MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN
MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a co...
Ausführliche Beschreibung
Autor*in: |
Guo, Kun [verfasserIn] Wang, Jialiang [verfasserIn] Shu, Ling [verfasserIn] Zhou, Guangjun [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Tissue and cell - New York, NY : Elsevier, 1969, 73 |
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Übergeordnetes Werk: |
volume:73 |
DOI / URN: |
10.1016/j.tice.2021.101647 |
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Katalog-ID: |
ELV006976034 |
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520 | |a MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. | ||
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allfields |
10.1016/j.tice.2021.101647 doi (DE-627)ELV006976034 (ELSEVIER)S0040-8166(21)00163-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 42.00 bkl Guo, Kun verfasserin aut MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. miR-200c PTC PTEN Prognosis Biomarker Wang, Jialiang verfasserin aut Shu, Ling verfasserin aut Zhou, Guangjun verfasserin aut Enthalten in Tissue and cell New York, NY : Elsevier, 1969 73 Online-Ressource (DE-627)32042135X (DE-600)2002599-3 (DE-576)103746897 1532-3072 nnns volume:73 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines AR 73 |
spelling |
10.1016/j.tice.2021.101647 doi (DE-627)ELV006976034 (ELSEVIER)S0040-8166(21)00163-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 42.00 bkl Guo, Kun verfasserin aut MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. miR-200c PTC PTEN Prognosis Biomarker Wang, Jialiang verfasserin aut Shu, Ling verfasserin aut Zhou, Guangjun verfasserin aut Enthalten in Tissue and cell New York, NY : Elsevier, 1969 73 Online-Ressource (DE-627)32042135X (DE-600)2002599-3 (DE-576)103746897 1532-3072 nnns volume:73 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines AR 73 |
allfields_unstemmed |
10.1016/j.tice.2021.101647 doi (DE-627)ELV006976034 (ELSEVIER)S0040-8166(21)00163-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 42.00 bkl Guo, Kun verfasserin aut MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. miR-200c PTC PTEN Prognosis Biomarker Wang, Jialiang verfasserin aut Shu, Ling verfasserin aut Zhou, Guangjun verfasserin aut Enthalten in Tissue and cell New York, NY : Elsevier, 1969 73 Online-Ressource (DE-627)32042135X (DE-600)2002599-3 (DE-576)103746897 1532-3072 nnns volume:73 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines AR 73 |
allfieldsGer |
10.1016/j.tice.2021.101647 doi (DE-627)ELV006976034 (ELSEVIER)S0040-8166(21)00163-4 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 42.00 bkl Guo, Kun verfasserin aut MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. miR-200c PTC PTEN Prognosis Biomarker Wang, Jialiang verfasserin aut Shu, Ling verfasserin aut Zhou, Guangjun verfasserin aut Enthalten in Tissue and cell New York, NY : Elsevier, 1969 73 Online-Ressource (DE-627)32042135X (DE-600)2002599-3 (DE-576)103746897 1532-3072 nnns volume:73 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 42.00 Biologie: Allgemeines AR 73 |
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MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN |
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(DE-627)ELV006976034 (ELSEVIER)S0040-8166(21)00163-4 |
title_full |
MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN |
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Guo, Kun |
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Tissue and cell |
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Tissue and cell |
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eng |
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500 - Science |
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marc |
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2021 |
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zzz |
author_browse |
Guo, Kun Wang, Jialiang Shu, Ling Zhou, Guangjun |
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73 |
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Elektronische Aufsätze |
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Guo, Kun |
doi_str_mv |
10.1016/j.tice.2021.101647 |
dewey-full |
570 |
author2-role |
verfasserin |
title_sort |
mir-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating pten |
title_auth |
MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN |
abstract |
MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. |
abstractGer |
MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. |
abstract_unstemmed |
MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR. Survival analysis was performed in a cohort of 88 PTC patients. The effects of miR-200c on cell proliferation, migration, and invasion capacities were analyzed using CCK-8 and transwell assays. Target genes of miR-200c were assessed using luciferase reporter assay, RT-qPCR, Western blot and rescue experiments. MiR-200c was found to be upregulated in human PTC tissues and closely associated with pN stage and distant metastasis. High expression of miR-200c was associated with poor clinical prognosis in PTC patients. Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. Bioinformatics analysis and luciferase reporter assays confirmed that PTEN is a downstream target of miR-200c. Functional assays demonstrated that PTC cell proliferation, migration, and invasion were promoted by miR-200c via negative regulation of PTEN. Finally, overexpression of PTEN was shown to partially reverse the tumor promoting effect of miR-200c. In conclusion, this study indicates that miR-200c is a crucial prognostic biomarker of PTC, and that targeting of miR-200c/ PTEN axis may be of therapeutic significance in PTC patients. |
collection_details |
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title_short |
MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN |
remote_bool |
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author2 |
Wang, Jialiang Shu, Ling Zhou, Guangjun |
author2Str |
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doi_str |
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up_date |
2024-07-06T23:11:40.225Z |
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