Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis
Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of y...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Musillo, Chiara [verfasserIn] Borgi, Marta [verfasserIn] Saul, Nadine [verfasserIn] Möller, Steffen [verfasserIn] Luyten, Walter [verfasserIn] Berry, Alessandra [verfasserIn] Cirulli, Francesca [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Neuroscience & biobehavioral reviews - Amsterdam [u.a.] : Elsevier Science, 1978, 121, Seite 89-105 |
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| Übergeordnetes Werk: |
volume:121 ; pages:89-105 |
| DOI / URN: |
10.1016/j.neubiorev.2020.12.001 |
|---|
| Katalog-ID: |
ELV005386233 |
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| 245 | 1 | 0 | |a Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis |
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| 520 | |a Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. | ||
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Animal model | |
| 650 | 4 | |a Ageing | |
| 650 | 4 | |a Memory | |
| 650 | 4 | |a Dietary supplements | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a Physiological stress | |
| 650 | 4 | |a Locomotion | |
| 650 | 4 | |a Healthy ageing | |
| 700 | 1 | |a Borgi, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Saul, Nadine |e verfasserin |0 (orcid)0000-0002-6798-0918 |4 aut | |
| 700 | 1 | |a Möller, Steffen |e verfasserin |4 aut | |
| 700 | 1 | |a Luyten, Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Berry, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Cirulli, Francesca |e verfasserin |4 aut | |
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10.1016/j.neubiorev.2020.12.001 doi (DE-627)ELV005386233 (ELSEVIER)S0149-7634(20)30674-6 DE-627 ger DE-627 rda eng 150 610 DE-600 BIODIV DE-30 fid 77.50 bkl 44.90 bkl Musillo, Chiara verfasserin aut Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. Mice Rats Animal model Ageing Memory Dietary supplements Metabolism Physiological stress Locomotion Healthy ageing Borgi, Marta verfasserin aut Saul, Nadine verfasserin (orcid)0000-0002-6798-0918 aut Möller, Steffen verfasserin aut Luyten, Walter verfasserin aut Berry, Alessandra verfasserin aut Cirulli, Francesca verfasserin aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 121, Seite 89-105 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:121 pages:89-105 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.90 Neurologie AR 121 89-105 |
| spelling |
10.1016/j.neubiorev.2020.12.001 doi (DE-627)ELV005386233 (ELSEVIER)S0149-7634(20)30674-6 DE-627 ger DE-627 rda eng 150 610 DE-600 BIODIV DE-30 fid 77.50 bkl 44.90 bkl Musillo, Chiara verfasserin aut Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. Mice Rats Animal model Ageing Memory Dietary supplements Metabolism Physiological stress Locomotion Healthy ageing Borgi, Marta verfasserin aut Saul, Nadine verfasserin (orcid)0000-0002-6798-0918 aut Möller, Steffen verfasserin aut Luyten, Walter verfasserin aut Berry, Alessandra verfasserin aut Cirulli, Francesca verfasserin aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 121, Seite 89-105 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:121 pages:89-105 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.90 Neurologie AR 121 89-105 |
| allfields_unstemmed |
10.1016/j.neubiorev.2020.12.001 doi (DE-627)ELV005386233 (ELSEVIER)S0149-7634(20)30674-6 DE-627 ger DE-627 rda eng 150 610 DE-600 BIODIV DE-30 fid 77.50 bkl 44.90 bkl Musillo, Chiara verfasserin aut Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. Mice Rats Animal model Ageing Memory Dietary supplements Metabolism Physiological stress Locomotion Healthy ageing Borgi, Marta verfasserin aut Saul, Nadine verfasserin (orcid)0000-0002-6798-0918 aut Möller, Steffen verfasserin aut Luyten, Walter verfasserin aut Berry, Alessandra verfasserin aut Cirulli, Francesca verfasserin aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 121, Seite 89-105 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:121 pages:89-105 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.90 Neurologie AR 121 89-105 |
| allfieldsGer |
10.1016/j.neubiorev.2020.12.001 doi (DE-627)ELV005386233 (ELSEVIER)S0149-7634(20)30674-6 DE-627 ger DE-627 rda eng 150 610 DE-600 BIODIV DE-30 fid 77.50 bkl 44.90 bkl Musillo, Chiara verfasserin aut Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. Mice Rats Animal model Ageing Memory Dietary supplements Metabolism Physiological stress Locomotion Healthy ageing Borgi, Marta verfasserin aut Saul, Nadine verfasserin (orcid)0000-0002-6798-0918 aut Möller, Steffen verfasserin aut Luyten, Walter verfasserin aut Berry, Alessandra verfasserin aut Cirulli, Francesca verfasserin aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 121, Seite 89-105 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:121 pages:89-105 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.90 Neurologie AR 121 89-105 |
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Musillo, Chiara Borgi, Marta Saul, Nadine Möller, Steffen Luyten, Walter Berry, Alessandra Cirulli, Francesca |
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natural products improve healthspan in aged mice and rats: a systematic review and meta-analysis |
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Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis |
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Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. |
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Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. |
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Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. |
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