Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced fun...
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Autor*in:	Madsen, Martin K. [verfasserIn] Stenbæk, Dea S. [verfasserIn] Arvidsson, Albin [verfasserIn] Armand, Sophia [verfasserIn] Marstrand-Joergensen, Maja R. [verfasserIn] Johansen, Sys S. [verfasserIn] Linnet, Kristian [verfasserIn] Ozenne, Brice [verfasserIn] Knudsen, Gitte M. [verfasserIn] Fisher, Patrick M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI

Übergeordnetes Werk:	Enthalten in: European neuropsychopharmacology - Amsterdam : Elsevier, 1990, 50, Seite 121-132
Übergeordnetes Werk:	volume:50 ; pages:121-132

DOI / URN:	10.1016/j.euroneuro.2021.06.001

Katalog-ID:	ELV006496040

Internformat


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245	1	0	\|a Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
264		1	\|c 2021
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520			\|a The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness.
650		4	\|a Psilocybin
650		4	\|a Psilocin
650		4	\|a Psychedelic
650		4	\|a Experience
650		4	\|a Functional connectivity
650		4	\|a fMRI
700	1		\|a Stenbæk, Dea S. \|e verfasserin \|4 aut
700	1		\|a Arvidsson, Albin \|e verfasserin \|4 aut
700	1		\|a Armand, Sophia \|e verfasserin \|4 aut
700	1		\|a Marstrand-Joergensen, Maja R. \|e verfasserin \|4 aut
700	1		\|a Johansen, Sys S. \|e verfasserin \|4 aut
700	1		\|a Linnet, Kristian \|e verfasserin \|4 aut
700	1		\|a Ozenne, Brice \|e verfasserin \|4 aut
700	1		\|a Knudsen, Gitte M. \|e verfasserin \|4 aut
700	1		\|a Fisher, Patrick M. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t European neuropsychopharmacology \|d Amsterdam : Elsevier, 1990 \|g 50, Seite 121-132 \|h Online-Ressource \|w (DE-627)320594025 \|w (DE-600)2019305-1 \|w (DE-576)266224334 \|x 1873-7862 \|7 nnns
773	1	8	\|g volume:50 \|g pages:121-132
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936	b	k	\|a 44.38 \|j Pharmakologie
936	b	k	\|a 44.90 \|j Neurologie
951			\|a AR
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publishDate	2021
allfields	10.1016/j.euroneuro.2021.06.001 doi (DE-627)ELV006496040 (ELSEVIER)S0924-977X(21)00250-9 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Madsen, Martin K. verfasserin aut Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness. Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI Stenbæk, Dea S. verfasserin aut Arvidsson, Albin verfasserin aut Armand, Sophia verfasserin aut Marstrand-Joergensen, Maja R. verfasserin aut Johansen, Sys S. verfasserin aut Linnet, Kristian verfasserin aut Ozenne, Brice verfasserin aut Knudsen, Gitte M. verfasserin aut Fisher, Patrick M. verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 50, Seite 121-132 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:50 pages:121-132 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 50 121-132
spelling	10.1016/j.euroneuro.2021.06.001 doi (DE-627)ELV006496040 (ELSEVIER)S0924-977X(21)00250-9 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Madsen, Martin K. verfasserin aut Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness. Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI Stenbæk, Dea S. verfasserin aut Arvidsson, Albin verfasserin aut Armand, Sophia verfasserin aut Marstrand-Joergensen, Maja R. verfasserin aut Johansen, Sys S. verfasserin aut Linnet, Kristian verfasserin aut Ozenne, Brice verfasserin aut Knudsen, Gitte M. verfasserin aut Fisher, Patrick M. verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 50, Seite 121-132 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:50 pages:121-132 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 50 121-132
allfields_unstemmed	10.1016/j.euroneuro.2021.06.001 doi (DE-627)ELV006496040 (ELSEVIER)S0924-977X(21)00250-9 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Madsen, Martin K. verfasserin aut Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness. Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI Stenbæk, Dea S. verfasserin aut Arvidsson, Albin verfasserin aut Armand, Sophia verfasserin aut Marstrand-Joergensen, Maja R. verfasserin aut Johansen, Sys S. verfasserin aut Linnet, Kristian verfasserin aut Ozenne, Brice verfasserin aut Knudsen, Gitte M. verfasserin aut Fisher, Patrick M. verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 50, Seite 121-132 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:50 pages:121-132 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 50 121-132
allfieldsGer	10.1016/j.euroneuro.2021.06.001 doi (DE-627)ELV006496040 (ELSEVIER)S0924-977X(21)00250-9 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Madsen, Martin K. verfasserin aut Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness. Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI Stenbæk, Dea S. verfasserin aut Arvidsson, Albin verfasserin aut Armand, Sophia verfasserin aut Marstrand-Joergensen, Maja R. verfasserin aut Johansen, Sys S. verfasserin aut Linnet, Kristian verfasserin aut Ozenne, Brice verfasserin aut Knudsen, Gitte M. verfasserin aut Fisher, Patrick M. verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 50, Seite 121-132 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:50 pages:121-132 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 50 121-132
allfieldsSound	10.1016/j.euroneuro.2021.06.001 doi (DE-627)ELV006496040 (ELSEVIER)S0924-977X(21)00250-9 DE-627 ger DE-627 rda eng 150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Madsen, Martin K. verfasserin aut Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness. Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI Stenbæk, Dea S. verfasserin aut Arvidsson, Albin verfasserin aut Armand, Sophia verfasserin aut Marstrand-Joergensen, Maja R. verfasserin aut Johansen, Sys S. verfasserin aut Linnet, Kristian verfasserin aut Ozenne, Brice verfasserin aut Knudsen, Gitte M. verfasserin aut Fisher, Patrick M. verfasserin aut Enthalten in European neuropsychopharmacology Amsterdam : Elsevier, 1990 50, Seite 121-132 Online-Ressource (DE-627)320594025 (DE-600)2019305-1 (DE-576)266224334 1873-7862 nnns volume:50 pages:121-132 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.38 Pharmakologie 44.90 Neurologie AR 50 121-132
language	English
source	Enthalten in European neuropsychopharmacology 50, Seite 121-132 volume:50 pages:121-132
sourceStr	Enthalten in European neuropsychopharmacology 50, Seite 121-132 volume:50 pages:121-132
format_phy_str_mv	Article
bklname	Pharmakologie Neurologie
institution	findex.gbv.de
topic_facet	Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI
dewey-raw	150
isfreeaccess_bool	false
container_title	European neuropsychopharmacology
authorswithroles_txt_mv	Madsen, Martin K. @@aut@@ Stenbæk, Dea S. @@aut@@ Arvidsson, Albin @@aut@@ Armand, Sophia @@aut@@ Marstrand-Joergensen, Maja R. @@aut@@ Johansen, Sys S. @@aut@@ Linnet, Kristian @@aut@@ Ozenne, Brice @@aut@@ Knudsen, Gitte M. @@aut@@ Fisher, Patrick M. @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	320594025
dewey-sort	3150
id	ELV006496040
language_de	englisch
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author	Madsen, Martin K.
spellingShingle	Madsen, Martin K. ddc 150 fid PHARM bkl 44.38 bkl 44.90 misc Psilocybin misc Psilocin misc Psychedelic misc Experience misc Functional connectivity misc fMRI Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
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topic_title	150 610 DE-600 PHARM DE-84 fid 44.38 bkl 44.90 bkl Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience Psilocybin Psilocin Psychedelic Experience Functional connectivity fMRI
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title	Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
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title_full	Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
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author_browse	Madsen, Martin K. Stenbæk, Dea S. Arvidsson, Albin Armand, Sophia Marstrand-Joergensen, Maja R. Johansen, Sys S. Linnet, Kristian Ozenne, Brice Knudsen, Gitte M. Fisher, Patrick M.
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title_sort	psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
title_auth	Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
abstract	The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness.
abstractGer	The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness.
abstract_unstemmed	The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., reduced integrity) and increased FC between networks (i.e., reduced segregation). Reduced integrity of the default mode network (DMN) is proposed to play a particularly prominent role in psychedelic phenomenology, including perceived ego-dissolution. Here, we investigate the effects of a psychoactive peroral dose of psilocybin (0.2–0.3 mg/kg) on plasma psilocin level (PPL), subjective drug intensity (SDI) and their association in fifteen healthy individuals. We further evaluate associations between these measures and resting-state FC, measured with functional magnetic resonance imaging, acquired over the course of five hours after psilocybin administration. We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. Our findings provide novel insight into the neurobiological mechanisms underlying profound perceptual experiences evoked by this emerging transnosological therapeutic and implicate the expression of network integrity and segregation in the psychedelic experience and consciousness.
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title_short	Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience
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author2	Stenbæk, Dea S. Arvidsson, Albin Armand, Sophia Marstrand-Joergensen, Maja R. Johansen, Sys S. Linnet, Kristian Ozenne, Brice Knudsen, Gitte M. Fisher, Patrick M.
author2Str	Stenbæk, Dea S. Arvidsson, Albin Armand, Sophia Marstrand-Joergensen, Maja R. Johansen, Sys S. Linnet, Kristian Ozenne, Brice Knudsen, Gitte M. Fisher, Patrick M.
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We show that PPL and SDI correlate negatively with measures of network integrity (including DMN) and segregation, both spatially constrained and unconstrained. We also find that the executive control network and dorsal attention network desegregate, increasing connectivity with other networks and throughout the brain as a function of PPL and SDI. These findings provide direct evidence that psilocin critically shapes the time course and magnitude of changes in the cerebral functional architecture and subjective experience following psilocybin administration. 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Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

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