Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia

Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vanessa Fiorentino, Teresa [verfasserIn] Miceli, Sofia [verfasserIn] Succurro, Elena [verfasserIn] Sciacqua, Angela [verfasserIn] Andreozzi, Francesco [verfasserIn] Sesti, Giorgio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics

Übergeordnetes Werk:	Enthalten in: Diabetes research and clinical practice - Amsterdam [u.a.] : Elsevier Science, 1985, 177
Übergeordnetes Werk:	volume:177

DOI / URN:	10.1016/j.diabres.2021.108883

Katalog-ID:	ELV006382142

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024	7		\|a 10.1016/j.diabres.2021.108883 \|2 doi
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100	1		\|a Vanessa Fiorentino, Teresa \|e verfasserin \|4 aut
245	1	0	\|a Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
264		1	\|c 2021
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE.
650		4	\|a Prediabetes
650		4	\|a Impaired fasting glucose
650		4	\|a Impaired glucose tolerance
650		4	\|a 1h post-load glucose
650		4	\|a Myocardial energetic efficiency
650		4	\|a Cardiovascular disease
650		4	\|a Cardiac energetics
700	1		\|a Miceli, Sofia \|e verfasserin \|4 aut
700	1		\|a Succurro, Elena \|e verfasserin \|4 aut
700	1		\|a Sciacqua, Angela \|e verfasserin \|4 aut
700	1		\|a Andreozzi, Francesco \|e verfasserin \|4 aut
700	1		\|a Sesti, Giorgio \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Diabetes research and clinical practice \|d Amsterdam [u.a.] : Elsevier Science, 1985 \|g 177 \|h Online-Ressource \|w (DE-627)320440907 \|w (DE-600)2004910-9 \|w (DE-576)267761813 \|x 1872-8227 \|7 nnns
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912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.89 \|j Endokrinologie
951			\|a AR
952			\|d 177

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publishDate	2021
allfields	10.1016/j.diabres.2021.108883 doi (DE-627)ELV006382142 (ELSEVIER)S0168-8227(21)00243-6 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Vanessa Fiorentino, Teresa verfasserin aut Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE. Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics Miceli, Sofia verfasserin aut Succurro, Elena verfasserin aut Sciacqua, Angela verfasserin aut Andreozzi, Francesco verfasserin aut Sesti, Giorgio verfasserin aut Enthalten in Diabetes research and clinical practice Amsterdam [u.a.] : Elsevier Science, 1985 177 Online-Ressource (DE-627)320440907 (DE-600)2004910-9 (DE-576)267761813 1872-8227 nnns volume:177 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 177
spelling	10.1016/j.diabres.2021.108883 doi (DE-627)ELV006382142 (ELSEVIER)S0168-8227(21)00243-6 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Vanessa Fiorentino, Teresa verfasserin aut Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE. Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics Miceli, Sofia verfasserin aut Succurro, Elena verfasserin aut Sciacqua, Angela verfasserin aut Andreozzi, Francesco verfasserin aut Sesti, Giorgio verfasserin aut Enthalten in Diabetes research and clinical practice Amsterdam [u.a.] : Elsevier Science, 1985 177 Online-Ressource (DE-627)320440907 (DE-600)2004910-9 (DE-576)267761813 1872-8227 nnns volume:177 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 177
allfields_unstemmed	10.1016/j.diabres.2021.108883 doi (DE-627)ELV006382142 (ELSEVIER)S0168-8227(21)00243-6 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Vanessa Fiorentino, Teresa verfasserin aut Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE. Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics Miceli, Sofia verfasserin aut Succurro, Elena verfasserin aut Sciacqua, Angela verfasserin aut Andreozzi, Francesco verfasserin aut Sesti, Giorgio verfasserin aut Enthalten in Diabetes research and clinical practice Amsterdam [u.a.] : Elsevier Science, 1985 177 Online-Ressource (DE-627)320440907 (DE-600)2004910-9 (DE-576)267761813 1872-8227 nnns volume:177 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 177
allfieldsGer	10.1016/j.diabres.2021.108883 doi (DE-627)ELV006382142 (ELSEVIER)S0168-8227(21)00243-6 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Vanessa Fiorentino, Teresa verfasserin aut Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE. Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics Miceli, Sofia verfasserin aut Succurro, Elena verfasserin aut Sciacqua, Angela verfasserin aut Andreozzi, Francesco verfasserin aut Sesti, Giorgio verfasserin aut Enthalten in Diabetes research and clinical practice Amsterdam [u.a.] : Elsevier Science, 1985 177 Online-Ressource (DE-627)320440907 (DE-600)2004910-9 (DE-576)267761813 1872-8227 nnns volume:177 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 177
allfieldsSound	10.1016/j.diabres.2021.108883 doi (DE-627)ELV006382142 (ELSEVIER)S0168-8227(21)00243-6 DE-627 ger DE-627 rda eng 610 DE-600 44.89 bkl Vanessa Fiorentino, Teresa verfasserin aut Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE. Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics Miceli, Sofia verfasserin aut Succurro, Elena verfasserin aut Sciacqua, Angela verfasserin aut Andreozzi, Francesco verfasserin aut Sesti, Giorgio verfasserin aut Enthalten in Diabetes research and clinical practice Amsterdam [u.a.] : Elsevier Science, 1985 177 Online-Ressource (DE-627)320440907 (DE-600)2004910-9 (DE-576)267761813 1872-8227 nnns volume:177 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.89 Endokrinologie AR 177
language	English
source	Enthalten in Diabetes research and clinical practice 177 volume:177
sourceStr	Enthalten in Diabetes research and clinical practice 177 volume:177
format_phy_str_mv	Article
bklname	Endokrinologie
institution	findex.gbv.de
topic_facet	Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics
dewey-raw	610
isfreeaccess_bool	false
container_title	Diabetes research and clinical practice
authorswithroles_txt_mv	Vanessa Fiorentino, Teresa @@aut@@ Miceli, Sofia @@aut@@ Succurro, Elena @@aut@@ Sciacqua, Angela @@aut@@ Andreozzi, Francesco @@aut@@ Sesti, Giorgio @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	320440907
dewey-sort	3610
id	ELV006382142
language_de	englisch
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author	Vanessa Fiorentino, Teresa
spellingShingle	Vanessa Fiorentino, Teresa ddc 610 bkl 44.89 misc Prediabetes misc Impaired fasting glucose misc Impaired glucose tolerance misc 1h post-load glucose misc Myocardial energetic efficiency misc Cardiovascular disease misc Cardiac energetics Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
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topic_title	610 DE-600 44.89 bkl Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia Prediabetes Impaired fasting glucose Impaired glucose tolerance 1h post-load glucose Myocardial energetic efficiency Cardiovascular disease Cardiac energetics
topic	ddc 610 bkl 44.89 misc Prediabetes misc Impaired fasting glucose misc Impaired glucose tolerance misc 1h post-load glucose misc Myocardial energetic efficiency misc Cardiovascular disease misc Cardiac energetics
topic_unstemmed	ddc 610 bkl 44.89 misc Prediabetes misc Impaired fasting glucose misc Impaired glucose tolerance misc 1h post-load glucose misc Myocardial energetic efficiency misc Cardiovascular disease misc Cardiac energetics
topic_browse	ddc 610 bkl 44.89 misc Prediabetes misc Impaired fasting glucose misc Impaired glucose tolerance misc 1h post-load glucose misc Myocardial energetic efficiency misc Cardiovascular disease misc Cardiac energetics
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title	Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
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title_full	Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
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journal	Diabetes research and clinical practice
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author_browse	Vanessa Fiorentino, Teresa Miceli, Sofia Succurro, Elena Sciacqua, Angela Andreozzi, Francesco Sesti, Giorgio
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author-letter	Vanessa Fiorentino, Teresa
doi_str_mv	10.1016/j.diabres.2021.108883
dewey-full	610
author2-role	verfasserin
title_sort	depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
title_auth	Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
abstract	Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE.
abstractGer	Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE.
abstract_unstemmed	Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE.Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403).Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE.Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE.
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title_short	Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia
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author2	Miceli, Sofia Succurro, Elena Sciacqua, Angela Andreozzi, Francesco Sesti, Giorgio
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up_date	2024-07-06T21:11:23.514Z
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Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia

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