Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality
Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared...
Ausführliche Beschreibung
Gespeichert in:
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of infection - Amsterdam [u.a.] : Elsevier, 1979, 81 |
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| Übergeordnetes Werk: |
volume:81 |
| DOI / URN: |
10.1016/j.jinf.2020.11.002 |
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| Katalog-ID: |
ELV005182573 |
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| 024 | 7 | |a 10.1016/j.jinf.2020.11.002 |2 doi | |
| 035 | |a (DE-627)ELV005182573 | ||
| 035 | |a (ELSEVIER)S0163-4453(20)30697-6 | ||
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| 100 | 1 | |a Averbuch, Diana |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
| 264 | 1 | |c 2020 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. | ||
| 650 | 4 | |a Bacteremia | |
| 650 | 4 | |a Stem cell transplantation | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Gram-negative | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Fluoroquinolone prophylaxis | |
| 650 | 4 | |a Pre-engraftment | |
| 650 | 4 | |a Post-engraftment | |
| 700 | 1 | |a Tridello, Gloria |e verfasserin |4 aut | |
| 700 | 1 | |a Hoek, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Mikulska, Malgorzata |e verfasserin |4 aut | |
| 700 | 1 | |a Pabst, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Yaňez San Segundo, Lucrecia |e verfasserin |4 aut | |
| 700 | 1 | |a Akan, Hamdi |e verfasserin |4 aut | |
| 700 | 1 | |a Özçelik, Tülay |e verfasserin |4 aut | |
| 700 | 1 | |a Donnini, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Klyasova, Galina |e verfasserin |4 aut | |
| 700 | 1 | |a Botelho de Sousa, Aida |e verfasserin |4 aut | |
| 700 | 1 | |a Zuckerman, Tsila |e verfasserin |4 aut | |
| 700 | 1 | |a Tecchio, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a de la Camara, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Aki, Sahika Zeynep |e verfasserin |4 aut | |
| 700 | 1 | |a Ljungman, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Gülbas, Zafer |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolas-Virelizier, Emmanuelle |e verfasserin |4 aut | |
| 700 | 1 | |a Calore, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Perruccio, Katia |e verfasserin |4 aut | |
| 700 | 1 | |a Ram, Ron |e verfasserin |4 aut | |
| 700 | 1 | |a Annaloro, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Martino, Rodrigo |e verfasserin |4 aut | |
| 700 | 1 | |a Avni, Batia |e verfasserin |4 aut | |
| 700 | 1 | |a Shaw, Peter J. |e verfasserin |4 aut | |
| 700 | 1 | |a Jungova, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Codeluppi, Katia |e verfasserin |4 aut | |
| 700 | 1 | |a O'Brien, Tracey |e verfasserin |4 aut | |
| 700 | 1 | |a Waszczuk-Gajda, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Batlle, Montserrat |e verfasserin |4 aut | |
| 700 | 1 | |a Pouli, Anastasia |e verfasserin |4 aut | |
| 700 | 1 | |a Lueck, Catherina |e verfasserin |4 aut | |
| 700 | 1 | |a Gil, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Iacobelli, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Styczynski, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Engelhard, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Cesaro, Simone |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of infection |d Amsterdam [u.a.] : Elsevier, 1979 |g 81 |h Online-Ressource |w (DE-627)320506436 |w (DE-600)2012883-6 |w (DE-576)104344717 |x 1532-2742 |7 nnns |
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| 936 | b | k | |a 44.75 |j Infektionskrankheiten |j parasitäre Krankheiten |x Medizin |
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2020 |
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10.1016/j.jinf.2020.11.002 doi (DE-627)ELV005182573 (ELSEVIER)S0163-4453(20)30697-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Averbuch, Diana verfasserin aut Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment Tridello, Gloria verfasserin aut Hoek, Jennifer verfasserin aut Mikulska, Malgorzata verfasserin aut Pabst, Thomas verfasserin aut Yaňez San Segundo, Lucrecia verfasserin aut Akan, Hamdi verfasserin aut Özçelik, Tülay verfasserin aut Donnini, Irene verfasserin aut Klyasova, Galina verfasserin aut Botelho de Sousa, Aida verfasserin aut Zuckerman, Tsila verfasserin aut Tecchio, Cristina verfasserin aut de la Camara, Rafael verfasserin aut Aki, Sahika Zeynep verfasserin aut Ljungman, Per verfasserin aut Gülbas, Zafer verfasserin aut Nicolas-Virelizier, Emmanuelle verfasserin aut Calore, Elisabetta verfasserin aut Perruccio, Katia verfasserin aut Ram, Ron verfasserin aut Annaloro, Claudio verfasserin aut Martino, Rodrigo verfasserin aut Avni, Batia verfasserin aut Shaw, Peter J. verfasserin aut Jungova, Alexandra verfasserin aut Codeluppi, Katia verfasserin aut O'Brien, Tracey verfasserin aut Waszczuk-Gajda, Anna verfasserin aut Batlle, Montserrat verfasserin aut Pouli, Anastasia verfasserin aut Lueck, Catherina verfasserin aut Gil, Lidia verfasserin aut Iacobelli, Simona verfasserin aut Styczynski, Jan verfasserin aut Engelhard, Dan verfasserin aut Cesaro, Simone verfasserin aut Enthalten in Journal of infection Amsterdam [u.a.] : Elsevier, 1979 81 Online-Ressource (DE-627)320506436 (DE-600)2012883-6 (DE-576)104344717 1532-2742 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 81 |
| spelling |
10.1016/j.jinf.2020.11.002 doi (DE-627)ELV005182573 (ELSEVIER)S0163-4453(20)30697-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Averbuch, Diana verfasserin aut Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment Tridello, Gloria verfasserin aut Hoek, Jennifer verfasserin aut Mikulska, Malgorzata verfasserin aut Pabst, Thomas verfasserin aut Yaňez San Segundo, Lucrecia verfasserin aut Akan, Hamdi verfasserin aut Özçelik, Tülay verfasserin aut Donnini, Irene verfasserin aut Klyasova, Galina verfasserin aut Botelho de Sousa, Aida verfasserin aut Zuckerman, Tsila verfasserin aut Tecchio, Cristina verfasserin aut de la Camara, Rafael verfasserin aut Aki, Sahika Zeynep verfasserin aut Ljungman, Per verfasserin aut Gülbas, Zafer verfasserin aut Nicolas-Virelizier, Emmanuelle verfasserin aut Calore, Elisabetta verfasserin aut Perruccio, Katia verfasserin aut Ram, Ron verfasserin aut Annaloro, Claudio verfasserin aut Martino, Rodrigo verfasserin aut Avni, Batia verfasserin aut Shaw, Peter J. verfasserin aut Jungova, Alexandra verfasserin aut Codeluppi, Katia verfasserin aut O'Brien, Tracey verfasserin aut Waszczuk-Gajda, Anna verfasserin aut Batlle, Montserrat verfasserin aut Pouli, Anastasia verfasserin aut Lueck, Catherina verfasserin aut Gil, Lidia verfasserin aut Iacobelli, Simona verfasserin aut Styczynski, Jan verfasserin aut Engelhard, Dan verfasserin aut Cesaro, Simone verfasserin aut Enthalten in Journal of infection Amsterdam [u.a.] : Elsevier, 1979 81 Online-Ressource (DE-627)320506436 (DE-600)2012883-6 (DE-576)104344717 1532-2742 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 81 |
| allfields_unstemmed |
10.1016/j.jinf.2020.11.002 doi (DE-627)ELV005182573 (ELSEVIER)S0163-4453(20)30697-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Averbuch, Diana verfasserin aut Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment Tridello, Gloria verfasserin aut Hoek, Jennifer verfasserin aut Mikulska, Malgorzata verfasserin aut Pabst, Thomas verfasserin aut Yaňez San Segundo, Lucrecia verfasserin aut Akan, Hamdi verfasserin aut Özçelik, Tülay verfasserin aut Donnini, Irene verfasserin aut Klyasova, Galina verfasserin aut Botelho de Sousa, Aida verfasserin aut Zuckerman, Tsila verfasserin aut Tecchio, Cristina verfasserin aut de la Camara, Rafael verfasserin aut Aki, Sahika Zeynep verfasserin aut Ljungman, Per verfasserin aut Gülbas, Zafer verfasserin aut Nicolas-Virelizier, Emmanuelle verfasserin aut Calore, Elisabetta verfasserin aut Perruccio, Katia verfasserin aut Ram, Ron verfasserin aut Annaloro, Claudio verfasserin aut Martino, Rodrigo verfasserin aut Avni, Batia verfasserin aut Shaw, Peter J. verfasserin aut Jungova, Alexandra verfasserin aut Codeluppi, Katia verfasserin aut O'Brien, Tracey verfasserin aut Waszczuk-Gajda, Anna verfasserin aut Batlle, Montserrat verfasserin aut Pouli, Anastasia verfasserin aut Lueck, Catherina verfasserin aut Gil, Lidia verfasserin aut Iacobelli, Simona verfasserin aut Styczynski, Jan verfasserin aut Engelhard, Dan verfasserin aut Cesaro, Simone verfasserin aut Enthalten in Journal of infection Amsterdam [u.a.] : Elsevier, 1979 81 Online-Ressource (DE-627)320506436 (DE-600)2012883-6 (DE-576)104344717 1532-2742 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 81 |
| allfieldsGer |
10.1016/j.jinf.2020.11.002 doi (DE-627)ELV005182573 (ELSEVIER)S0163-4453(20)30697-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Averbuch, Diana verfasserin aut Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment Tridello, Gloria verfasserin aut Hoek, Jennifer verfasserin aut Mikulska, Malgorzata verfasserin aut Pabst, Thomas verfasserin aut Yaňez San Segundo, Lucrecia verfasserin aut Akan, Hamdi verfasserin aut Özçelik, Tülay verfasserin aut Donnini, Irene verfasserin aut Klyasova, Galina verfasserin aut Botelho de Sousa, Aida verfasserin aut Zuckerman, Tsila verfasserin aut Tecchio, Cristina verfasserin aut de la Camara, Rafael verfasserin aut Aki, Sahika Zeynep verfasserin aut Ljungman, Per verfasserin aut Gülbas, Zafer verfasserin aut Nicolas-Virelizier, Emmanuelle verfasserin aut Calore, Elisabetta verfasserin aut Perruccio, Katia verfasserin aut Ram, Ron verfasserin aut Annaloro, Claudio verfasserin aut Martino, Rodrigo verfasserin aut Avni, Batia verfasserin aut Shaw, Peter J. verfasserin aut Jungova, Alexandra verfasserin aut Codeluppi, Katia verfasserin aut O'Brien, Tracey verfasserin aut Waszczuk-Gajda, Anna verfasserin aut Batlle, Montserrat verfasserin aut Pouli, Anastasia verfasserin aut Lueck, Catherina verfasserin aut Gil, Lidia verfasserin aut Iacobelli, Simona verfasserin aut Styczynski, Jan verfasserin aut Engelhard, Dan verfasserin aut Cesaro, Simone verfasserin aut Enthalten in Journal of infection Amsterdam [u.a.] : Elsevier, 1979 81 Online-Ressource (DE-627)320506436 (DE-600)2012883-6 (DE-576)104344717 1532-2742 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 81 |
| allfieldsSound |
10.1016/j.jinf.2020.11.002 doi (DE-627)ELV005182573 (ELSEVIER)S0163-4453(20)30697-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Averbuch, Diana verfasserin aut Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment Tridello, Gloria verfasserin aut Hoek, Jennifer verfasserin aut Mikulska, Malgorzata verfasserin aut Pabst, Thomas verfasserin aut Yaňez San Segundo, Lucrecia verfasserin aut Akan, Hamdi verfasserin aut Özçelik, Tülay verfasserin aut Donnini, Irene verfasserin aut Klyasova, Galina verfasserin aut Botelho de Sousa, Aida verfasserin aut Zuckerman, Tsila verfasserin aut Tecchio, Cristina verfasserin aut de la Camara, Rafael verfasserin aut Aki, Sahika Zeynep verfasserin aut Ljungman, Per verfasserin aut Gülbas, Zafer verfasserin aut Nicolas-Virelizier, Emmanuelle verfasserin aut Calore, Elisabetta verfasserin aut Perruccio, Katia verfasserin aut Ram, Ron verfasserin aut Annaloro, Claudio verfasserin aut Martino, Rodrigo verfasserin aut Avni, Batia verfasserin aut Shaw, Peter J. verfasserin aut Jungova, Alexandra verfasserin aut Codeluppi, Katia verfasserin aut O'Brien, Tracey verfasserin aut Waszczuk-Gajda, Anna verfasserin aut Batlle, Montserrat verfasserin aut Pouli, Anastasia verfasserin aut Lueck, Catherina verfasserin aut Gil, Lidia verfasserin aut Iacobelli, Simona verfasserin aut Styczynski, Jan verfasserin aut Engelhard, Dan verfasserin aut Cesaro, Simone verfasserin aut Enthalten in Journal of infection Amsterdam [u.a.] : Elsevier, 1979 81 Online-Ressource (DE-627)320506436 (DE-600)2012883-6 (DE-576)104344717 1532-2742 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 81 |
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Enthalten in Journal of infection 81 volume:81 |
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Infektionskrankheiten parasitäre Krankheiten |
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findex.gbv.de |
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Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment |
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Averbuch, Diana @@aut@@ Tridello, Gloria @@aut@@ Hoek, Jennifer @@aut@@ Mikulska, Malgorzata @@aut@@ Pabst, Thomas @@aut@@ Yaňez San Segundo, Lucrecia @@aut@@ Akan, Hamdi @@aut@@ Özçelik, Tülay @@aut@@ Donnini, Irene @@aut@@ Klyasova, Galina @@aut@@ Botelho de Sousa, Aida @@aut@@ Zuckerman, Tsila @@aut@@ Tecchio, Cristina @@aut@@ de la Camara, Rafael @@aut@@ Aki, Sahika Zeynep @@aut@@ Ljungman, Per @@aut@@ Gülbas, Zafer @@aut@@ Nicolas-Virelizier, Emmanuelle @@aut@@ Calore, Elisabetta @@aut@@ Perruccio, Katia @@aut@@ Ram, Ron @@aut@@ Annaloro, Claudio @@aut@@ Martino, Rodrigo @@aut@@ Avni, Batia @@aut@@ Shaw, Peter J. @@aut@@ Jungova, Alexandra @@aut@@ Codeluppi, Katia @@aut@@ O'Brien, Tracey @@aut@@ Waszczuk-Gajda, Anna @@aut@@ Batlle, Montserrat @@aut@@ Pouli, Anastasia @@aut@@ Lueck, Catherina @@aut@@ Gil, Lidia @@aut@@ Iacobelli, Simona @@aut@@ Styczynski, Jan @@aut@@ Engelhard, Dan @@aut@@ Cesaro, Simone @@aut@@ |
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2020-01-01T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV005182573</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524143419.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230503s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jinf.2020.11.002</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV005182573</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0163-4453(20)30697-6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.75</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Averbuch, Diana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. 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|
| author |
Averbuch, Diana |
| spellingShingle |
Averbuch, Diana ddc 610 bkl 44.75 misc Bacteremia misc Stem cell transplantation misc Risk factors misc Gram-negative misc Mortality misc Fluoroquinolone prophylaxis misc Pre-engraftment misc Post-engraftment Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
| authorStr |
Averbuch, Diana |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)320506436 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1532-2742 |
| topic_title |
610 DE-600 44.75 bkl Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality Bacteremia Stem cell transplantation Risk factors Gram-negative Mortality Fluoroquinolone prophylaxis Pre-engraftment Post-engraftment |
| topic |
ddc 610 bkl 44.75 misc Bacteremia misc Stem cell transplantation misc Risk factors misc Gram-negative misc Mortality misc Fluoroquinolone prophylaxis misc Pre-engraftment misc Post-engraftment |
| topic_unstemmed |
ddc 610 bkl 44.75 misc Bacteremia misc Stem cell transplantation misc Risk factors misc Gram-negative misc Mortality misc Fluoroquinolone prophylaxis misc Pre-engraftment misc Post-engraftment |
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Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
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Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
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Averbuch, Diana |
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Journal of infection |
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Averbuch, Diana Tridello, Gloria Hoek, Jennifer Mikulska, Malgorzata Pabst, Thomas Yaňez San Segundo, Lucrecia Akan, Hamdi Özçelik, Tülay Donnini, Irene Klyasova, Galina Botelho de Sousa, Aida Zuckerman, Tsila Tecchio, Cristina de la Camara, Rafael Aki, Sahika Zeynep Ljungman, Per Gülbas, Zafer Nicolas-Virelizier, Emmanuelle Calore, Elisabetta Perruccio, Katia Ram, Ron Annaloro, Claudio Martino, Rodrigo Avni, Batia Shaw, Peter J. Jungova, Alexandra Codeluppi, Katia O'Brien, Tracey Waszczuk-Gajda, Anna Batlle, Montserrat Pouli, Anastasia Lueck, Catherina Gil, Lidia Iacobelli, Simona Styczynski, Jan Engelhard, Dan Cesaro, Simone |
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Averbuch, Diana |
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10.1016/j.jinf.2020.11.002 |
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610 |
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intercontinental study on pre-engraftment and post-engraftment gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: risk factors and association with mortality |
| title_auth |
Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
| abstract |
Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. |
| abstractGer |
Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. |
| abstract_unstemmed |
Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality.Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT).Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality.Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. |
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Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality |
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Tridello, Gloria Hoek, Jennifer Mikulska, Malgorzata Pabst, Thomas Yaňez San Segundo, Lucrecia Akan, Hamdi Özçelik, Tülay Donnini, Irene Klyasova, Galina Botelho de Sousa, Aida Zuckerman, Tsila Tecchio, Cristina de la Camara, Rafael Aki, Sahika Zeynep Ljungman, Per Gülbas, Zafer Nicolas-Virelizier, Emmanuelle Calore, Elisabetta Perruccio, Katia Ram, Ron Annaloro, Claudio Martino, Rodrigo Avni, Batia Shaw, Peter J. Jungova, Alexandra Codeluppi, Katia O'Brien, Tracey Waszczuk-Gajda, Anna Batlle, Montserrat Pouli, Anastasia Lueck, Catherina Gil, Lidia Iacobelli, Simona Styczynski, Jan Engelhard, Dan Cesaro, Simone |
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Tridello, Gloria Hoek, Jennifer Mikulska, Malgorzata Pabst, Thomas Yaňez San Segundo, Lucrecia Akan, Hamdi Özçelik, Tülay Donnini, Irene Klyasova, Galina Botelho de Sousa, Aida Zuckerman, Tsila Tecchio, Cristina de la Camara, Rafael Aki, Sahika Zeynep Ljungman, Per Gülbas, Zafer Nicolas-Virelizier, Emmanuelle Calore, Elisabetta Perruccio, Katia Ram, Ron Annaloro, Claudio Martino, Rodrigo Avni, Batia Shaw, Peter J. Jungova, Alexandra Codeluppi, Katia O'Brien, Tracey Waszczuk-Gajda, Anna Batlle, Montserrat Pouli, Anastasia Lueck, Catherina Gil, Lidia Iacobelli, Simona Styczynski, Jan Engelhard, Dan Cesaro, Simone |
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| score |
7.3995953 |