Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bae, Su Bin [verfasserIn] Jeong, Jae Eun [verfasserIn] Park, Su A. [verfasserIn] Park, Won Ho [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage

Übergeordnetes Werk:	Enthalten in: Polymer - Oxford : Elsevier Science, 1960, 224
Übergeordnetes Werk:	volume:224

DOI / URN:	10.1016/j.polymer.2021.123739

Katalog-ID:	ELV005922798

Internformat


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245	1	0	\|a Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
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520			\|a Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage.
650		4	\|a Silk fibroin
650		4	\|a Butyl glycidyl ether
650		4	\|a Hydrogels
650		4	\|a Photocrosslinking
650		4	\|a Alcohol treatment
650		4	\|a Articular cartilage
700	1		\|a Jeong, Jae Eun \|e verfasserin \|4 aut
700	1		\|a Park, Su A. \|e verfasserin \|4 aut
700	1		\|a Park, Won Ho \|e verfasserin \|4 aut
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936	b	k	\|a 35.80 \|j Makromolekulare Chemie
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publishDate	2021
allfields	10.1016/j.polymer.2021.123739 doi (DE-627)ELV005922798 (ELSEVIER)S0032-3861(21)00362-1 DE-627 ger DE-627 rda eng 540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Bae, Su Bin verfasserin aut Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage Jeong, Jae Eun verfasserin aut Park, Su A. verfasserin aut Park, Won Ho verfasserin aut Enthalten in Polymer Oxford : Elsevier Science, 1960 224 Online-Ressource (DE-627)32051613X (DE-600)2013972-X (DE-576)093888422 0032-3861 nnns volume:224 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 51.70 Polymerwerkstoffe Kunststoffe Werkstoffkunde 58.22 Kunststofftechnologie AR 224
spelling	10.1016/j.polymer.2021.123739 doi (DE-627)ELV005922798 (ELSEVIER)S0032-3861(21)00362-1 DE-627 ger DE-627 rda eng 540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Bae, Su Bin verfasserin aut Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage Jeong, Jae Eun verfasserin aut Park, Su A. verfasserin aut Park, Won Ho verfasserin aut Enthalten in Polymer Oxford : Elsevier Science, 1960 224 Online-Ressource (DE-627)32051613X (DE-600)2013972-X (DE-576)093888422 0032-3861 nnns volume:224 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 51.70 Polymerwerkstoffe Kunststoffe Werkstoffkunde 58.22 Kunststofftechnologie AR 224
allfields_unstemmed	10.1016/j.polymer.2021.123739 doi (DE-627)ELV005922798 (ELSEVIER)S0032-3861(21)00362-1 DE-627 ger DE-627 rda eng 540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Bae, Su Bin verfasserin aut Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage Jeong, Jae Eun verfasserin aut Park, Su A. verfasserin aut Park, Won Ho verfasserin aut Enthalten in Polymer Oxford : Elsevier Science, 1960 224 Online-Ressource (DE-627)32051613X (DE-600)2013972-X (DE-576)093888422 0032-3861 nnns volume:224 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 51.70 Polymerwerkstoffe Kunststoffe Werkstoffkunde 58.22 Kunststofftechnologie AR 224
allfieldsGer	10.1016/j.polymer.2021.123739 doi (DE-627)ELV005922798 (ELSEVIER)S0032-3861(21)00362-1 DE-627 ger DE-627 rda eng 540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Bae, Su Bin verfasserin aut Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage Jeong, Jae Eun verfasserin aut Park, Su A. verfasserin aut Park, Won Ho verfasserin aut Enthalten in Polymer Oxford : Elsevier Science, 1960 224 Online-Ressource (DE-627)32051613X (DE-600)2013972-X (DE-576)093888422 0032-3861 nnns volume:224 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 51.70 Polymerwerkstoffe Kunststoffe Werkstoffkunde 58.22 Kunststofftechnologie AR 224
allfieldsSound	10.1016/j.polymer.2021.123739 doi (DE-627)ELV005922798 (ELSEVIER)S0032-3861(21)00362-1 DE-627 ger DE-627 rda eng 540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Bae, Su Bin verfasserin aut Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage Jeong, Jae Eun verfasserin aut Park, Su A. verfasserin aut Park, Won Ho verfasserin aut Enthalten in Polymer Oxford : Elsevier Science, 1960 224 Online-Ressource (DE-627)32051613X (DE-600)2013972-X (DE-576)093888422 0032-3861 nnns volume:224 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie 51.70 Polymerwerkstoffe Kunststoffe Werkstoffkunde 58.22 Kunststofftechnologie AR 224
language	English
source	Enthalten in Polymer 224 volume:224
sourceStr	Enthalten in Polymer 224 volume:224
format_phy_str_mv	Article
bklname	Makromolekulare Chemie Polymerwerkstoffe Kunststoffe Kunststofftechnologie
institution	findex.gbv.de
topic_facet	Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage
dewey-raw	540
isfreeaccess_bool	false
container_title	Polymer
authorswithroles_txt_mv	Bae, Su Bin @@aut@@ Jeong, Jae Eun @@aut@@ Park, Su A. @@aut@@ Park, Won Ho @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	32051613X
dewey-sort	3540
id	ELV005922798
language_de	englisch
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author	Bae, Su Bin
spellingShingle	Bae, Su Bin ddc 540 bkl 35.80 bkl 51.70 bkl 58.22 misc Silk fibroin misc Butyl glycidyl ether misc Hydrogels misc Photocrosslinking misc Alcohol treatment misc Articular cartilage Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
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topic_title	540 DE-600 35.80 bkl 51.70 bkl 58.22 bkl Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage Silk fibroin Butyl glycidyl ether Hydrogels Photocrosslinking Alcohol treatment Articular cartilage
topic	ddc 540 bkl 35.80 bkl 51.70 bkl 58.22 misc Silk fibroin misc Butyl glycidyl ether misc Hydrogels misc Photocrosslinking misc Alcohol treatment misc Articular cartilage
topic_unstemmed	ddc 540 bkl 35.80 bkl 51.70 bkl 58.22 misc Silk fibroin misc Butyl glycidyl ether misc Hydrogels misc Photocrosslinking misc Alcohol treatment misc Articular cartilage
topic_browse	ddc 540 bkl 35.80 bkl 51.70 bkl 58.22 misc Silk fibroin misc Butyl glycidyl ether misc Hydrogels misc Photocrosslinking misc Alcohol treatment misc Articular cartilage
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title	Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
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title_full	Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
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author_browse	Bae, Su Bin Jeong, Jae Eun Park, Su A. Park, Won Ho
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title_sort	dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
title_auth	Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
abstract	Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage.
abstractGer	Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage.
abstract_unstemmed	Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage.
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title_short	Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage
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author2	Jeong, Jae Eun Park, Su A. Park, Won Ho
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doi_str	10.1016/j.polymer.2021.123739
up_date	2024-07-06T19:37:36.076Z
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Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

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