Post-inhalation cough with therapeutic aerosols: Formulation considerations

This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sahakijpijarn, Sawittree [verfasserIn] Smyth, Hugh D.C. [verfasserIn] Miller, Danforth P. [verfasserIn] Weers, Jeffry G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors

Übergeordnetes Werk:	Enthalten in: Advanced drug delivery reviews - Amsterdam [u.a.] : Elsevier Science, 1987, 165, Seite 127-141
Übergeordnetes Werk:	volume:165 ; pages:127-141

DOI / URN:	10.1016/j.addr.2020.05.003

Katalog-ID:	ELV005193583

Internformat


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245	1	0	\|a Post-inhalation cough with therapeutic aerosols: Formulation considerations
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520			\|a This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients.
650		4	\|a Osmolality, disproportionation
650		4	\|a Hypersensitivity
650		4	\|a Lung inflammation
650		4	\|a Respiratory adverse events
650		4	\|a C-fiber nociceptors
650		4	\|a Widdicombe cough receptors
700	1		\|a Smyth, Hugh D.C. \|e verfasserin \|4 aut
700	1		\|a Miller, Danforth P. \|e verfasserin \|4 aut
700	1		\|a Weers, Jeffry G. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Advanced drug delivery reviews \|d Amsterdam [u.a.] : Elsevier Science, 1987 \|g 165, Seite 127-141 \|h Online-Ressource \|w (DE-627)320602346 \|w (DE-600)2020327-5 \|w (DE-576)255622589 \|x 1872-8294 \|7 nnns
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912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
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912			\|a GBV_ILN_2148
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912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
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912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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936	b	k	\|a 58.28 \|j Pharmazeutische Technologie
936	b	k	\|a 44.40 \|j Pharmazie \|j Pharmazeutika
951			\|a AR
952			\|d 165 \|h 127-141

Indexfelder

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bklnumber	58.28 44.40
publishDate	2020
allfields	10.1016/j.addr.2020.05.003 doi (DE-627)ELV005193583 (ELSEVIER)S0169-409X(20)30036-3 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Sahakijpijarn, Sawittree verfasserin aut Post-inhalation cough with therapeutic aerosols: Formulation considerations 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients. Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors Smyth, Hugh D.C. verfasserin aut Miller, Danforth P. verfasserin aut Weers, Jeffry G. verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 165, Seite 127-141 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:165 pages:127-141 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.28 Pharmazeutische Technologie 44.40 Pharmazie Pharmazeutika AR 165 127-141
spelling	10.1016/j.addr.2020.05.003 doi (DE-627)ELV005193583 (ELSEVIER)S0169-409X(20)30036-3 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Sahakijpijarn, Sawittree verfasserin aut Post-inhalation cough with therapeutic aerosols: Formulation considerations 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients. Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors Smyth, Hugh D.C. verfasserin aut Miller, Danforth P. verfasserin aut Weers, Jeffry G. verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 165, Seite 127-141 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:165 pages:127-141 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.28 Pharmazeutische Technologie 44.40 Pharmazie Pharmazeutika AR 165 127-141
allfields_unstemmed	10.1016/j.addr.2020.05.003 doi (DE-627)ELV005193583 (ELSEVIER)S0169-409X(20)30036-3 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Sahakijpijarn, Sawittree verfasserin aut Post-inhalation cough with therapeutic aerosols: Formulation considerations 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients. Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors Smyth, Hugh D.C. verfasserin aut Miller, Danforth P. verfasserin aut Weers, Jeffry G. verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 165, Seite 127-141 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:165 pages:127-141 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.28 Pharmazeutische Technologie 44.40 Pharmazie Pharmazeutika AR 165 127-141
allfieldsGer	10.1016/j.addr.2020.05.003 doi (DE-627)ELV005193583 (ELSEVIER)S0169-409X(20)30036-3 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Sahakijpijarn, Sawittree verfasserin aut Post-inhalation cough with therapeutic aerosols: Formulation considerations 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients. Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors Smyth, Hugh D.C. verfasserin aut Miller, Danforth P. verfasserin aut Weers, Jeffry G. verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 165, Seite 127-141 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:165 pages:127-141 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.28 Pharmazeutische Technologie 44.40 Pharmazie Pharmazeutika AR 165 127-141
allfieldsSound	10.1016/j.addr.2020.05.003 doi (DE-627)ELV005193583 (ELSEVIER)S0169-409X(20)30036-3 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Sahakijpijarn, Sawittree verfasserin aut Post-inhalation cough with therapeutic aerosols: Formulation considerations 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients. Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors Smyth, Hugh D.C. verfasserin aut Miller, Danforth P. verfasserin aut Weers, Jeffry G. verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 165, Seite 127-141 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:165 pages:127-141 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.28 Pharmazeutische Technologie 44.40 Pharmazie Pharmazeutika AR 165 127-141
language	English
source	Enthalten in Advanced drug delivery reviews 165, Seite 127-141 volume:165 pages:127-141
sourceStr	Enthalten in Advanced drug delivery reviews 165, Seite 127-141 volume:165 pages:127-141
format_phy_str_mv	Article
bklname	Pharmazeutische Technologie Pharmazie Pharmazeutika
institution	findex.gbv.de
topic_facet	Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors
dewey-raw	610
isfreeaccess_bool	false
container_title	Advanced drug delivery reviews
authorswithroles_txt_mv	Sahakijpijarn, Sawittree @@aut@@ Smyth, Hugh D.C. @@aut@@ Miller, Danforth P. @@aut@@ Weers, Jeffry G. @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	320602346
dewey-sort	3610
id	ELV005193583
language_de	englisch
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author	Sahakijpijarn, Sawittree
spellingShingle	Sahakijpijarn, Sawittree ddc 610 ssgn 15,3 fid PHARM bkl 58.28 bkl 44.40 misc Osmolality, disproportionation misc Hypersensitivity misc Lung inflammation misc Respiratory adverse events misc C-fiber nociceptors misc Widdicombe cough receptors Post-inhalation cough with therapeutic aerosols: Formulation considerations
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topic_title	610 DE-600 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Post-inhalation cough with therapeutic aerosols: Formulation considerations Osmolality, disproportionation Hypersensitivity Lung inflammation Respiratory adverse events C-fiber nociceptors Widdicombe cough receptors
topic	ddc 610 ssgn 15,3 fid PHARM bkl 58.28 bkl 44.40 misc Osmolality, disproportionation misc Hypersensitivity misc Lung inflammation misc Respiratory adverse events misc C-fiber nociceptors misc Widdicombe cough receptors
topic_unstemmed	ddc 610 ssgn 15,3 fid PHARM bkl 58.28 bkl 44.40 misc Osmolality, disproportionation misc Hypersensitivity misc Lung inflammation misc Respiratory adverse events misc C-fiber nociceptors misc Widdicombe cough receptors
topic_browse	ddc 610 ssgn 15,3 fid PHARM bkl 58.28 bkl 44.40 misc Osmolality, disproportionation misc Hypersensitivity misc Lung inflammation misc Respiratory adverse events misc C-fiber nociceptors misc Widdicombe cough receptors
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title	Post-inhalation cough with therapeutic aerosols: Formulation considerations
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title_full	Post-inhalation cough with therapeutic aerosols: Formulation considerations
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title_sort	post-inhalation cough with therapeutic aerosols: formulation considerations
title_auth	Post-inhalation cough with therapeutic aerosols: Formulation considerations
abstract	This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients.
abstractGer	This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients.
abstract_unstemmed	This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation, and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stimuli. Hypersensitivity is increased when the drug, formulation or disease result in increases in lung inflammation. Cough related to changes in epithelial lining fluid composition can be limited by using insoluble neutral forms of drugs and excipients.
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title_short	Post-inhalation cough with therapeutic aerosols: Formulation considerations
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doi_str	10.1016/j.addr.2020.05.003
up_date	2024-07-06T17:07:57.994Z
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