Transcriptome profiling in adult attention-deficit hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underly...
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Autor*in:	Mortimer, Niall [verfasserIn] Sánchez-Mora, Cristina [verfasserIn] Rovira, Paula [verfasserIn] Vilar-Ribó, Laura [verfasserIn] Richarte, Vanesa [verfasserIn] Corrales, Montse [verfasserIn] Fadeuilhe, Christian [verfasserIn] Rivero, Olga [verfasserIn] Lesch, Klaus-Peter [verfasserIn] Casas, Miguel [verfasserIn] Ramos-Quiroga, Josep Antoni [verfasserIn] Artigas, María Soler [verfasserIn] Ribasés, Marta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures

Übergeordnetes Werk:	Enthalten in: European neuropsychopharmacology - Amsterdam : Elsevier, 1990, 41, Seite 160-166
Übergeordnetes Werk:	volume:41 ; pages:160-166

DOI / URN:	10.1016/j.euroneuro.2020.11.005

Katalog-ID:	ELV005137764

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520			\|a Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD.
650		4	\|a Attention-deficit/hyperactivity disorder (ADHD)
650		4	\|a Transcriptomic assays
650		4	\|a Gene-expression signatures
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700	1		\|a Lesch, Klaus-Peter \|e verfasserin \|4 aut
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700	1		\|a Ramos-Quiroga, Josep Antoni \|e verfasserin \|4 aut
700	1		\|a Artigas, María Soler \|e verfasserin \|4 aut
700	1		\|a Ribasés, Marta \|e verfasserin \|4 aut
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936	b	k	\|a 44.38 \|j Pharmakologie
936	b	k	\|a 44.90 \|j Neurologie
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publishDate	2020
allfields	10.1016/j.euroneuro.2020.11.005 doi (DE-627)ELV005137764 (ELSEVIER)S0924-977X(20)30937-8 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Mortimer, Niall verfasserin aut Transcriptome profiling in adult attention-deficit hyperactivity disorder 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures Sánchez-Mora, Cristina verfasserin aut Rovira, Paula verfasserin aut Vilar-Ribó, Laura verfasserin aut Richarte, Vanesa verfasserin aut Corrales, Montse verfasserin aut Fadeuilhe, Christian verfasserin aut Rivero, Olga verfasserin aut Lesch, Klaus-Peter verfasserin aut Casas, Miguel verfasserin aut Ramos-Quiroga, Josep Antoni verfasserin aut Artigas, María Soler verfasserin aut Ribasés, Marta verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 41, Seite 160-166 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:41 pages:160-166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 41 160-166
spelling	10.1016/j.euroneuro.2020.11.005 doi (DE-627)ELV005137764 (ELSEVIER)S0924-977X(20)30937-8 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Mortimer, Niall verfasserin aut Transcriptome profiling in adult attention-deficit hyperactivity disorder 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures Sánchez-Mora, Cristina verfasserin aut Rovira, Paula verfasserin aut Vilar-Ribó, Laura verfasserin aut Richarte, Vanesa verfasserin aut Corrales, Montse verfasserin aut Fadeuilhe, Christian verfasserin aut Rivero, Olga verfasserin aut Lesch, Klaus-Peter verfasserin aut Casas, Miguel verfasserin aut Ramos-Quiroga, Josep Antoni verfasserin aut Artigas, María Soler verfasserin aut Ribasés, Marta verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 41, Seite 160-166 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:41 pages:160-166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 41 160-166
allfields_unstemmed	10.1016/j.euroneuro.2020.11.005 doi (DE-627)ELV005137764 (ELSEVIER)S0924-977X(20)30937-8 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Mortimer, Niall verfasserin aut Transcriptome profiling in adult attention-deficit hyperactivity disorder 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures Sánchez-Mora, Cristina verfasserin aut Rovira, Paula verfasserin aut Vilar-Ribó, Laura verfasserin aut Richarte, Vanesa verfasserin aut Corrales, Montse verfasserin aut Fadeuilhe, Christian verfasserin aut Rivero, Olga verfasserin aut Lesch, Klaus-Peter verfasserin aut Casas, Miguel verfasserin aut Ramos-Quiroga, Josep Antoni verfasserin aut Artigas, María Soler verfasserin aut Ribasés, Marta verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 41, Seite 160-166 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:41 pages:160-166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 41 160-166
allfieldsGer	10.1016/j.euroneuro.2020.11.005 doi (DE-627)ELV005137764 (ELSEVIER)S0924-977X(20)30937-8 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Mortimer, Niall verfasserin aut Transcriptome profiling in adult attention-deficit hyperactivity disorder 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures Sánchez-Mora, Cristina verfasserin aut Rovira, Paula verfasserin aut Vilar-Ribó, Laura verfasserin aut Richarte, Vanesa verfasserin aut Corrales, Montse verfasserin aut Fadeuilhe, Christian verfasserin aut Rivero, Olga verfasserin aut Lesch, Klaus-Peter verfasserin aut Casas, Miguel verfasserin aut Ramos-Quiroga, Josep Antoni verfasserin aut Artigas, María Soler verfasserin aut Ribasés, Marta verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 41, Seite 160-166 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:41 pages:160-166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 41 160-166
allfieldsSound	10.1016/j.euroneuro.2020.11.005 doi (DE-627)ELV005137764 (ELSEVIER)S0924-977X(20)30937-8 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Mortimer, Niall verfasserin aut Transcriptome profiling in adult attention-deficit hyperactivity disorder 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures Sánchez-Mora, Cristina verfasserin aut Rovira, Paula verfasserin aut Vilar-Ribó, Laura verfasserin aut Richarte, Vanesa verfasserin aut Corrales, Montse verfasserin aut Fadeuilhe, Christian verfasserin aut Rivero, Olga verfasserin aut Lesch, Klaus-Peter verfasserin aut Casas, Miguel verfasserin aut Ramos-Quiroga, Josep Antoni verfasserin aut Artigas, María Soler verfasserin aut Ribasés, Marta verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 41, Seite 160-166 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:41 pages:160-166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 41 160-166
language	English
source	Enthalten in European neuropsychopharmacology 41, Seite 160-166 volume:41 pages:160-166
sourceStr	Enthalten in European neuropsychopharmacology 41, Seite 160-166 volume:41 pages:160-166
format_phy_str_mv	Article
bklname	Pharmakologie Neurologie
institution	findex.gbv.de
topic_facet	Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures
dewey-raw	150
isfreeaccess_bool	false
container_title	European neuropsychopharmacology
authorswithroles_txt_mv	Mortimer, Niall @@aut@@ Sánchez-Mora, Cristina @@aut@@ Rovira, Paula @@aut@@ Vilar-Ribó, Laura @@aut@@ Richarte, Vanesa @@aut@@ Corrales, Montse @@aut@@ Fadeuilhe, Christian @@aut@@ Rivero, Olga @@aut@@ Lesch, Klaus-Peter @@aut@@ Casas, Miguel @@aut@@ Ramos-Quiroga, Josep Antoni @@aut@@ Artigas, María Soler @@aut@@ Ribasés, Marta @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	320594025
dewey-sort	3150
id	ELV005137764
language_de	englisch
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author	Mortimer, Niall
spellingShingle	Mortimer, Niall ddc 150 fid PHARM bkl 44.38 bkl 44.90 misc Attention-deficit/hyperactivity disorder (ADHD) misc Transcriptomic assays misc Gene-expression signatures Transcriptome profiling in adult attention-deficit hyperactivity disorder
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topic_title	150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Transcriptome profiling in adult attention-deficit hyperactivity disorder Attention-deficit/hyperactivity disorder (ADHD) Transcriptomic assays Gene-expression signatures
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title	Transcriptome profiling in adult attention-deficit hyperactivity disorder
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title_full	Transcriptome profiling in adult attention-deficit hyperactivity disorder
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author_browse	Mortimer, Niall Sánchez-Mora, Cristina Rovira, Paula Vilar-Ribó, Laura Richarte, Vanesa Corrales, Montse Fadeuilhe, Christian Rivero, Olga Lesch, Klaus-Peter Casas, Miguel Ramos-Quiroga, Josep Antoni Artigas, María Soler Ribasés, Marta
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title_sort	transcriptome profiling in adult attention-deficit hyperactivity disorder
title_auth	Transcriptome profiling in adult attention-deficit hyperactivity disorder
abstract	Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD.
abstractGer	Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD.
abstract_unstemmed	Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD.
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title_short	Transcriptome profiling in adult attention-deficit hyperactivity disorder
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author2	Sánchez-Mora, Cristina Rovira, Paula Vilar-Ribó, Laura Richarte, Vanesa Corrales, Montse Fadeuilhe, Christian Rivero, Olga Lesch, Klaus-Peter Casas, Miguel Ramos-Quiroga, Josep Antoni Artigas, María Soler Ribasés, Marta
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up_date	2024-07-06T16:56:39.451Z
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Transcriptome profiling in adult attention-deficit hyperactivity disorder

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