miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely rel...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wei, Qinyao [verfasserIn] Li, Juan [verfasserIn] He, Haorong [verfasserIn] Cao, Yuchen [verfasserIn] Li, Dongmei [verfasserIn] Amevor, Felix Kwame [verfasserIn] Zhang, Yao [verfasserIn] Wang, Jianping [verfasserIn] Yu, Chunlin [verfasserIn] Yang, Chaowu [verfasserIn] Du, Huarui [verfasserIn] Jiang, Xiaosong [verfasserIn] Zhu, Qing [verfasserIn] Yin, Huadong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Theriogenology - Amsterdam [u.a.] : Elsevier Science, 1974, 177, Seite 84-93 |
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| Übergeordnetes Werk: |
volume:177 ; pages:84-93 |
| DOI / URN: |
10.1016/j.theriogenology.2021.10.011 |
|---|
| Katalog-ID: |
ELV006929524 |
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| 245 | 1 | 0 | |a miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 |
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| 520 | |a MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. | ||
| 650 | 4 | |a miR-23b-3p | |
| 650 | 4 | |a GDF9 | |
| 650 | 4 | |a Chicken | |
| 650 | 4 | |a Granulosa cells | |
| 650 | 4 | |a Cell proliferation | |
| 650 | 4 | |a Steroid hormone synthesis | |
| 700 | 1 | |a Li, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a He, Haorong |e verfasserin |0 (orcid)0000-0002-7460-2843 |4 aut | |
| 700 | 1 | |a Cao, Yuchen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Dongmei |e verfasserin |4 aut | |
| 700 | 1 | |a Amevor, Felix Kwame |e verfasserin |0 (orcid)0000-0003-2682-1993 |4 aut | |
| 700 | 1 | |a Zhang, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jianping |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Chunlin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Chaowu |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Huarui |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Xiaosong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Huadong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Theriogenology |d Amsterdam [u.a.] : Elsevier Science, 1974 |g 177, Seite 84-93 |h Online-Ressource |w (DE-627)306591952 |w (DE-600)1498777-6 |w (DE-576)263808203 |x 1879-3231 |7 nnns |
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10.1016/j.theriogenology.2021.10.011 doi (DE-627)ELV006929524 (ELSEVIER)S0093-691X(21)00381-2 DE-627 ger DE-627 rda eng 590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl Wei, Qinyao verfasserin aut miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis Li, Juan verfasserin aut He, Haorong verfasserin (orcid)0000-0002-7460-2843 aut Cao, Yuchen verfasserin aut Li, Dongmei verfasserin aut Amevor, Felix Kwame verfasserin (orcid)0000-0003-2682-1993 aut Zhang, Yao verfasserin aut Wang, Jianping verfasserin aut Yu, Chunlin verfasserin aut Yang, Chaowu verfasserin aut Du, Huarui verfasserin aut Jiang, Xiaosong verfasserin aut Zhu, Qing verfasserin aut Yin, Huadong verfasserin aut Enthalten in Theriogenology Amsterdam [u.a.] : Elsevier Science, 1974 177, Seite 84-93 Online-Ressource (DE-627)306591952 (DE-600)1498777-6 (DE-576)263808203 1879-3231 nnns volume:177 pages:84-93 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OPC-FOR GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines 48.00 Land- und Forstwirtschaft: Allgemeines AR 177 84-93 |
| spelling |
10.1016/j.theriogenology.2021.10.011 doi (DE-627)ELV006929524 (ELSEVIER)S0093-691X(21)00381-2 DE-627 ger DE-627 rda eng 590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl Wei, Qinyao verfasserin aut miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis Li, Juan verfasserin aut He, Haorong verfasserin (orcid)0000-0002-7460-2843 aut Cao, Yuchen verfasserin aut Li, Dongmei verfasserin aut Amevor, Felix Kwame verfasserin (orcid)0000-0003-2682-1993 aut Zhang, Yao verfasserin aut Wang, Jianping verfasserin aut Yu, Chunlin verfasserin aut Yang, Chaowu verfasserin aut Du, Huarui verfasserin aut Jiang, Xiaosong verfasserin aut Zhu, Qing verfasserin aut Yin, Huadong verfasserin aut Enthalten in Theriogenology Amsterdam [u.a.] : Elsevier Science, 1974 177, Seite 84-93 Online-Ressource (DE-627)306591952 (DE-600)1498777-6 (DE-576)263808203 1879-3231 nnns volume:177 pages:84-93 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OPC-FOR GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines 48.00 Land- und Forstwirtschaft: Allgemeines AR 177 84-93 |
| allfields_unstemmed |
10.1016/j.theriogenology.2021.10.011 doi (DE-627)ELV006929524 (ELSEVIER)S0093-691X(21)00381-2 DE-627 ger DE-627 rda eng 590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl Wei, Qinyao verfasserin aut miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis Li, Juan verfasserin aut He, Haorong verfasserin (orcid)0000-0002-7460-2843 aut Cao, Yuchen verfasserin aut Li, Dongmei verfasserin aut Amevor, Felix Kwame verfasserin (orcid)0000-0003-2682-1993 aut Zhang, Yao verfasserin aut Wang, Jianping verfasserin aut Yu, Chunlin verfasserin aut Yang, Chaowu verfasserin aut Du, Huarui verfasserin aut Jiang, Xiaosong verfasserin aut Zhu, Qing verfasserin aut Yin, Huadong verfasserin aut Enthalten in Theriogenology Amsterdam [u.a.] : Elsevier Science, 1974 177, Seite 84-93 Online-Ressource (DE-627)306591952 (DE-600)1498777-6 (DE-576)263808203 1879-3231 nnns volume:177 pages:84-93 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OPC-FOR GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines 48.00 Land- und Forstwirtschaft: Allgemeines AR 177 84-93 |
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10.1016/j.theriogenology.2021.10.011 doi (DE-627)ELV006929524 (ELSEVIER)S0093-691X(21)00381-2 DE-627 ger DE-627 rda eng 590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl Wei, Qinyao verfasserin aut miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis Li, Juan verfasserin aut He, Haorong verfasserin (orcid)0000-0002-7460-2843 aut Cao, Yuchen verfasserin aut Li, Dongmei verfasserin aut Amevor, Felix Kwame verfasserin (orcid)0000-0003-2682-1993 aut Zhang, Yao verfasserin aut Wang, Jianping verfasserin aut Yu, Chunlin verfasserin aut Yang, Chaowu verfasserin aut Du, Huarui verfasserin aut Jiang, Xiaosong verfasserin aut Zhu, Qing verfasserin aut Yin, Huadong verfasserin aut Enthalten in Theriogenology Amsterdam [u.a.] : Elsevier Science, 1974 177, Seite 84-93 Online-Ressource (DE-627)306591952 (DE-600)1498777-6 (DE-576)263808203 1879-3231 nnns volume:177 pages:84-93 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OPC-FOR GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines 48.00 Land- und Forstwirtschaft: Allgemeines AR 177 84-93 |
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10.1016/j.theriogenology.2021.10.011 doi (DE-627)ELV006929524 (ELSEVIER)S0093-691X(21)00381-2 DE-627 ger DE-627 rda eng 590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl Wei, Qinyao verfasserin aut miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis Li, Juan verfasserin aut He, Haorong verfasserin (orcid)0000-0002-7460-2843 aut Cao, Yuchen verfasserin aut Li, Dongmei verfasserin aut Amevor, Felix Kwame verfasserin (orcid)0000-0003-2682-1993 aut Zhang, Yao verfasserin aut Wang, Jianping verfasserin aut Yu, Chunlin verfasserin aut Yang, Chaowu verfasserin aut Du, Huarui verfasserin aut Jiang, Xiaosong verfasserin aut Zhu, Qing verfasserin aut Yin, Huadong verfasserin aut Enthalten in Theriogenology Amsterdam [u.a.] : Elsevier Science, 1974 177, Seite 84-93 Online-Ressource (DE-627)306591952 (DE-600)1498777-6 (DE-576)263808203 1879-3231 nnns volume:177 pages:84-93 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OPC-FOR GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines 48.00 Land- und Forstwirtschaft: Allgemeines AR 177 84-93 |
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Enthalten in Theriogenology 177, Seite 84-93 volume:177 pages:84-93 |
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miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis |
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Theriogenology |
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Wei, Qinyao @@aut@@ Li, Juan @@aut@@ He, Haorong @@aut@@ Cao, Yuchen @@aut@@ Li, Dongmei @@aut@@ Amevor, Felix Kwame @@aut@@ Zhang, Yao @@aut@@ Wang, Jianping @@aut@@ Yu, Chunlin @@aut@@ Yang, Chaowu @@aut@@ Du, Huarui @@aut@@ Jiang, Xiaosong @@aut@@ Zhu, Qing @@aut@@ Yin, Huadong @@aut@@ |
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2021-01-01T00:00:00Z |
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Wei, Qinyao ddc 590 fid BIODIV bkl 42.00 bkl 48.00 misc miR-23b-3p misc GDF9 misc Chicken misc Granulosa cells misc Cell proliferation misc Steroid hormone synthesis miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 |
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590 DE-600 BIODIV DE-30 fid 42.00 bkl 48.00 bkl miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 miR-23b-3p GDF9 Chicken Granulosa cells Cell proliferation Steroid hormone synthesis |
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Wei, Qinyao Li, Juan He, Haorong Cao, Yuchen Li, Dongmei Amevor, Felix Kwame Zhang, Yao Wang, Jianping Yu, Chunlin Yang, Chaowu Du, Huarui Jiang, Xiaosong Zhu, Qing Yin, Huadong |
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mir-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting gdf9 |
| title_auth |
miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 |
| abstract |
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. |
| abstractGer |
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. |
| abstract_unstemmed |
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct post-transcriptional repression of mRNA targets in diverse eukaryotic lineages. Granulosa cells (GCs) are the earliest differentiated follicular somatic cells. From the initiation of primordial follicles, their differentiation and growth are closely related to the development of follicles. The research on follicular development mostly focused on the granular layer, as well as the hormone synthesis induced by granulosa cell differentiation before and after follicular selection. In this study, we evaluated the effects of miR-23b-3p on chicken granulosa cells, including granulosa cell proliferation and steroid hormone synthesis. Elevated expression of miR-23b-3p significantly inhibited granulosa cell proliferation and steroid hormone synthesis, but did not affect apoptosis. Furthermore, it was observed that the forecast growth differentiation factor 9 (GDF9) is a target gene of miR-23b-3p and miR-23b-3p can down-regulate expression of GDF9. Overall, this study demonstrated that miR-23b-3p can regulate the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. |
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| title_short |
miR-23b-3p inhibits chicken granulosa cell proliferation and steroid hormone synthesis via targeting GDF9 |
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Li, Juan He, Haorong Cao, Yuchen Li, Dongmei Amevor, Felix Kwame Zhang, Yao Wang, Jianping Yu, Chunlin Yang, Chaowu Du, Huarui Jiang, Xiaosong Zhu, Qing Yin, Huadong |
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