Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma
Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophore...
Ausführliche Beschreibung
Autor*in: |
Sia, Tiffany Y. [verfasserIn] Huang, Yongmei [verfasserIn] Gockley, Allison [verfasserIn] Melamed, Alexander [verfasserIn] Khoury-Collado, Fady [verfasserIn] St. Clair, Caryn [verfasserIn] Hou, June Y. [verfasserIn] Tergas, Ana I. [verfasserIn] Hershman, Dawn L. [verfasserIn] Wright, Jason D. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Gynecologic oncology - Orlando, Fla. : Academic Press, 1972, 161 |
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Übergeordnetes Werk: |
volume:161 |
DOI / URN: |
10.1016/j.ygyno.2021.03.027 |
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Katalog-ID: |
ELV006071856 |
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245 | 1 | 0 | |a Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma |
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520 | |a Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. | ||
650 | 4 | |a Leiomyosarcoma | |
650 | 4 | |a Ovarian conservation | |
650 | 4 | |a Oophorectomy | |
700 | 1 | |a Huang, Yongmei |e verfasserin |4 aut | |
700 | 1 | |a Gockley, Allison |e verfasserin |4 aut | |
700 | 1 | |a Melamed, Alexander |e verfasserin |4 aut | |
700 | 1 | |a Khoury-Collado, Fady |e verfasserin |4 aut | |
700 | 1 | |a St. Clair, Caryn |e verfasserin |4 aut | |
700 | 1 | |a Hou, June Y. |e verfasserin |4 aut | |
700 | 1 | |a Tergas, Ana I. |e verfasserin |4 aut | |
700 | 1 | |a Hershman, Dawn L. |e verfasserin |4 aut | |
700 | 1 | |a Wright, Jason D. |e verfasserin |4 aut | |
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2021 |
allfields |
10.1016/j.ygyno.2021.03.027 doi (DE-627)ELV006071856 (ELSEVIER)S0090-8258(21)00265-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Sia, Tiffany Y. verfasserin aut Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. Leiomyosarcoma Ovarian conservation Oophorectomy Huang, Yongmei verfasserin aut Gockley, Allison verfasserin aut Melamed, Alexander verfasserin aut Khoury-Collado, Fady verfasserin aut St. Clair, Caryn verfasserin aut Hou, June Y. verfasserin aut Tergas, Ana I. verfasserin aut Hershman, Dawn L. verfasserin aut Wright, Jason D. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 161 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 161 |
spelling |
10.1016/j.ygyno.2021.03.027 doi (DE-627)ELV006071856 (ELSEVIER)S0090-8258(21)00265-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Sia, Tiffany Y. verfasserin aut Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. Leiomyosarcoma Ovarian conservation Oophorectomy Huang, Yongmei verfasserin aut Gockley, Allison verfasserin aut Melamed, Alexander verfasserin aut Khoury-Collado, Fady verfasserin aut St. Clair, Caryn verfasserin aut Hou, June Y. verfasserin aut Tergas, Ana I. verfasserin aut Hershman, Dawn L. verfasserin aut Wright, Jason D. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 161 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 161 |
allfields_unstemmed |
10.1016/j.ygyno.2021.03.027 doi (DE-627)ELV006071856 (ELSEVIER)S0090-8258(21)00265-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Sia, Tiffany Y. verfasserin aut Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. Leiomyosarcoma Ovarian conservation Oophorectomy Huang, Yongmei verfasserin aut Gockley, Allison verfasserin aut Melamed, Alexander verfasserin aut Khoury-Collado, Fady verfasserin aut St. Clair, Caryn verfasserin aut Hou, June Y. verfasserin aut Tergas, Ana I. verfasserin aut Hershman, Dawn L. verfasserin aut Wright, Jason D. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 161 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 161 |
allfieldsGer |
10.1016/j.ygyno.2021.03.027 doi (DE-627)ELV006071856 (ELSEVIER)S0090-8258(21)00265-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Sia, Tiffany Y. verfasserin aut Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. Leiomyosarcoma Ovarian conservation Oophorectomy Huang, Yongmei verfasserin aut Gockley, Allison verfasserin aut Melamed, Alexander verfasserin aut Khoury-Collado, Fady verfasserin aut St. Clair, Caryn verfasserin aut Hou, June Y. verfasserin aut Tergas, Ana I. verfasserin aut Hershman, Dawn L. verfasserin aut Wright, Jason D. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 161 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 161 |
allfieldsSound |
10.1016/j.ygyno.2021.03.027 doi (DE-627)ELV006071856 (ELSEVIER)S0090-8258(21)00265-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Sia, Tiffany Y. verfasserin aut Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. Leiomyosarcoma Ovarian conservation Oophorectomy Huang, Yongmei verfasserin aut Gockley, Allison verfasserin aut Melamed, Alexander verfasserin aut Khoury-Collado, Fady verfasserin aut St. Clair, Caryn verfasserin aut Hou, June Y. verfasserin aut Tergas, Ana I. verfasserin aut Hershman, Dawn L. verfasserin aut Wright, Jason D. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 161 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 161 |
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Sia, Tiffany Y. @@aut@@ Huang, Yongmei @@aut@@ Gockley, Allison @@aut@@ Melamed, Alexander @@aut@@ Khoury-Collado, Fady @@aut@@ St. Clair, Caryn @@aut@@ Hou, June Y. @@aut@@ Tergas, Ana I. @@aut@@ Hershman, Dawn L. @@aut@@ Wright, Jason D. @@aut@@ |
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Sia, Tiffany Y. |
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Sia, Tiffany Y. ddc 610 bkl 44.81 bkl 44.92 misc Leiomyosarcoma misc Ovarian conservation misc Oophorectomy Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma |
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610 DE-600 44.81 bkl 44.92 bkl Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma Leiomyosarcoma Ovarian conservation Oophorectomy |
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Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma |
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Sia, Tiffany Y. Huang, Yongmei Gockley, Allison Melamed, Alexander Khoury-Collado, Fady St. Clair, Caryn Hou, June Y. Tergas, Ana I. Hershman, Dawn L. Wright, Jason D. |
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trends in ovarian conservation and association with survival in premenopausal patients with stage i leiomyosarcoma |
title_auth |
Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma |
abstract |
Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. |
abstractGer |
Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. |
abstract_unstemmed |
Objective: To explore trends of ovarian conservation (OCN) over time in young women with early stage leiomyosarcoma (LMS) and examine the association between OCN and survival.Methods: Patients under the age of 50 who were diagnosed with stage I LMS who underwent hysterectomy with and without oophorectomy between 2010 and 2016 were identified in the National Cancer Database (NCDB). Performance of oophorectomy vs. OCN was determined using surgery codes. Trends of OCN were reported. Multivariable regression models were fit to estimate predictors of OCN. An inverse probability of treatment weighted propensity score method was used to examine the association between all-cause mortality and OCN.Results: Overall, 225 patients (28%) underwent OCN. Rates of OCN decreased from 41.2% (2010) to 14.3% (2016); this finding was consistent across age groups: <35, 35–39, 40–44, and 45–49 years. Race, insurance, and stage did not affect performance of OCN. Women with poorly differentiated tumors were less likely to undergo OCN compared to well-differentiated tumors (aRR 0.59; 95% CI 0.40–0.86). After propensity score weighting, there was no association between OCN and mortality (HR 1.19, 95% CI 0.80–1.77). Five-year survival for the OCN group was 67.1% (95% CI 59.8–75.2%) compared to 72.2% for the oophorectomy group (95% CI 67.2–77.5%).Conclusions: OCN for early stage LMS in premenopausal women has decreased over time. There was no association between OCN and mortality among women with stage I LMS. OCN should be considered in premenopausal women with stage I LMS given the health benefits. |
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title_short |
Trends in ovarian conservation and association with survival in premenopausal patients with stage I leiomyosarcoma |
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Huang, Yongmei Gockley, Allison Melamed, Alexander Khoury-Collado, Fady St. Clair, Caryn Hou, June Y. Tergas, Ana I. Hershman, Dawn L. Wright, Jason D. |
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|
score |
7.4008007 |