20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility
We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericyt...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, Yedan [verfasserIn] Zhang, Huawei [verfasserIn] Wu, Celeste YC. [verfasserIn] Yu, Tina [verfasserIn] Fang, Xing [verfasserIn] Ryu, Jane J. [verfasserIn] Zheng, Baoying [verfasserIn] Chen, Zongbo [verfasserIn] Roman, Richard J. [verfasserIn] Fan, Fan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Prostaglandins & other lipid mediators - New York, NY : Elsevier, 1997, 154 |
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| Übergeordnetes Werk: |
volume:154 |
| DOI / URN: |
10.1016/j.prostaglandins.2021.106548 |
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| Katalog-ID: |
ELV006047653 |
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| 520 | |a We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. | ||
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| 650 | 4 | |a Pericytes | |
| 650 | 4 | |a Vascular smooth muscle cells | |
| 650 | 4 | |a Cell contractility | |
| 650 | 4 | |a Myogenic response | |
| 650 | 4 | |a Cerebral blood flow autoregulation | |
| 700 | 1 | |a Zhang, Huawei |e verfasserin |0 (orcid)0000-0002-0804-0686 |4 aut | |
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10.1016/j.prostaglandins.2021.106548 doi (DE-627)ELV006047653 (ELSEVIER)S1098-8823(21)00023-X DE-627 ger DE-627 rda eng 590 580 610 DE-600 12 ssgn BIODIV DE-30 fid 35.78 bkl Liu, Yedan verfasserin (orcid)0000-0002-5973-0572 aut 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. 20-Hydroxyeicosatetraenoic acid Pericytes Vascular smooth muscle cells Cell contractility Myogenic response Cerebral blood flow autoregulation Zhang, Huawei verfasserin (orcid)0000-0002-0804-0686 aut Wu, Celeste YC. verfasserin aut Yu, Tina verfasserin aut Fang, Xing verfasserin aut Ryu, Jane J. verfasserin aut Zheng, Baoying verfasserin aut Chen, Zongbo verfasserin aut Roman, Richard J. verfasserin aut Fan, Fan verfasserin (orcid)0000-0003-1463-3610 aut Enthalten in Prostaglandins & other lipid mediators New York, NY : Elsevier, 1997 154 Online-Ressource (DE-627)320510638 (DE-600)2013367-4 (DE-576)116705299 2212-196X nnns volume:154 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 35.78 Lipide Biochemie AR 154 |
| spelling |
10.1016/j.prostaglandins.2021.106548 doi (DE-627)ELV006047653 (ELSEVIER)S1098-8823(21)00023-X DE-627 ger DE-627 rda eng 590 580 610 DE-600 12 ssgn BIODIV DE-30 fid 35.78 bkl Liu, Yedan verfasserin (orcid)0000-0002-5973-0572 aut 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. 20-Hydroxyeicosatetraenoic acid Pericytes Vascular smooth muscle cells Cell contractility Myogenic response Cerebral blood flow autoregulation Zhang, Huawei verfasserin (orcid)0000-0002-0804-0686 aut Wu, Celeste YC. verfasserin aut Yu, Tina verfasserin aut Fang, Xing verfasserin aut Ryu, Jane J. verfasserin aut Zheng, Baoying verfasserin aut Chen, Zongbo verfasserin aut Roman, Richard J. verfasserin aut Fan, Fan verfasserin (orcid)0000-0003-1463-3610 aut Enthalten in Prostaglandins & other lipid mediators New York, NY : Elsevier, 1997 154 Online-Ressource (DE-627)320510638 (DE-600)2013367-4 (DE-576)116705299 2212-196X nnns volume:154 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 35.78 Lipide Biochemie AR 154 |
| allfields_unstemmed |
10.1016/j.prostaglandins.2021.106548 doi (DE-627)ELV006047653 (ELSEVIER)S1098-8823(21)00023-X DE-627 ger DE-627 rda eng 590 580 610 DE-600 12 ssgn BIODIV DE-30 fid 35.78 bkl Liu, Yedan verfasserin (orcid)0000-0002-5973-0572 aut 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. 20-Hydroxyeicosatetraenoic acid Pericytes Vascular smooth muscle cells Cell contractility Myogenic response Cerebral blood flow autoregulation Zhang, Huawei verfasserin (orcid)0000-0002-0804-0686 aut Wu, Celeste YC. verfasserin aut Yu, Tina verfasserin aut Fang, Xing verfasserin aut Ryu, Jane J. verfasserin aut Zheng, Baoying verfasserin aut Chen, Zongbo verfasserin aut Roman, Richard J. verfasserin aut Fan, Fan verfasserin (orcid)0000-0003-1463-3610 aut Enthalten in Prostaglandins & other lipid mediators New York, NY : Elsevier, 1997 154 Online-Ressource (DE-627)320510638 (DE-600)2013367-4 (DE-576)116705299 2212-196X nnns volume:154 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 35.78 Lipide Biochemie AR 154 |
| allfieldsGer |
10.1016/j.prostaglandins.2021.106548 doi (DE-627)ELV006047653 (ELSEVIER)S1098-8823(21)00023-X DE-627 ger DE-627 rda eng 590 580 610 DE-600 12 ssgn BIODIV DE-30 fid 35.78 bkl Liu, Yedan verfasserin (orcid)0000-0002-5973-0572 aut 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. 20-Hydroxyeicosatetraenoic acid Pericytes Vascular smooth muscle cells Cell contractility Myogenic response Cerebral blood flow autoregulation Zhang, Huawei verfasserin (orcid)0000-0002-0804-0686 aut Wu, Celeste YC. verfasserin aut Yu, Tina verfasserin aut Fang, Xing verfasserin aut Ryu, Jane J. verfasserin aut Zheng, Baoying verfasserin aut Chen, Zongbo verfasserin aut Roman, Richard J. verfasserin aut Fan, Fan verfasserin (orcid)0000-0003-1463-3610 aut Enthalten in Prostaglandins & other lipid mediators New York, NY : Elsevier, 1997 154 Online-Ressource (DE-627)320510638 (DE-600)2013367-4 (DE-576)116705299 2212-196X nnns volume:154 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 35.78 Lipide Biochemie AR 154 |
| allfieldsSound |
10.1016/j.prostaglandins.2021.106548 doi (DE-627)ELV006047653 (ELSEVIER)S1098-8823(21)00023-X DE-627 ger DE-627 rda eng 590 580 610 DE-600 12 ssgn BIODIV DE-30 fid 35.78 bkl Liu, Yedan verfasserin (orcid)0000-0002-5973-0572 aut 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. 20-Hydroxyeicosatetraenoic acid Pericytes Vascular smooth muscle cells Cell contractility Myogenic response Cerebral blood flow autoregulation Zhang, Huawei verfasserin (orcid)0000-0002-0804-0686 aut Wu, Celeste YC. verfasserin aut Yu, Tina verfasserin aut Fang, Xing verfasserin aut Ryu, Jane J. verfasserin aut Zheng, Baoying verfasserin aut Chen, Zongbo verfasserin aut Roman, Richard J. verfasserin aut Fan, Fan verfasserin (orcid)0000-0003-1463-3610 aut Enthalten in Prostaglandins & other lipid mediators New York, NY : Elsevier, 1997 154 Online-Ressource (DE-627)320510638 (DE-600)2013367-4 (DE-576)116705299 2212-196X nnns volume:154 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 35.78 Lipide Biochemie AR 154 |
| language |
English |
| source |
Enthalten in Prostaglandins & other lipid mediators 154 volume:154 |
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Enthalten in Prostaglandins & other lipid mediators 154 volume:154 |
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20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility |
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We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. |
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We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. |
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We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The present study demonstrated that CYP4A was coexpressed with alpha-smooth muscle actin (α-SMA) in vascular smooth muscle cells (VSMCs) and most pericytes along parenchymal arteries (PAs) isolated from SD rats. Cell contractile capabilities of cerebral VSMCs and pericytes were reduced with a 20-HETE synthesis inhibitor, HET0016, but restored with 20-HETE analog WIT003. Similarly, intact myogenic responses of the middle cerebral artery and PA of SD rats decreased with HET0016 and were rescued by WIT003. The myogenic response of the PA was abolished in SS and was restored in SS.BN5 and SS.Cyp4a1 rats. HET0016 enhanced CBF and impaired its autoregulation in the surface and deep cortex of SD rats. These results demonstrate that 20-HETE has a direct effect on cerebral mural cell contractility that may play an essential role in controlling cerebral vascular function. |
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