting as inhibitors of F1Fo-ATP synthase. The present study aimed at exploring whether sclareol, a diterpene, interacts with F1Fo-ATP synthase mitigating the light-induced free radical production in the rod OS. |
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Sclareol modulates free radical production in the retinal rod outer segment by inhibiting the ectopic f |
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Esposito, Alfonso Degan, Paolo Caicci, Federico Calzia, Daniela Perrotta, Eleonora Manni, Lucia Bisio, Angela Iobbi, Valeria Schito, Anna Traverso, Carlo Enrico Panfoli, Isabella |
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| score |
7.400139 |