Multiomic biological approaches to the study of child abuse and neglect
Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a w...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Layfield, Savannah Dee [verfasserIn] Duffy, Lucie Anne [verfasserIn] Phillips, Karlye Allison [verfasserIn] Lardenoije, Roy [verfasserIn] Klengel, Torsten [verfasserIn] Ressler, Kerry J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Pharmacology, biochemistry and behavior - Amsterdam [u.a.] : Elsevier Science, 1973, 210 |
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| Übergeordnetes Werk: |
volume:210 |
| DOI / URN: |
10.1016/j.pbb.2021.173271 |
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| 520 | |a Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. | ||
| 650 | 4 | |a Childhood adversity | |
| 650 | 4 | |a Maltreatment | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a RNA sequencing | |
| 650 | 4 | |a G × E | |
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a Risk | |
| 650 | 4 | |a Resilience | |
| 650 | 4 | |a Psychiatry | |
| 650 | 4 | |a Development | |
| 700 | 1 | |a Duffy, Lucie Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Phillips, Karlye Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Lardenoije, Roy |e verfasserin |4 aut | |
| 700 | 1 | |a Klengel, Torsten |e verfasserin |4 aut | |
| 700 | 1 | |a Ressler, Kerry J. |e verfasserin |4 aut | |
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10.1016/j.pbb.2021.173271 doi (DE-627)ELV006702627 (ELSEVIER)S0091-3057(21)00170-2 DE-627 ger DE-627 rda eng 540 DE-600 15,3 ssgn PHARM DE-84 fid 44.00 bkl 44.38 bkl 42.66 bkl 44.40 bkl Layfield, Savannah Dee verfasserin aut Multiomic biological approaches to the study of child abuse and neglect 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. Childhood adversity Maltreatment Genetics Proteomics RNA sequencing G × E Epigenetics Risk Resilience Psychiatry Development Duffy, Lucie Anne verfasserin aut Phillips, Karlye Allison verfasserin aut Lardenoije, Roy verfasserin aut Klengel, Torsten verfasserin aut Ressler, Kerry J. verfasserin aut Enthalten in Pharmacology, biochemistry and behavior Amsterdam [u.a.] : Elsevier Science, 1973 210 Online-Ressource (DE-627)320472655 (DE-600)2008734-2 (DE-576)096433515 1873-5177 nnns volume:210 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.00 Medizin: Allgemeines 44.38 Pharmakologie 42.66 Ethologie Biologie 44.40 Pharmazie Pharmazeutika AR 210 |
| spelling |
10.1016/j.pbb.2021.173271 doi (DE-627)ELV006702627 (ELSEVIER)S0091-3057(21)00170-2 DE-627 ger DE-627 rda eng 540 DE-600 15,3 ssgn PHARM DE-84 fid 44.00 bkl 44.38 bkl 42.66 bkl 44.40 bkl Layfield, Savannah Dee verfasserin aut Multiomic biological approaches to the study of child abuse and neglect 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. Childhood adversity Maltreatment Genetics Proteomics RNA sequencing G × E Epigenetics Risk Resilience Psychiatry Development Duffy, Lucie Anne verfasserin aut Phillips, Karlye Allison verfasserin aut Lardenoije, Roy verfasserin aut Klengel, Torsten verfasserin aut Ressler, Kerry J. verfasserin aut Enthalten in Pharmacology, biochemistry and behavior Amsterdam [u.a.] : Elsevier Science, 1973 210 Online-Ressource (DE-627)320472655 (DE-600)2008734-2 (DE-576)096433515 1873-5177 nnns volume:210 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.00 Medizin: Allgemeines 44.38 Pharmakologie 42.66 Ethologie Biologie 44.40 Pharmazie Pharmazeutika AR 210 |
| allfields_unstemmed |
10.1016/j.pbb.2021.173271 doi (DE-627)ELV006702627 (ELSEVIER)S0091-3057(21)00170-2 DE-627 ger DE-627 rda eng 540 DE-600 15,3 ssgn PHARM DE-84 fid 44.00 bkl 44.38 bkl 42.66 bkl 44.40 bkl Layfield, Savannah Dee verfasserin aut Multiomic biological approaches to the study of child abuse and neglect 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. Childhood adversity Maltreatment Genetics Proteomics RNA sequencing G × E Epigenetics Risk Resilience Psychiatry Development Duffy, Lucie Anne verfasserin aut Phillips, Karlye Allison verfasserin aut Lardenoije, Roy verfasserin aut Klengel, Torsten verfasserin aut Ressler, Kerry J. verfasserin aut Enthalten in Pharmacology, biochemistry and behavior Amsterdam [u.a.] : Elsevier Science, 1973 210 Online-Ressource (DE-627)320472655 (DE-600)2008734-2 (DE-576)096433515 1873-5177 nnns volume:210 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.00 Medizin: Allgemeines 44.38 Pharmakologie 42.66 Ethologie Biologie 44.40 Pharmazie Pharmazeutika AR 210 |
| allfieldsGer |
10.1016/j.pbb.2021.173271 doi (DE-627)ELV006702627 (ELSEVIER)S0091-3057(21)00170-2 DE-627 ger DE-627 rda eng 540 DE-600 15,3 ssgn PHARM DE-84 fid 44.00 bkl 44.38 bkl 42.66 bkl 44.40 bkl Layfield, Savannah Dee verfasserin aut Multiomic biological approaches to the study of child abuse and neglect 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. Childhood adversity Maltreatment Genetics Proteomics RNA sequencing G × E Epigenetics Risk Resilience Psychiatry Development Duffy, Lucie Anne verfasserin aut Phillips, Karlye Allison verfasserin aut Lardenoije, Roy verfasserin aut Klengel, Torsten verfasserin aut Ressler, Kerry J. verfasserin aut Enthalten in Pharmacology, biochemistry and behavior Amsterdam [u.a.] : Elsevier Science, 1973 210 Online-Ressource (DE-627)320472655 (DE-600)2008734-2 (DE-576)096433515 1873-5177 nnns volume:210 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_2522 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 44.00 Medizin: Allgemeines 44.38 Pharmakologie 42.66 Ethologie Biologie 44.40 Pharmazie Pharmazeutika AR 210 |
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multiomic biological approaches to the study of child abuse and neglect |
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Multiomic biological approaches to the study of child abuse and neglect |
| abstract |
Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. |
| abstractGer |
Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. |
| abstract_unstemmed |
Childhood maltreatment, occurring in up to 20-30% of the population, remains far too common, and incorporates a range of active and passive factors, from abuse, to neglect, to the impacts of broader structural and systemic adversity. Despite the effects of childhood maltreatment and adversity on a wide range of adult physical and psychological negative outcomes, not all individuals respond similarly. Understanding the differential biological mechanisms contributing to risk vs. resilience in the face of developmental adversity is critical to improving preventions, treatments, and policy recommendations. This review begins by providing an overview of childhood abuse, neglect, maltreatment, threat, and toxic stress, and the effects of these forms of adversity on the developing body, brain, and behavior. It then examines examples from the current literature of genomic, epigenomic, transcriptomic, and proteomic discoveries and biomarkers that may help to understand risk and resilience in the aftermath of trauma, predictors of traumatic exposure risk, and potential targets for intervention and prevention. While the majority of genetic, epigenetic, and gene expression analyses to date have focused on targeted genes and hypotheses, large-scale consortia are now well-positioned to better understand interactions of environment and biology with much more statistical power. Ongoing and future work aimed at understanding the biology of childhood adversity and its effects will help to provide targets for intervention and prevention, as well as identify paths for how science, health care, and policy can combine efforts to protect and promote the psychological and physiological wellbeing of future generations. |
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Multiomic biological approaches to the study of child abuse and neglect |
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Duffy, Lucie Anne Phillips, Karlye Allison Lardenoije, Roy Klengel, Torsten Ressler, Kerry J. |
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