Strategies to overcome resistance to immune checkpoint blockade in lung cancer

The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Attili, Ilaria [verfasserIn] Tarantino, Paolo [verfasserIn] Passaro, Antonio [verfasserIn] Stati, Valeria [verfasserIn] Curigliano, Giuseppe [verfasserIn] de Marinis, Filippo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota

Übergeordnetes Werk:	Enthalten in: Lung cancer - Amsterdam [u.a.] : Elsevier, 1985, 154, Seite 151-160
Übergeordnetes Werk:	volume:154 ; pages:151-160

DOI / URN:	10.1016/j.lungcan.2021.02.035

Katalog-ID:	ELV005793076

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520			\|a The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review.
650		4	\|a Immunotherapy
650		4	\|a Resistance mechanisms
650		4	\|a Tumour microenvironment
650		4	\|a TIGIT
650		4	\|a Adoptive cell therapy
650		4	\|a Gut microbiota
700	1		\|a Tarantino, Paolo \|e verfasserin \|4 aut
700	1		\|a Passaro, Antonio \|e verfasserin \|4 aut
700	1		\|a Stati, Valeria \|e verfasserin \|4 aut
700	1		\|a Curigliano, Giuseppe \|e verfasserin \|4 aut
700	1		\|a de Marinis, Filippo \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Lung cancer \|d Amsterdam [u.a.] : Elsevier, 1985 \|g 154, Seite 151-160 \|h Online-Ressource \|w (DE-627)320649733 \|w (DE-600)2025812-4 \|w (DE-576)264627539 \|x 1872-8332 \|7 nnns
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2050
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912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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allfields	10.1016/j.lungcan.2021.02.035 doi (DE-627)ELV005793076 (ELSEVIER)S0169-5002(21)00095-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Attili, Ilaria verfasserin aut Strategies to overcome resistance to immune checkpoint blockade in lung cancer 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review. Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota Tarantino, Paolo verfasserin aut Passaro, Antonio verfasserin aut Stati, Valeria verfasserin aut Curigliano, Giuseppe verfasserin aut de Marinis, Filippo verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 154, Seite 151-160 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:154 pages:151-160 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 154 151-160
spelling	10.1016/j.lungcan.2021.02.035 doi (DE-627)ELV005793076 (ELSEVIER)S0169-5002(21)00095-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Attili, Ilaria verfasserin aut Strategies to overcome resistance to immune checkpoint blockade in lung cancer 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review. Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota Tarantino, Paolo verfasserin aut Passaro, Antonio verfasserin aut Stati, Valeria verfasserin aut Curigliano, Giuseppe verfasserin aut de Marinis, Filippo verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 154, Seite 151-160 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:154 pages:151-160 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 154 151-160
allfields_unstemmed	10.1016/j.lungcan.2021.02.035 doi (DE-627)ELV005793076 (ELSEVIER)S0169-5002(21)00095-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Attili, Ilaria verfasserin aut Strategies to overcome resistance to immune checkpoint blockade in lung cancer 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review. Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota Tarantino, Paolo verfasserin aut Passaro, Antonio verfasserin aut Stati, Valeria verfasserin aut Curigliano, Giuseppe verfasserin aut de Marinis, Filippo verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 154, Seite 151-160 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:154 pages:151-160 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 154 151-160
allfieldsGer	10.1016/j.lungcan.2021.02.035 doi (DE-627)ELV005793076 (ELSEVIER)S0169-5002(21)00095-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Attili, Ilaria verfasserin aut Strategies to overcome resistance to immune checkpoint blockade in lung cancer 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review. Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota Tarantino, Paolo verfasserin aut Passaro, Antonio verfasserin aut Stati, Valeria verfasserin aut Curigliano, Giuseppe verfasserin aut de Marinis, Filippo verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 154, Seite 151-160 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:154 pages:151-160 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 154 151-160
allfieldsSound	10.1016/j.lungcan.2021.02.035 doi (DE-627)ELV005793076 (ELSEVIER)S0169-5002(21)00095-7 DE-627 ger DE-627 rda eng 610 DE-600 44.83 bkl Attili, Ilaria verfasserin aut Strategies to overcome resistance to immune checkpoint blockade in lung cancer 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review. Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota Tarantino, Paolo verfasserin aut Passaro, Antonio verfasserin aut Stati, Valeria verfasserin aut Curigliano, Giuseppe verfasserin aut de Marinis, Filippo verfasserin aut Enthalten in Lung cancer Amsterdam [u.a.] : Elsevier, 1985 154, Seite 151-160 Online-Ressource (DE-627)320649733 (DE-600)2025812-4 (DE-576)264627539 1872-8332 nnns volume:154 pages:151-160 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.83 Rheumatologie Orthopädie AR 154 151-160
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source	Enthalten in Lung cancer 154, Seite 151-160 volume:154 pages:151-160
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authorswithroles_txt_mv	Attili, Ilaria @@aut@@ Tarantino, Paolo @@aut@@ Passaro, Antonio @@aut@@ Stati, Valeria @@aut@@ Curigliano, Giuseppe @@aut@@ de Marinis, Filippo @@aut@@
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author	Attili, Ilaria
spellingShingle	Attili, Ilaria ddc 610 bkl 44.83 misc Immunotherapy misc Resistance mechanisms misc Tumour microenvironment misc TIGIT misc Adoptive cell therapy misc Gut microbiota Strategies to overcome resistance to immune checkpoint blockade in lung cancer
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topic_title	610 DE-600 44.83 bkl Strategies to overcome resistance to immune checkpoint blockade in lung cancer Immunotherapy Resistance mechanisms Tumour microenvironment TIGIT Adoptive cell therapy Gut microbiota
topic	ddc 610 bkl 44.83 misc Immunotherapy misc Resistance mechanisms misc Tumour microenvironment misc TIGIT misc Adoptive cell therapy misc Gut microbiota
topic_unstemmed	ddc 610 bkl 44.83 misc Immunotherapy misc Resistance mechanisms misc Tumour microenvironment misc TIGIT misc Adoptive cell therapy misc Gut microbiota
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title	Strategies to overcome resistance to immune checkpoint blockade in lung cancer
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title_full	Strategies to overcome resistance to immune checkpoint blockade in lung cancer
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author_browse	Attili, Ilaria Tarantino, Paolo Passaro, Antonio Stati, Valeria Curigliano, Giuseppe de Marinis, Filippo
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title_sort	strategies to overcome resistance to immune checkpoint blockade in lung cancer
title_auth	Strategies to overcome resistance to immune checkpoint blockade in lung cancer
abstract	The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review.
abstractGer	The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review.
abstract_unstemmed	The adoption of Immune checkpoint inhibitors (ICIs) allowed the achievement of impressive long-term survival results in non-small cell lung cancer (NSCLC), but most patients develop resistance to ICI treatment over time. Resistance to ICIs is mediated by several complex mechanisms affecting, but not limited to, tumour cell-intrinsic alterations and the tumour microenvironment. The possibility of modulating the immune response by interfering with specific alternative immune receptors, pathways and mediators might provide additional strategies to delay or prevent the development of resistance. Therefore, a greater in-depth investigation and understanding of these mechanisms aims to identify novel classes of immune targets and subsequently to evaluate potential new strategies for overcoming resistance, which will be assessed in this review.
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title_short	Strategies to overcome resistance to immune checkpoint blockade in lung cancer
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author2	Tarantino, Paolo Passaro, Antonio Stati, Valeria Curigliano, Giuseppe de Marinis, Filippo
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doi_str	10.1016/j.lungcan.2021.02.035
up_date	2024-07-06T19:10:54.875Z
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Strategies to overcome resistance to immune checkpoint blockade in lung cancer

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