A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression
Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted...
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| Autor*in: |
Zajkowska, Zuzanna [verfasserIn] Walsh, Annabel [verfasserIn] Zonca, Valentina [verfasserIn] Gullett, Nancy [verfasserIn] Pedersen, Gloria A. [verfasserIn] Kieling, Christian [verfasserIn] Swartz, Johnna R. [verfasserIn] Karmacharya, Rakesh [verfasserIn] Fisher, Helen L. [verfasserIn] Kohrt, Brandon A. [verfasserIn] Mondelli, Valeria [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of psychiatric research - Amsterdam [u.a.] : Elsevier Science, 1961, 138, Seite 163-175 |
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| Übergeordnetes Werk: |
volume:138 ; pages:163-175 |
| DOI / URN: |
10.1016/j.jpsychires.2021.04.003 |
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| 100 | 1 | |a Zajkowska, Zuzanna |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression |
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| 520 | |a Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). | ||
| 650 | 4 | |a Adolescence | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a MDD | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Cortisol | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Brain | |
| 650 | 4 | |a Early life adversity | |
| 650 | 4 | |a Child maltreatment | |
| 650 | 4 | |a Youth | |
| 650 | 4 | |a Young people | |
| 700 | 1 | |a Walsh, Annabel |e verfasserin |4 aut | |
| 700 | 1 | |a Zonca, Valentina |e verfasserin |0 (orcid)0000-0002-6628-5999 |4 aut | |
| 700 | 1 | |a Gullett, Nancy |e verfasserin |0 (orcid)0000-0002-9885-5431 |4 aut | |
| 700 | 1 | |a Pedersen, Gloria A. |e verfasserin |4 aut | |
| 700 | 1 | |a Kieling, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Swartz, Johnna R. |e verfasserin |4 aut | |
| 700 | 1 | |a Karmacharya, Rakesh |e verfasserin |0 (orcid)0000-0002-0565-5482 |4 aut | |
| 700 | 1 | |a Fisher, Helen L. |e verfasserin |4 aut | |
| 700 | 1 | |a Kohrt, Brandon A. |e verfasserin |4 aut | |
| 700 | 1 | |a Mondelli, Valeria |e verfasserin |0 (orcid)0000-0001-8690-6839 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of psychiatric research |d Amsterdam [u.a.] : Elsevier Science, 1961 |g 138, Seite 163-175 |h Online-Ressource |w (DE-627)30666111X |w (DE-600)1500641-4 |w (DE-576)081986718 |x 1879-1379 |7 nnns |
| 773 | 1 | 8 | |g volume:138 |g pages:163-175 |
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10.1016/j.jpsychires.2021.04.003 doi (DE-627)ELV006138934 (ELSEVIER)S0022-3956(21)00221-1 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Zajkowska, Zuzanna verfasserin aut A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people Walsh, Annabel verfasserin aut Zonca, Valentina verfasserin (orcid)0000-0002-6628-5999 aut Gullett, Nancy verfasserin (orcid)0000-0002-9885-5431 aut Pedersen, Gloria A. verfasserin aut Kieling, Christian verfasserin aut Swartz, Johnna R. verfasserin aut Karmacharya, Rakesh verfasserin (orcid)0000-0002-0565-5482 aut Fisher, Helen L. verfasserin aut Kohrt, Brandon A. verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 138, Seite 163-175 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:138 pages:163-175 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 138 163-175 |
| spelling |
10.1016/j.jpsychires.2021.04.003 doi (DE-627)ELV006138934 (ELSEVIER)S0022-3956(21)00221-1 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Zajkowska, Zuzanna verfasserin aut A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people Walsh, Annabel verfasserin aut Zonca, Valentina verfasserin (orcid)0000-0002-6628-5999 aut Gullett, Nancy verfasserin (orcid)0000-0002-9885-5431 aut Pedersen, Gloria A. verfasserin aut Kieling, Christian verfasserin aut Swartz, Johnna R. verfasserin aut Karmacharya, Rakesh verfasserin (orcid)0000-0002-0565-5482 aut Fisher, Helen L. verfasserin aut Kohrt, Brandon A. verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 138, Seite 163-175 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:138 pages:163-175 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 138 163-175 |
| allfields_unstemmed |
10.1016/j.jpsychires.2021.04.003 doi (DE-627)ELV006138934 (ELSEVIER)S0022-3956(21)00221-1 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Zajkowska, Zuzanna verfasserin aut A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people Walsh, Annabel verfasserin aut Zonca, Valentina verfasserin (orcid)0000-0002-6628-5999 aut Gullett, Nancy verfasserin (orcid)0000-0002-9885-5431 aut Pedersen, Gloria A. verfasserin aut Kieling, Christian verfasserin aut Swartz, Johnna R. verfasserin aut Karmacharya, Rakesh verfasserin (orcid)0000-0002-0565-5482 aut Fisher, Helen L. verfasserin aut Kohrt, Brandon A. verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 138, Seite 163-175 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:138 pages:163-175 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 138 163-175 |
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10.1016/j.jpsychires.2021.04.003 doi (DE-627)ELV006138934 (ELSEVIER)S0022-3956(21)00221-1 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Zajkowska, Zuzanna verfasserin aut A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people Walsh, Annabel verfasserin aut Zonca, Valentina verfasserin (orcid)0000-0002-6628-5999 aut Gullett, Nancy verfasserin (orcid)0000-0002-9885-5431 aut Pedersen, Gloria A. verfasserin aut Kieling, Christian verfasserin aut Swartz, Johnna R. verfasserin aut Karmacharya, Rakesh verfasserin (orcid)0000-0002-0565-5482 aut Fisher, Helen L. verfasserin aut Kohrt, Brandon A. verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 138, Seite 163-175 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:138 pages:163-175 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 138 163-175 |
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10.1016/j.jpsychires.2021.04.003 doi (DE-627)ELV006138934 (ELSEVIER)S0022-3956(21)00221-1 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Zajkowska, Zuzanna verfasserin aut A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people Walsh, Annabel verfasserin aut Zonca, Valentina verfasserin (orcid)0000-0002-6628-5999 aut Gullett, Nancy verfasserin (orcid)0000-0002-9885-5431 aut Pedersen, Gloria A. verfasserin aut Kieling, Christian verfasserin aut Swartz, Johnna R. verfasserin aut Karmacharya, Rakesh verfasserin (orcid)0000-0002-0565-5482 aut Fisher, Helen L. verfasserin aut Kohrt, Brandon A. verfasserin aut Mondelli, Valeria verfasserin (orcid)0000-0001-8690-6839 aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 138, Seite 163-175 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:138 pages:163-175 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 138 163-175 |
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Zajkowska, Zuzanna @@aut@@ Walsh, Annabel @@aut@@ Zonca, Valentina @@aut@@ Gullett, Nancy @@aut@@ Pedersen, Gloria A. @@aut@@ Kieling, Christian @@aut@@ Swartz, Johnna R. @@aut@@ Karmacharya, Rakesh @@aut@@ Fisher, Helen L. @@aut@@ Kohrt, Brandon A. @@aut@@ Mondelli, Valeria @@aut@@ |
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Zajkowska, Zuzanna |
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Zajkowska, Zuzanna ddc 610 bkl 44.91 misc Adolescence misc Depression misc Major depressive disorder misc MDD misc Risk factors misc Biomarkers misc Inflammation misc Cortisol misc MRI misc Brain misc Early life adversity misc Child maltreatment misc Youth misc Young people A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression |
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610 DE-600 44.91 bkl A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression Adolescence Depression Major depressive disorder MDD Risk factors Biomarkers Inflammation Cortisol MRI Brain Early life adversity Child maltreatment Youth Young people |
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Zajkowska, Zuzanna Walsh, Annabel Zonca, Valentina Gullett, Nancy Pedersen, Gloria A. Kieling, Christian Swartz, Johnna R. Karmacharya, Rakesh Fisher, Helen L. Kohrt, Brandon A. Mondelli, Valeria |
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a systematic review of the association between biological markers and environmental stress risk factors for adolescent depression |
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A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression |
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Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). |
| abstractGer |
Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). |
| abstract_unstemmed |
Introduction: Although the aetiology and pathophysiology of depression are multifactorial, to date most studies have examined either biological or environmental mechanisms without looking at the integration of both; with most studies conducted in high-income countries (HICs). Therefore, we conducted a systematic review of worldwide studies investigating the relationship between biological and environmental stress risk factors for major depressive disorder (MDD) in adolescence.Methods: We searched MEDLINE (via Ovid), PsycINFO, Cochrane Database of Systematic Reviews, Web of Science (Core Collection), Lilacs, African Journals Online and Global Health for prospective and cross-sectional studies that examined the association between biological markers and environmental stress risk factors in MDD during adolescence.Findings: Of 11,089 articles identified, 21 were included, with only two from middle-income countries. Increased inflammation, telomere length and brain abnormalities, including blunted reward-related activity, white matter disruptions, and altered volume of limbic brain regions, were associated with increased risk for MDD mainly in the context of early life adversity. There is little evidence suggesting that the neurobiological changes investigated were associated with MDD in the context of recent life stress.Interpretation: The developmental trajectory of depression appears to start with early life adversities and occurs in the context of immune and brain abnormalities. Understanding these biopsychosocial processes will help to improve our ability to detect individuals at risk of developing depression in adolescence. However, generalizability is limited by few studies examining both biological and environmental stress risk factors and a lack of studies on adolescents and young adults in low-and-middle-income countries (LMICs). |
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