Effects of infliximab on brain neurochemistry of adults with bipolar depression
Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mansur, Rodrigo B. [verfasserIn] Subramaniapillai, Mehala [verfasserIn] Lee, Yena [verfasserIn] Pan, Zihang [verfasserIn] Carmona, Nicole E. [verfasserIn] Shekotikhina, Margarita [verfasserIn] Iacobucci, Michelle [verfasserIn] Rodrigues, Nelson [verfasserIn] Nasri, Flora [verfasserIn] Rosenblat, Joshua D. [verfasserIn] Brietzke, Elisa [verfasserIn] Cosgrove, Victoria E. [verfasserIn] Kramer, Nicole E. [verfasserIn] Suppes, Trisha [verfasserIn] Newport, Jason [verfasserIn] Hajek, Tomas [verfasserIn] McIntyre, Roger S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of affective disorders - Amsterdam [u.a.] : Elsevier Science, 1979, 281, Seite 61-66 |
|---|---|
| Übergeordnetes Werk: |
volume:281 ; pages:61-66 |
| DOI / URN: |
10.1016/j.jad.2020.11.128 |
|---|
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ELV005403308 |
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| 100 | 1 | |a Mansur, Rodrigo B. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of infliximab on brain neurochemistry of adults with bipolar depression |
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| 520 | |a Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. | ||
| 650 | 4 | |a bipolar disorder | |
| 650 | 4 | |a neurochemistry | |
| 650 | 4 | |a magnetic resonance spectroscopy | |
| 650 | 4 | |a infliximab | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a cognition | |
| 700 | 1 | |a Subramaniapillai, Mehala |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yena |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Zihang |e verfasserin |4 aut | |
| 700 | 1 | |a Carmona, Nicole E. |e verfasserin |4 aut | |
| 700 | 1 | |a Shekotikhina, Margarita |e verfasserin |4 aut | |
| 700 | 1 | |a Iacobucci, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Nelson |e verfasserin |4 aut | |
| 700 | 1 | |a Nasri, Flora |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenblat, Joshua D. |e verfasserin |4 aut | |
| 700 | 1 | |a Brietzke, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Cosgrove, Victoria E. |e verfasserin |4 aut | |
| 700 | 1 | |a Kramer, Nicole E. |e verfasserin |4 aut | |
| 700 | 1 | |a Suppes, Trisha |e verfasserin |4 aut | |
| 700 | 1 | |a Newport, Jason |e verfasserin |4 aut | |
| 700 | 1 | |a Hajek, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a McIntyre, Roger S. |e verfasserin |4 aut | |
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10.1016/j.jad.2020.11.128 doi (DE-627)ELV005403308 (ELSEVIER)S0165-0327(20)33069-X DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Mansur, Rodrigo B. verfasserin aut Effects of infliximab on brain neurochemistry of adults with bipolar depression 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition Subramaniapillai, Mehala verfasserin aut Lee, Yena verfasserin aut Pan, Zihang verfasserin aut Carmona, Nicole E. verfasserin aut Shekotikhina, Margarita verfasserin aut Iacobucci, Michelle verfasserin aut Rodrigues, Nelson verfasserin aut Nasri, Flora verfasserin aut Rosenblat, Joshua D. verfasserin aut Brietzke, Elisa verfasserin aut Cosgrove, Victoria E. verfasserin aut Kramer, Nicole E. verfasserin aut Suppes, Trisha verfasserin aut Newport, Jason verfasserin aut Hajek, Tomas verfasserin aut McIntyre, Roger S. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 281, Seite 61-66 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:281 pages:61-66 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 281 61-66 |
| spelling |
10.1016/j.jad.2020.11.128 doi (DE-627)ELV005403308 (ELSEVIER)S0165-0327(20)33069-X DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Mansur, Rodrigo B. verfasserin aut Effects of infliximab on brain neurochemistry of adults with bipolar depression 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition Subramaniapillai, Mehala verfasserin aut Lee, Yena verfasserin aut Pan, Zihang verfasserin aut Carmona, Nicole E. verfasserin aut Shekotikhina, Margarita verfasserin aut Iacobucci, Michelle verfasserin aut Rodrigues, Nelson verfasserin aut Nasri, Flora verfasserin aut Rosenblat, Joshua D. verfasserin aut Brietzke, Elisa verfasserin aut Cosgrove, Victoria E. verfasserin aut Kramer, Nicole E. verfasserin aut Suppes, Trisha verfasserin aut Newport, Jason verfasserin aut Hajek, Tomas verfasserin aut McIntyre, Roger S. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 281, Seite 61-66 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:281 pages:61-66 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 281 61-66 |
| allfields_unstemmed |
10.1016/j.jad.2020.11.128 doi (DE-627)ELV005403308 (ELSEVIER)S0165-0327(20)33069-X DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Mansur, Rodrigo B. verfasserin aut Effects of infliximab on brain neurochemistry of adults with bipolar depression 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition Subramaniapillai, Mehala verfasserin aut Lee, Yena verfasserin aut Pan, Zihang verfasserin aut Carmona, Nicole E. verfasserin aut Shekotikhina, Margarita verfasserin aut Iacobucci, Michelle verfasserin aut Rodrigues, Nelson verfasserin aut Nasri, Flora verfasserin aut Rosenblat, Joshua D. verfasserin aut Brietzke, Elisa verfasserin aut Cosgrove, Victoria E. verfasserin aut Kramer, Nicole E. verfasserin aut Suppes, Trisha verfasserin aut Newport, Jason verfasserin aut Hajek, Tomas verfasserin aut McIntyre, Roger S. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 281, Seite 61-66 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:281 pages:61-66 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 281 61-66 |
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10.1016/j.jad.2020.11.128 doi (DE-627)ELV005403308 (ELSEVIER)S0165-0327(20)33069-X DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Mansur, Rodrigo B. verfasserin aut Effects of infliximab on brain neurochemistry of adults with bipolar depression 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition Subramaniapillai, Mehala verfasserin aut Lee, Yena verfasserin aut Pan, Zihang verfasserin aut Carmona, Nicole E. verfasserin aut Shekotikhina, Margarita verfasserin aut Iacobucci, Michelle verfasserin aut Rodrigues, Nelson verfasserin aut Nasri, Flora verfasserin aut Rosenblat, Joshua D. verfasserin aut Brietzke, Elisa verfasserin aut Cosgrove, Victoria E. verfasserin aut Kramer, Nicole E. verfasserin aut Suppes, Trisha verfasserin aut Newport, Jason verfasserin aut Hajek, Tomas verfasserin aut McIntyre, Roger S. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 281, Seite 61-66 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:281 pages:61-66 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 281 61-66 |
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10.1016/j.jad.2020.11.128 doi (DE-627)ELV005403308 (ELSEVIER)S0165-0327(20)33069-X DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Mansur, Rodrigo B. verfasserin aut Effects of infliximab on brain neurochemistry of adults with bipolar depression 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition Subramaniapillai, Mehala verfasserin aut Lee, Yena verfasserin aut Pan, Zihang verfasserin aut Carmona, Nicole E. verfasserin aut Shekotikhina, Margarita verfasserin aut Iacobucci, Michelle verfasserin aut Rodrigues, Nelson verfasserin aut Nasri, Flora verfasserin aut Rosenblat, Joshua D. verfasserin aut Brietzke, Elisa verfasserin aut Cosgrove, Victoria E. verfasserin aut Kramer, Nicole E. verfasserin aut Suppes, Trisha verfasserin aut Newport, Jason verfasserin aut Hajek, Tomas verfasserin aut McIntyre, Roger S. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 281, Seite 61-66 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:281 pages:61-66 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 281 61-66 |
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Mansur, Rodrigo B. @@aut@@ Subramaniapillai, Mehala @@aut@@ Lee, Yena @@aut@@ Pan, Zihang @@aut@@ Carmona, Nicole E. @@aut@@ Shekotikhina, Margarita @@aut@@ Iacobucci, Michelle @@aut@@ Rodrigues, Nelson @@aut@@ Nasri, Flora @@aut@@ Rosenblat, Joshua D. @@aut@@ Brietzke, Elisa @@aut@@ Cosgrove, Victoria E. @@aut@@ Kramer, Nicole E. @@aut@@ Suppes, Trisha @@aut@@ Newport, Jason @@aut@@ Hajek, Tomas @@aut@@ McIntyre, Roger S. @@aut@@ |
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Mansur, Rodrigo B. |
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Mansur, Rodrigo B. ddc 610 bkl 44.91 misc bipolar disorder misc neurochemistry misc magnetic resonance spectroscopy misc infliximab misc inflammation misc cognition Effects of infliximab on brain neurochemistry of adults with bipolar depression |
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610 DE-600 44.91 bkl Effects of infliximab on brain neurochemistry of adults with bipolar depression bipolar disorder neurochemistry magnetic resonance spectroscopy infliximab inflammation cognition |
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ddc 610 bkl 44.91 misc bipolar disorder misc neurochemistry misc magnetic resonance spectroscopy misc infliximab misc inflammation misc cognition |
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ddc 610 bkl 44.91 misc bipolar disorder misc neurochemistry misc magnetic resonance spectroscopy misc infliximab misc inflammation misc cognition |
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ddc 610 bkl 44.91 misc bipolar disorder misc neurochemistry misc magnetic resonance spectroscopy misc infliximab misc inflammation misc cognition |
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Effects of infliximab on brain neurochemistry of adults with bipolar depression |
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Effects of infliximab on brain neurochemistry of adults with bipolar depression |
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Mansur, Rodrigo B. |
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Mansur, Rodrigo B. Subramaniapillai, Mehala Lee, Yena Pan, Zihang Carmona, Nicole E. Shekotikhina, Margarita Iacobucci, Michelle Rodrigues, Nelson Nasri, Flora Rosenblat, Joshua D. Brietzke, Elisa Cosgrove, Victoria E. Kramer, Nicole E. Suppes, Trisha Newport, Jason Hajek, Tomas McIntyre, Roger S. |
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Mansur, Rodrigo B. |
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10.1016/j.jad.2020.11.128 |
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effects of infliximab on brain neurochemistry of adults with bipolar depression |
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Effects of infliximab on brain neurochemistry of adults with bipolar depression |
| abstract |
Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. |
| abstractGer |
Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. |
| abstract_unstemmed |
Objectives: To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depressionMethods: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).Results: Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.Conclusions: Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. |
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Effects of infliximab on brain neurochemistry of adults with bipolar depression |
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Subramaniapillai, Mehala Lee, Yena Pan, Zihang Carmona, Nicole E. Shekotikhina, Margarita Iacobucci, Michelle Rodrigues, Nelson Nasri, Flora Rosenblat, Joshua D. Brietzke, Elisa Cosgrove, Victoria E. Kramer, Nicole E. Suppes, Trisha Newport, Jason Hajek, Tomas McIntyre, Roger S. |
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| score |
7.399823 |