Aspects of histocompatibility testing in xenotransplantation

Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ladowski, Joseph M. [verfasserIn] Houp, Julie [verfasserIn] Hauptfeld-Dolejsek, Vera [verfasserIn] Javed, Mariyam [verfasserIn] Hara, Hidetaka [verfasserIn] Cooper, David K.C. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation

Übergeordnetes Werk:	Enthalten in: Transplant immunology - Amsterdam [u.a.] : Elsevier, 1993, 67
Übergeordnetes Werk:	volume:67

DOI / URN:	10.1016/j.trim.2021.101409

Katalog-ID:	ELV006153240

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520			\|a Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation.
650		4	\|a Histocompatibility
650		4	\|a Human leukocyte antigens
650		4	\|a Major histocompatibility complex
650		4	\|a Swine leukocyte antigens
650		4	\|a Xenotransplantation
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700	1		\|a Hauptfeld-Dolejsek, Vera \|e verfasserin \|4 aut
700	1		\|a Javed, Mariyam \|e verfasserin \|4 aut
700	1		\|a Hara, Hidetaka \|e verfasserin \|4 aut
700	1		\|a Cooper, David K.C. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Transplant immunology \|d Amsterdam [u.a.] : Elsevier, 1993 \|g 67 \|h Online-Ressource \|w (DE-627)324489110 \|w (DE-600)2027651-5 \|w (DE-576)26442414X \|x 1878-5492 \|7 nnns
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936	b	k	\|a 44.45 \|j Immunologie
936	b	k	\|a 44.65 \|j Chirurgie
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allfields	10.1016/j.trim.2021.101409 doi (DE-627)ELV006153240 (ELSEVIER)S0966-3274(21)00049-6 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.65 bkl Ladowski, Joseph M. verfasserin aut Aspects of histocompatibility testing in xenotransplantation 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation. Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation Houp, Julie verfasserin aut Hauptfeld-Dolejsek, Vera verfasserin aut Javed, Mariyam verfasserin aut Hara, Hidetaka verfasserin aut Cooper, David K.C. verfasserin aut Enthalten in Transplant immunology Amsterdam [u.a.] : Elsevier, 1993 67 Online-Ressource (DE-627)324489110 (DE-600)2027651-5 (DE-576)26442414X 1878-5492 nnns volume:67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie 44.65 Chirurgie AR 67
spelling	10.1016/j.trim.2021.101409 doi (DE-627)ELV006153240 (ELSEVIER)S0966-3274(21)00049-6 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.65 bkl Ladowski, Joseph M. verfasserin aut Aspects of histocompatibility testing in xenotransplantation 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation. Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation Houp, Julie verfasserin aut Hauptfeld-Dolejsek, Vera verfasserin aut Javed, Mariyam verfasserin aut Hara, Hidetaka verfasserin aut Cooper, David K.C. verfasserin aut Enthalten in Transplant immunology Amsterdam [u.a.] : Elsevier, 1993 67 Online-Ressource (DE-627)324489110 (DE-600)2027651-5 (DE-576)26442414X 1878-5492 nnns volume:67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie 44.65 Chirurgie AR 67
allfields_unstemmed	10.1016/j.trim.2021.101409 doi (DE-627)ELV006153240 (ELSEVIER)S0966-3274(21)00049-6 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.65 bkl Ladowski, Joseph M. verfasserin aut Aspects of histocompatibility testing in xenotransplantation 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation. Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation Houp, Julie verfasserin aut Hauptfeld-Dolejsek, Vera verfasserin aut Javed, Mariyam verfasserin aut Hara, Hidetaka verfasserin aut Cooper, David K.C. verfasserin aut Enthalten in Transplant immunology Amsterdam [u.a.] : Elsevier, 1993 67 Online-Ressource (DE-627)324489110 (DE-600)2027651-5 (DE-576)26442414X 1878-5492 nnns volume:67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie 44.65 Chirurgie AR 67
allfieldsGer	10.1016/j.trim.2021.101409 doi (DE-627)ELV006153240 (ELSEVIER)S0966-3274(21)00049-6 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.65 bkl Ladowski, Joseph M. verfasserin aut Aspects of histocompatibility testing in xenotransplantation 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation. Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation Houp, Julie verfasserin aut Hauptfeld-Dolejsek, Vera verfasserin aut Javed, Mariyam verfasserin aut Hara, Hidetaka verfasserin aut Cooper, David K.C. verfasserin aut Enthalten in Transplant immunology Amsterdam [u.a.] : Elsevier, 1993 67 Online-Ressource (DE-627)324489110 (DE-600)2027651-5 (DE-576)26442414X 1878-5492 nnns volume:67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie 44.65 Chirurgie AR 67
allfieldsSound	10.1016/j.trim.2021.101409 doi (DE-627)ELV006153240 (ELSEVIER)S0966-3274(21)00049-6 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.65 bkl Ladowski, Joseph M. verfasserin aut Aspects of histocompatibility testing in xenotransplantation 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation. Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation Houp, Julie verfasserin aut Hauptfeld-Dolejsek, Vera verfasserin aut Javed, Mariyam verfasserin aut Hara, Hidetaka verfasserin aut Cooper, David K.C. verfasserin aut Enthalten in Transplant immunology Amsterdam [u.a.] : Elsevier, 1993 67 Online-Ressource (DE-627)324489110 (DE-600)2027651-5 (DE-576)26442414X 1878-5492 nnns volume:67 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie 44.65 Chirurgie AR 67
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authorswithroles_txt_mv	Ladowski, Joseph M. @@aut@@ Houp, Julie @@aut@@ Hauptfeld-Dolejsek, Vera @@aut@@ Javed, Mariyam @@aut@@ Hara, Hidetaka @@aut@@ Cooper, David K.C. @@aut@@
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author	Ladowski, Joseph M.
spellingShingle	Ladowski, Joseph M. ddc 610 bkl 44.45 bkl 44.65 misc Histocompatibility misc Human leukocyte antigens misc Major histocompatibility complex misc Swine leukocyte antigens misc Xenotransplantation Aspects of histocompatibility testing in xenotransplantation
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topic_title	610 DE-600 44.45 bkl 44.65 bkl Aspects of histocompatibility testing in xenotransplantation Histocompatibility Human leukocyte antigens Major histocompatibility complex Swine leukocyte antigens Xenotransplantation
topic	ddc 610 bkl 44.45 bkl 44.65 misc Histocompatibility misc Human leukocyte antigens misc Major histocompatibility complex misc Swine leukocyte antigens misc Xenotransplantation
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title	Aspects of histocompatibility testing in xenotransplantation
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title_full	Aspects of histocompatibility testing in xenotransplantation
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author_browse	Ladowski, Joseph M. Houp, Julie Hauptfeld-Dolejsek, Vera Javed, Mariyam Hara, Hidetaka Cooper, David K.C.
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title_sort	aspects of histocompatibility testing in xenotransplantation
title_auth	Aspects of histocompatibility testing in xenotransplantation
abstract	Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation.
abstractGer	Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation.
abstract_unstemmed	Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering have led to the development of a pig lacking the three known glycan xenoantigens (triple-knockout [TKO] pigs). A significant number of human sera demonstrate no antibody binding to TKO pig cells. As a result of the TKO pig's low antigen expression, survival of life-supporting pig organs in immunosuppressed nonhuman primates has significantly increased, and hope has been renewed for clinical trials of xenotransplantation.
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title_short	Aspects of histocompatibility testing in xenotransplantation
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up_date	2024-07-06T20:24:21.536Z
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Aspects of histocompatibility testing in xenotransplantation

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