Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Campanacci, Laura [verfasserIn] Bianchi, Giuseppe [verfasserIn] Cevolani, Luca [verfasserIn] Errani, Costantino [verfasserIn] Ciani, Giovanni [verfasserIn] Facchini, Giancarlo [verfasserIn] Spinnato, Paolo [verfasserIn] Tognù, Andrea [verfasserIn] Massari, Leo [verfasserIn] Cornelis, Francois H. [verfasserIn] Mosconi, Mario [verfasserIn] Screpis, Daniele [verfasserIn] Benazzo, Francesco [verfasserIn] Rossi, Barbara [verfasserIn] Bonicoli, Enrico [verfasserIn] Fazioli, Flavio [verfasserIn] Nicolosi, Mario [verfasserIn] Boffano, Michele [verfasserIn] Piana, Raimondo [verfasserIn] De Terlizzi, Francesca [verfasserIn] Cadossi, Matteo [verfasserIn] Donati, Davide Maria [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of surgical oncology - Burlington, Mass. : Harcourt, 1995, 47 |
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| Übergeordnetes Werk: |
volume:47 |
| DOI / URN: |
10.1016/j.ejso.2021.05.004 |
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ELV006606563 |
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| 245 | 1 | 0 | |a Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
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| 520 | |a Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. | ||
| 650 | 4 | |a Electrochemotherapy (ECT) | |
| 650 | 4 | |a Bone metastases | |
| 650 | 4 | |a Pain control | |
| 650 | 4 | |a Palliative care | |
| 650 | 4 | |a Metastatic bone disease (MBD) | |
| 700 | 1 | |a Bianchi, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Cevolani, Luca |e verfasserin |0 (orcid)0000-0002-3190-1034 |4 aut | |
| 700 | 1 | |a Errani, Costantino |e verfasserin |4 aut | |
| 700 | 1 | |a Ciani, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Facchini, Giancarlo |e verfasserin |0 (orcid)0000-0002-6739-7335 |4 aut | |
| 700 | 1 | |a Spinnato, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Tognù, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Massari, Leo |e verfasserin |4 aut | |
| 700 | 1 | |a Cornelis, Francois H. |e verfasserin |0 (orcid)0000-0002-1058-0884 |4 aut | |
| 700 | 1 | |a Mosconi, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Screpis, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Benazzo, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Bonicoli, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Fazioli, Flavio |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolosi, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Boffano, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Piana, Raimondo |e verfasserin |4 aut | |
| 700 | 1 | |a De Terlizzi, Francesca |e verfasserin |0 (orcid)0000-0002-2676-4549 |4 aut | |
| 700 | 1 | |a Cadossi, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Donati, Davide Maria |e verfasserin |0 (orcid)0000-0002-9170-0576 |4 aut | |
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10.1016/j.ejso.2021.05.004 doi (DE-627)ELV006606563 (ELSEVIER)S0748-7983(21)00480-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Campanacci, Laura verfasserin (orcid)0000-0002-4734-6741 aut Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) Bianchi, Giuseppe verfasserin aut Cevolani, Luca verfasserin (orcid)0000-0002-3190-1034 aut Errani, Costantino verfasserin aut Ciani, Giovanni verfasserin aut Facchini, Giancarlo verfasserin (orcid)0000-0002-6739-7335 aut Spinnato, Paolo verfasserin aut Tognù, Andrea verfasserin aut Massari, Leo verfasserin aut Cornelis, Francois H. verfasserin (orcid)0000-0002-1058-0884 aut Mosconi, Mario verfasserin aut Screpis, Daniele verfasserin aut Benazzo, Francesco verfasserin aut Rossi, Barbara verfasserin aut Bonicoli, Enrico verfasserin aut Fazioli, Flavio verfasserin aut Nicolosi, Mario verfasserin aut Boffano, Michele verfasserin aut Piana, Raimondo verfasserin aut De Terlizzi, Francesca verfasserin (orcid)0000-0002-2676-4549 aut Cadossi, Matteo verfasserin aut Donati, Davide Maria verfasserin (orcid)0000-0002-9170-0576 aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 47 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 47 |
| spelling |
10.1016/j.ejso.2021.05.004 doi (DE-627)ELV006606563 (ELSEVIER)S0748-7983(21)00480-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Campanacci, Laura verfasserin (orcid)0000-0002-4734-6741 aut Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) Bianchi, Giuseppe verfasserin aut Cevolani, Luca verfasserin (orcid)0000-0002-3190-1034 aut Errani, Costantino verfasserin aut Ciani, Giovanni verfasserin aut Facchini, Giancarlo verfasserin (orcid)0000-0002-6739-7335 aut Spinnato, Paolo verfasserin aut Tognù, Andrea verfasserin aut Massari, Leo verfasserin aut Cornelis, Francois H. verfasserin (orcid)0000-0002-1058-0884 aut Mosconi, Mario verfasserin aut Screpis, Daniele verfasserin aut Benazzo, Francesco verfasserin aut Rossi, Barbara verfasserin aut Bonicoli, Enrico verfasserin aut Fazioli, Flavio verfasserin aut Nicolosi, Mario verfasserin aut Boffano, Michele verfasserin aut Piana, Raimondo verfasserin aut De Terlizzi, Francesca verfasserin (orcid)0000-0002-2676-4549 aut Cadossi, Matteo verfasserin aut Donati, Davide Maria verfasserin (orcid)0000-0002-9170-0576 aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 47 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 47 |
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10.1016/j.ejso.2021.05.004 doi (DE-627)ELV006606563 (ELSEVIER)S0748-7983(21)00480-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Campanacci, Laura verfasserin (orcid)0000-0002-4734-6741 aut Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) Bianchi, Giuseppe verfasserin aut Cevolani, Luca verfasserin (orcid)0000-0002-3190-1034 aut Errani, Costantino verfasserin aut Ciani, Giovanni verfasserin aut Facchini, Giancarlo verfasserin (orcid)0000-0002-6739-7335 aut Spinnato, Paolo verfasserin aut Tognù, Andrea verfasserin aut Massari, Leo verfasserin aut Cornelis, Francois H. verfasserin (orcid)0000-0002-1058-0884 aut Mosconi, Mario verfasserin aut Screpis, Daniele verfasserin aut Benazzo, Francesco verfasserin aut Rossi, Barbara verfasserin aut Bonicoli, Enrico verfasserin aut Fazioli, Flavio verfasserin aut Nicolosi, Mario verfasserin aut Boffano, Michele verfasserin aut Piana, Raimondo verfasserin aut De Terlizzi, Francesca verfasserin (orcid)0000-0002-2676-4549 aut Cadossi, Matteo verfasserin aut Donati, Davide Maria verfasserin (orcid)0000-0002-9170-0576 aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 47 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 47 |
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10.1016/j.ejso.2021.05.004 doi (DE-627)ELV006606563 (ELSEVIER)S0748-7983(21)00480-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Campanacci, Laura verfasserin (orcid)0000-0002-4734-6741 aut Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) Bianchi, Giuseppe verfasserin aut Cevolani, Luca verfasserin (orcid)0000-0002-3190-1034 aut Errani, Costantino verfasserin aut Ciani, Giovanni verfasserin aut Facchini, Giancarlo verfasserin (orcid)0000-0002-6739-7335 aut Spinnato, Paolo verfasserin aut Tognù, Andrea verfasserin aut Massari, Leo verfasserin aut Cornelis, Francois H. verfasserin (orcid)0000-0002-1058-0884 aut Mosconi, Mario verfasserin aut Screpis, Daniele verfasserin aut Benazzo, Francesco verfasserin aut Rossi, Barbara verfasserin aut Bonicoli, Enrico verfasserin aut Fazioli, Flavio verfasserin aut Nicolosi, Mario verfasserin aut Boffano, Michele verfasserin aut Piana, Raimondo verfasserin aut De Terlizzi, Francesca verfasserin (orcid)0000-0002-2676-4549 aut Cadossi, Matteo verfasserin aut Donati, Davide Maria verfasserin (orcid)0000-0002-9170-0576 aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 47 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 47 |
| allfieldsSound |
10.1016/j.ejso.2021.05.004 doi (DE-627)ELV006606563 (ELSEVIER)S0748-7983(21)00480-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Campanacci, Laura verfasserin (orcid)0000-0002-4734-6741 aut Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) Bianchi, Giuseppe verfasserin aut Cevolani, Luca verfasserin (orcid)0000-0002-3190-1034 aut Errani, Costantino verfasserin aut Ciani, Giovanni verfasserin aut Facchini, Giancarlo verfasserin (orcid)0000-0002-6739-7335 aut Spinnato, Paolo verfasserin aut Tognù, Andrea verfasserin aut Massari, Leo verfasserin aut Cornelis, Francois H. verfasserin (orcid)0000-0002-1058-0884 aut Mosconi, Mario verfasserin aut Screpis, Daniele verfasserin aut Benazzo, Francesco verfasserin aut Rossi, Barbara verfasserin aut Bonicoli, Enrico verfasserin aut Fazioli, Flavio verfasserin aut Nicolosi, Mario verfasserin aut Boffano, Michele verfasserin aut Piana, Raimondo verfasserin aut De Terlizzi, Francesca verfasserin (orcid)0000-0002-2676-4549 aut Cadossi, Matteo verfasserin aut Donati, Davide Maria verfasserin (orcid)0000-0002-9170-0576 aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 47 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 47 |
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Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) |
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Campanacci, Laura @@aut@@ Bianchi, Giuseppe @@aut@@ Cevolani, Luca @@aut@@ Errani, Costantino @@aut@@ Ciani, Giovanni @@aut@@ Facchini, Giancarlo @@aut@@ Spinnato, Paolo @@aut@@ Tognù, Andrea @@aut@@ Massari, Leo @@aut@@ Cornelis, Francois H. @@aut@@ Mosconi, Mario @@aut@@ Screpis, Daniele @@aut@@ Benazzo, Francesco @@aut@@ Rossi, Barbara @@aut@@ Bonicoli, Enrico @@aut@@ Fazioli, Flavio @@aut@@ Nicolosi, Mario @@aut@@ Boffano, Michele @@aut@@ Piana, Raimondo @@aut@@ De Terlizzi, Francesca @@aut@@ Cadossi, Matteo @@aut@@ Donati, Davide Maria @@aut@@ |
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2021-01-01T00:00:00Z |
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Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. 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Campanacci, Laura |
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Campanacci, Laura ddc 610 bkl 44.81 bkl 44.65 misc Electrochemotherapy (ECT) misc Bone metastases misc Pain control misc Palliative care misc Metastatic bone disease (MBD) Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
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610 DE-600 44.81 bkl 44.65 bkl Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients Electrochemotherapy (ECT) Bone metastases Pain control Palliative care Metastatic bone disease (MBD) |
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ddc 610 bkl 44.81 bkl 44.65 misc Electrochemotherapy (ECT) misc Bone metastases misc Pain control misc Palliative care misc Metastatic bone disease (MBD) |
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ddc 610 bkl 44.81 bkl 44.65 misc Electrochemotherapy (ECT) misc Bone metastases misc Pain control misc Palliative care misc Metastatic bone disease (MBD) |
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ddc 610 bkl 44.81 bkl 44.65 misc Electrochemotherapy (ECT) misc Bone metastases misc Pain control misc Palliative care misc Metastatic bone disease (MBD) |
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Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
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Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
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Campanacci, Laura |
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European journal of surgical oncology |
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Campanacci, Laura Bianchi, Giuseppe Cevolani, Luca Errani, Costantino Ciani, Giovanni Facchini, Giancarlo Spinnato, Paolo Tognù, Andrea Massari, Leo Cornelis, Francois H. Mosconi, Mario Screpis, Daniele Benazzo, Francesco Rossi, Barbara Bonicoli, Enrico Fazioli, Flavio Nicolosi, Mario Boffano, Michele Piana, Raimondo De Terlizzi, Francesca Cadossi, Matteo Donati, Davide Maria |
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Campanacci, Laura |
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10.1016/j.ejso.2021.05.004 |
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(ORCID)0000-0002-4734-6741 (ORCID)0000-0002-3190-1034 (ORCID)0000-0002-6739-7335 (ORCID)0000-0002-1058-0884 (ORCID)0000-0002-2676-4549 (ORCID)0000-0002-9170-0576 |
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operating procedures for electrochemotherapy in bone metastases: results from a multicenter prospective study on 102 patients |
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Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
| abstract |
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. |
| abstractGer |
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. |
| abstract_unstemmed |
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions.Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered.Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up.Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. |
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| title_short |
Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients |
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| author2 |
Bianchi, Giuseppe Cevolani, Luca Errani, Costantino Ciani, Giovanni Facchini, Giancarlo Spinnato, Paolo Tognù, Andrea Massari, Leo Cornelis, Francois H. Mosconi, Mario Screpis, Daniele Benazzo, Francesco Rossi, Barbara Bonicoli, Enrico Fazioli, Flavio Nicolosi, Mario Boffano, Michele Piana, Raimondo De Terlizzi, Francesca Cadossi, Matteo Donati, Davide Maria |
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Bianchi, Giuseppe Cevolani, Luca Errani, Costantino Ciani, Giovanni Facchini, Giancarlo Spinnato, Paolo Tognù, Andrea Massari, Leo Cornelis, Francois H. Mosconi, Mario Screpis, Daniele Benazzo, Francesco Rossi, Barbara Bonicoli, Enrico Fazioli, Flavio Nicolosi, Mario Boffano, Michele Piana, Raimondo De Terlizzi, Francesca Cadossi, Matteo Donati, Davide Maria |
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| doi_str |
10.1016/j.ejso.2021.05.004 |
| up_date |
2024-07-06T21:57:18.260Z |
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1803868478648614912 |
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