Effect of medium chain fatty acid in human health and disease

Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Roopashree, P.G. [verfasserIn] Shetty, Shilpa S. [verfasserIn] Suchetha Kumari, N. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Medium chain triglycerides Medium chain fatty acid GPR84 GPR40 Obesity Cancer

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 87
Übergeordnetes Werk:	volume:87

DOI / URN:	10.1016/j.jff.2021.104724

Katalog-ID:	ELV007101651

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520			\|a Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84.
650		4	\|a Medium chain triglycerides
650		4	\|a Medium chain fatty acid
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650		4	\|a Obesity
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700	1		\|a Suchetha Kumari, N. \|e verfasserin \|4 aut
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spelling	10.1016/j.jff.2021.104724 doi (DE-627)ELV007101651 (ELSEVIER)S1756-4646(21)00373-X DE-627 ger DE-627 rda eng 630 640 610 DE-600 Roopashree, P.G. verfasserin aut Effect of medium chain fatty acid in human health and disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84. Medium chain triglycerides Medium chain fatty acid GPR84 GPR40 Obesity Cancer Shetty, Shilpa S. verfasserin aut Suchetha Kumari, N. verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 87 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 87
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allfieldsSound	10.1016/j.jff.2021.104724 doi (DE-627)ELV007101651 (ELSEVIER)S1756-4646(21)00373-X DE-627 ger DE-627 rda eng 630 640 610 DE-600 Roopashree, P.G. verfasserin aut Effect of medium chain fatty acid in human health and disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84. Medium chain triglycerides Medium chain fatty acid GPR84 GPR40 Obesity Cancer Shetty, Shilpa S. verfasserin aut Suchetha Kumari, N. verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 87 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 87
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author	Roopashree, P.G.
spellingShingle	Roopashree, P.G. ddc 630 misc Medium chain triglycerides misc Medium chain fatty acid misc GPR84 misc GPR40 misc Obesity misc Cancer Effect of medium chain fatty acid in human health and disease
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topic_unstemmed	ddc 630 misc Medium chain triglycerides misc Medium chain fatty acid misc GPR84 misc GPR40 misc Obesity misc Cancer
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title	Effect of medium chain fatty acid in human health and disease
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title_full	Effect of medium chain fatty acid in human health and disease
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title_sort	effect of medium chain fatty acid in human health and disease
title_auth	Effect of medium chain fatty acid in human health and disease
abstract	Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84.
abstractGer	Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84.
abstract_unstemmed	Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary supplementation with MCFAs can improve metabolic features as well as cognition in humans. Some of the effects of MCFAs may be through direct receptor-mediated intracellular pathways, but MCFAs are also metabolic regulators that can alter circulating levels of hormones and metabolites, and hence may indirectly mediate body metabolism. Here we describe how dietary medium chain fatty acid, previously found to improve immune response and insulin secretion via G-protein coupled receptors, can increase apoptosis in cancer cells through the activation of the EGFR/ERK/AP1 transduction pathway. MCFA-enriched diets could therefore be used to manage metabolic diseases through the modification of gut microbiota, activation of GPR 40 and GPR 84.
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title_short	Effect of medium chain fatty acid in human health and disease
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doi_str	10.1016/j.jff.2021.104724
up_date	2024-07-06T23:37:17.532Z
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Effect of medium chain fatty acid in human health and disease

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