Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats

Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid per...
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Autor*in:	Komoltsev, Ilia G. [verfasserIn] Frankevich, Stepan O. [verfasserIn] Shirobokova, Natalia I. [verfasserIn] Volkova, Aleksandra A. [verfasserIn] Levshina, Irina P. [verfasserIn] Novikova, Margarita R. [verfasserIn] Manolova, Anna O. [verfasserIn] Gulyaeva, Natalia V. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex

Übergeordnetes Werk:	Enthalten in: Neuroscience research - Amsterdam [u.a.] : Elsevier Science, 1984, 166, Seite 42-54
Übergeordnetes Werk:	volume:166 ; pages:42-54

DOI / URN:	10.1016/j.neures.2020.05.005

Katalog-ID:	ELV005895375

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100	1		\|a Komoltsev, Ilia G. \|e verfasserin \|4 aut
245	1	0	\|a Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
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520			\|a Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology.
650		4	\|a Traumatic brain injury
650		4	\|a Epileptiform activity
650		4	\|a Spike-wave discharges
650		4	\|a Epileptogenesis
650		4	\|a Anxiety behavior
650		4	\|a Neuroinflammation
650		4	\|a Hippocampus
650		4	\|a Neocortex
700	1		\|a Frankevich, Stepan O. \|e verfasserin \|4 aut
700	1		\|a Shirobokova, Natalia I. \|e verfasserin \|4 aut
700	1		\|a Volkova, Aleksandra A. \|e verfasserin \|4 aut
700	1		\|a Levshina, Irina P. \|e verfasserin \|4 aut
700	1		\|a Novikova, Margarita R. \|e verfasserin \|4 aut
700	1		\|a Manolova, Anna O. \|e verfasserin \|4 aut
700	1		\|a Gulyaeva, Natalia V. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Neuroscience research \|d Amsterdam [u.a.] : Elsevier Science, 1984 \|g 166, Seite 42-54 \|h Online-Ressource \|w (DE-627)306589702 \|w (DE-600)1498536-6 \|w (DE-576)27234950X \|x 1872-8111 \|7 nnns
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allfields	10.1016/j.neures.2020.05.005 doi (DE-627)ELV005895375 (ELSEVIER)S0168-0102(19)30718-7 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Komoltsev, Ilia G. verfasserin aut Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex Frankevich, Stepan O. verfasserin aut Shirobokova, Natalia I. verfasserin aut Volkova, Aleksandra A. verfasserin aut Levshina, Irina P. verfasserin aut Novikova, Margarita R. verfasserin aut Manolova, Anna O. verfasserin aut Gulyaeva, Natalia V. verfasserin aut Enthalten in Neuroscience research Amsterdam [u.a.] : Elsevier Science, 1984 166, Seite 42-54 Online-Ressource (DE-627)306589702 (DE-600)1498536-6 (DE-576)27234950X 1872-8111 nnns volume:166 pages:42-54 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 166 42-54
spelling	10.1016/j.neures.2020.05.005 doi (DE-627)ELV005895375 (ELSEVIER)S0168-0102(19)30718-7 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Komoltsev, Ilia G. verfasserin aut Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex Frankevich, Stepan O. verfasserin aut Shirobokova, Natalia I. verfasserin aut Volkova, Aleksandra A. verfasserin aut Levshina, Irina P. verfasserin aut Novikova, Margarita R. verfasserin aut Manolova, Anna O. verfasserin aut Gulyaeva, Natalia V. verfasserin aut Enthalten in Neuroscience research Amsterdam [u.a.] : Elsevier Science, 1984 166, Seite 42-54 Online-Ressource (DE-627)306589702 (DE-600)1498536-6 (DE-576)27234950X 1872-8111 nnns volume:166 pages:42-54 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 166 42-54
allfields_unstemmed	10.1016/j.neures.2020.05.005 doi (DE-627)ELV005895375 (ELSEVIER)S0168-0102(19)30718-7 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Komoltsev, Ilia G. verfasserin aut Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex Frankevich, Stepan O. verfasserin aut Shirobokova, Natalia I. verfasserin aut Volkova, Aleksandra A. verfasserin aut Levshina, Irina P. verfasserin aut Novikova, Margarita R. verfasserin aut Manolova, Anna O. verfasserin aut Gulyaeva, Natalia V. verfasserin aut Enthalten in Neuroscience research Amsterdam [u.a.] : Elsevier Science, 1984 166, Seite 42-54 Online-Ressource (DE-627)306589702 (DE-600)1498536-6 (DE-576)27234950X 1872-8111 nnns volume:166 pages:42-54 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 166 42-54
allfieldsGer	10.1016/j.neures.2020.05.005 doi (DE-627)ELV005895375 (ELSEVIER)S0168-0102(19)30718-7 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Komoltsev, Ilia G. verfasserin aut Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex Frankevich, Stepan O. verfasserin aut Shirobokova, Natalia I. verfasserin aut Volkova, Aleksandra A. verfasserin aut Levshina, Irina P. verfasserin aut Novikova, Margarita R. verfasserin aut Manolova, Anna O. verfasserin aut Gulyaeva, Natalia V. verfasserin aut Enthalten in Neuroscience research Amsterdam [u.a.] : Elsevier Science, 1984 166, Seite 42-54 Online-Ressource (DE-627)306589702 (DE-600)1498536-6 (DE-576)27234950X 1872-8111 nnns volume:166 pages:42-54 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 166 42-54
allfieldsSound	10.1016/j.neures.2020.05.005 doi (DE-627)ELV005895375 (ELSEVIER)S0168-0102(19)30718-7 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Komoltsev, Ilia G. verfasserin aut Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex Frankevich, Stepan O. verfasserin aut Shirobokova, Natalia I. verfasserin aut Volkova, Aleksandra A. verfasserin aut Levshina, Irina P. verfasserin aut Novikova, Margarita R. verfasserin aut Manolova, Anna O. verfasserin aut Gulyaeva, Natalia V. verfasserin aut Enthalten in Neuroscience research Amsterdam [u.a.] : Elsevier Science, 1984 166, Seite 42-54 Online-Ressource (DE-627)306589702 (DE-600)1498536-6 (DE-576)27234950X 1872-8111 nnns volume:166 pages:42-54 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 166 42-54
language	English
source	Enthalten in Neuroscience research 166, Seite 42-54 volume:166 pages:42-54
sourceStr	Enthalten in Neuroscience research 166, Seite 42-54 volume:166 pages:42-54
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex
dewey-raw	610
isfreeaccess_bool	false
container_title	Neuroscience research
authorswithroles_txt_mv	Komoltsev, Ilia G. @@aut@@ Frankevich, Stepan O. @@aut@@ Shirobokova, Natalia I. @@aut@@ Volkova, Aleksandra A. @@aut@@ Levshina, Irina P. @@aut@@ Novikova, Margarita R. @@aut@@ Manolova, Anna O. @@aut@@ Gulyaeva, Natalia V. @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	306589702
dewey-sort	3610
id	ELV005895375
language_de	englisch
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author	Komoltsev, Ilia G.
spellingShingle	Komoltsev, Ilia G. ddc 610 bkl 44.90 misc Traumatic brain injury misc Epileptiform activity misc Spike-wave discharges misc Epileptogenesis misc Anxiety behavior misc Neuroinflammation misc Hippocampus misc Neocortex Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
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topic_title	610 DE-600 44.90 bkl Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats Traumatic brain injury Epileptiform activity Spike-wave discharges Epileptogenesis Anxiety behavior Neuroinflammation Hippocampus Neocortex
topic	ddc 610 bkl 44.90 misc Traumatic brain injury misc Epileptiform activity misc Spike-wave discharges misc Epileptogenesis misc Anxiety behavior misc Neuroinflammation misc Hippocampus misc Neocortex
topic_unstemmed	ddc 610 bkl 44.90 misc Traumatic brain injury misc Epileptiform activity misc Spike-wave discharges misc Epileptogenesis misc Anxiety behavior misc Neuroinflammation misc Hippocampus misc Neocortex
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title	Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
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title_full	Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
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author_browse	Komoltsev, Ilia G. Frankevich, Stepan O. Shirobokova, Natalia I. Volkova, Aleksandra A. Levshina, Irina P. Novikova, Margarita R. Manolova, Anna O. Gulyaeva, Natalia V.
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title_sort	differential early effects of traumatic brain injury on spike-wave discharges in sprague-dawley rats
title_auth	Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
abstract	Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology.
abstractGer	Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology.
abstract_unstemmed	Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology.
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title_short	Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
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author2	Frankevich, Stepan O. Shirobokova, Natalia I. Volkova, Aleksandra A. Levshina, Irina P. Novikova, Margarita R. Manolova, Anna O. Gulyaeva, Natalia V.
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Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats

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