The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma
The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alon...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pu, Y. [verfasserIn] Wang, Y. [verfasserIn] Huang, X. [verfasserIn] Chen, S. [verfasserIn] Wang, Z. [verfasserIn] Sun, G. [verfasserIn] Tang, E. [verfasserIn] Zhao, S. [verfasserIn] Ni, Y. [verfasserIn] Hu, Q. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of oral and maxillofacial surgery - London : Churchill Livingstone, 1986, 45, Seite 1372-1377 |
|---|---|
| Übergeordnetes Werk: |
volume:45 ; pages:1372-1377 |
| DOI / URN: |
10.1016/j.ijom.2016.08.019 |
|---|
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ELV005274079 |
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| 520 | |a The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. | ||
| 650 | 4 | |a oral squamous cell carcinoma | |
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| 650 | 4 | |a mild dysplasia | |
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2016 |
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10.1016/j.ijom.2016.08.019 doi (DE-627)ELV005274079 (ELSEVIER)S0901-5027(16)30210-7 DE-627 ger DE-627 rda eng 610 DE-600 44.65 bkl 44.96 bkl Pu, Y. verfasserin aut The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. oral squamous cell carcinoma surgical margin mild dysplasia prognosis Wang, Y. verfasserin aut Huang, X. verfasserin aut Chen, S. verfasserin aut Wang, Z. verfasserin aut Sun, G. verfasserin aut Tang, E. verfasserin aut Zhao, S. verfasserin aut Ni, Y. verfasserin aut Hu, Q. verfasserin aut Enthalten in International journal of oral and maxillofacial surgery London : Churchill Livingstone, 1986 45, Seite 1372-1377 Online-Ressource (DE-627)320478467 (DE-600)2009468-1 (DE-576)091143047 1399-0020 nnns volume:45 pages:1372-1377 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.65 Chirurgie 44.96 Zahnmedizin AR 45 1372-1377 |
| spelling |
10.1016/j.ijom.2016.08.019 doi (DE-627)ELV005274079 (ELSEVIER)S0901-5027(16)30210-7 DE-627 ger DE-627 rda eng 610 DE-600 44.65 bkl 44.96 bkl Pu, Y. verfasserin aut The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. oral squamous cell carcinoma surgical margin mild dysplasia prognosis Wang, Y. verfasserin aut Huang, X. verfasserin aut Chen, S. verfasserin aut Wang, Z. verfasserin aut Sun, G. verfasserin aut Tang, E. verfasserin aut Zhao, S. verfasserin aut Ni, Y. verfasserin aut Hu, Q. verfasserin aut Enthalten in International journal of oral and maxillofacial surgery London : Churchill Livingstone, 1986 45, Seite 1372-1377 Online-Ressource (DE-627)320478467 (DE-600)2009468-1 (DE-576)091143047 1399-0020 nnns volume:45 pages:1372-1377 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.65 Chirurgie 44.96 Zahnmedizin AR 45 1372-1377 |
| allfields_unstemmed |
10.1016/j.ijom.2016.08.019 doi (DE-627)ELV005274079 (ELSEVIER)S0901-5027(16)30210-7 DE-627 ger DE-627 rda eng 610 DE-600 44.65 bkl 44.96 bkl Pu, Y. verfasserin aut The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. oral squamous cell carcinoma surgical margin mild dysplasia prognosis Wang, Y. verfasserin aut Huang, X. verfasserin aut Chen, S. verfasserin aut Wang, Z. verfasserin aut Sun, G. verfasserin aut Tang, E. verfasserin aut Zhao, S. verfasserin aut Ni, Y. verfasserin aut Hu, Q. verfasserin aut Enthalten in International journal of oral and maxillofacial surgery London : Churchill Livingstone, 1986 45, Seite 1372-1377 Online-Ressource (DE-627)320478467 (DE-600)2009468-1 (DE-576)091143047 1399-0020 nnns volume:45 pages:1372-1377 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.65 Chirurgie 44.96 Zahnmedizin AR 45 1372-1377 |
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10.1016/j.ijom.2016.08.019 doi (DE-627)ELV005274079 (ELSEVIER)S0901-5027(16)30210-7 DE-627 ger DE-627 rda eng 610 DE-600 44.65 bkl 44.96 bkl Pu, Y. verfasserin aut The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. oral squamous cell carcinoma surgical margin mild dysplasia prognosis Wang, Y. verfasserin aut Huang, X. verfasserin aut Chen, S. verfasserin aut Wang, Z. verfasserin aut Sun, G. verfasserin aut Tang, E. verfasserin aut Zhao, S. verfasserin aut Ni, Y. verfasserin aut Hu, Q. verfasserin aut Enthalten in International journal of oral and maxillofacial surgery London : Churchill Livingstone, 1986 45, Seite 1372-1377 Online-Ressource (DE-627)320478467 (DE-600)2009468-1 (DE-576)091143047 1399-0020 nnns volume:45 pages:1372-1377 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.65 Chirurgie 44.96 Zahnmedizin AR 45 1372-1377 |
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10.1016/j.ijom.2016.08.019 doi (DE-627)ELV005274079 (ELSEVIER)S0901-5027(16)30210-7 DE-627 ger DE-627 rda eng 610 DE-600 44.65 bkl 44.96 bkl Pu, Y. verfasserin aut The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. oral squamous cell carcinoma surgical margin mild dysplasia prognosis Wang, Y. verfasserin aut Huang, X. verfasserin aut Chen, S. verfasserin aut Wang, Z. verfasserin aut Sun, G. verfasserin aut Tang, E. verfasserin aut Zhao, S. verfasserin aut Ni, Y. verfasserin aut Hu, Q. verfasserin aut Enthalten in International journal of oral and maxillofacial surgery London : Churchill Livingstone, 1986 45, Seite 1372-1377 Online-Ressource (DE-627)320478467 (DE-600)2009468-1 (DE-576)091143047 1399-0020 nnns volume:45 pages:1372-1377 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.65 Chirurgie 44.96 Zahnmedizin AR 45 1372-1377 |
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Pu, Y. |
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Pu, Y. ddc 610 bkl 44.65 bkl 44.96 misc oral squamous cell carcinoma misc surgical margin misc mild dysplasia misc prognosis The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
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610 DE-600 44.65 bkl 44.96 bkl The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma oral squamous cell carcinoma surgical margin mild dysplasia prognosis |
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ddc 610 bkl 44.65 bkl 44.96 misc oral squamous cell carcinoma misc surgical margin misc mild dysplasia misc prognosis |
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ddc 610 bkl 44.65 bkl 44.96 misc oral squamous cell carcinoma misc surgical margin misc mild dysplasia misc prognosis |
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The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
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The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
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Pu, Y. |
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International journal of oral and maxillofacial surgery |
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International journal of oral and maxillofacial surgery |
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Pu, Y. Wang, Y. Huang, X. Chen, S. Wang, Z. Sun, G. Tang, E. Zhao, S. Ni, Y. Hu, Q. |
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the influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
| title_auth |
The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
| abstract |
The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. |
| abstractGer |
The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. |
| abstract_unstemmed |
The purpose of this study was to evaluate the clinical relevance between different margin statuses and local recurrence rate in patients undergoing primary surgical treatment for oral squamous cell carcinoma (OSCC). Five hundred and thirty-nine patients with T1–4N0M0 OSCC, who underwent surgery alone at a stomatology hospital in Nanjing, China during the years 2005–2014, were included. Tumour and margin status were assessed. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) were calculated by Kaplan–Meier method. Predictors of RFS, OS, and DFS were analysed. Positive or dysplastic margins were found in the initial specimen in 20.0% of the cases. On multivariate analysis, there was no significant difference between RFS (hazard ratio (HR) 1.379, P =0.361) or DFS (HR 1.452, P =0.183) of those with mild dysplasia and those with negative margins. However, patients with mild dysplasia who did not undergo re-excision demonstrated significantly worse RFS (HR 2.286, P =0.010) and DFS (HR 2.070, P =0.014) than those with negative margins. It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. Additional attention should be drawn to mild dysplasia at the initial margin in OSCC, and extended excision is suggested. |
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The influence of mild dysplasia at the surgical margin on the prognosis of oral squamous cell carcinoma |
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It is concluded that there appears to be a correlation between initial mild dysplastic margins that are not subjected to re-excision and inferior RFS and DFS. 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code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Z.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sun, G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tang, E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhao, S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ni, Y.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hu, Q.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">International journal of oral and maxillofacial surgery</subfield><subfield code="d">London : Churchill Livingstone, 1986</subfield><subfield code="g">45, Seite 1372-1377</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)320478467</subfield><subfield code="w">(DE-600)2009468-1</subfield><subfield code="w">(DE-576)091143047</subfield><subfield code="x">1399-0020</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:45</subfield><subfield code="g">pages:1372-1377</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield 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