Involvement of dopamine D

The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal mo...
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Gespeichert in:

Autor*in:	Raupp-Barcaro, Inara Fernanda Misiuta [verfasserIn] da Silva Dias, Isabella Caroline [verfasserIn] Meyer, Erika [verfasserIn] Vieira, Jeane Cristina Fonseca [verfasserIn] da Silva Pereira, Giovana [verfasserIn] Petkowicz, Arthur Ribeiro [verfasserIn] de Oliveira, Rúbia Maria Weffort [verfasserIn] Andreatini, Roberto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Amantadine Antidepressant Glutamate Catecholamines Neurogenesis

Übergeordnetes Werk:	Enthalten in: Behavioural brain research - Amsterdam : Elsevier, 1980, 413
Übergeordnetes Werk:	volume:413

DOI / URN:	10.1016/j.bbr.2021.113443

Katalog-ID:	ELV006437532

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520			\|a The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis.
650		4	\|a Amantadine
650		4	\|a Antidepressant
650		4	\|a Glutamate
650		4	\|a Catecholamines
650		4	\|a Neurogenesis
700	1		\|a da Silva Dias, Isabella Caroline \|e verfasserin \|0 (orcid)0000-0001-9915-6862 \|4 aut
700	1		\|a Meyer, Erika \|e verfasserin \|0 (orcid)0000-0002-8425-6358 \|4 aut
700	1		\|a Vieira, Jeane Cristina Fonseca \|e verfasserin \|0 (orcid)0000-0002-3643-1019 \|4 aut
700	1		\|a da Silva Pereira, Giovana \|e verfasserin \|0 (orcid)0000-0002-6952-4318 \|4 aut
700	1		\|a Petkowicz, Arthur Ribeiro \|e verfasserin \|4 aut
700	1		\|a de Oliveira, Rúbia Maria Weffort \|e verfasserin \|4 aut
700	1		\|a Andreatini, Roberto \|e verfasserin \|0 (orcid)0000-0002-8661-9132 \|4 aut
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936	b	k	\|a 44.90 \|j Neurologie
951			\|a AR
952			\|d 413

Indexfelder

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publishDate	2021
allfields	10.1016/j.bbr.2021.113443 doi (DE-627)ELV006437532 (ELSEVIER)S0166-4328(21)00331-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Raupp-Barcaro, Inara Fernanda Misiuta verfasserin aut Involvement of dopamine D 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis. Amantadine Antidepressant Glutamate Catecholamines Neurogenesis da Silva Dias, Isabella Caroline verfasserin (orcid)0000-0001-9915-6862 aut Meyer, Erika verfasserin (orcid)0000-0002-8425-6358 aut Vieira, Jeane Cristina Fonseca verfasserin (orcid)0000-0002-3643-1019 aut da Silva Pereira, Giovana verfasserin (orcid)0000-0002-6952-4318 aut Petkowicz, Arthur Ribeiro verfasserin aut de Oliveira, Rúbia Maria Weffort verfasserin aut Andreatini, Roberto verfasserin (orcid)0000-0002-8661-9132 aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 413 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:413 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 413
spelling	10.1016/j.bbr.2021.113443 doi (DE-627)ELV006437532 (ELSEVIER)S0166-4328(21)00331-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Raupp-Barcaro, Inara Fernanda Misiuta verfasserin aut Involvement of dopamine D 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis. Amantadine Antidepressant Glutamate Catecholamines Neurogenesis da Silva Dias, Isabella Caroline verfasserin (orcid)0000-0001-9915-6862 aut Meyer, Erika verfasserin (orcid)0000-0002-8425-6358 aut Vieira, Jeane Cristina Fonseca verfasserin (orcid)0000-0002-3643-1019 aut da Silva Pereira, Giovana verfasserin (orcid)0000-0002-6952-4318 aut Petkowicz, Arthur Ribeiro verfasserin aut de Oliveira, Rúbia Maria Weffort verfasserin aut Andreatini, Roberto verfasserin (orcid)0000-0002-8661-9132 aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 413 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:413 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 413
allfields_unstemmed	10.1016/j.bbr.2021.113443 doi (DE-627)ELV006437532 (ELSEVIER)S0166-4328(21)00331-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Raupp-Barcaro, Inara Fernanda Misiuta verfasserin aut Involvement of dopamine D 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis. Amantadine Antidepressant Glutamate Catecholamines Neurogenesis da Silva Dias, Isabella Caroline verfasserin (orcid)0000-0001-9915-6862 aut Meyer, Erika verfasserin (orcid)0000-0002-8425-6358 aut Vieira, Jeane Cristina Fonseca verfasserin (orcid)0000-0002-3643-1019 aut da Silva Pereira, Giovana verfasserin (orcid)0000-0002-6952-4318 aut Petkowicz, Arthur Ribeiro verfasserin aut de Oliveira, Rúbia Maria Weffort verfasserin aut Andreatini, Roberto verfasserin (orcid)0000-0002-8661-9132 aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 413 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:413 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 413
allfieldsGer	10.1016/j.bbr.2021.113443 doi (DE-627)ELV006437532 (ELSEVIER)S0166-4328(21)00331-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Raupp-Barcaro, Inara Fernanda Misiuta verfasserin aut Involvement of dopamine D 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis. Amantadine Antidepressant Glutamate Catecholamines Neurogenesis da Silva Dias, Isabella Caroline verfasserin (orcid)0000-0001-9915-6862 aut Meyer, Erika verfasserin (orcid)0000-0002-8425-6358 aut Vieira, Jeane Cristina Fonseca verfasserin (orcid)0000-0002-3643-1019 aut da Silva Pereira, Giovana verfasserin (orcid)0000-0002-6952-4318 aut Petkowicz, Arthur Ribeiro verfasserin aut de Oliveira, Rúbia Maria Weffort verfasserin aut Andreatini, Roberto verfasserin (orcid)0000-0002-8661-9132 aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 413 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:413 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 413
allfieldsSound	10.1016/j.bbr.2021.113443 doi (DE-627)ELV006437532 (ELSEVIER)S0166-4328(21)00331-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Raupp-Barcaro, Inara Fernanda Misiuta verfasserin aut Involvement of dopamine D 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis. Amantadine Antidepressant Glutamate Catecholamines Neurogenesis da Silva Dias, Isabella Caroline verfasserin (orcid)0000-0001-9915-6862 aut Meyer, Erika verfasserin (orcid)0000-0002-8425-6358 aut Vieira, Jeane Cristina Fonseca verfasserin (orcid)0000-0002-3643-1019 aut da Silva Pereira, Giovana verfasserin (orcid)0000-0002-6952-4318 aut Petkowicz, Arthur Ribeiro verfasserin aut de Oliveira, Rúbia Maria Weffort verfasserin aut Andreatini, Roberto verfasserin (orcid)0000-0002-8661-9132 aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 413 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:413 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 413
language	English
source	Enthalten in Behavioural brain research 413 volume:413
sourceStr	Enthalten in Behavioural brain research 413 volume:413
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Amantadine Antidepressant Glutamate Catecholamines Neurogenesis
dewey-raw	610
isfreeaccess_bool	false
container_title	Behavioural brain research
authorswithroles_txt_mv	Raupp-Barcaro, Inara Fernanda Misiuta @@aut@@ da Silva Dias, Isabella Caroline @@aut@@ Meyer, Erika @@aut@@ Vieira, Jeane Cristina Fonseca @@aut@@ da Silva Pereira, Giovana @@aut@@ Petkowicz, Arthur Ribeiro @@aut@@ de Oliveira, Rúbia Maria Weffort @@aut@@ Andreatini, Roberto @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	320512746
dewey-sort	3610
id	ELV006437532
language_de	englisch
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author	Raupp-Barcaro, Inara Fernanda Misiuta
spellingShingle	Raupp-Barcaro, Inara Fernanda Misiuta ddc 610 bkl 44.90 misc Amantadine misc Antidepressant misc Glutamate misc Catecholamines misc Neurogenesis Involvement of dopamine D
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topic_title	610 DE-600 44.90 bkl Involvement of dopamine D Amantadine Antidepressant Glutamate Catecholamines Neurogenesis
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title	Involvement of dopamine D
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title_full	Involvement of dopamine D
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author_browse	Raupp-Barcaro, Inara Fernanda Misiuta da Silva Dias, Isabella Caroline Meyer, Erika Vieira, Jeane Cristina Fonseca da Silva Pereira, Giovana Petkowicz, Arthur Ribeiro de Oliveira, Rúbia Maria Weffort Andreatini, Roberto
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title_sort	involvement of dopamine d
title_auth	Involvement of dopamine D
abstract	The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis.
abstractGer	The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis.
abstract_unstemmed	The present study investigated the pharmacological mechanisms of the antidepressant-like effects of amantadine in mice and their influence on hippocampal neurogenesis. To improve the translational validity of preclinical results, reproducibility across laboratories and replication in other animal models and species are crucial. Single amantadine administration at doses of 50 and 75 mg/kg resulted in antidepressant-like effects in mice in the tail suspension test (TST), reflected by an increase in immobility time. The effects of amantadine were seen at doses that did not alter locomotor activity. The tyrosine hydroxylase inhibitor α-methyl-ρ-tyrosine did not influence the anti-immobility effect of amantadine in the TST. Pretreatment with the α1 adrenergic receptor antagonist prazosin, β adrenergic receptor antagonist propranolol, α2 adrenergic receptor antagonist yohimbine, and α2 adrenergic receptor agonist clonidine did not alter the antidepressant-like effect of amantadine. However, amantadine’s effect was blocked by the dopamine D2 receptor antagonist haloperidol and glutamate receptor agonist N-methyl-D-aspartate (NMDA). Repeated amantadine administration (50 mg/kg) also exerted an antidepressant-like effect, paralleled by an increase in hippocampal neurogenesis. The present results demonstrate that the antidepressant-like effects of amantadine may be mediated by its actions on D2 and NMDA receptors and likely involve hippocampal neurogenesis.
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title_short	Involvement of dopamine D
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author2	da Silva Dias, Isabella Caroline Meyer, Erika Vieira, Jeane Cristina Fonseca da Silva Pereira, Giovana Petkowicz, Arthur Ribeiro de Oliveira, Rúbia Maria Weffort Andreatini, Roberto
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up_date	2024-07-06T21:22:30.949Z
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score	7.399315

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