Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3
Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Krings, James G. [verfasserIn] Goss, Charles W. [verfasserIn] Lew, Daphne [verfasserIn] Samant, Maanasi [verfasserIn] McGregor, Mary Clare [verfasserIn] Boomer, Jonathan [verfasserIn] Bacharier, Leonard B. [verfasserIn] Sheshadri, Ajay [verfasserIn] Hall, Chase [verfasserIn] Brownell, Joshua [verfasserIn] Schechtman, Ken B. [verfasserIn] Peterson, Samuel [verfasserIn] McEleney, Stephen [verfasserIn] Mauger, David T. [verfasserIn] Fahy, John V. [verfasserIn] Fain, Sean B. [verfasserIn] Denlinger, Loren C. [verfasserIn] Israel, Elliot [verfasserIn] Washko, George [verfasserIn] Hoffman, Eric [verfasserIn] Wenzel, Sally E. [verfasserIn] Castro, Mario [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: The journal of allergy and clinical immunology - Amsterdam [u.a.] : Elsevier, 1971, 148, Seite 752-762 |
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| Übergeordnetes Werk: |
volume:148 ; pages:752-762 |
| DOI / URN: |
10.1016/j.jaci.2021.01.029 |
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| Katalog-ID: |
ELV006557147 |
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| 024 | 7 | |a 10.1016/j.jaci.2021.01.029 |2 doi | |
| 035 | |a (DE-627)ELV006557147 | ||
| 035 | |a (ELSEVIER)S0091-6749(21)00176-7 | ||
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| 100 | 1 | |a Krings, James G. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
| 264 | 1 | |c 2021 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. | ||
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a severe asthma | |
| 650 | 4 | |a CT imaging | |
| 650 | 4 | |a asthma morbidity | |
| 650 | 4 | |a asthma exacerbations | |
| 650 | 4 | |a longitudinal | |
| 650 | 4 | |a lung function | |
| 700 | 1 | |a Goss, Charles W. |e verfasserin |4 aut | |
| 700 | 1 | |a Lew, Daphne |e verfasserin |4 aut | |
| 700 | 1 | |a Samant, Maanasi |e verfasserin |4 aut | |
| 700 | 1 | |a McGregor, Mary Clare |e verfasserin |4 aut | |
| 700 | 1 | |a Boomer, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Bacharier, Leonard B. |e verfasserin |4 aut | |
| 700 | 1 | |a Sheshadri, Ajay |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Chase |e verfasserin |4 aut | |
| 700 | 1 | |a Brownell, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a Schechtman, Ken B. |e verfasserin |4 aut | |
| 700 | 1 | |a Peterson, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a McEleney, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Mauger, David T. |e verfasserin |4 aut | |
| 700 | 1 | |a Fahy, John V. |e verfasserin |4 aut | |
| 700 | 1 | |a Fain, Sean B. |e verfasserin |4 aut | |
| 700 | 1 | |a Denlinger, Loren C. |e verfasserin |4 aut | |
| 700 | 1 | |a Israel, Elliot |e verfasserin |4 aut | |
| 700 | 1 | |a Washko, George |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Wenzel, Sally E. |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Mario |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of allergy and clinical immunology |d Amsterdam [u.a.] : Elsevier, 1971 |g 148, Seite 752-762 |h Online-Ressource |w (DE-627)32045553X |w (DE-600)2006613-2 |w (DE-576)094478864 |x 1097-6825 |7 nnns |
| 773 | 1 | 8 | |g volume:148 |g pages:752-762 |
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| 936 | b | k | |a 44.45 |j Immunologie |
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10.1016/j.jaci.2021.01.029 doi (DE-627)ELV006557147 (ELSEVIER)S0091-6749(21)00176-7 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Krings, James G. verfasserin aut Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function Goss, Charles W. verfasserin aut Lew, Daphne verfasserin aut Samant, Maanasi verfasserin aut McGregor, Mary Clare verfasserin aut Boomer, Jonathan verfasserin aut Bacharier, Leonard B. verfasserin aut Sheshadri, Ajay verfasserin aut Hall, Chase verfasserin aut Brownell, Joshua verfasserin aut Schechtman, Ken B. verfasserin aut Peterson, Samuel verfasserin aut McEleney, Stephen verfasserin aut Mauger, David T. verfasserin aut Fahy, John V. verfasserin aut Fain, Sean B. verfasserin aut Denlinger, Loren C. verfasserin aut Israel, Elliot verfasserin aut Washko, George verfasserin aut Hoffman, Eric verfasserin aut Wenzel, Sally E. verfasserin aut Castro, Mario verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 148, Seite 752-762 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:148 pages:752-762 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 148 752-762 |
| spelling |
10.1016/j.jaci.2021.01.029 doi (DE-627)ELV006557147 (ELSEVIER)S0091-6749(21)00176-7 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Krings, James G. verfasserin aut Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function Goss, Charles W. verfasserin aut Lew, Daphne verfasserin aut Samant, Maanasi verfasserin aut McGregor, Mary Clare verfasserin aut Boomer, Jonathan verfasserin aut Bacharier, Leonard B. verfasserin aut Sheshadri, Ajay verfasserin aut Hall, Chase verfasserin aut Brownell, Joshua verfasserin aut Schechtman, Ken B. verfasserin aut Peterson, Samuel verfasserin aut McEleney, Stephen verfasserin aut Mauger, David T. verfasserin aut Fahy, John V. verfasserin aut Fain, Sean B. verfasserin aut Denlinger, Loren C. verfasserin aut Israel, Elliot verfasserin aut Washko, George verfasserin aut Hoffman, Eric verfasserin aut Wenzel, Sally E. verfasserin aut Castro, Mario verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 148, Seite 752-762 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:148 pages:752-762 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 148 752-762 |
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10.1016/j.jaci.2021.01.029 doi (DE-627)ELV006557147 (ELSEVIER)S0091-6749(21)00176-7 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Krings, James G. verfasserin aut Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function Goss, Charles W. verfasserin aut Lew, Daphne verfasserin aut Samant, Maanasi verfasserin aut McGregor, Mary Clare verfasserin aut Boomer, Jonathan verfasserin aut Bacharier, Leonard B. verfasserin aut Sheshadri, Ajay verfasserin aut Hall, Chase verfasserin aut Brownell, Joshua verfasserin aut Schechtman, Ken B. verfasserin aut Peterson, Samuel verfasserin aut McEleney, Stephen verfasserin aut Mauger, David T. verfasserin aut Fahy, John V. verfasserin aut Fain, Sean B. verfasserin aut Denlinger, Loren C. verfasserin aut Israel, Elliot verfasserin aut Washko, George verfasserin aut Hoffman, Eric verfasserin aut Wenzel, Sally E. verfasserin aut Castro, Mario verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 148, Seite 752-762 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:148 pages:752-762 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 148 752-762 |
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10.1016/j.jaci.2021.01.029 doi (DE-627)ELV006557147 (ELSEVIER)S0091-6749(21)00176-7 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Krings, James G. verfasserin aut Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function Goss, Charles W. verfasserin aut Lew, Daphne verfasserin aut Samant, Maanasi verfasserin aut McGregor, Mary Clare verfasserin aut Boomer, Jonathan verfasserin aut Bacharier, Leonard B. verfasserin aut Sheshadri, Ajay verfasserin aut Hall, Chase verfasserin aut Brownell, Joshua verfasserin aut Schechtman, Ken B. verfasserin aut Peterson, Samuel verfasserin aut McEleney, Stephen verfasserin aut Mauger, David T. verfasserin aut Fahy, John V. verfasserin aut Fain, Sean B. verfasserin aut Denlinger, Loren C. verfasserin aut Israel, Elliot verfasserin aut Washko, George verfasserin aut Hoffman, Eric verfasserin aut Wenzel, Sally E. verfasserin aut Castro, Mario verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 148, Seite 752-762 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:148 pages:752-762 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 148 752-762 |
| allfieldsSound |
10.1016/j.jaci.2021.01.029 doi (DE-627)ELV006557147 (ELSEVIER)S0091-6749(21)00176-7 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Krings, James G. verfasserin aut Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function Goss, Charles W. verfasserin aut Lew, Daphne verfasserin aut Samant, Maanasi verfasserin aut McGregor, Mary Clare verfasserin aut Boomer, Jonathan verfasserin aut Bacharier, Leonard B. verfasserin aut Sheshadri, Ajay verfasserin aut Hall, Chase verfasserin aut Brownell, Joshua verfasserin aut Schechtman, Ken B. verfasserin aut Peterson, Samuel verfasserin aut McEleney, Stephen verfasserin aut Mauger, David T. verfasserin aut Fahy, John V. verfasserin aut Fain, Sean B. verfasserin aut Denlinger, Loren C. verfasserin aut Israel, Elliot verfasserin aut Washko, George verfasserin aut Hoffman, Eric verfasserin aut Wenzel, Sally E. verfasserin aut Castro, Mario verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 148, Seite 752-762 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:148 pages:752-762 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 148 752-762 |
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Enthalten in The journal of allergy and clinical immunology 148, Seite 752-762 volume:148 pages:752-762 |
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Krings, James G. @@aut@@ Goss, Charles W. @@aut@@ Lew, Daphne @@aut@@ Samant, Maanasi @@aut@@ McGregor, Mary Clare @@aut@@ Boomer, Jonathan @@aut@@ Bacharier, Leonard B. @@aut@@ Sheshadri, Ajay @@aut@@ Hall, Chase @@aut@@ Brownell, Joshua @@aut@@ Schechtman, Ken B. @@aut@@ Peterson, Samuel @@aut@@ McEleney, Stephen @@aut@@ Mauger, David T. @@aut@@ Fahy, John V. @@aut@@ Fain, Sean B. @@aut@@ Denlinger, Loren C. @@aut@@ Israel, Elliot @@aut@@ Washko, George @@aut@@ Hoffman, Eric @@aut@@ Wenzel, Sally E. @@aut@@ Castro, Mario @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV006557147</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524155911.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230505s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jaci.2021.01.029</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV006557147</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0091-6749(21)00176-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.45</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.78</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Krings, James G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Asthma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">severe asthma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CT imaging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">asthma morbidity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">asthma exacerbations</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">longitudinal</subfield></datafield><datafield tag="650" ind1=" " 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Krings, James G. |
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Krings, James G. ddc 610 bkl 44.45 bkl 44.78 misc Asthma misc severe asthma misc CT imaging misc asthma morbidity misc asthma exacerbations misc longitudinal misc lung function Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
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610 DE-600 44.45 bkl 44.78 bkl Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 Asthma severe asthma CT imaging asthma morbidity asthma exacerbations longitudinal lung function |
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ddc 610 bkl 44.45 bkl 44.78 misc Asthma misc severe asthma misc CT imaging misc asthma morbidity misc asthma exacerbations misc longitudinal misc lung function |
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ddc 610 bkl 44.45 bkl 44.78 misc Asthma misc severe asthma misc CT imaging misc asthma morbidity misc asthma exacerbations misc longitudinal misc lung function |
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ddc 610 bkl 44.45 bkl 44.78 misc Asthma misc severe asthma misc CT imaging misc asthma morbidity misc asthma exacerbations misc longitudinal misc lung function |
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Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
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Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
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Krings, James G. |
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The journal of allergy and clinical immunology |
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Krings, James G. Goss, Charles W. Lew, Daphne Samant, Maanasi McGregor, Mary Clare Boomer, Jonathan Bacharier, Leonard B. Sheshadri, Ajay Hall, Chase Brownell, Joshua Schechtman, Ken B. Peterson, Samuel McEleney, Stephen Mauger, David T. Fahy, John V. Fain, Sean B. Denlinger, Loren C. Israel, Elliot Washko, George Hoffman, Eric Wenzel, Sally E. Castro, Mario |
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quantitative ct metrics are associated with longitudinal lung function decline and future asthma exacerbations: results from sarp-3 |
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Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
| abstract |
Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. |
| abstractGer |
Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. |
| abstract_unstemmed |
Background: Currently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.Objectives: We aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.Methods: We analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.Results: Greater baseline wall area percent (β = –0.15 [95% CI = –0.26 to –0.05]; P < .01), hyperinflation percent (β = –0.25 [95% CI = –0.41 to –0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = –9.14, [95% CI = –15.49 to –2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.Conclusions: Baseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations. |
| collection_details |
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| title_short |
Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3 |
| remote_bool |
true |
| author2 |
Goss, Charles W. Lew, Daphne Samant, Maanasi McGregor, Mary Clare Boomer, Jonathan Bacharier, Leonard B. Sheshadri, Ajay Hall, Chase Brownell, Joshua Schechtman, Ken B. Peterson, Samuel McEleney, Stephen Mauger, David T. Fahy, John V. Fain, Sean B. Denlinger, Loren C. Israel, Elliot Washko, George Hoffman, Eric Wenzel, Sally E. Castro, Mario |
| author2Str |
Goss, Charles W. Lew, Daphne Samant, Maanasi McGregor, Mary Clare Boomer, Jonathan Bacharier, Leonard B. Sheshadri, Ajay Hall, Chase Brownell, Joshua Schechtman, Ken B. Peterson, Samuel McEleney, Stephen Mauger, David T. Fahy, John V. Fain, Sean B. Denlinger, Loren C. Israel, Elliot Washko, George Hoffman, Eric Wenzel, Sally E. Castro, Mario |
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32045553X |
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c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1016/j.jaci.2021.01.029 |
| up_date |
2024-07-06T21:47:13.190Z |
| _version_ |
1803867844185686016 |
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| score |
7.4031916 |