Effect of a carotenoid-producing

The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impa...
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Autor*in:	Stevens, Yala [verfasserIn] Pinheiro, Iris [verfasserIn] Salden, Bouke [verfasserIn] Duysburgh, Cindy [verfasserIn] Bolca, Selin [verfasserIn] Degroote, Jeroen [verfasserIn] Majdeddin, Maryam [verfasserIn] Van Noten, Noémie [verfasserIn] Gleize, Béatrice [verfasserIn] Caris-Veyrat, Catherine [verfasserIn] Michiels, Joris [verfasserIn] Jonkers, Daisy [verfasserIn] Troost, Freddy [verfasserIn] Possemiers, Sam [verfasserIn] Masclee, Ad [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Intestinal barrier function Probiotics Carotenoids

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 80
Übergeordnetes Werk:	volume:80

DOI / URN:	10.1016/j.jff.2021.104445

Katalog-ID:	ELV005845653

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520			\|a The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes.
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allfields	10.1016/j.jff.2021.104445 doi (DE-627)ELV005845653 (ELSEVIER)S1756-4646(21)00094-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Stevens, Yala verfasserin (orcid)0000-0003-4671-7739 aut Effect of a carotenoid-producing 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes. Intestinal barrier function Probiotics Carotenoids Pinheiro, Iris verfasserin aut Salden, Bouke verfasserin aut Duysburgh, Cindy verfasserin aut Bolca, Selin verfasserin (orcid)0000-0002-0609-1236 aut Degroote, Jeroen verfasserin aut Majdeddin, Maryam verfasserin aut Van Noten, Noémie verfasserin aut Gleize, Béatrice verfasserin aut Caris-Veyrat, Catherine verfasserin aut Michiels, Joris verfasserin aut Jonkers, Daisy verfasserin aut Troost, Freddy verfasserin aut Possemiers, Sam verfasserin (orcid)0000-0002-6893-5780 aut Masclee, Ad verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 80 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:80 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80
spelling	10.1016/j.jff.2021.104445 doi (DE-627)ELV005845653 (ELSEVIER)S1756-4646(21)00094-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Stevens, Yala verfasserin (orcid)0000-0003-4671-7739 aut Effect of a carotenoid-producing 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes. Intestinal barrier function Probiotics Carotenoids Pinheiro, Iris verfasserin aut Salden, Bouke verfasserin aut Duysburgh, Cindy verfasserin aut Bolca, Selin verfasserin (orcid)0000-0002-0609-1236 aut Degroote, Jeroen verfasserin aut Majdeddin, Maryam verfasserin aut Van Noten, Noémie verfasserin aut Gleize, Béatrice verfasserin aut Caris-Veyrat, Catherine verfasserin aut Michiels, Joris verfasserin aut Jonkers, Daisy verfasserin aut Troost, Freddy verfasserin aut Possemiers, Sam verfasserin (orcid)0000-0002-6893-5780 aut Masclee, Ad verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 80 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:80 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80
allfields_unstemmed	10.1016/j.jff.2021.104445 doi (DE-627)ELV005845653 (ELSEVIER)S1756-4646(21)00094-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Stevens, Yala verfasserin (orcid)0000-0003-4671-7739 aut Effect of a carotenoid-producing 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes. Intestinal barrier function Probiotics Carotenoids Pinheiro, Iris verfasserin aut Salden, Bouke verfasserin aut Duysburgh, Cindy verfasserin aut Bolca, Selin verfasserin (orcid)0000-0002-0609-1236 aut Degroote, Jeroen verfasserin aut Majdeddin, Maryam verfasserin aut Van Noten, Noémie verfasserin aut Gleize, Béatrice verfasserin aut Caris-Veyrat, Catherine verfasserin aut Michiels, Joris verfasserin aut Jonkers, Daisy verfasserin aut Troost, Freddy verfasserin aut Possemiers, Sam verfasserin (orcid)0000-0002-6893-5780 aut Masclee, Ad verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 80 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:80 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80
allfieldsGer	10.1016/j.jff.2021.104445 doi (DE-627)ELV005845653 (ELSEVIER)S1756-4646(21)00094-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Stevens, Yala verfasserin (orcid)0000-0003-4671-7739 aut Effect of a carotenoid-producing 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes. Intestinal barrier function Probiotics Carotenoids Pinheiro, Iris verfasserin aut Salden, Bouke verfasserin aut Duysburgh, Cindy verfasserin aut Bolca, Selin verfasserin (orcid)0000-0002-0609-1236 aut Degroote, Jeroen verfasserin aut Majdeddin, Maryam verfasserin aut Van Noten, Noémie verfasserin aut Gleize, Béatrice verfasserin aut Caris-Veyrat, Catherine verfasserin aut Michiels, Joris verfasserin aut Jonkers, Daisy verfasserin aut Troost, Freddy verfasserin aut Possemiers, Sam verfasserin (orcid)0000-0002-6893-5780 aut Masclee, Ad verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 80 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:80 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80
allfieldsSound	10.1016/j.jff.2021.104445 doi (DE-627)ELV005845653 (ELSEVIER)S1756-4646(21)00094-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Stevens, Yala verfasserin (orcid)0000-0003-4671-7739 aut Effect of a carotenoid-producing 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes. Intestinal barrier function Probiotics Carotenoids Pinheiro, Iris verfasserin aut Salden, Bouke verfasserin aut Duysburgh, Cindy verfasserin aut Bolca, Selin verfasserin (orcid)0000-0002-0609-1236 aut Degroote, Jeroen verfasserin aut Majdeddin, Maryam verfasserin aut Van Noten, Noémie verfasserin aut Gleize, Béatrice verfasserin aut Caris-Veyrat, Catherine verfasserin aut Michiels, Joris verfasserin aut Jonkers, Daisy verfasserin aut Troost, Freddy verfasserin aut Possemiers, Sam verfasserin (orcid)0000-0002-6893-5780 aut Masclee, Ad verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 80 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:80 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 80
language	English
source	Enthalten in Journal of functional foods 80 volume:80
sourceStr	Enthalten in Journal of functional foods 80 volume:80
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Intestinal barrier function Probiotics Carotenoids
dewey-raw	630
isfreeaccess_bool	false
container_title	Journal of functional foods
authorswithroles_txt_mv	Stevens, Yala @@aut@@ Pinheiro, Iris @@aut@@ Salden, Bouke @@aut@@ Duysburgh, Cindy @@aut@@ Bolca, Selin @@aut@@ Degroote, Jeroen @@aut@@ Majdeddin, Maryam @@aut@@ Van Noten, Noémie @@aut@@ Gleize, Béatrice @@aut@@ Caris-Veyrat, Catherine @@aut@@ Michiels, Joris @@aut@@ Jonkers, Daisy @@aut@@ Troost, Freddy @@aut@@ Possemiers, Sam @@aut@@ Masclee, Ad @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	587138432
dewey-sort	3630
id	ELV005845653
language_de	englisch
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author	Stevens, Yala
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topic_title	630 640 610 DE-600 Effect of a carotenoid-producing Intestinal barrier function Probiotics Carotenoids
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title	Effect of a carotenoid-producing
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title_full	Effect of a carotenoid-producing
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author_browse	Stevens, Yala Pinheiro, Iris Salden, Bouke Duysburgh, Cindy Bolca, Selin Degroote, Jeroen Majdeddin, Maryam Van Noten, Noémie Gleize, Béatrice Caris-Veyrat, Catherine Michiels, Joris Jonkers, Daisy Troost, Freddy Possemiers, Sam Masclee, Ad
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title_sort	effect of a carotenoid-producing
title_auth	Effect of a carotenoid-producing
abstract	The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes.
abstractGer	The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes.
abstract_unstemmed	The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8′-lycopenoate and glycosyl-apo-8′-lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 µM, respectively; p < 0.001). PD01 supplementation resulted in higher expression levels of occludin in the distal small intestine (1.38 ± 0.31 vs 0.59 ± 0.14; p = 0.044) and transepithelial electrical resistance in the mid colon (34.1 ± 3.01 vs 24.3 ± 1.13 Ω.cm2; p = 0.019) of early weaned piglets compared to control. In overweight/obese individuals with preserved barrier integrity, PD01 did not affect sugar excretion (p ≥ 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes.
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title_short	Effect of a carotenoid-producing
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author2	Pinheiro, Iris Salden, Bouke Duysburgh, Cindy Bolca, Selin Degroote, Jeroen Majdeddin, Maryam Van Noten, Noémie Gleize, Béatrice Caris-Veyrat, Catherine Michiels, Joris Jonkers, Daisy Troost, Freddy Possemiers, Sam Masclee, Ad
author2Str	Pinheiro, Iris Salden, Bouke Duysburgh, Cindy Bolca, Selin Degroote, Jeroen Majdeddin, Maryam Van Noten, Noémie Gleize, Béatrice Caris-Veyrat, Catherine Michiels, Joris Jonkers, Daisy Troost, Freddy Possemiers, Sam Masclee, Ad
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up_date	2024-07-06T19:21:47.716Z
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