In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin
Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Siddiquee, Md. Abrar [verfasserIn] Saraswat, Juhi [verfasserIn] Imtiyaz, Khalid [verfasserIn] Bhat, Ab Raouf [verfasserIn] Wani, Farooq Ahmad [verfasserIn] Alanazi, Amer M. [verfasserIn] Khan, Azmat Ali [verfasserIn] Rizvi, M. Moshahid Alam [verfasserIn] Patel, Rajan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of molecular liquids - New York, NY [u.a.] : Elsevier, 1983, 325 |
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| Übergeordnetes Werk: |
volume:325 |
| DOI / URN: |
10.1016/j.molliq.2020.115125 |
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| Katalog-ID: |
ELV005568501 |
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| 245 | 1 | 0 | |a In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin |
| 264 | 1 | |c 2020 | |
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| 520 | |a Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. | ||
| 650 | 4 | |a Ionic liquids | |
| 650 | 4 | |a Levofloxacin | |
| 650 | 4 | |a Antibacterial activity | |
| 650 | 4 | |a Synergistic interaction | |
| 650 | 4 | |a MTT assay | |
| 700 | 1 | |a Saraswat, Juhi |e verfasserin |4 aut | |
| 700 | 1 | |a Imtiyaz, Khalid |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Ab Raouf |e verfasserin |4 aut | |
| 700 | 1 | |a Wani, Farooq Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Alanazi, Amer M. |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Azmat Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Rizvi, M. Moshahid Alam |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Rajan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular liquids |d New York, NY [u.a.] : Elsevier, 1983 |g 325 |h Online-Ressource |w (DE-627)302469664 |w (DE-600)1491496-7 |w (DE-576)259483915 |x 1873-3166 |7 nnns |
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| 912 | |a GBV_ILN_4305 | ||
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| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
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10.1016/j.molliq.2020.115125 doi (DE-627)ELV005568501 (ELSEVIER)S0167-7322(20)37367-0 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Siddiquee, Md. Abrar verfasserin aut In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay Saraswat, Juhi verfasserin aut Imtiyaz, Khalid verfasserin aut Bhat, Ab Raouf verfasserin aut Wani, Farooq Ahmad verfasserin aut Alanazi, Amer M. verfasserin aut Khan, Azmat Ali verfasserin aut Rizvi, M. Moshahid Alam verfasserin aut Patel, Rajan verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 325 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:325 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 325 |
| spelling |
10.1016/j.molliq.2020.115125 doi (DE-627)ELV005568501 (ELSEVIER)S0167-7322(20)37367-0 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Siddiquee, Md. Abrar verfasserin aut In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay Saraswat, Juhi verfasserin aut Imtiyaz, Khalid verfasserin aut Bhat, Ab Raouf verfasserin aut Wani, Farooq Ahmad verfasserin aut Alanazi, Amer M. verfasserin aut Khan, Azmat Ali verfasserin aut Rizvi, M. Moshahid Alam verfasserin aut Patel, Rajan verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 325 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:325 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 325 |
| allfields_unstemmed |
10.1016/j.molliq.2020.115125 doi (DE-627)ELV005568501 (ELSEVIER)S0167-7322(20)37367-0 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Siddiquee, Md. Abrar verfasserin aut In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay Saraswat, Juhi verfasserin aut Imtiyaz, Khalid verfasserin aut Bhat, Ab Raouf verfasserin aut Wani, Farooq Ahmad verfasserin aut Alanazi, Amer M. verfasserin aut Khan, Azmat Ali verfasserin aut Rizvi, M. Moshahid Alam verfasserin aut Patel, Rajan verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 325 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:325 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 325 |
| allfieldsGer |
10.1016/j.molliq.2020.115125 doi (DE-627)ELV005568501 (ELSEVIER)S0167-7322(20)37367-0 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Siddiquee, Md. Abrar verfasserin aut In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay Saraswat, Juhi verfasserin aut Imtiyaz, Khalid verfasserin aut Bhat, Ab Raouf verfasserin aut Wani, Farooq Ahmad verfasserin aut Alanazi, Amer M. verfasserin aut Khan, Azmat Ali verfasserin aut Rizvi, M. Moshahid Alam verfasserin aut Patel, Rajan verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 325 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:325 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 325 |
| allfieldsSound |
10.1016/j.molliq.2020.115125 doi (DE-627)ELV005568501 (ELSEVIER)S0167-7322(20)37367-0 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Siddiquee, Md. Abrar verfasserin aut In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay Saraswat, Juhi verfasserin aut Imtiyaz, Khalid verfasserin aut Bhat, Ab Raouf verfasserin aut Wani, Farooq Ahmad verfasserin aut Alanazi, Amer M. verfasserin aut Khan, Azmat Ali verfasserin aut Rizvi, M. Moshahid Alam verfasserin aut Patel, Rajan verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 325 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:325 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 325 |
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Enthalten in Journal of molecular liquids 325 volume:325 |
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Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay |
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Siddiquee, Md. Abrar @@aut@@ Saraswat, Juhi @@aut@@ Imtiyaz, Khalid @@aut@@ Bhat, Ab Raouf @@aut@@ Wani, Farooq Ahmad @@aut@@ Alanazi, Amer M. @@aut@@ Khan, Azmat Ali @@aut@@ Rizvi, M. Moshahid Alam @@aut@@ Patel, Rajan @@aut@@ |
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Siddiquee, Md. Abrar |
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Siddiquee, Md. Abrar ddc 540 bkl 35.21 misc Ionic liquids misc Levofloxacin misc Antibacterial activity misc Synergistic interaction misc MTT assay In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin |
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540 DE-600 35.21 bkl In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin Ionic liquids Levofloxacin Antibacterial activity Synergistic interaction MTT assay |
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ddc 540 bkl 35.21 misc Ionic liquids misc Levofloxacin misc Antibacterial activity misc Synergistic interaction misc MTT assay |
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Siddiquee, Md. Abrar Saraswat, Juhi Imtiyaz, Khalid Bhat, Ab Raouf Wani, Farooq Ahmad Alanazi, Amer M. Khan, Azmat Ali Rizvi, M. Moshahid Alam Patel, Rajan |
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in-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin |
| title_auth |
In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin |
| abstract |
Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. |
| abstractGer |
Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. |
| abstract_unstemmed |
Nowadays, the third generation of ionic liquids (ILs) emerged as a new active pharmaceutical ingredient (API) as they possess biological activity. These active pharmaceutical ingredients in combination with available antimicrobials may enhance their selectivity and activity. Therefore, the screening and development of these API are very important for pharmaceutical industries. Thus, herein, the efforts have been made to study the synergistic interaction between antibacterial drug levofloxacin (LVF) and imidazolium-based ILs such as 1-butyl-3-methylimidazolium chloride (C4mimCl) and 1-decyl-3-methylimidazolium chloride (C10mimCl). The in-vitro cytotoxicity of ILs was done using MTT assay on HEK293 (Human embryonic kidney cells). The antibacterial activities of these imidazolium based ILs have been evaluated against E. coli and S. aureus strain. Further, the effect of these ILs on the antibacterial property of LVF was checked by preparing various combinations of ILs with LVF. The results showed the remarkable enhancement in the antibacterial activity of LVF with ILs, however, the effect is more prominent with higher alkyl chain length IL.The critical micellar concentration (cmc), of ILs and ILs with LVF were also measured which further utilized to evaluate Gibss free energy of adsorption (∆G ad ). The value of ∆G ad , further showed that IL with a larger alkyl chain has greater efficiency towards the antibacterial activity. The other surface-active and thermodynamic parameters like maximum excess concentration (Γ max ) minimum area per molecules (A min ), Gibbs free energy change of micellization (ΔG m ), enthalpy change of micellization (ΔH m ), entropy change of micellization (ΔS m ), and Gibbs excess energy (G s min ) for pure ILs and ILs + LVF mixtures were also determined. |
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In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin |
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Saraswat, Juhi Imtiyaz, Khalid Bhat, Ab Raouf Wani, Farooq Ahmad Alanazi, Amer M. Khan, Azmat Ali Rizvi, M. Moshahid Alam Patel, Rajan |
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| score |
7.3975096 |