DNA methylation-based age clocks: From age prediction to age reversion

Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and...
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Autor*in:	Noroozi, Rezvan [verfasserIn] Ghafouri-Fard, Soudeh [verfasserIn] Pisarek, Aleksandra [verfasserIn] Rudnicka, Joanna [verfasserIn] Spólnicka, Magdalena [verfasserIn] Branicki, Wojciech [verfasserIn] Taheri, Mohammad [verfasserIn] Pośpiech, Ewelina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming

Übergeordnetes Werk:	Enthalten in: Ageing research reviews - Oxford [u.a.] : Elsevier, 2002, 68
Übergeordnetes Werk:	volume:68

DOI / URN:	10.1016/j.arr.2021.101314

Katalog-ID:	ELV006002897

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520			\|a Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks.
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650		4	\|a Epigenetic age
650		4	\|a Biological age
650		4	\|a Phenotypic age
650		4	\|a Epigenetic age acceleration
650		4	\|a Epigenetic clocks
650		4	\|a Epigenetic reprogramming
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700	1		\|a Rudnicka, Joanna \|e verfasserin \|0 (orcid)0000-0002-4658-3972 \|4 aut
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700	1		\|a Branicki, Wojciech \|e verfasserin \|0 (orcid)0000-0002-7412-5733 \|4 aut
700	1		\|a Taheri, Mohammad \|e verfasserin \|0 (orcid)0000-0001-8381-0591 \|4 aut
700	1		\|a Pośpiech, Ewelina \|e verfasserin \|0 (orcid)0000-0001-8867-0727 \|4 aut
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936	b	k	\|a 44.68 \|j Gerontologie \|j Geriatrie
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publishDate	2021
allfields	10.1016/j.arr.2021.101314 doi (DE-627)ELV006002897 (ELSEVIER)S1568-1637(21)00061-1 DE-627 ger DE-627 rda eng 610 DE-600 44.68 bkl Noroozi, Rezvan verfasserin aut DNA methylation-based age clocks: From age prediction to age reversion 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks. DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming Ghafouri-Fard, Soudeh verfasserin aut Pisarek, Aleksandra verfasserin (orcid)0000-0001-5445-0398 aut Rudnicka, Joanna verfasserin (orcid)0000-0002-4658-3972 aut Spólnicka, Magdalena verfasserin aut Branicki, Wojciech verfasserin (orcid)0000-0002-7412-5733 aut Taheri, Mohammad verfasserin (orcid)0000-0001-8381-0591 aut Pośpiech, Ewelina verfasserin (orcid)0000-0001-8867-0727 aut Enthalten in Ageing research reviews Oxford [u.a.] : Elsevier, 2002 68 Online-Ressource (DE-627)360307752 (DE-600)2099320-1 (DE-576)255635648 1872-9649 nnns volume:68 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.68 Gerontologie Geriatrie AR 68
spelling	10.1016/j.arr.2021.101314 doi (DE-627)ELV006002897 (ELSEVIER)S1568-1637(21)00061-1 DE-627 ger DE-627 rda eng 610 DE-600 44.68 bkl Noroozi, Rezvan verfasserin aut DNA methylation-based age clocks: From age prediction to age reversion 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks. DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming Ghafouri-Fard, Soudeh verfasserin aut Pisarek, Aleksandra verfasserin (orcid)0000-0001-5445-0398 aut Rudnicka, Joanna verfasserin (orcid)0000-0002-4658-3972 aut Spólnicka, Magdalena verfasserin aut Branicki, Wojciech verfasserin (orcid)0000-0002-7412-5733 aut Taheri, Mohammad verfasserin (orcid)0000-0001-8381-0591 aut Pośpiech, Ewelina verfasserin (orcid)0000-0001-8867-0727 aut Enthalten in Ageing research reviews Oxford [u.a.] : Elsevier, 2002 68 Online-Ressource (DE-627)360307752 (DE-600)2099320-1 (DE-576)255635648 1872-9649 nnns volume:68 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.68 Gerontologie Geriatrie AR 68
allfields_unstemmed	10.1016/j.arr.2021.101314 doi (DE-627)ELV006002897 (ELSEVIER)S1568-1637(21)00061-1 DE-627 ger DE-627 rda eng 610 DE-600 44.68 bkl Noroozi, Rezvan verfasserin aut DNA methylation-based age clocks: From age prediction to age reversion 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks. DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming Ghafouri-Fard, Soudeh verfasserin aut Pisarek, Aleksandra verfasserin (orcid)0000-0001-5445-0398 aut Rudnicka, Joanna verfasserin (orcid)0000-0002-4658-3972 aut Spólnicka, Magdalena verfasserin aut Branicki, Wojciech verfasserin (orcid)0000-0002-7412-5733 aut Taheri, Mohammad verfasserin (orcid)0000-0001-8381-0591 aut Pośpiech, Ewelina verfasserin (orcid)0000-0001-8867-0727 aut Enthalten in Ageing research reviews Oxford [u.a.] : Elsevier, 2002 68 Online-Ressource (DE-627)360307752 (DE-600)2099320-1 (DE-576)255635648 1872-9649 nnns volume:68 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.68 Gerontologie Geriatrie AR 68
allfieldsGer	10.1016/j.arr.2021.101314 doi (DE-627)ELV006002897 (ELSEVIER)S1568-1637(21)00061-1 DE-627 ger DE-627 rda eng 610 DE-600 44.68 bkl Noroozi, Rezvan verfasserin aut DNA methylation-based age clocks: From age prediction to age reversion 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks. DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming Ghafouri-Fard, Soudeh verfasserin aut Pisarek, Aleksandra verfasserin (orcid)0000-0001-5445-0398 aut Rudnicka, Joanna verfasserin (orcid)0000-0002-4658-3972 aut Spólnicka, Magdalena verfasserin aut Branicki, Wojciech verfasserin (orcid)0000-0002-7412-5733 aut Taheri, Mohammad verfasserin (orcid)0000-0001-8381-0591 aut Pośpiech, Ewelina verfasserin (orcid)0000-0001-8867-0727 aut Enthalten in Ageing research reviews Oxford [u.a.] : Elsevier, 2002 68 Online-Ressource (DE-627)360307752 (DE-600)2099320-1 (DE-576)255635648 1872-9649 nnns volume:68 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.68 Gerontologie Geriatrie AR 68
allfieldsSound	10.1016/j.arr.2021.101314 doi (DE-627)ELV006002897 (ELSEVIER)S1568-1637(21)00061-1 DE-627 ger DE-627 rda eng 610 DE-600 44.68 bkl Noroozi, Rezvan verfasserin aut DNA methylation-based age clocks: From age prediction to age reversion 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks. DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming Ghafouri-Fard, Soudeh verfasserin aut Pisarek, Aleksandra verfasserin (orcid)0000-0001-5445-0398 aut Rudnicka, Joanna verfasserin (orcid)0000-0002-4658-3972 aut Spólnicka, Magdalena verfasserin aut Branicki, Wojciech verfasserin (orcid)0000-0002-7412-5733 aut Taheri, Mohammad verfasserin (orcid)0000-0001-8381-0591 aut Pośpiech, Ewelina verfasserin (orcid)0000-0001-8867-0727 aut Enthalten in Ageing research reviews Oxford [u.a.] : Elsevier, 2002 68 Online-Ressource (DE-627)360307752 (DE-600)2099320-1 (DE-576)255635648 1872-9649 nnns volume:68 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.68 Gerontologie Geriatrie AR 68
language	English
source	Enthalten in Ageing research reviews 68 volume:68
sourceStr	Enthalten in Ageing research reviews 68 volume:68
format_phy_str_mv	Article
bklname	Gerontologie Geriatrie
institution	findex.gbv.de
topic_facet	DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming
dewey-raw	610
isfreeaccess_bool	false
container_title	Ageing research reviews
authorswithroles_txt_mv	Noroozi, Rezvan @@aut@@ Ghafouri-Fard, Soudeh @@aut@@ Pisarek, Aleksandra @@aut@@ Rudnicka, Joanna @@aut@@ Spólnicka, Magdalena @@aut@@ Branicki, Wojciech @@aut@@ Taheri, Mohammad @@aut@@ Pośpiech, Ewelina @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	360307752
dewey-sort	3610
id	ELV006002897
language_de	englisch
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author	Noroozi, Rezvan
spellingShingle	Noroozi, Rezvan ddc 610 bkl 44.68 misc DNA methylation misc Epigenetic age misc Biological age misc Phenotypic age misc Epigenetic age acceleration misc Epigenetic clocks misc Epigenetic reprogramming DNA methylation-based age clocks: From age prediction to age reversion
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topic_title	610 DE-600 44.68 bkl DNA methylation-based age clocks: From age prediction to age reversion DNA methylation Epigenetic age Biological age Phenotypic age Epigenetic age acceleration Epigenetic clocks Epigenetic reprogramming
topic	ddc 610 bkl 44.68 misc DNA methylation misc Epigenetic age misc Biological age misc Phenotypic age misc Epigenetic age acceleration misc Epigenetic clocks misc Epigenetic reprogramming
topic_unstemmed	ddc 610 bkl 44.68 misc DNA methylation misc Epigenetic age misc Biological age misc Phenotypic age misc Epigenetic age acceleration misc Epigenetic clocks misc Epigenetic reprogramming
topic_browse	ddc 610 bkl 44.68 misc DNA methylation misc Epigenetic age misc Biological age misc Phenotypic age misc Epigenetic age acceleration misc Epigenetic clocks misc Epigenetic reprogramming
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title	DNA methylation-based age clocks: From age prediction to age reversion
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title_full	DNA methylation-based age clocks: From age prediction to age reversion
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author_browse	Noroozi, Rezvan Ghafouri-Fard, Soudeh Pisarek, Aleksandra Rudnicka, Joanna Spólnicka, Magdalena Branicki, Wojciech Taheri, Mohammad Pośpiech, Ewelina
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title_sort	dna methylation-based age clocks: from age prediction to age reversion
title_auth	DNA methylation-based age clocks: From age prediction to age reversion
abstract	Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks.
abstractGer	Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks.
abstract_unstemmed	Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases. Several investigations have attempted to predict chronological age using the age-related alterations in the DNAm of certain CpG sites. Here we categorize different studies that tracked the aging process in the DNAm landscape to show how epigenetic age clocks evolved from a chronological age estimator to an indicator of lifespan and healthspan. We also describe the health and disease predictive potential of estimated epigenetic age acceleration regarding different clinical conditions and lifestyle factors. Considering the revealed age-related epigenetic changes, the recent age-reprogramming strategies are discussed which are promising methods for resetting the aging clocks.
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title_short	DNA methylation-based age clocks: From age prediction to age reversion
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author2	Ghafouri-Fard, Soudeh Pisarek, Aleksandra Rudnicka, Joanna Spólnicka, Magdalena Branicki, Wojciech Taheri, Mohammad Pośpiech, Ewelina
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up_date	2024-07-06T19:53:26.739Z
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DNA methylation-based age clocks: From age prediction to age reversion

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